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Detecting Malignant Urothelial Cells by Morphometric Analysis of $ThinPrep^{(R)}$ Liquid-based Urine Cytology Specimens (형태 계측학적 분석과 $ThinPrep^{(R)}$ 액상 소변세포검사를 이용한 악성 요로상피 세포 검출)

  • Shin, Bong-Kyung;Lee, Young-Suk;Jeong, Hoi-Seon;Lee, Sang-Ho;Kim, Hyun-Chul;Kim, A-Ree;Kim, In-Sun;Kim, Han-Kyeom
    • The Korean Journal of Cytopathology
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    • v.19 no.2
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    • pp.136-143
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    • 2008
  • Urothelial carcinoma accounts for 90% of all the cases of bladder cancer. Although many cases can be easily managed by local excision, urothelial carcinoma rather frequently recurs, tends to progress to muscle invasion, and requires regular follow-ups. Urine cytology is a main approach for the follow-up of bladder tumors. It is noninvasive, but it has low sensitivity of around 50% with using the conventional cytospin preparation. Liquid-based cytology (LBC) has been developed as a replacement for the conventional technique. We compared the cytomorphometric parameters of $ThinPrep^{(R)}$ and cytospin preparation urine cytology to see whether there are definite differences between the two methods and which technique allows malignant cells to be more effectively discriminated from benign cells. The nuclear-to-cytoplasmic ratio value, as measured by digital image analysis, was efficient for differentiating malignant and benign urothelial cells, and this was irrespective of the preparation method and the tumor grade. Neither the $ThinPrep^{(R)}$ nor the conventional preparation cytology was definitely superior for distinguishing malignant cells from benign cells by cytomorphometric analysis of the adequately preserved cells. However, the $ThinPrep^{(R)}$ preparation showed significant advantages when considering the better preservation and cellularity with a clear background.

Development Strategies of The Hanwoo [Korean Native Cattle] Industry (한우산업의 발전전략)

  • Kim Jin Suk
    • Proceedings of the Korean Society of Crop Science Conference
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    • 1998.10a
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    • pp.68-111
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    • 1998
  • The structure of the Hanwoo (Korean Native Cattle) Industry remains very weak and vulnerable to the WTO/IMF system. Considering that the majority of cattle farmers are small sized, and that marketing systems are outdated and inefficient, rapid expansion of lower priced beef imports by WTO system and rapid increasing of production costs by IMF system would lead to the deprivation of a regular source of farm income and threaten the stability of rural life. Accordingly, the Hanwoo industry should be expanded in accordance with progress in the implementation of (1) programs for the structural adjustment and (2) measures to compensate for the loss. Efforts for lowering major production factor costs needs to continue, In order to increase the supply of calves at low cost, the programs of collective cow-calf farms should be expanded, thereby reducing the cost of calf purchase, which constitutes the largest share of Hanwoo production cost. Also, feedlot operations should be encouraged for small herd farms in order to achieve a substantial saving in beef production costs by integrated operations from calf production to cattle fattening. A substantial saving would also be made by collective purchase and distribution of various inputs through the cooperatives' channels. Extension services should be strengthened for cattle farm management, cattle care and feeding, prevention of cattle disease, etc. In order to minimize cash outlays for commercial mixed feeds, utilization of far by-products as feeds should be enhanced and production of forage crops productive of resources, such as land and rural labor, during the farm o(f-season, needs to be encouraged. Also, technological development for enhancing the nutritional value of farm by-products should be encouraged. Measures for successful segregation of the Hanwoo beef market should be implemented, thereby enhancing incentive for quality beef producers and protecting consumers willing to pay higher price for quality beef. For development of the Hanwoo industry, a considerable time frame would be required in order for (1) small livestock farmers to make a successful adjustment by staying in the enterprise and achieving increased price efficiency (2) livestock farmers to acquire know-how for producing quality Hanwoo beef, (3) the ongoing Government policy of enhancing price-quality competitiveness, and for improving the quality Hanwoo beef marketing to take root. (4) consumers to increase their ability to distinguish meat quality, and others.

