• Title/Summary/Keyword: radicals

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Antioxidant effects of the Root of Vitis labrusca Water and Aqua-acupuncture Solution (포도근 열수 추출액 및 약침액이 항산화에 미치는 효과)

  • Lim Seong-Cheorl;Moon Jin-Young
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.1
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    • pp.76-82
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    • 2006
  • This study was purposed to investigated the antioxidant effects of water (VLWS) and aqua-acupuncture solution (VLAS) from root of Vitis labrusca. VLWS and VLAS was were assessed to determine the mechanisms of its antioxidant activities. The VLWS and VLAS exhibitde a concentration-dependent inhibition of DPPH free radicals. This VLWS-mediated antioxidant activity was similar to that L-ascorbic acid (vitamin C). In addition, the VLWS and VLAS showed dose-dependent free radical scavenging activity, including superoxide anions and hydroxyl radicals, using different assay systems. The VLWS and VLAS were also found to be strongly inhibited linoleic acid oxidation in a ferric thiocyanate assay (FTC) system. Finally, the VLWS and VLAS significantly prevented Fenton's reagent-induced DNA nicking.

Effects of Glycerol on the Oxygen Free Radical Reactions and Renal Functions in the Renal Cortex of Rats (Glycerol이 흰쥐 신피질에서의 산소유리기반응과 신기능에 미치는 영향)

  • 고현철;신인철
    • Biomolecules & Therapeutics
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    • v.3 no.4
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    • pp.260-265
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    • 1995
  • In an attempt to define the early biochemical determinants that participate in the pathogenesis of glycerol-induced nephrotoxicity, especially focusing on oxygen free radicals, we studied malondialdehyde (MDA) level and the activities of catalase and superoxide dismutase in the renal cortex of rats, and the concentrations of blood urea nitrogen(BUH) and serum creatinine of rats at 24hr after the injection of a 50% solution of glycerol. Sprague-Dawley albino rats weighing 240 to 260 mg were injected intramuscularly with a 50% solution of glycerol(2 mι/kg, 4 mι/kg and 8 mι/kg). The group treated with glycerol showed significantlv higher MDA level and catalase activity, lower SOD activity and higher BUN and serum creatinine concentrations at 24 hr after the injection as compared to those of control group. These results suggest that the excessive oxygen free radicals resulting from the depression of SOD activity is an important determinant in the pathogenesis of glycerol-induced nephrotoxicity.

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Antibacterial Activities of Methylelaiophylin (Methylelaiophylin의 항균활성)

  • Lee, Dong-Sun;Lee, Sang-Han;WOO, Ju-Hyung;Lee, Jin-Man;Seu, Young-Bae;Hong, Soon-Duck
    • Journal of Life Science
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    • v.7 no.3
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    • pp.180-185
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    • 1997
  • Methylelaiophylin generated superoxide radicals in Bacillus subtilis and showed antibacterial activity against a broad range of gram positive bacteria. The inhibition of DNA synthesis was more sensitive than one of RNA synthesis. A recombination-deficient mutant strain of B. subtilis was 2-fold more sensitive than a wild strain, and this sensitivity was reduced in the presence of an antioxidant, dithiothreitol. Methylelaiophylin generated superoxide radicals in B. subtilis lysates, and this suggests that the antibacterial activity of methylelaiophylin is related to the generation of active oxygen species in the cells.

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Screening of Antioxidative Components from Red Ginseng Saponin (홍삼 사포닌의 항산화활성 성분 Screening)

  • 김정선;김규원
    • Journal of Ginseng Research
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    • v.20 no.2
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    • pp.173-178
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    • 1996
  • Aerobic cells are normally protected from the damage of free radicals by antioxidative on , zymes such as superoxide dismutase (SOD), catalase, glutathione (GSH) peroxidase, GSH S- transferase and GSH reductase which scavenge free radicals as well as nonenzymatic antioxidants such as ceruloplasmin, albumin and nonprotein-SH including GSH. The effects of each component (ginsenoside $Rb_1$, $Rb_2$, Rc, Rd, Re, $Rb_1$, Rf, $Rh_1$ and $Rh_2$) of red ginseng on the antioxidative enzyme activities were investigated in the liver in order to screen antioxidative components of red ginseng. Ginsenoside $Rb_1$ and Rc showed a tendency to increase GSH peroxidase activity, while ginsenoside Rc significantly decreased Cu,Zn-SOD activity. Especially, ginsenoside $Rh_2$ significantly increased catalase activity. These results suggest that ginsenoside $Rh_2$ is an important active component among total saponins of red ginseng.

