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A Literature Review of Clinical Trials on Alternative Medicine (대체의학 임상실험 현황에 대한 문헌고찰)

  • Cho, Hyun;Yoo, Jin-Yeong;Park, Soo-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.11
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    • pp.4395-4403
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    • 2010
  • The aim of this study is to know about condition of alternative medicine. Methods which An literature search in Pubmed January 2000 to March, 2010 was performed. RCT(Randomized Controlled Trial), CCT(Controled Clinical Trials), and OD(efficacy studies with either a controlled or an Other than controlled Design) were included. PubMed databases were searched using key terms relating to alternative medicine. 19 clinical trials were included among 682 studies searched. RCT was 44%, CCT was 16% and OD was 40% in the review. In the all of included studies, the acupuncture and the massage was the biggest part. The using rate was 20% of pain control about Disease of the Musculoskeletal system and Connective tissue, 15% of Certain infectious and parasitic diseases, and 15% of Neoplasms. There was lack of evidence that alternative medicine was effective for progress. Future well-designed clinical trials is needed.

A Review on Clinical Studies of Acupuncture Treatment for Breast Cancer-Related Lymphedema (유방암 환자의 이차성 림프부종에 대한 침 치료 임상 연구 고찰)

  • Park, Kyung-Dug;Hwang, Su-In;Park, Jang-Kyung;Yoon, Young-Jin
    • The Journal of Korean Obstetrics and Gynecology
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    • v.32 no.3
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    • pp.102-115
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    • 2019
  • Objectives: The purpose of this study is to confirm the effectiveness and safety of acupuncture for treating breast cancer-related lymphedema (BCRL), thus providing a clinical basis for acupuncture treatment and helping to develop clinical practice guideline through consideration of used meridians and acupoints. Methods: Clinical studies applying acupuncture on breast cancer-related lymphedema were searched through 7 databases such as The Cochrane Library Central, Embase, Pubmed and CAJ. Interventions and results of the selected clinical studies were analyzed. Results: 8 Clinical studies were finally included according to inclusion and exclusion criteria. There were 6 randomized controlled studies and 2 single-arm pilot studies. All of those studies were searched in The Cochrane Library Central, Embase, Pubmed and CAJ and written in English and Chinese. Treatment group applied acupuncture as a Korean medicine intervention. Interventions of control group were made with non-treatment, upper limb exercise, and oral administration of capillary stabilizer or diuretics. Outcome measurements varied from paper to paper but every study measured reduction in arm circumference. Among 8 studies, 6 studies reported statistically significant reduction in arm circumference in treatment group and there were no serious adverse effects. Conclusions: This study suggested that acupuncture has few side effects as well as statistically significant effects on many aspects in treating breast cancer-related lymphedema. However the results should be taken cautiously as more clinical studies are needed.

The Domains of the Competencies of Trauma Nursing : A Scoping Review (외상간호 역량의 주요 영역 연구 : 범주 문헌고찰)

  • Kim, Young Hee;Choi, Mo Na;Kang, Hye Kyung
    • The Journal of the Korea Contents Association
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    • v.19 no.5
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    • pp.497-510
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    • 2019
  • This study was conducted to identify the domains of the competencies of trauma nursing through a scoping review using the JBI(Joanna Briggs Institute) methodology. The keywords are trauma, $nurs^*$, $competenc^*$, $role^*$, attitude, and knowledge and skill. The review used information from six databases: CINAHL, Pubmed, ProQuest, Web of Science, Scopus, and ERIC. Inclusion and exclusion criteria were identified as strategies to use in this review. 8 studies were eligible for result extraction, as they listed domains of the competencies. These domains among studies were analyzed based on Trauma Care System and Lenburg's COPA(Competency Outcomes and Performance Assessment) model. Domains in 'Prehospital care & transport', 'Hospital care' and 'Rehabilitation' of Trauma Care System were present, but no domain in 'Injury prevention' was.

