• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1757-1762
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• 2014

Development of drugs from natural products has been undergoing a gradual evoluation. Many plant derived compounds have excellent therapeutic potential against various human ailments. They are important sources especially for anticancer agents. A number of promising new agents are in clinical development based on their selective molecular targets in the field of oncology. D-pinitol is a naturally occurring compound derived from soy which has significant pharmacological activitites. Therefore we selected D-pinitol in order to evaluate apoptotic potential in the MCF-7 cell line. Human breast cancer cells were treated with different concentrations of D-pinitol and cytotoxicity was measured by MTT and LDH assays. The mechanism of apoptosis was studied with reference to expression of p53, Bcl-2, Bax and NF-kB proteins. The results revealed that D-pinitol significantly inhibited the proliferation of MCF-7 cells in a concentration-dependent manner, while upregulating the expression of p53, Bax and down regulating Bcl-2 and NF-kB. Thus the results obtained in this study clearly vindicated that D-pinitol induces apotosis in MCF-7 cells through regulation of proteins of pro- and anti-apoptotic cascades.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.10
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• pp.239-244
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• 2013

This paper presents a design of the CMOS LDO regulator with a UVLO protection function for a high speed PMIC. Proposed LDO regulator circuit consists of a BGR reference circuit, an error amplifier and a power transistor and so on. UVLO block between the power transistor and the power supply is added for a low input protection function. Also, UVLO block showed normal operation with turn-off voltage of 2.7V and turn-on voltage of 4 V in condition of 5 V power supply. Proposed circuit generated fixed 3.3 V from a supply of 5V. From SPICE simulation results using a $1{\mu}m$ high voltage CMOS technology, simulation results were 5.88 mV/V line regulation and 27.5 uV/mA load regulation with load current 0 mA to 200 mA.

• Korean Journal of Optics and Photonics
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• v.15 no.6
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• pp.569-574
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• 2004

We stabilized the frequency and power of a CW radio-frequency-excited $CO_2$ laser on the peak of the Doppler broadened gain curve using the photoacoustic effect generated from the laser itself. The condenser microphone is installed in the radio frequency discharge chamber to detect a photoacoustic signal. The photoacoustic signal is fed to a lock-in stabilizer as a reference signal for stabilization. The frequency stability is estimated to be better then 5.4${\times}$10$^{-8}$ at the P(20) line. The stabilized output variation was reduced 9.3%, compared to 100% for a free running laser.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.5 no.2
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• pp.1-8
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• 2002

The aim of this study was to generate systemic data for the aquatic plant distribution according to water depth and crossing slope in the shoreline. The results of this study were as follows; 1. Anxiety to 0 near area Bidens frondosa, Scirpus tabernaemontani, Carex dispalata etc. total class 21 observe, and Phragmites communis, Iris pseudoacorus etc. class 6 of anxiety 0-70cm extent examined. Class 21 of anxiety observed all such as Bidens frondosa, Scirpus tabernaemontani, Carex dispalata in near area to 0, and Phragmites communis, Iris pseudoacorus etc. class 6 of anxiety 0-70cm extent examined. Anxiety 70-100cm extent Nymphoides indica, Ttapa japonica etc.. class 2 appeared to line Zizania latifolia, Typha angustata back 2 papers, 130cm and examined that Nelumbo nucifera was limit anxiety state 230cm. 2. Aquatic plants of Phragmites communis, Zizania latifolia, Typha angustata etc. range mainly to gentle gradient of slant 10 degree low and distribution pattern was ranging by Zizania latifolia, Typha angustata, Phragmites communis period of ten days from deepwater place. Nelumbo nucifera was forming become independent stock keeping away invasion of plant that ability to breed was different because was prosperous. Slant 10 bores was growing near sleep in been strange steep slope earth and distribution of emerged plant appeared punily and emerged plant and swampy land plant were ranged extensively in gentle gradient of 10 degree low. 3. On lake surrounding plant when wish to do distribution of natural conditions reference need to. That is, gentle gradient and distribution form of steep slope earth are different, and same pitch must consider enough this because appear as distribution, distribution according to that some plant species were growing was different.

