• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.309-318
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• 2024

Compared to other organs, the brain has limited antioxidant defenses. In particular, the hippocampus is the central region for learning and memory and is highly susceptible to oxidative stress. Glial cells are the most abundant cells in the brain, and sustained glial cell activation is critical to the neuroinflammation that aggravates neuropathology and neurotoxicity. Therefore, regulating glial cell activation is a promising neurotherapeutic treatment. Quinic acid (QA) and its derivatives possess anti-oxidant and anti-inflammatory properties. Although previous studies have evidenced QA's benefit on the brain, in vivo and in vitro analyses of its anti-oxidant and anti-inflammatory properties in glial cells have yet to be established. This study investigated QA's rescue effect in lipopolysaccharide (LPS)-induced behavior impairment. Orally administering QA restored social impairment and LPS-induced spatial and fear memory. In addition, QA inhibited proinflammatory mediator, oxidative stress marker, and mitogen-activated protein kinase (MAPK) activation in the LPS-injected hippocampus. QA inhibited nitrite release and extracellular signal-regulated kinase (ERK) phosphorylation in LPS-stimulated astrocytes. Collectively, QA restored impaired neuroinflammation-induced behavior by regulating proinflammatory mediator and ERK activation in astrocytes, demonstrating its potential as a therapeutic agent for neuroinflammation-induced brain disease treatments.

• Fire Science and Engineering
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• v.33 no.6
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• pp.35-42
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• 2019

The aim of this study is to investigate the direction of improvement of safety experience education through the analysis of the evacuation time experiment. For the study, test subjects were divided into groups of similar body size and weight. The test subjects were directly experienced four evacuation devices, and the experience time was measured. As a result of the analysis of the total time from the installation of the evacuation device to the escape, the time was measured in the order of Descending Life Line-Tilt-Down Rescue Line-Vertical Escape Chute-air safety mat. In the case of evaluating the evacuation time using evacuation mechanisms, the evacuation time was measured in the order of air safety mat-Tilt-Tilt-Down Rescue Line-Descending Life Line-Vertical Escape Chute. In the first and second experiments of the Descending Life Line, time differences were observed. The escape time using the Descending Life Line was reduced in the second experiment than in the first experiment. As shown in this result, education through experience has shown that behavioral confidence and time can be managed. The conclusion of this study is that the goal of safety education is to minimize human life and property damage. Therefore, in order to bring this effect to more people, it is necessary to make efforts to keep self-safe through experiential education.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.1
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• pp.25-33
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• 2016

Ion channels in carcinoma and their roles in cell proliferation are drawing attention. Intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$)-dependent signaling affects the fate of cancer cells. Here we investigate the role of $Ca^{2+}$-activated $K^+$ channel (SK4) in head and neck squamous cell carcinoma cells (HNSCCs) of dif-ferent cell lines; SNU-1076, OSC-19 and HN5. Treatment with $1{\mu}M$ ionomycin induced cell death in all the three cell lines. Whole-cell patch clamp study suggested common expressions of $Ca^{2+}$-activated $Cl^-$ channels (Ano-1) and $Ca^{2+}$-activated nonselective cation channels (CAN). 1-EBIO, an activator of SK4, induced outward $K^+$ current (ISK4) in SNU-1076 and OSC-19. In HN5, ISK4 was not observed or negligible. The 1-EBIO-induced current was abolished by TRAM-34, a selective SK4 blocker. Interestingly, the ionomycin-induced cell death was effectively prevented by 1-EBIO in SNU-1076 and OSC-19, and the rescue effect was annihilated by combined TRAM-34. Con-sistent with the lower level of ISK4, the rescue by 1-EBIO was least effective in HN5. The results newly demonstrate the role of SK4 in the fate of HNSCCs under the $Ca^{2+}$ overloaded condition. Pharmacological modulation of SK4 might provide an intriguing novel tool for the anti-cancer strategy in HNSCC.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.6
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• pp.4040-4047
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• 2015

