• 지역사회간호학회지
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• 제14권3호
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• pp.507-519
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• 2003

Purpose: The purpose of this study was to identify the prevalence, health behaviors, and control of hypertension in rural areas in Korea. Method: A total of 927 subjects above age 20 were selected from the areas which fell under the jurisdiction of the 24 Community Health Center located in Chungcheongbuk-do. The employees in the Community Health Center visited and interviewed patients. Data were collected using a questionnaire from July to October 2002. Result: The result showed that women had higher hypertension prevalence rates than men and the increment of its rate leveled up according to age. The hypertension prevalence rate was significantly high when the monthly income was less than 1 million won, their type of the Medical Insurance was the Guardian, they were only able to read Korean characters, and they were bereaved of spouses. In the Health behavior related to hypertension, the hypertension group showed a significantly lower level than the non- hypertension group in terms of drinking rate, smoking rate, intake of salt and intake of meat. There was no significant difference in the exercise rate and coffee intake rate between these groups. In the degree of the obesity the hypertension group was significantly higher than the non-hypertension group. The factors related to hypertension were that the duration for the incidence of hypertension was 12 to 60 months and took up 41.2%. The places where the medical check-ups occurred were the Community Health Center at 46.6%, the medical institution was mostly hospitals recording 46.5%. There were 66.1% of the targets who knew well about their blood pressure and there were 64.7% people who received education about it. As for the education place, the rate of Community Health Center was mostly high and it stood at 77.0%. In the aspect of the management of hypertension, the targets who took medicine on a regular basis were up to 76.1% and the targets who measured blood pressure once a month happened to be about 46.1 %. The targets who always recorded their blood pressure were 3.8%, chest X-ray as a related examination of hypertension reached 32.6%, electrocardiogram examination was 36.2%, cholesterol and serum lipid examination took up 33.6%, and the eye ground examination took 7.3%, which showed the lowest level of all.

• 농촌의학ㆍ지역보건
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• 제30권1호
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• pp.29-38
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• 2005

전북지역의 김제시의 2개 초등학교 4-6학년 학부모 434명을 대상으로 2003년 11월 20일부터 2003년 11월 30일까지 10일간 자기 기입식 방법으로 설문조사한 결과는 다음과 같다. 첫째, 고혈압 관련 지식의 정답률은 77.4%-94.5%로서 비교적 높게 나타났으며 이중 고혈압에 대한 혈압수치의 정답률이 77.4%로서 제일 낮았다. 그러나 비만인 사람이 고혈압에 더 걸리기 쉽다는 응답의 정답률이 94.5%로서 높은 지식을 나타냈다. 둘째, 혈압측정을 실천했는지를 분석한 결과 아버지 측정율이 53.7%인 반면 어머니의 측정율은 54.8%로서 높지 않게 나타났다. 셋째, 측정한 학부모들의 자기혈압을 알고 있는지 분석한 결과 알고 있다는 인지율이 아버지는 84.1%, 어머니는 91.1%로서 비교적 잘 알고 있었으며 이들이 작성한 자기 혈압 수치를 혈압 분류기준에 따라 분석한 결과 아버지들의 고혈압 전단계(120-139mmHg/80-89mmHg) 비율이 12.2% 및 고혈압(140/90mmHg)이 28.6%로 나타났다, 반면 어미니들의 고혈압 전 단계 비율이 7.7% 및 18.2%로 나타났다. 이와 같은 연구 결과를 기초로 다음과 같은 결론 및 제안을 하고자 한다. 첫째, 고혈압의 예방 및 관리를 위하여 지역 사회 대상 접근 방법이 기존의 보건의료기관에서 내소자를 중심으로 개인 대상 접근 방법보다 더 중요함을 시사하므로 적극적인 홍보가 실시되어야 한다. 둘째, 지역주민이 갖고 있는 고혈압관련지식 수준은 비교적 높은데 이러한 지식을 생활하면서 실천 하는 능력을 향상시키는 것이 매우 중요하다. 그러므로 지역사회 고혈압 예방 및 관리에서 학교라는 지역 사회시설과 감수성이 높고 교육효과가 크다고 증명된 초등학생들을 적극 활용하는 것이 중요하므로 초등학교에 고혈압 예방교육이 실시되어야 한다.