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The Optimal Timing of Markdowns: A Decision Model for Jean Market (가격인하 최적시기 연구: Jean Market을 대상으로 한 Decision Model를 중심으로)

  • 곽영식;김용준;남용식;이진화
    • Journal of the Korean Society of Clothing and Textiles
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    • v.26 no.5
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    • pp.606-617
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    • 2002
  • The purpose of this study is to develop a decision model that helps manufacturers and retailers determine the optimal timing of markdown in order to maximize their profit. An optimal timing decision model was developed based on three steps; conjoint measurement, scenario analysis and simulation. Data were collected from the sample of 149 out of 170 undergraduate and graduate students in Seoul in 1997. From the Jeans market, 8 brands; Levi's, lee, Guess, Calvin Klein, Pintos, Get used, MFG, and Basic, were selected as competitors for this study. In the conjoint measurement, respondents estimated the level of preference, from 1 to 100, for each item in which brand, price, style, and colors were used to explain product characteristics. Then, in order to reflect competitive situation in Jeans market, four types of scenarios were developed. In each scenario, simulations were applied to decide optimal timing of markdowns that leads to maximal profitability and sales volume. The profit was calculated based on the equation; Profit = Jean's market volume x market share of each brand - cost, where market volume was obtained by integral calculus for market utility function, and market share by logit value of part-worth from the conjoint analysis. For the purpose of the parsimony of the research, costs and the level of markdown were fixed to 30% of the regular price. In results, the optimal timing decision model identified 3 different types of brands. The brands that do not need to take markdown were Ievi's, MFG, and Basic Jeans characterized by the highest brand power and the highest price zone. The brands that needed to take early markdowns were Guess, Lee, Calvin Klein, and Get Used with the intermediate level of brand power and price. The brand that need late markdown was Pintos with the weakest brand power among the competitors and the lowest price. The optimal range of markdown remains for further research.

Differences in oral health behavior and quality of life among the elderly depending on income and education levels (노인의 소득 및 교육수준에 따른 구강건강행태와 구강건강 삶의 질)

  • Yang, Hye-Jung;Suh, Won-Sik
    • Journal of Korean society of Dental Hygiene
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    • v.18 no.2
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    • pp.217-226
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    • 2018
  • Objectives: The purpose of this study is to find out differences in oral health status, defined as their oral health and oral health quality of life among the elderly depending on their income and education levels. Methods: This study used 922 senior citizens over 65 from the data (2015) of the 6th National Health and Nutrition Survey (NHNS). The regression analysis was adopted to identify factors affecting their oral health status which has effect on their oral health quality of life. The statistical package SPSS 21.0 was employed. Frequency analysis, chi-squared analysis and regression analysis were used, and the significance level or Cronbach's alpha value was 0.05. Results: Depending on income levels, there were differences in their oral health status as to whether they use oral hygiene products, take dental examinations, join private health-insurances, and delay dental treatments or not. And educational levels also made significant differences in their oral health status as to whether they smoke, drink alcohol, how many times they brush teeth a day, whether they use oral hygiene products, take dental treatments, and join private health-insurances. Regression analysis on the relationship between their oral health status and the oral health quality of life showed that there were significant differences depending on whether they take dental treatments, delay dental medical treatments, smoke, take oral examinations, how many times they brush teeth a day, and whether they use oral hygiene products, or join private health-insurances. Conclusions: The study shows that a comprehensive plan is needed to raise attention on proper oral health-care and ultimately to improve the quality of life by considering the daily number of tooth brushing, oral hygiene product use, regular dental treatments, and other medical uses.

COMPARISON OF CANAL FILLING EFFICIENCY ON THE INTERNALLY RESORBED ROOT ACCORDING TO CANAL FILLING TEHNIQUES (근관충전방법에 따른 내흡수 치근의 근관충전 효율성 비교)