The purpose of this study was to analyze a change in Post-traumatic Stress Disorder (PTSD) level and the continuity of the effects in music therapy by applying short-term music therapy program in fire fighters with Post-traumatic Stress (PTS). Forty two fire fighters in 3 districts were randomly assigned to experimental group (21 subjects) and control group (21 subjects). Music therapy was applied in totally 10 sessions by two sessions (120 minutes) a day for 5 days. PTS level was measured immediately after the end of program, after 4 weeks, and after 12 weeks. As a result, PTS level has significantly decreased into $8.90{\pm}4.55$ from $26.52{\pm}2.32$ right after the music therapy program(p<0.05). And the effect was shown to be continued significantly up to after 4 weeks($11.95{\pm}4.57$) and after 12 weeks($13.76{\pm}5.62$)(p<0.05). As a result of research, it is considered that the music therapy is effective approach for reduction in PTS as for fire fighters who belong to the group with high risk of PTSD. Accordingly, the application of regular program for managing fire fighters' mental health is understood to likely to contribute to enhancing the field service competence.

• The Korean Journal of Zoology
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• v.27 no.3
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• pp.127-136
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• 1984

The specification of dorsal/ventral axis in the egg of Xenopus laevis was investigated as a series of oblique orientation to gravity by tilt and clinostat. The results are as follows. (1) If the eggs were oriented, in the early period after fertilization, to novel gravity by $15^\\circ, 30^\\circ, 45^\\circ$ and $60^\\circ$ tilt until gastrula stage, the site of involution was usually formed in the OpG side (the side opposing gravity). As the degree of tilt was raised from $15^\\circ to 60^\\circ$, the rate of relocation of the involution site was proportionally increased. (2) When UV-irradiated eggs were tilted period to first cleavage by $15^\\circ, 30^\\circ, 45^\\circ$ and $6\^\\circ$, the effect of UV syndrome was rescued, and the extent of rescue was propotional to the tilt degree. (3) The fertile eggs were loaded on the clinostats of several speeds. In the range of low speeds between $0.45 \\sim 9.0$ rph, the location of dorsal lip was dependent on the direction of rotation, and in $40 \\sim 360$ rph, lip was formed at a random position. In addition, some of the tadpoles experienced with clinostat showed the typical syndrome of "dorsal axis reduction". The above results were discussed regarding the mechanism of the establishment of dorsal/ventral palarity. palarity.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.8
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• pp.336-342
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• 2018

Noise reduction is an important issue in auxiliary power unit(APU) of tracking equipments for using military. In this study, we designed and tested reduction methods of structure borne noise and airborne source noise at the auxiliary power unit. From the bench test results, it is found that the effect of noise reduction is about 22 dB(A) if the silencer is redesigned, which is the rescue structure. However, the influence of noise reduction by air is insufficient. In addition, it is confirmed that the effect of noise reduction is excellent when structure borne noise reduction is applied to the vehicle. We expected that the test results of this study are used as basic data to reduce the noise of other tracking equipment developed later.

• Journal of the Korea Convergence Society
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• v.11 no.2
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• pp.309-314
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• 2020

This study was designed to investigate the antioxidant effects of 10 kinds of medicinal plants and vegetable extracts and total extracts. The cytotoxicity was measured by MTS assay, and the antioxidant activity was measured by DPPH free radical scavenging activity and Riboflavin-derived superoxide inhibitory activity (SQA). As a result, cytotoxicity was safe for all 10 medicinal plants, vegetable extracts and total extracts. DPPH free radical scavenging ability was observed in Cinnamomum cassia Blume, Eugenia caryophyllata Thunb. Arctium lappa, Total extract was excellent, and Riboflavin-derived superoxide inhibitory activity (SQA) was found in Cinnamomum cassia Blume, Arctium lappa, Prunus mume Sieb. et Zucc., Excellent, but total extract showed the best antioxidant effect. As a result of comparing the antioxidant effects of medicinal plants and vegetables using traditional ingredients, the antioxidant activity was increased when used as a mixture than when used alone. It is considered that it can be used as an antioxidant functional material, and it is expected to be of value when developing antioxidant material in the future.