• Tunnel and Underground Space
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• v.8 no.3
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• pp.226-233
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• 1998

Microcracks in rock materials, whether natural or induced, provide useful information on the engineering performance of in situ rockmasses. A population of preferentially oriented microcracks has observable effects on the physical properties of a rockmass, but their effects may not be evident if the rock material is highly anisotropic due to other causes. An experimental program was undertaken to investigate the effect of rock fabrics on the physical properties of rock materials. In this study, anisotropy in the circumferential wave velocity and the direction of induced fractures under axial point loading were measured. Rock specimens (NX-size) of the leucocractic Pocheon granite were cored from rock blocks, retaining the relative directions of each specimen. Another set of specimens was prepared from the rock cores of the same meterial, obtained in the field. The master orientation line (MOL) was set to be the representative direction of the microcracks in the specimen. Variation of the circumferential wave velocity of each specimen was then measured along the core, keeping the MOL as reference. The direction of the minimum wave velocity was nearly perpendicular to the direction of the MOL. Coring of smaller-sized (EX-size), concentric specimens from the NX specimens were then followed, and axial point loading was applied. The direction of induced fractures due to axial point loading was closely related to the MOL direction, confirming the prior test result.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.19 no.11
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• pp.1126-1132
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• 2009

Bridge structures are designed to support ordinary loadings such as vehicles, wind, temperature and current as well as unexpected loadings like earthquakes and storm. Especially, the displacement of Flexible bridges like an suspension bridge under ordinary loading conditions is necessary to be monitored. In case of long span bridges, there are some difficulties in monitoring the displacement of center of the main span using traditional laser displacement sensors. In this study, the static and dynamic displacement responses due to vehicle loadings were measured by DGPS(differential global positioning system) technique. The displacement response data were compared with data obtained from traditional laser displacement sensors so that the static and dynamic behavior of the bridge under vehicle loadings was examined and the applicability of the displacement response measurement using DGPS technique was verified. The static and dynamic loading test for an self-anchored suspension bridge, So-rok Bridge, was performed using vehicles. The displacement response from DGPS technique and that from laser displacement sensors of the bridge monitoring system were compared. The amplitude of white noise from DGPS based measurement was about 7 mm and that of laser displacement sensor based measurement was about 3 mm. On the other hand, dynamic behavior of the center of main span from DGPS based measurement showed better agreement with influence line of the bridge than that from laser displacement sensors. In addition, there were some irregular and discontinuous variation of data due to the instability of GPS receivers or frequent appearance of GPS satellites. Post-processing via the reference station close to an observation post provided by NGII(National Geographic Information Institute) will be a counter-plan for these defects.

• Journal of Preventive Medicine and Public Health
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• v.20 no.2 s.22
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• pp.270-279
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• 1987

In all enterprises of Korea employing workers more than five, employeers have a duty of conducting a periodic health screening for improvement and maintaining healthful living and working conditions of employees. The health screening is performed annually in line workers and biennially in table workers under the supervision of the government. But there are some argument to the health screening programme in view of effectiveness, efficiency, reliability and etc. In order to obtain basic reference materials for increasing the efficiency of peridoic health screening programme for workers and understand the attitude of health screening institutions and enterprises toward the periodic health screening, mail questionnaire survey was conducted in July 1987. The questionnaire sent to 950 health screening institutions. and 700 enterprises in whole land but they were returned from 254 health istitutions and 187 enterprises, which were analyzed. The results were as follows: 1) The attitude of the respondents toward the necessity and benefit of the periodic health screening was showed highly positive responses in both of screening institutions and enterprises, and it was more positive in screening institutions. The attitude toward the affirmative and the contentment was showed less positive than that of the necessity and benefit. 2) The respondent recognized may problems on regard to the screening programme. The health screening institutions lie in the state of competition with other institutions for undertaking the screening programme. 3) One of major complaints from enterprises was the lack of sincerity in performing the screening programme. They wanted more practical and reliable health screening examination rather than showy one. 4) Health screening institutions and enterprises showed some mutual contradictions in the matter of screening fee, and so the screening fee should be adjusted to the appropriate cost.