• 한국식품영양과학회지
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• 제34권1호
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• pp.57-65
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• 2005

본 연구는 산야초 추출물이 함유된 식사대용식을 이용한 초저열량 식사요법의 체중감량과 건강개선에 미치는 효과를 평가하고자 실시되었다 그 결과 식사대용식을 이용하여 초저열량 식사요법을 한 성인 비만여성들의 경우 일반 음식으로만 초저 열량 식사요법을 한 성인 비만여성들보다 체중과 체지방율이 유의하게 감소하였음을 알 수 있었다. 건강관련 인자는 두 군간에 유의한 차이는 없었으나 산야초 추출물이 함유된 식사대용식을 섭취한 군내에서 식사중재 기간 동안 유의하게 지질 개선 효과가 있었다. 한편, 산야초 추출물이 함유된 식사대용식의 맛에 대한 기호도도 긍정적으로 평가되었다. 그러므로, 본 연구에서 사용된 산야초 추출물을 주성분으로 하여 제조된 식사대용식은 향후 임상에서 비만치료제로 응용함에 있어 크게 도움이 될 것으로 사료된다. 단, 앞으로 요요 현상의 가능성에 대한 보다 장기간에 걸친 임상연구가 이루어져야 할 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제42권2호
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• pp.206-217
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• 1995

연구배경: 폐쇄성 수면 무호흡증후군 환자들은 기도저항을 증가시킬 수 있는 상기도의 해부학적 혹은 기능적 특성을 가지고 있을 뿐만 아니라 이들에게 흔히 동반되는 비만과 같은 체형상의 특성은 다른 폐기능의 변화도 가져올 수 있고, 이러한 폐기능의 변화는 수면 무호흡시 나타나는 저산소증 및 환자의 임상양상에 영향을 미칠 수 있을 것으로 생각되었다. 또한 현재까지 병태생리학적 관련성에 대하여 많은 논란이 있으나 수면 무호흡증후군은 많은 환자에서 고혈압을 동반하는것으로 알려져 있다. 따라서 저자들은 폐쇄성 수면 무호흡증후군 환자들에서 기도저항을 포함한 폐기능 검사소견과 수면다원검사 각 지표 상호간의 관련성 여부를 관찰하고, 이들중 고혈압을 동반하고 있는 환자들과 혈압이 정상인 환자들에서 연령, 비만도, 수면다원검사의 각 지표, 폐기능 검사소견 사이에 어떠한 차이점이 있는지 살펴 보고자 하였다. 방법: 수면장애 크리닉에서 수면설문지검사와 수면 다원검사를 실시하여 무호흡지수가 5이상인 폐쇄성 수면 무호흡증후군 환자 32명을 대상으로 하였다. 폐기능 검사는 주간의 각성상태에서 body plethysmograph를 이용하여 기도저항, 일산화탄소 폐확산능, 노력성호기곡선, 기능적 잔기용량과 총폐용량을 포함한 폐의 용적과 용량을 측정하였고, 수축기혈압이 160mmHg 이상이거나 이완기혈압이 95mmHg이상으로 고혈압의 병력이 있어 항고혈압제를 복용중인 12명(37.5%)을 고혈압환자군으로 하였다. 이들에서 연령, 비만도, 무호흡지수, 호흡장애지수, 수면중 동맥혈 최저산소포화도 및 산소탈포화정도, 폐기능 검사소견들 상호간의 관련성을 검증하였으며 고현압환자군과 혈압이 정상인 환자군을 구분하여 비교함으로서 두군간에 어떠한 차이점이 있는지 살펴 보았다. 결과: 1) 비만도는 무호흡지수, 호흡장애지수, 수면중 동맥혈 최저산소포화도 및 산소탈포화정도와 상호관련성이 있었다. 2) 수면중 동맥혈 최저산소포화도는 무호흡지수, 호흡장애지수와 각각 유의한 역상관관계를 나타냈으며 산소탈포화정도는 무호흡지수, 호흡장애지수와 각각 유의한 상관관계가 있었다. 3) 주간에 실시한 폐기능검사중 기도저항과 무호흡지수는 유의한 상관관계가 있었으며, 일산화탄소 확산능은 수면중 산소탈포화정도와 유의한 역상관관계를 보였다. 4) 비만도와 $FEV_1,\;FEV_1/FVC$, DLco 사이에는 각각 역상관관계가 있었다. 5) 고혈압환자군이 혈압이 정상인 환자군에 비하여 평균연령이 높았으나 비만도, 무호흡지수, 호흡장애지수, 동맥혈 최저산소포화도 및 산소탈포화정도, 폐기능 검사소견등에는 유의한 차이가 없었다. 결론: 이상의 결과에서 비만은 폐쇄성 수면 무호흡증후군의 발생과 밀접한 관계가 있으며, 무호흡지수와 호흡장애지수는 수면중 저산소증의 정도를 반영하는 유의한 지표였다. 주간의 각성시 폐기능검사중 기도저항은 무호흡지수와 상관관계가 있었으므로 기도저항의 측정은 폐쇄성 수면 무호흡의 발생 가능성을 예측하는 보조적 방법으로 이용될 수 있으며, 일산화탄소 확산능은 수면중 저산소증의 정도와 관계가 있었으므로 이들 환자의 진단과 치료시 폐기능의 정확한 평가가 필요하다고 생각되었다. 그러나 폐쇄성 수면 무호흡증후군과 고혈압의 병태생리학적 연관성을 이해하기 위해서는 앞으로 관찰방법을 달리한 다각적인 연구가 필요할 것으로 생각되었다.

