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http://dx.doi.org/10.14406/acu.2021.023

Antidepressant Effect of Liver Tonification and Four Gate Acupuncture Treatments and Its Brain Neural Activity  

Eom, Geun-Hyang (College of Korean Medicine, Daejeon University)
Ryu, Jae-Sang (College of Korean Medicine, Daejeon University)
Park, Ji-Yeun (College of Korean Medicine, Daejeon University)
Publication Information
Korean Journal of Acupuncture / v.38, no.3, 2021 , pp. 162-174 More about this Journal
Abstract
Objectives : We aimed to identify the antidepressant effect of liver tonification acupuncture treatment (ACU (LT); KI10, LR8, LU8, LR4) and four gate acupuncture treatment (ACU (FG); LI4, LR3) and its brain neural activity in the normal and chronic restraint stress (CRS)-induced mouse model. Methods : Firstly, normal mice were given ACU (LT) or ACU (FG) and the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Secondly, CRS was administered to mice for 4 weeks, then ACU (LT) or ACU (FG) was performed for 2 weeks. The depression-like behavior was evaluated using open field test (OFT) before and after acupuncture treatment. Then, the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Results : In normal mice, ACU (FG) regulated brain neural activities in the hypothalamus, hippocampus, and periaqueductal gray. ACU (LT) changed more brain regions in the prefrontal cortex, insular cortex, striatum, and hippocampus, including those altered by ACU (FG). In CRS-induced model, ACU (LT) alleviated depression-like behavior more than ACU (FG). Also, brain neural activities in the motor cortex area 2 (M2), agranular ventral part and piriform of insular cortex (AIV and Pir), and cornu ammonis (CA) 1 and CA3 of hippocampus were changed by ACU (LT), and those of AIV and CA3 were also changed by ACU (FG). As in normal mice, ACU (LT) resulted in changes in more brain regions, including those altered by ACU (FG) in CRS model. M2, Pir, and CA1 were only changed by ACU (LT) in depression model, suggesting that these brain regions reflect the specific effect of ACU (LT). Conclusions : ACU (LT) relieved depression-like behavior more than ACU (FG), and this acupuncture effect was associated with modulation of brain neural activities in the motor cortex, insular cortex, and hippocampus.
Keywords
depression; sa-am acupuncture; liver tonification acupuncture; four gate acupuncture; brain neural activity;
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1 Park JY, Kim SN, Yoo J, Jang J, Lee A, Oh JY, et al. Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease. Mol Neurobiol. 2017 ; 54(10) : 7706-21. http://doi.org/10.1007/s12035-016-0258-8   DOI
2 Dong B, Chen Z, Yin X, Li D, Ma J, Yin P, et al. The Efficacy of Acupuncture for Treating Depression-Related Insomnia Compared with a Control Group: A Systematic Review and MetaAnalysis. BioMed Research International. 2017 ; 2017 : 9614810. http://doi.org/10.1155/2017/9614810   DOI
3 Deng D, Liao H, Duan G, Liu Y, He Q, Liu H, et al. Modulation of the default mode network in first-episode, drug-naive major depressive disorder via acupuncture at Baihui (GV20) acupoint. Front Hum Neurosci. 2016 ; 10 : 230. https://doi.org/10.3389/fnhum.2016.00230   DOI
4 Seo SY, Moon JY, Kang SY, Kwon OS, Kwon S, Bang SK, et al. An estradiol-independent BDNF-NPY cascade is involved in the antidepressant effect of mechanical acupuncture instruments in ovariectomized rats. Sci Rep. 2018 ; 8(1) : 5849. http://doi.org/10.1038/s41598-018-23824-2   DOI
5 Zhang X, Song Y, Bao T, Yu M, Xu M, Guo Y, et al. Antidepressant-like effects of acupuncture involved the ERK signaling pathway in rats. BMC Complement Altern Med. 2016 ; 16(1) : 380. https://doi.org/10.1186/s12906-016-1356-x   DOI