A Review of the Chinese Traditional Medicine Thesis on the Treatment of Hyperopia (원시(遠視) 치료에 관한 중의(中醫) 논문 고찰)

  • Kang, Jae-Hyun;Hong, Jin-Young;Seo, Hyung-Sik
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.34 no.4
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    • pp.37-48
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    • 2021
  • Objectives : The purpose of this study is to investigate treatment trends on hyperopia of chinese traditional medicine. Methods : We searched papers using CNKI and Pubmed. The keyword used on searching was 'Hyperopia' combined with 'Chinese medicine', 'Acupuncture' and 'herbal medicine'. Searching duration was not specified. The search was conducted from January 2020 to July 2021, and the final selected papers were from 1983 to 2014. Results : Studies found in CNKI were 27 and 20 sutdies were excluded. Studies found in Pubmed were 57 and 57 studies were excluded. Finally 7 sutdies were selected and analyzed. Five studies of selected ones were case reports and two were review papers. Among 5 case reports, two of them used herbal medicine with pressing auricular acupoints with beans. Another one used electronic plum acupuncture only. Another one used acupuncture with electronic heat and pulsed current stimulation. The other one compared acupuncture alone and acupuncture combined with massage. All studies report high efficacy rates on treatments. Conclusions : According to this study we found the possibility of acupuncture and herbal medicine on hyperopia. We expect that further studies will be conducted and the results of them could be actively applied to clinical treatments.

Nurse Staffing and Patient Outcomes in Korea: A Systematic Review (간호인력과 환자결과: 체계적 문헌고찰)

  • Lee, Ji Yeon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.1
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    • pp.104-115
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    • 2021
  • The purpose of this review was to systematically assess empirical studies on the relationship between nurse staffing and patient outcomes through systematic literature review. Peer-reviewed articles published between January 2009 and December 2018 were identified in CINAHL, Pubmed, EBSCOhost, RISS, and Dbpia databases. A total of 13 articles relating to nurse staffing and patient outcomes in Korea were systematically reviewed and analyzed. The review showed that better nurse staffing aligned with better patient outcomes. However, some studies did not directly correlate patient outcomes with nurse staffing. This is because each study examined varied aspects of nurse staffing and different patient outcomes. These inconsistent study results indicate that continuous study is required. There should be continued efforts to establish guidelines and strategies for deploying nurse staff by maintaining optimal patient-to-nurse ratio.

A Systematic Review of the Virtual Reality Program for Dementia Education (치매교육을 위한 가상현실 프로그램에 대한 체계적 고찰)

  • Kim, Suhyun;Park, Heeok
    • Journal of Digital Convergence
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    • v.19 no.3
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    • pp.195-202
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    • 2021
  • This study is a systematic review study to confirm the characteristics, effects, and application strategies of domestic and foreign virtual reality programs provided by dementia education. This study is based on the literature published up to July 2020, CINAHL, Cochrane, EMBASE, and Pubmed electronic databases were used overseas, and RISS, KISS, and DBpia were searched in Korea. Based on the selection criteria and exclusion criteria, the final six papers were used for analysis. As a result of the analysis, the subjects of the selected literature were two informal caregivers (33.3%), one general (16.7%), and three students (50.0%) including nursing students and medical and pharmacy students. The virtual reality program was effective in a total of five areas(empathy ability, dementia attitude including knowledge and comfort of dementia, trust in own abilities, dyadic relationship scale), of which 75% of the studies measured empathy ability had significant effects. The results of this study confirm that virtual reality technology can be used for human-centered nursing based on empathy.

Metabolic Syndrome Prediction Model for Koreans in Recent 20 Years: A Systematic review (최근 10년간 한국인 대상 대사증후군 예측 모델에 대한 체계적 문헌고찰)

  • Seong, Daikyung;Jeong, Kyoungsik;Lee, Siwoo;Baek, Younghwa
    • The Journal of the Korea Contents Association
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    • v.21 no.8
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    • pp.662-674
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    • 2021
  • Metabolic syndrome is closely associated with cardiovascular disease, there is increasing attentions in prevention of metabolic syndrome through prediction. The aim of this study was to systematically review the literature by collecting, analyzing, and synthesizing articles of predicting metabolic syndrome in Koreans. For systemic review, data search was conducted on Global journals Pubmed, WoS and domestic journals DBPia, KISS published in 2011-2020 year. Three keyword 'Metabolic syndrome', 'predict', and 'korea' were used for searching under AND condition. Total 560 articles were searched and the final 22 articles were selected according to the data selection criteria. The most useful variable was WHtR(AUC=0.897), most frequently used analysis method was logistic regression(63.6%), and most accurate analysis method was XGBOOST(AUC=0.879) for predicting metabolic syndrome. Prediction accuracy was slightly improved when sasang constitution types was used. Based on the results of this study, it is believed that various large-scale longitudinal studies for the prediction and management of the Metabolic syndrome in Korean should be followed in the future.