• 동의생리병리학회지
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• 제24권3호
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• pp.504-511
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• 2010

Diabetes is a disease that contains a high concentration of glucose in blood and due to defects in either insulin secretion or insulin action. Although the distinctive causes and factors of diabetes have not been clarified, the genetic factors are suggested as a main susceptibility until now. SNP (Single Nucleotide Polymorphism), as the most common genetic variation, has an influence on personal susceptibility for diseases. A nonsynonymous SNP, which changes the amino acid of the protein and its function, is especially important. Therefore, this study hypothesized that there are associations between specific SNPs of the targeted genes. Transcription factor 7-like 2 (TCF7L2) and fat mass and obesity associated (FTO) genes were selected as target genes from the results of genome-wide association and other related research studies. Second, four nonsynonymous SNPs (three in TCF7L2 and one in FTO gene) were selected as target SNPs by using public database of NCBI (National Center for Biotechnology Information). The recruited personnel was classified into three subgroups of diabetes, impaired fasting glucose (IFG) and normal groups. The individual genotypes of each group were analyzed by resequencing. None of genetic variations at four targeted SNP sites was revealed in all samples of this study. However, this study found two new SNPs that were not reported in TCF7L2 gene. One is synonymous SNP, which is heterozygous of C/T and no amino acid change of asparagine/asparagines, was located at c1641 and found in one normal person. Another is nonsynonymous SNP, which is heterozygous of G/A, was located at c1501 and found in two samples. This new discovered nonsynonymous SNP induce the amino acid change from alanine to threonine. Moreover, this new nonsynonymous SNP was found among two persons, one of whom was a diabetes patient and the other one was a person at boundary between IFG and normal, suggesting that this variant might be associated with IFG or diabetes. Even if there is a limitation of sample number for statistical power, this study has an importance due to the discovery of new SNPs. In the future study, a large sample number of diabetes cohort will be needed to investigate the frequency and association with new discovered SNP.

• 대한중풍순환신경학회지
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• 제13권1호
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• pp.13-23
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• 2012

Object : The aim of this study was to assess the relationship between left ventricular hypertrophy and Dampness-Phlegm diagnosis in cerebral infarction patients. Methods : Among 227 of the total recruited patients, 59 patients were diagnosed as left ventricular hypertrophy. We assessed their general characteristics, risk factors, lab findings and Korean medical diagnosis. We compared the assessed variables between left ventricular hypertrophy group and non left ventricular group. We analyzed the relationship between left ventricular hypertrophy and risk factors. And we also analyzed the relationship between left ventricular hypertrophy and dampness-phlegm diagnosis. Results : 1. The rate of left ventricular hypertrophy in female patients was larger than the rate of male patients. 2. There were more patients finally diagnosed hypertension in left ventricular hypertrophy group. 3. According to the analysis about the rate of Dampness-phlegm related Index for Pattern Identification by left ventricular hypertrophy, Sallow complexion and obesity were significantly higher in the left ventricular hypertrophy than in the non left ventricular hypertrophy group. 4. In multivariate analysis, Dampness-phlegm group showed close relationship with left ventricular hypertrophy. Conclusions : According to the analysis, significance between dampness-phlegm diagnosis diagnosed group and left ventricular hypertrophy were clarified. These results can be utilized in the future as a basic material to be used for diagnosis and management of dampness-phlegm diagnosis on cardiovascular diseases.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3595-3604
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• 2015