6 Paelecke-Habermann Y PJ, Leplow B. Attention and executive functions in remitted major depression patients. J Affect Disord. 2005 ; 89(1-3) : 125-35. http://doi.org/https://doi.org/10.1016/j.jad.2005.09.006   DOI
7 Blumenthal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KA, et al. Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosom Med. 2007 ; 69(7) : 587-96. https://doi.org/10.1097/PSY.0b013e318148c19a   DOI
8 Wu J, Yeung AS, Schnyer R, Wang Y, Mischoulon D. Acupuncture for depression: a review of clinical applications. Can J Psychiatry. 2012 ; 57(7) : 397-405. https://doi.org/10.1177/070674371205700702   DOI
9 Reddy M. Depression: the disorder and the burden. Indian J Psychol Med. 2010 ; 32(1) : 1-2. https://doi.org/10.4103/0253-7176.70510   DOI
10 Semenkovich K, Brown ME, Svrakic DM, Lustman PJ. Depression in type 2 diabetes mellitus: prevalence, impact, and treatment. Drugs. 2015 ; 75(6) : 577-87. https://doi.org/10.1007/s40265-015-0347-4   DOI
11 Bachmann S. Epidemiology of suicide and the psychiatric perspective. Int J Environ Res Public Health. 2018 ; 15(7) : 1425. https://doi.org/10.3390/ijerph15071425   DOI
12 Liu Q, Li B, Zhu HY, Wang YQ, Yu J, Wu GC. Glia atrophy in the hippocampus of chronic unpredictable stress-induced depression model rats is reversed by electroacupuncture treatment. J Affect Disord. 2011 ; 128(3) : 309-13. https://doi.org/10.1016/j.jad.2010.07.007   DOI
13 Newman DWA. Dorland's pocket medical dictionary. 25th ed. Philadelphia : Saunders; 1995.
14 Park JY, Park JJ, Jeon S, Doo AR, Kim SN, Lee H, et al. From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia. J Pain. 2014 ; 15(5) : 535-49. https://doi.org/10.1016/j.jpain.2014.01.498   DOI
15 Yang L, Zhao Y, Wang Y, Liu L, Zhang X, Li B, et al. The effects of psychological stress on depression. Curr Neuropharmacol. 2015 ; 13(4) : 494-504. https://doi.org/10.2174/1570159x1304150831150507   DOI
16 Bennett M. The prefrontal-limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain. Prog Neurobiol. 2011 ; 93(4) : 468-87. https://doi.org/10.1016/j.pneurobio.2011.01.006   DOI
17 Winokur A, Gary KA, Rodner S, Rae-Red C, Fernando AT, Szuba MP. Depression, sleep physiology, and antidepressant drugs. Depress Anxiety. 2001 ; 14(1) : 19-28. https://doi.org/10.1002/da.1043   DOI
18 Gualano M, Bert F, Martorana M, Voglino G, Andriolo V, Thomas R, et al. The long-term effects of bibliotherapy in depression treatment: Systematic review of randomized clinical trials. Clin Psychol Rev. 2017 ; 58 : 49-58. https://doi.org/10.1016/j.cpr.2017.09.006   DOI
19 David HB. Clinical handbook of psychological disorders: A step-by-step treatment manual. 4th ed. The Guilford Press. 2008 : 275-331.
20 de Mello MF, de Jesus Mari J, Bacaltchuk J, Verdeli H, Neugebauer R. A systematic review of research findings on the efficacy of interpersonal therapy for depressive disorders. Eur Arch Psychiatry Clin Neurosc. 2005 ; 255(2) : 75-82. https://doi.org/10.1007/s00406-004-0542-x   DOI
21 Zhang R, Lao L, Ren K, Berman BM. Mechanisms of acupuncture-electroacupuncture on persistent pain. Anesthesiology. 2014 ; 120(2) : 482-503. https://doi.org/10.1097/aln.0000000000000101   DOI
22 Pandya M, Altinay M, Malone DA, Anand A. Where in the brain is depression? Curr Psychiatry Rep. 2012 ; 14(6) : 634-42. https://doi.org/10.1007/s11920-012-0322-7   DOI
23 Park JY, Choi H, Baek S, Jang J, Lee A, Jeon S, et al. p53 signalling mediates acupuncture-induced neuroprotection in Parkinson's disease. Biochem Biophys Res Commun. 2015 ; 460(3) : 772-9. http://doi.org/S0006-291X(15)00571-9   DOI
