• Journal of Welding and Joining
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• v.15 no.4
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• pp.143-153
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• 1997

In this study, bending test was performed on the real-scale, built-up beam test model fabricated by the $CO_2$ arc spot welding to evaluate the applicability of the welding method to the production of the stiffened plate in car-carrying ship. The built-up beam models which were fixed at both ends in longitudinal direction or simply supported to the rigid foundation, depending on the restraint condition of the corresponding car decks considered, were subjected to simulated design vehicle loads or concentrated point loads. During the test, the central deflection and the longitudinal bending stresses were measured from several points on the longitudinal flange face to predict the section properties of the built-up beams. The longitudinal bending stress on each spot weld were also measured to calculate the average horizontal shear force subjected to spot welds. Test results revealed that the shear strength of spot welds with their current weld nugget size and welding pitch was adequate enough to withstand the horizontal shear forces under the design vehicle loads. Although the built-up beam fabricated by the arc spot welding was a discontinuous beam, its mechanical behavior was well explained by the continuous beam theory using the effective breadth of plate. Based on test results, the criterion for the size of spot weld of which the average shear stress might meet the allowable stress requirement of AWS Code could be established.

• Journal of Ginseng Research
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• v.42 no.1
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• pp.107-115
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• 2018

Background: Depression is one of the most commonly diagnosed neuropsychiatric diseases, but the underlying mechanism and medicine are not well-known. Although Panax ginseng has been reported to exert protective effects in various neurological studies, little information is available regarding its antidepressant effects. Methods: Here, we examined the antidepressant effect and underlying mechanism of P. ginseng extract (PGE) in a chronic restraint stress (CRS)-induced depression model in mice. Results: Oral administration of PGE for 14 d decreased immobility (depression-like behaviors) time in forced swim and tail suspended tests after CRS induction, which corresponded with attenuation of the levels of serum adrenocorticotropic hormone and corticosterone, as well as attenuated c-Fos expression in the amygdala. PGE enhanced messenger RNA expression level of brain-derived neurotrophic factor but ameliorated microglial activation and neuroinflammation (the level of messenger RNA and protein expression of cyclooxygenase-2 and inducible nitric oxide synthase) in the amygdala of mice after CRS induction. Interestingly, 14-d treatment with celecoxib, a selective cyclooxygenase-2 inhibitor, and $N_{\omega}$-nitro-L-arginine methyl ester hydrochloride, a selective inducible nitric oxide synthase inhibitor, attenuated depression-like behaviors after CRS induction. Additionally, PGE inhibited the upregulation of the nuclear factor erythroid 2 related factor 2 and heme oxygenase-1 pathways. Conclusion: Taken together, our findings suggest that PGE exerts antidepressant-like effect of CRS-induced depression by antineuroinflammatory and antioxidant (nuclear factor erythroid 2 related factor 2/heme oxygenase-1 activation) activities by inhibiting the hypothalamo-pituitary-adrenal axis mechanism. Further studies are needed to evaluate the potential of components of P. ginseng as an alternative treatment of depression, including clinical trial evaluation.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.6
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• pp.1393-1403
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• 2003

The genetic effects of restraint stress challenge on HPA axis and the therapeutic effect of Boshimgeonbi-Tang on the stress were studied with cDNA microarray analyses on hypothalamus using an immobilization-stress mouse as stress model. Male CD-1 mice were restrained in a tightly fitted and ventilated vinyl holder for 2hours once a day, and this challenge was repeated for seven consecutive days. The body weights of the immobilization-stress mice were diminished about 25 percent degree as compared to normal ones. Seven days later, total RNA was extracted from the organs of the mouse, body-labeled with CyDye/sup TM/ fluorescence dyes (Amersham Bioscience Co., NJ), and then hybridized to cDNA microarray chip. Scanning and analyzing the array slides were carried out using GenePix 4000 series scanner and GenePix Pro/sup TM/ analyzing program, respectively. The expression profiles of 109 genes out of 6000 genes on the chip were significantly modulated in hypothalamus by the immobilization stress. Energy metabolism-, lipid metabolism-, apoptosis- and signal transduction-related genes were transcriptionally activated whereas DNA repair-, protein biosynthesis-, and structure integrity-related genes were down-regulated in hypothalamus. The 58 genes were up-regulated by the mRNA expression folds of 1.5 to 7.9. and the 51 genes were down-regulated by 1.5 - 3.5 fold. The 20 genes among them were selected to confirm the expression profiles by RT-PCR. The mRNA expression levels of Tnfrsf1a (apoptosis), Calm2 (cell cycle), Bag3 (apoptosis), Hspe1 (protein folding), Aatk (apoptosis), Dffa (apoptosis), Itgb1 (cell adhesion), Vcam1 (cell adhesion), Fkbp5 (protein folding), BDNF (neuron survival) were restored to the normal one by the treatment of Boshimgeonbi-Tang.