Hepatocellular carcinoma (HCC) has been one of the most fatal malignant tumors worldwide and its associated morbidity and mortality remain of significant concern. Based on in-depth reviews of serological diagnosis of HCC, in addition to AFP, there are other biomarkers: Lens culinaris agglutinin-reactive AFP (AFP-L3), descarboxyprothrombin (DCP), tyrosine kinase with Ig and eprdermal growth factor (EGF) homology domains 2 (TIE2)-espressing monocytes (TEMs), glypican-3 (GPC3), Golgi protein 73 (GP73), interleukin-6 (IL-6), and squamous cell carcinoma antigen (SCCA) have been proposed as biomarkers for the early detection of HCC. The diagnosis of HCC is primarily based on noninvasive standard imaging methods, such as ultrasound (US), dynamic multiphasic multidetector-row CT (MDCT) and magnetic resonance imaging (MRI). Some experts advocate gadolinium diethyl-enetriamine pentaacetic acid (Gd-EOB-DTPA) MRI and contrast-enhanced US as the promising imaging madalities of choice. With regard to recent advancements in tissue markers, many cuting-edge technologies using genome-wide DNA microarrays, qRT-PCR, and proteomic and inmunostaining studies have been implemented in an attempt to identify markers for early diagnosis of HCC. Only less than half of HCC patients at initial diagnosis are at an early stage treatable with curative options: local ablation, surgical resection, or liver transplant. Transarterial chemoembolization (TACE) is considered the standard of care with palliation for intermediate stage HCC. Recent innovative procedures using drug-eluting-beads and radioembolization using Yttrium-90 may exhibit beneficial effects in HCC treatment. During the past few years, several molecular targeted agents have been evaluated in clinical trials in advanced HCC. Sorafenib is currently the only approved systemic treatment for HCC. It has been approved for the therapy of asymptomatic HCC patients with well-preserved liver function who are not candidates for potentially curative treatments, such as surgical resection or liver transplantation. In the USA, Europe and particularly Japan, hepatitis C virus (HCV) related HCC accounts for most liver cancer, as compared with Asia-Pacific regions, where hepatitis B virus (HBV) may play a more important role in HCC development. HBV vaccination, while a vaccine is not yet available against HCV, has been recognized as a best primary prevention method for HBV-related HCC, although in patients already infected with HBV or HCV, secondary prevention with antiviral therapy is still a reasonable strategy. In addition to HBV and HCV, attention should be paid to other relevant HCC risk factors, including nonalcoholic fatty liver disease due to obesity and diabetes, heavy alcohol consumption, and prolonged aflatoxin exposure. Interestingly, coffee and vitamin K2 have been proven to provide protective effects against HCC. Regarding tertiary prevention of HCC recurrence after surgical resection, addition of antiviral treatment has proven to be a rational strategy.

• Journal of Nutrition and Health
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• 제40권3호
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• pp.259-269
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• 2007