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NORMALITY ON JACOBSON AND NIL RADICALS

  • Kim, Dong Hwa;Yun, Sang Jo
    • Communications of the Korean Mathematical Society
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    • v.34 no.1
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    • pp.127-136
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    • 2019
  • This article concerns the normal property of elements on Jacobson and nil radicals which are generalizations of commutativity. A ring is said to be right njr if it satisfies the normal property on the Jacobson radical. Similarly a ring is said to be right nunr (resp., right nlnr) if it satisfies the normal property on the upper (resp., lower) nilradical. We investigate the relations between right duo property and the normality on Jacobson (nil) radicals. Related examples are investigated in the procedure of studying the structures of right njr, nunr, and nlnr rings.

Reactivity and Mechanism for Aryl Carbenic Anion Radicals

  • Sung, Dae-Dong;Uhm, Tae-Seop;Lee, Jong-Pal;Ryu, Zoon-Ha;Kim, Hyung-Tae
    • Bulletin of the Korean Chemical Society
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    • v.14 no.2
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    • pp.183-187
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    • 1993
  • Aryl carbenic anion radicals have been generated from the corresponding alkoxy-aryl diazo compounds by unimolecular decomposition reaction in various electrolyte/solvent systems. The electrochemical reductions of alkoxy-aryl diazo compounds in the electrolyte/solvent system are shown to initially be a one-electron process which affords the corresponding anion radicals. The unimolecular loss of nitrogen is favored at the propagation step and accelerated by the oxygen and carbon atoms of alkoxy group adjacent to the diazo function. The structure of the carbene anion radical in the termination is considered to be a resonance hybrid.

Effect of Low Ambient Temperature on the Concentration of Free Radicals Related to Ascites in Broiler Chickens

  • Han, Bo;Yoon, Soon-Seek;Han, Hong-Ryul;Qu, Wei-jie;Nigussie, Fikru
    • Asian-Australasian Journal of Animal Sciences
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    • v.18 no.8
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    • pp.1182-1187
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    • 2005
  • A flock of Arbor Acres chickens were reared in cages and provided with high energy pelleted feed. At 14 d of age, a total of 350 birds were separated into 3 groups randomly as follows: 100 birds were exposed to ambient temperature of 20$^{\circ}C$ as a control group, 150 birds were exposed to lower ambient temperature of 11$^{\circ}C$ to induce ascites (group I), and another group of 100 birds were exposed to lower ambient temperature of 11$^{\circ}C$ and fed diet containing 1% L-arginine for ascitic prophylactic treatment (group II). Blood and tissue samples (lung and liver) were collected from chickens at 3, 4, 5, 6 and 7 wk of age subsequently, to analyze the concentration and activities of free radicals, mononaldehyde (MDA), superoxide dismutase (SOD), Nitric Oxide (NO) and Nitric oxide synthase (NOS). The results showed that the prevalence of ascites in the control, group I and group II was 3%, 9.33% and 3% respectively (p<0.01). The concentration of free radicals in the lungs of 3 wks old preascitic broilers in group I was significantly higher than in the corresponding control group (p<0.05). The concentrations of free radicals in lung and liver in the 7 wk period, and that of NO and SOD in the plasma were significantly lower in group I than in the control group (p<0.01). However, the accumulated MDA contents in group I were higher than in the control group and group II (p<0.05), respectively. In the same way, the activity of NOS in group II was higher than both group I and control group (p<0.01) during the 7 wk period. There was no significant difference between SOD activities of group II and the control group (p>0.05), and also insignificant difference between NOS in group I and the control group (p>0.05). The results of this study indicate that there was a significant decrease in the concentration of MDA in group II. On the other hand, the concentration of free radicals decreased and MDA concentration increased in group I during the 7 wk period. The reduction in concentration of MDA in group II, following arginine supplementation may be associated with the scavenging activity of NO.

PRIME RADICALS OF FORMAL POWER SERIES RINGS

  • Huh, Chan;Kim, Hong-Kee;Lee, Dong-Su;Lee, Yang
    • Bulletin of the Korean Mathematical Society
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    • v.38 no.4
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    • pp.623-633
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    • 2001
  • In this note we study the prime radicals of formal power series rings, and the shapes of them under the condition that the prime radical is nilpotent. Furthermore we observe the condition structurally, adding related examples to the situations that occur naturally in the process.

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Alkyl Group Dissociation During Corona Excitation of Alkylbenzenes

  • Yoon, Young-Wook;Lee, Sang-Kuk
    • Journal of the Korean Chemical Society
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    • v.55 no.5
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    • pp.741-745
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    • 2011
  • Well-resolved vibronic emission spectra were recorded in the visible region from the corona discharge of precursor alkylbenzenes in a technique of corona excited supersonic expansion using a pinhole-type glass nozzle. From the observed spectra, we found the evidence of the presence of benzyl-type radicals generated by dissociation of C-C or C-H bonds of alkyl group. After identification of benzyl-type radicals formed in the corona discharge, we suggest that energy densities in alkyl chain play a crucial role in determining the bond dissociation during corona excitation.