• Journal of Welding and Joining
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• v.17 no.6
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• pp.53-61
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• 1999

The use of thick plate in increasing in recent years due to the rapid expansion of chemical plants, nuclear plants, ships and other industrial plants. Welding is the most popular joining techniques employed in manufacturing industrial machineries and structures. Normally, Groove shapes are prepared according to appropriate rules and regulations such as KS, JIS, AWS, LR, DNV and etc. for various thicknesses of plate. However those groove angles tend to be too large. As a result of large groove angle, residual stress, deformation of material and strength reduction is obtained. Therefore, the reliability and safety of structures and machinery tend to be decreasing. Therefore, in this paper, theoretical as well as experimental study are carried out to find optimum groove shapes for T-welded joint of mild steel. The test specimen are made in same condition with simulation model. Welding residual stresses measurement by sectional cutting method. ⅰ) The mechanical difference for change the thickness of plate and groove angle are not appeared. ⅱ) In a mechanical point of view minimum preparation angle(40°) is more suitable than maximum groove angle(60℃). ⅲ) The measurement value and distribution of welding residual stresses are not effected largely by groove angle. It is mechanical restraint that mainly affect welding residual stresses distribution. In mechanical point of view minimum groove angle is more suitable than maximum groove angle. Therefore, it is appropriate to minimize the size of groove shape in strength and safety.

• Korean Journal of Acupuncture
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• v.38 no.3
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• pp.162-174
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• 2021

Objectives : We aimed to identify the antidepressant effect of liver tonification acupuncture treatment (ACU (LT); KI10, LR8, LU8, LR4) and four gate acupuncture treatment (ACU (FG); LI4, LR3) and its brain neural activity in the normal and chronic restraint stress (CRS)-induced mouse model. Methods : Firstly, normal mice were given ACU (LT) or ACU (FG) and the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Secondly, CRS was administered to mice for 4 weeks, then ACU (LT) or ACU (FG) was performed for 2 weeks. The depression-like behavior was evaluated using open field test (OFT) before and after acupuncture treatment. Then, the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Results : In normal mice, ACU (FG) regulated brain neural activities in the hypothalamus, hippocampus, and periaqueductal gray. ACU (LT) changed more brain regions in the prefrontal cortex, insular cortex, striatum, and hippocampus, including those altered by ACU (FG). In CRS-induced model, ACU (LT) alleviated depression-like behavior more than ACU (FG). Also, brain neural activities in the motor cortex area 2 (M2), agranular ventral part and piriform of insular cortex (AIV and Pir), and cornu ammonis (CA) 1 and CA3 of hippocampus were changed by ACU (LT), and those of AIV and CA3 were also changed by ACU (FG). As in normal mice, ACU (LT) resulted in changes in more brain regions, including those altered by ACU (FG) in CRS model. M2, Pir, and CA1 were only changed by ACU (LT) in depression model, suggesting that these brain regions reflect the specific effect of ACU (LT). Conclusions : ACU (LT) relieved depression-like behavior more than ACU (FG), and this acupuncture effect was associated with modulation of brain neural activities in the motor cortex, insular cortex, and hippocampus.

• Geomechanics and Engineering
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• v.7 no.5
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• pp.495-524
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• 2014

To investigate the soil-pile interactive performance under lateral loads, a set of laboratory model tests was conducted on remoulded test bed of soft clay and medium dense sand. Then, a simplified boundary element analysis had been carried out assuming floating pile. In case of soft clay, it has been observed that lateral loads on piles can initiate the formation of a gap, soil heave and the tension crack in the vicinity of the soil surface and the interface, whereas in medium dense sand, a semi-elliptical depression zone can develop. Comparison of test and boundary element results indicates the accuracy of the solution developed. However, in the boundary element analysis, the possible shear stresses likely to be developed at the interface are ignored in order to simplify the existing complex equations. Moreover, it is unable to capture the influence of base restraint in case of a socketed pile. To bridge up this gap and to study the influence of the initial stress state and interface parameters, a field based case-study of laterally-loaded pile in layered soil with socketed tip is explored and modelled using the finite element method. The results of the model have been verified against known field measurements from a case-study. Parametric studies have been conducted to investigate the influence of the coefficient of lateral earth pressure and the interface strength reduction factor on the results of the model.