  • Ha, Sang-Yoon;Shin, Dong-Hoon;Hong, Chan-Ui
    • Restorative Dentistry and Endodontics
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    • v.20 no.2
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    • pp.789-801
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    • 1995
  • Canals with artificially made internal resorption were filled with 4 techniques(Lateral condensation, Ultrafil, Obtura II, Thermafil) to compare the efficacy of canal filling according to the filling techniques. After canal filling, radiographic examination, dye penetration through the apical portion and percentage of G-P filled area on the internal resorption area were evaluated. To examine the degree of crystal-like structure and the interface between filled G-P and canal wall, SM and SEM images were taken too. The results were as follows : 1. There was no statistically significant difference in apical microleakage among the 4 root canal filling techniques. 2. As a result of radiographic examination, Ultrafil was the best and Obtura II was acceptable but Lateral condensation and Thermafil showed unfavorable canal filling pattern similarly. 3. Ultrafil filled most of artificially made internal resorption area and Obtura II, Lateral condensation, Thermafil in that order filled unfavorably. 4. Degree of crystal like structure was the highest in the group filled with Ultrafil and those of Obtura II and Thermafil were similar and that of gutta percha used in Lateral condensation showed the lowest value. 5. Penetration of gutta percha into the dentinal tubules couldn't be seen in all groups. In the contact surface between the filled G-P and the canal wall, Lateral condensation showed relatively close sealing, Obtura II and Thermafil had irregular contact surface and Ultrafil showed regular filling pattern. 6. Contact surface between the core of Thermafil and the gutta percha showed close relationship without gap formation.

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Eating Habit Management Application for Body Health (몸 건강을 위한 식습관 관리 어플리케이션)

  • Kim, Yoon-Na;Jung, Seul-Ki;Choi, Yeon-Hwa;Park, Jung Kyu;Park, Su e
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2017.10a
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    • pp.216-218
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    • 2017
  • Clothing, Eating, and Living are three basic factors in human living. Eating is main factor of human's life maintenance and delightment. We are mostly interested in 'what to eat', but we have relatively less interest in 'how to eat.' So we are focusing on a dietary habit about 'how to eat'. Dietary habit highly affects on our body, and depending on dietary habit, our body can be healthy or our health can be destroyed. Therefore, we started a project which is based on motto of 'healthy dietary habit makes healthy life. We defined 20-30's adults whom have remarkable irregular and fast dietary habit as our target. Furthermore, we are willing to help them to have slow, regular dietary habit. Ultimately we want to deliver the value of health.

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Smallest-Small-World Cellular Genetic Algorithms (최소좁은세상 셀룰러 유전알고리즘)

  • Kang, Tae-Won
    • Journal of KIISE:Software and Applications
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    • v.34 no.11
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    • pp.971-983
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    • 2007
  • Cellular Genetic Algorithms(CGAs) are a subclass of Genetic Algorithms(GAs) in which each individuals are placed in a given geographical distribution. In general, CGAs# population space is a regular network that has relatively long characteristic path length and high clustering coefficient in the view of the Networks Theory. Long average path length makes the genetic interaction of remote nodes slow. If we have the population#s path length shorter with keeping the high clustering coefficient value, CGAs# population space will converge faster without loss of diversity. In this paper, we propose Smallest-Small-World Cellular Genetic Algorithms(SSWCGAs). In SSWCGAs, each individual lives in a population space that is highly clustered but having shorter characteristic path length, so that the SSWCGAs promote exploration of the search space with no loss of exploitation tendency that comes from being clustered. Some experiments along with four real variable functions and two GA-hard problems show that the SSWCGAs are more effective than SGAs and CGAs.

Individual Fit Testing of Hearing Protection Devices Based on Microphone in Real Ear