24 Ferguson AV, Latchford KJ, Samson WK. The paraventricular nucleus of the hypothalamus-a potential target for integrative treatment of autonomic dysfunction. Expert Opin Ther Targets 2008 ; 12(6) : 717-27. https://doi.org/10.1517/14728222.12.6.717   DOI
25 Cui S, Zhou Y, Wu S, Cao J, Zhu G, Zhou M. Electroacupuncture improved the function of myocardial ischemia involved in the hippocampus-paraventricular nucleus-sympathetic nerve pathway. Evid Based Complement Alternat Med. 2018 ; 2018 : 2870676. https://doi.org/10.1155/2018/2870676   DOI
26 Nagai M, Kishi K, Kato S. Insular cortex and neuropsychiatric disorders: a review of recent literature. Eur Psychiatry. 2007 ; 22(6) : 387-94. https://doi.org/10.1016/j.eurpsy.2007.02.006   DOI
27 Lee IS, Cheon S, Park JY. Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review. Evid Based Complement Alternat Med. 2019 ; 2019 : 1304152. https://doi.org/10.1155/2019/1304152   DOI
28 Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, et al. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010 ; 13(7) : 883-8. http://doi.org/10.1038/nn.2562   DOI
29 Lee MJ, Ryu JS, Won SK, Namgung U, Jung J, Lee SM, et al. Effects of Acupuncture on Chronic Stress-Induced Depression-Like Behavior and Its Central Neural Mechanism. Front Psychol. 2019 ; 10 : 1353. http://doi.org/10.3389/fpsyg.2019.01353   DOI
30 Park H, Yoo D, Kwon S, Yoo TW, Park HJ, Hahm DH, et al. Acupuncture stimulation at HT7 alleviates depression-induced behavioral changes via regulation of the serotonin system in the prefrontal cortex of maternally-separated rat pups. J Physiol Sci. 2012 ; 62(4) : 351-7. http://doi.org/10.1007/s12576-012-0211-1   DOI
31 Duan G, He Q, Pang Y, Chen W, Liao H, Liu H, et al. Altered amygdala resting-state functional connectivity following acupuncture stimulation at BaiHui (GV20) in first-episode drugNaive major depressive disorder. Brain Imaging Behav. 2020 ; 14(6) : 2269-80. https://doi.org/10.1007/s11682-019-00178-5   DOI
32 Massart R, Mongeau R, Lanfumey L. Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression. Philos Trans R Soc Lond B Biol Sci. 2012 ; 367(1601) : 2485-94. https://doi.org/10.1098/rstb.2012.0212   DOI
33 Lottering B, Lin YW. TRPV1 Responses in the Cerebellum Lobules VI, VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model. Int J Mol Sci. 2021 ; 22(9) : 5028. http://doi.org/10.3390/ijms22095028   DOI
34 Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, et al. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biol Psychiatry. 2004 ; 56(2) : 101-12. https://doi.org/10.1016/j.biopsych.2004.04.002   DOI
35 Belmaker R, Agam G. Major depressive disorder. N Engl J Med. 2008 ; 358(1) : 55-68. https://doi.org/10.1056/NEJMra073096   DOI
36 Kim H, Park HJ, Han SM, Hahm DH, Lee HJ, Kim KS, et al. The effects of acupuncture stimulation at PC6 (Neiguan) on chronic mild stress-induced biochemical and behavioral responses. Neurosci Lett. 2009 ; 460(1) : 56-60. https://doi.org/10.1016/j.neulet.2009.05.008   DOI
37 Duan Dm, Tu Y, Liu P, Jiao S. Antidepressant effect of electroacupuncture regulates signal targeting in the brain and increases brain-derived neurotrophic factor levels. Neural Regen Res. 2016 ; 11(10) : 1595-602. https://doi.org/10.4103/1673-5374.193238   DOI
38 Kou RZ, Chen H, Yu Ml, Xu TC, Fu SP, Lu SF. Acupuncture for behavioral changes of experimental depressive disorder: a systematic review and meta-analysis. Sci Rep. 2017 ; 7(1) : 9669. https://doi.org/10.1038/s41598-017-09712-1   DOI
39 Liu JH, Wu ZF, Sun J, Jiang L, Jiang S, Fu WB. Role of AC-cAMP-PKA cascade in antidepressant action of electroacupuncture treatment in rats. Evid Based Complement Alternat Med. 2012 ; 2012 : 932414. https://doi.org/10.1155/2012/932414   DOI