• Korean Journal of Applied Biomechanics
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• v.21 no.5
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• pp.503-510
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• 2011

The purpose of this study was to find the biomechanical research project result carried out at 2011 IAAF World championship in Daegu. This project was approved by the International Amateur Athletic Federation(IAAF) and financially supported by the Ministry of Culture, Sports and Tourism(MCST) and, Korea Association of Athletics Federations(KAAF). The total number of the project members was 20, including the members of the Scientific Committee, the Korean Society of Sport Biomechanics(KSSB) and graduate students as assistants. The objective of this project has been to analyze the performance in the track events(100 m, 110 mH) and field events(Long Jump, High Jump, Triple Jump, Pole Vault, Javelin Throw and Shot Put). This project was focused on the biomechanical research only. This kind of analysis has been carried out at major competitions for more than a decade, as it provides coaches and athletes with very useful information as an aid to training programmes and competition preparation. The biomechanical analysis of the top athletes in the world in each specialty serves as a reference for assessing technique and rationalizing the results achieved. The results will be disseminated world-wide and coaches will be in a better position to design training strategies in line with current world trends.

• Journal of Ecology and Environment
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• v.38 no.1
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• pp.75-84
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• 2015

Tropical forests play a critical role in mitigating climate change, and therefore, an accurate and precise estimation of tropical forest carbon (C) is needed. However, there are many uncertainties associated with C stock estimation in a tropical forest, mainly due to its large variations in biomass. Hence, we quantified C stocks in an intact lowland mixed dipterocarp forest (MDF) in Brunei, and investigated variations in biomass and topography. Tree, deadwood, and soil C stocks were estimated by using the allometric equation method, the line intersect method, and the sampling method, respectively. Understory vegetation and litter were also sampled. We then analyzed spatial variations in tree and deadwood biomass in relation to topography. The total C stock was 321.4 Mg C $ha^{-1}$, and living biomass, dead organic matter, and soil C stocks accounted for 67%, 11%, and 23%, respectively, of the total. The results reveal that there was a relatively high C stock, even compared to other tropical forests, and that there was no significant relationship between biomass and topography. Our results provide useful reference data and a greater understanding of biomass variations in lowland MDFs, which could be used for greenhouse gas emission-reduction projects.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.29 no.7
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• pp.414-423
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• 2016

In the present study, the $CuN_x-Cu-CuN_x$ layer the partial pressure ratio Cu metal of Ar and $N_2$ gas using a DC magnetron sputtering device, was generated by the In-situ method. $CuN_x$ layer was able to obtain a surface reflectance reduction effect from the advantages of the process and the external light. $CuN_x$ layer is gas partial pressure, DC the Power, the deposition time variable transmittance in response to the thickness and partial pressure ratio, the reflectance was measured. $Ar:N_2$ gas ratio 10:10(sccm), DC power 0.35 A, was derived Deposition time 90 sec optimum conditions. Thus, according to the optimal thickness and the composition ratio was derived surface reflectance of 20.75%. In addition, to derive the value of ${\Delta}$ Ra surface roughness of 0.467. It was derived $CuN_x$ band-gap energy of about 2.2 eV. Thus, to ensure a thickness and process conditions can be absorbed to maximize the light in a wavelength band in the visible light region. As a result, the implementation of the $12k{\Omega}$ base line resistance of using the Cu metal. This is, 5 inch Metal mesh TSP(L/S: $4/270{\mu}m$) is in the range of the reference operation.