  • Biabani, Azam;Aliabadi, Mohsen;Golmohammadi, Rostam;Farhadian, Maryam
    • Safety and Health at Work
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    • v.8 no.4
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    • pp.364-370
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    • 2017
  • Background: Labeled noise reduction (NR) data presented by manufacturers are considered one of the main challenging issues for occupational experts in employing hearing protection devices (HPDs). This study aimed to determine the actual NR data of typical HPDs using the objective fit testing method with a microphone in real ear (MIRE) method. Methods: Five available commercially earmuff protectors were investigated in 30 workers exposed to reference noise source according to the standard method, ISO 11904-1. Personal attenuation rating (PAR) of the earmuffs was measured based on the MIRE method using a noise dosimeter (SVANTEK, model SV102). Results: The results showed that means of PAR of the earmuffs are from 49% to 86% of the nominal NR rating. The PAR values of earmuffs when a typical eyewear was worn differed statistically (p < 0.05). It is revealed that a typical safety eyewear can reduce the mean of the PAR value by approximately 2.5 dB. The results also showed that measurements based on the MIRE method resulted in low variability. The variability in NR values between individuals, within individuals, and within earmuffs was not the statistically significant (p > 0.05). Conclusion: This study could provide local individual fit data. Ergonomic aspects of the earmuffs and different levels of users experience and awareness can be considered the main factors affecting individual fitting compared with the laboratory condition for acquiring the labeled NR data. Based on the obtained fit testing results, the field application of MIRE can be employed for complementary studies in real workstations while workers perform their regular work duties.

One Case of Drug Induced Hepatitis Caused by Dyctamnus dasycarpus (백선피(Dyctamnus dasycarpus)에 의한 약물유발성 간염 1예)

  • Seung Hyun-Suk;Rhew Kwang-Yul;Kim Young-Chul;Lee Jang-Hoon;Woo Hong-Jung;Han Chang-Woo
    • The Journal of Internal Korean Medicine
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    • v.24 no.2
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    • pp.374-379
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    • 2003
  • Herbal remedies are enjoying a growing popularity in the world. But, we still pay few attention to the potential hepatotoxicity of herbal remedies, and there are only a few reports about that. We recently experienced a case of drug induced hepatitis caused by ingestion of Dyctamnus dasycarpus, one of herbs used for dermatologic disorders. The patient, a 38 year old woman, was admitted due to jaundice after ingestion of some herbal mixture containing Dyctamnus dasycarpus to treat her atopic dermatitis for 4 months. Other possible causes of liver injury were excluded by laboratory test and imaging studies, and we could find a report on similar cases caused by ingestion of Dyctamnus dasycarpus. During conservative treatment, elevated liver enzyme and total bilirubin level slowly returned to normal value. This case stresses the need to warn the potential hepatotoxicity of Dyctamnus dasycarpus, especially for a long time ingestion. So we suggest the necessity of toxicology screen at regular intervals during long time ingestion of herbal medicine, and further evaluation of the safety and toxicity of Dyctamnus dasycarpus.

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Records Management Systems of the Colonial Chosun Government General (조선총독부의 기록관리제도)

  • Yi, Kyung-Yong
    • The Korean Journal of Archival Studies
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    • no.10
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    • pp.226-273
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    • 2004
  • The characteristics of the records management systems of the Japanese colonial government can be summarized as follows. First, the Government General adopted a "decentralized retention" of public records. The Government General did not establish its own archives for central preservation of permanent public records. Colonial agencies established its own records office and the records office managed the records its agency created. Secret records and police records were exception. They were retained by the Secretary Office of the General Affairs Division and Police Division of the Chosun Government General respectively. Second, filing systems and retention periods of the public records followed the hierarchic structure of organization. In the headquarter of the government, records were filed by a "bureau-division-activity-file" classification system and a retention period of a file was given automatically by each unit the file belonged. A closed and cut-off file was retained and arranged according to its creating unit, creating year, and retention period. The filing system was easy to use once the filing system was established well, but to make it work effectively changes in activities and organizations should be on a reflected regular basis. It had an advantageous effect that permanent records could be preserved in a unified way throughout the organization. However, it is very critical to determine the permanent records in a professional way. Selection of the permanent records should be done professionally and in a historical perspective. Otherwise, the records retained as permanent records were not the records having an enduring value. And that was not done by the colonial government. Third, classification and scheduling of records were carried out by a creating division, rather than by the Records Office, mostly from the 1920s. Compilation of the records was also done by the creating agency. It implies that the records management lacked the professionalism. In conclusion, the records management system of the Chosun Government General wes nither modern nor user oriented. It managed the records for solely administrative purpose, i.e. effective colonial rule. The legacy of the colonial records system still exists in the public records system in Korean government. One should criticize the lack of will and efforts to modernize the public records system since the establishment of the Korean government while should reflect the historical origins of the records system in Korea.