40 Wheeler AL, Teixeira CM, Wang AH, Xiong X, Kovacevic N, Lerch JP, et al. Identification of a functional connectome for long-term fear memory in mice. PLoS Comput Biol. 2013 ; 9(1) : e1002853. http://doi.org/10.1371/journal.pcbi.1002853   DOI
41 Aggleton JP, Brown MW, Albasser MM. Contrasting brain activity patterns for item recognition memory and associative recognition memory: insights from immediate-early gene functional imaging. Neuropsychologia. 2012 ; 50(13) : 3141-55. http://doi.org/10.1016/j.neuropsychologia.2012.05.018   DOI
42 Park JY, Cho SJ, Lee SH, Ryu Y, Jang JH, Kim SN, et al. Peripheral ERK modulates acupuncture-induced brain neural activity and its functional connectivity. Sci Rep. 2021 ; 11(1) : 5128. https://doi.org/10.1038/s41598-021-84273-y   DOI
43 Jung J, Lee SM, Lee MJ, Ryu JS, Song JH, Lee JE, et al. Lipidomics reveals that acupuncture modulates the lipid metabolism and inflammatory interaction in a mouse model of depression. Brain Behav Immun. 2021 ; 94 : 424-36. http://doi.org/10.1016/j.bbi.2021.02.003   DOI
44 Gallo FT, Katche C, Morici JF, Medina JH, Weisstaub NV. Immediate early genes, memory and psychiatric disorders: focus on c-Fos, Egr1 and Arc. Front Behav Neurosci. 2018 ; 12 : 79. https://doi.org/10.3389/fnbeh.2018.00079   DOI
45 Dragunow M, Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods. 1989 ; 29(3) : 261-5. https://doi.org/10.1016/0165-0270(89)90150-7   DOI
46 Park JY, Lee SH, Kim SY, Park HJ. Literature Review and Network Analysis on the Pain Disease Approach of Saam Acupuncture Method. Korean J Acupunct. 2017 ; 34(2) : 88-99. https://doi.org/10.14406/acu.2017.011   DOI
47 Yoon MJ, Kim SY, Park JY. Recent Study Trends of the Liver-tonification and Liver-sedation of Saam Acupuncture. Korean J Acupunct. 2018 ; 35(1) : 1-17. https://doi.org/10.14406/acu.2018.004   DOI
48 Fan L, Fu WB, Xu NG, Liu JH, Ou A. Impacts of acupuncture and moxibustion on outcome indeices of depression patients' subjective reports. Zhongguo Zhen Jiu. 2012 ; 32(5) : 385-9. https://doi.org/10.1016/s1003-5257(13)60039-2   DOI
49 Shin KM, Park JE, Lee S, Choi SM, Ahn YC, Lee JW, et al. Effect of siguan acupuncture on gastrointestinal motility: a randomized, sham-controlled, crossover trial. Evid Based Complement Alternat Med. 2013 ; 2013 : 918392. https://doi.org/10.1155/2013/918392   DOI
50 Quah-Smith I, Wen W, Chen X, Williams MA, Sachdev PS. The brain effects of laser acupuncture in depressed individuals: an fMRI investigation. Medical Acupuncture. 2012 ; 24(3) : 161-71. https://doi.org/10.1089/acu.2011.0870   DOI
51 Fanselow MS, Dong HW. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron. 2010 ; 65(1) : 7-19. https://doi.org/10.1016/j.neuron.2009.11.031   DOI
52 MacQueen GM, Campbell S, McEwen BS, Macdonald K, Amano S, Joffe RT, et al. Course of illness, hippocampal function, and hippocampal volume in major depression. Focus. 2005 ; 3(1) : 146-155. https://doi.org/10.1176/foc.3.1.146   DOI
53 de Freitas RL, de Oliveira RC, de Oliveira R, Paschoalin-Maurin T, de Aguiar Correa FM, Coimbra NC. The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5-HT2A and 5-HT2C serotonergic receptors in post-ictal antinociception. Synapse. 2014 ; 68(1) : 16-30. https://doi.org/10.1002/syn.21697   DOI
54 Vink M, Kahn RS, Raemaekers M, Van Den Heuvel M, Boersma M, Ramsey NF. Function of striatum beyond inhibition and execution of motor responses. Hum Brain Mapp. 2005 ; 25(3) : 336-44. https://doi.org/10.1002/hbm.20111   DOI
55 Teka WW, Hamade KC, Barnett WH, Kim T, Markin SN, Rybak IA, et al. From the motor cortex to the movement and back again. PLoS One. 2017 ; 12(6) : e0179288. https://doi.org/10.1371/journal.pone.0179288   DOI