The Literature Review on Life style Intervention Program for the Prevention of Cardiovascular Disease (심뇌혈관질환 예방을 위한 생활습관 개선 프로그램에 관한 문헌분석 연구)

  • Yang, Hye Kyung
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.1
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    • pp.157-166
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    • 2022
  • This study is a literature analysis study that analyzed program intervention research papers to understand the characteristics of lifestyle intervention programs to prevent cardiovascular disease. The final 18 papers were selected by applying search terms such as "cardio-cerebrovascular disease" and "intervention" through electronic databases such as Pubmed. As for the criteria for selecting program participants in the study, physiological criteria were mainly used, and there were many programs that mediated physical activity and eating habits. Education was the most widely used intervention type, and there were many studies that combined and applied several interventions. During the intervention period, long-term interventions averaged more than 22 weeks, and biophysical indicators were most frequently used as effect indicators for measuring the intervention effect. Through this study, it is suggested that environmental and social support is needed to develop intervention programs considering the interrelationship of various lifestyle habits and maintain healthy lifestyle habits.

Meta-Analysis of Effect in Serum Bio-Markers for Early Diagnosis: Rheumatoid Arthritis

  • Woo, Myoung Soo;Mun, Sora;Kang, Hee-Gyoo
    • Biomedical Science Letters
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    • v.27 no.4
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    • pp.298-309
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    • 2021
  • Rheumatoid arthritis refers to acute and chronic arthritis due to unexplained autoantibody attack. Rheumatoid arthritis should be accompanied by difficulty in mobility and severe distress due to the progression of systemic arthritis. Therefore, this study early diagnoses the effects of Rheumatoid factor (RF), C-reactive protein (CRP), and Anti-cyclic citrullinated peptide (Anti-CCP), which are typical serum markers for rheumatoid arthritis by meta-analysis. Pubmed and EMBASE, were used as PICO criteria, and two independent researchers selected papers according to the criteria set in this study. The selection criteria was a study of patients with rheumatoid arthritis who developed early onset, and the paper was evaluated using the NCS. Forest plot and Funnel plot graphs for each serum marker were calculated using Revman 5.4. After finding 193 papers on Pubmed and 184 papers on EMBASE and selecting according to the criteria, a total of 41 papers were used for the analysis. The magnitude of the effect that appears in the Forest plot of RF with the Mean differnce value is 134.34, CRP is 21.42 and Anti-CCP is 270.41. The magnitude of the effect of Anti-CCP in meta-analysis was analyzed to be larger than that of RF and CRP, and it is considered that the development of early-diagnosis serum markers using Anti-CCP and additional retrospective studies are highly effective. The combination of RF, CRP, and Anti-CCP as a panel marker is expected to be very efficient.

Zebrafish as a research tool for human diseases pathogenesis and drug development

  • Kim, Young Sook;Cho, Yong Wan;Lim, Hye-Won;Sun, Yonghua
    • Journal of the Korean Applied Science and Technology
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    • v.39 no.3
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    • pp.442-453
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    • 2022
  • Various animal models have been used to study the efficacy and action mechanisms of human diseases and medicines. Zebrafish (Danio rerio) is increasingly and successfully used as a model in translational research on human diseases. We obtained necessary information from original peer reviewed articles published in scientific 54 journals, such as Pubmed, Google Scholar, Scopus scince their inception until Dec, 2020 using the following terms: zebrafish animal models, herbal medicine, in vivo screening. In this review, we discuss the recent contributions of the various zebrafish disease models to study of herbal medicines. We focused on cancer, eye diseases, vascular diseases, diabetes and its complications, and cosmetic dermatology. We also highlight the molecular action mechanisms of medicines against these disease, demonstrated using zebrafish embryo. Zebrafish can be pivotal in bridging the gap from lab to clinical bedside. It is used as a model to understand human diseases pathogenies with further scope for drug development. Furthermore, zebrafish can reduce rat and mouse animals in biomedical research.