Recently, dietary pattern analysis was emerged as an approach to examine the relationships between diet and risk of chronic diseases. This study was to identify groups with population who report similar dietary pattern in Korean genome epidemiology study (KoGES) and association with several chronic diseases. The cohort participants living in Ansung and Ansan (Gyeonggi province) were totally 10,038. Among those, 6,873 subjects with no missing values in food frequency questionnaire were included in this analysis. After combining 103 food items into 17 food groups, 4 dietary factors were obtained by factor analysis based on their weights. Factor 1 showed high factor loadings in vegetables, mushrooms, meats, fish, beverages, and oriental-cereals. Factor 2 had high factor loadings in vegetables, fruits, fish, and factor 3 had high factor loadings in cereal-oriental, cerial-western and snacks. Factor 4 showed positive high factor loadings in rice and Kimchi and negative factor loadings in mushrooms and milk and dairy products. Using factor scores of four factors, subjects were classified into 3 clusters by K-means clustering. We named those 'Rice and Kimchi eating' group, 'Contented eating' group, and 'Healthy and light eating' group depending on their eating characteristics. 'Rice and Kimchi eating' group showed high prevalence in men, farmers and 60s. 'Contented eating' group and 'Healthy and light eating' group had high prevalence in women, people living in urban area (Ansan Citizen), with high-school education and above, and a monthly income of one million won and more. 'Contented eating' group appeared lower distribution proportion in the sixties and 'Healthy and light eating' group does higher in the fifties. 'Contented eating' versus 'Rice and Kimchi eating', odds ratio for hypertension, diabetes, metabolic syndrome and obesity significantly decreased after adjusting age and sex (OR=0.64, 0.73, and 0.85 respectively, 95% CI). Although our results were from a cross-sectional study, these imply that the dietary patterns were related to diseases.

• Journal of Nutrition and Health
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• 제47권1호
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• pp.23-32
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• 2014

해조류인 알쏭이 모자반 추출물의 섭취로 인한 체지방 감소 효능을 평가하고자 이중맹검법을 사용하여 BMI 23 이상의 과체중 혹은 비만 성인 여성에게 8주간 알쏭이 모자반 추출물을 섭취하게 한 후 체격지수, 혈액 분석, 식사섭취상황 등을 조사하였다. 최종 대조군은 14명, 실험군은 16명이었으며 1일3회 각 4개의 캡슐을 섭취시켰다. 인체시험 결과 시험전후 비교시 대조군에 비하여 시험군의 체지방률과 체지방량, 허리둘레가 지속적으로 유의하게 감소하였으며 혈청 트리글리세롤과 렙틴농도가 더욱 유의하게 감소하였고 변배설량은 유의하게 증가하여 지방 배설효과를 기대할 수 있었다. 시험기간 동안 7명의 피험자가 심각하지 않은 부작용으로 시험에서 탈락하였으나 건강상 불편함을 호소하는 피험자 수의 두 군간의 차이는 보이지 않았다. 따라서 알쏭이 모자반 추출물은 8주간 섭취 시 심각한 부작용을 유발하지 않으면서 피험자의 허리둘레, 체지방율과 함께 혈청 렘틴 수치를 유의하게 감소시킬 수 있고 배변횟수를 유의하게 증가시켜 특히 복부비만을 해소할 수 있는 비교적 안전한 기능성 소재로 기대되므로 작용기전을 설명할 수 있는 심층 연구가 필요로 된다.

• 한국의상디자인학회지
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• 제18권2호
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• pp.15-33
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• 2016

Women in their 30s and 40s, who are at the center of "ageless" and "down-aging" consumer trends, are likely to encounter problems with fitting and size conformity when they wear casual clothes targeting women in their 20s. Hence, differences in upper body sizes and body types between women in their 20s and women in their 30s and 40s were analyzed. The data for this study was from the 6th Size Korea survey of body measurements of 1,675 female adults in their 20s-40s. SPSS 21.0 for Windows was used for analysis of the collected data. To examine differences in average upper body size between women in their 20s and women in their 30s and 40s, descriptive statistics and independent sample t-tests were conducted. Factor and cluster analyses were used to classify body types by age groups. Comparing direct measurement items showed that women in their 20s tend to have higher average values for most height-related items-including body height-and lower average values for circumference, thickness, and width than women in their 30s and 40s. Factors in determining the upper body shapes of women in their 20s to 40s were narrowed to five; through a cluster analysis, upper body shapes of women were classified into three body types as follows. Type 1 women are shorter and thinner with small frames; Type 2 women have the highest vertical values for their upper bodies and average values for obesity-related categories of circumference, thickness, and width. Type 3 women are the shortest and has the highest body mass index (BMI), verifiable as obese. By analyzing differences in body type distribution according to age groups, it was found that more than 90% of women in their 20s belong to Types 1 and 2. On the other hand, most women in their 30s and 40s are identified as Type 3.