• PNF and Movement
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• v.17 no.3
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• pp.481-486
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• 2019

Purpose: This study examined the effect of calf muscle fatigue on postural sway according to foot posture (a pes cavus, a normal foot, and a pes planus). Methods: The subjects of this study were 12, 11, and 9 students of U University with a pes cavus, a normal foot, and a pes planus, respectively, according to a Navicular Drop Test. Postural sway was measured with a balance instrument (BioRescue, RM Ingenierie, France) while the subjects stood static on two legs as well as during one-leg standing using the dominant leg in two conditions (with the eyes open and with the eyes closed for 30 seconds). Muscle fatigue was then induced in the calf muscle of the dominant leg, and both muscle fatigue and postural sway were measured using an EMG. To compare the degree of postural sway between the three groups after muscle fatigue was induced, the change values were calculated. The results were analyzed using a Kruskal-Wallis test, and a post-hoc test was conducted using the Bonferroni correction. Results: Significant inter-group differences were detected for postural sway during two-leg standing with the eyes closed and during one-leg standing with the eyes open and with the eyes closed (p<0.05). The post-hoc test showed significant differences between the pes cavus and normal foot groups and between the pes planus and normal foot groups for all three variables (p<0.05). However, no significant difference was detected between the pes cavus and pes planus groups (p>0.05). Conclusion: The results of this study show that the pes cavus and pes planus cause more fatigue and postural sway than a normal foot. Therefore, attention should be paid to changes in balance caused by muscle fatigue.

• Journal of the Korean Society of Safety
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• v.34 no.5
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• pp.15-21
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• 2019

A rack-type warehouse has the advantage of storing a large amount in a small area by loading goods vertically. But in terms of fire risk, the fire load is very high, which can cause massive damage in the event of a fire. In the United States, research has been actively conducted to minimize the spread of vertical fires, and relevant standards have been established and operated. In Korea, research and related standards are insufficient to prevent the vertical spread of rack-type warehouse fires. In this study, an experimental study was conducted to prevent the vertical spread of a rack-type warehouse fire using a horizontal barrier and in-rack sprinklers. As a result of the test, the horizontal barrier considering the continuous flame prevented the vertical spread of the flame for a certain time. However, the horizontal barrier with continuous flame did not show the effect of preventing continuous flame. The combination of the horizontal barrier and the in-rack sprinkler prevented the vertical spread of fire effectively. In addition, the heat collecting effect through the horizontal barrier was shown and helped the early operation of the in-rack sprinklers.

• Journal of the Korea Convergence Society
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• v.12 no.9
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• pp.179-183
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• 2021

This study was carried out examine the effect of Celeriac Extract, which contains various anticancer ingredients, on the proliferation inhibition of human-derived cancer cells and the degree of inhibition. The five cell lines used in the experiment were lung cancer cells A549, prostate cancer cells DU-145, uterine cancer cells HeLa, breast cancer cells MCF-7, and liver cancer cells SNU-182. All cancer cells derived from the human body were used, and the inhibition of cancer cell proliferation with Celeriac Extract 10ug/mL, 100ug/mL, and 1000ug/mL was measured using the CCK-8 method. As a result of examining the inhibition of cancer cell proliferation, Celeriac Extract 1000ug/mL showed significant proliferation inhibition in lung cancer cells A549, prostate cancer cells DU-145, uterine cancer cells HeLa, and liver cancer cells SNU-182, and showed a concentration dependence. However, only a concentration-dependent decrease was observed in breast cancer cells MCF-7.In conclusion, it can be seen that the cell proliferation inhibition mechanisms of Celeriac Extract using various human-derived cancer cell lines provide the potential for cancer prevention and therapeutic development.