• Journal of Korean Society of Steel Construction
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• v.29 no.4
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• pp.281-289
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• 2017

The current AASHTO LRFD and Eurocode 3 specifications have been found to underestimate the flexural strength of longitudinally reinforced plate girders. This is because the web-flange interaction is not considered appropriately when a web is reinforced. The buckling strength of compression flange increases due to the improved rotational restraint to the compression flange. Also, the compression flange and the longitudinal stiffener could constrain the web rotation, so that a certain area of the web reaches yield strength. In this study, a model for evaluating the flexural strength is proposed for plate girders reinforced with one line of longitudinal stiffeners, considering the increase of the buckling strength of the compression flange and the actual stress distribution of the web. The flexural strengths of the conventional steel(SM490) and the high-strength steel(HSB800) plate girders were evaluated from the nonlinear analysis and the applicability of the proposed model was analyzed.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.750-758
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• 2009

This study, as basic research which was intended to develope the surface reinforcement method using reinforcement material which is applicable to very soft ground in Korea, was aimed at proposing the design parameter for the surface ground improvement method. To that end, a wide width tensile test using geotextile, geogrid and steel bar (substitute for bamboo) and 25 kinds of the laboratory model tests with the end restraint conditions of the reinforcement that comprises the constrained and partially constrained (3 types) conditions were conducted. And the result indicated that the modulus of subgrade reaction or $N_c$ value (5.3) apparently overestimated the bearing capacity of very soft ground such as dredged ground. Moreover, as a result of model test by partially constraining the preload of 23.0kgf using geotextile, the effect of bearing capacity($q_1$) appeared to be the largest till the loading stress was $0.4tf/m^2$ due to cohesion, while it reached 75% of the maximum bearing force after $0.4tf/m^2$ due to increase in the effect of bearing capacity($q_2$) caused by the tensile force of the reinforcement. Such results tended to have appeared constantly or very similarly with each other, irrespective of the type of reinforcement (geogrid, steel bar) and constraint conditions.

• International Journal of Highway Engineering
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• v.16 no.2
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• pp.25-34
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• 2014

PURPOSES : This paper numerically evaluates the contribution of transverse steel to the structural behavior of continuously reinforced concrete pavements to understand the role of transverse steel. METHODS : Two-lane continuously reinforced concrete pavements with and without transverse steel were analyzed through finite element analysis with the aid of commercial finite element analysis program DIANA; the difference in their structural behavior such as deflection, joint opening, and stress distribution was then evaluated. Twenty-node brick elements and three-node beam elements were used to model concrete and steel, respectively. Sub-layers were modeled with horizontal and vertical tensionless spring elements. The interactions between steel and surrounding concrete were considered by connecting their nodes with three orthogonal spring elements. Both wheel loading and environmental loading in addition to self-weight were considered. RESULTS : The use of transverse steel in continuously reinforced concrete pavements does not have significant effects on the structural behavior. The surface deflections change very little with the use of transverse steel. The joint opening decreases when transverse steel is used but the reduction is quite small. The transverse concrete stress, rather, increases when transverse steel is used due to the restraint exerted by the steel but the increase is quite small as well. CONCLUSIONS : The main role of transverse steel in continuously reinforced concrete pavements is supporting longitudinal steel and/or controlling unexpected longitudinal cracks rather than enhancing the structural capacity.

• Journal of Life Science
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• v.32 no.8
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• pp.601-610
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• 2022

P. tenebrifer (PT) belongs to the Diptera order and Stratiomyidae family. Recently, insect industry have been focused as food, animal feed and environmental advantages. γ-aminobutyric acid (GABA) and melatonin have been associated with regulating sleep and depression. GABA is the primary inhibitory neurotransmitter and is synthesized via biotransformation of monosodium glutamate (MSG) to GABA by lactic acid bacteria. In this study, we first used a GABA-enhanced PT extract, wherein GABA was enhanced by feeding MSG to PT. The underlying mechanisms preventing stress and insomnia were investigated in a corticosterone (CORT)-induced endoplasmic reticulum (ER) stress and chronic restraint stress (CRS)-exposed mouse model, as well as in pentobarbital (45 mg/kg)-induced sleep behaviors in mice. In the present study, the GABA peak was detected in high-performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) analysis and showed in Ptecticus tenebrifer water extract (PTW) but not in non-PTW extract. The results showed that PTW and Ptecticus tenebrifer with 70% ethanol extract (PTE) exerted neuroprotective effects by protecting against CORT-induced downregulation of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and cAMP-response element binding protein (CREB) expression. In addition, PTW (300 mg/kg) significantly reduced CORT levels in CRS-exposed mice. Furthermore, PTW (100 and 300 mg/kg) significantly reduced sleep latency and increased total sleep duration in pentobarbital (45 mg/kg)-induced sleeping behaviors, which was related to serum melatonin levels. In conclusion, our results suggest that PTW exerts anti-stress and sleep-enhancing effects by regulating serum CORT and melatonin levels.