[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.12925/jkocs.2022.39.3.442

Zebrafish as a research tool for human diseases pathogenesis and drug development

Kim, Young Sook (Herbal Medicine Convergence Research Division, Korea Institute of Oriental Medicine)
Cho, Yong Wan (Sheba Biotech Inc.)
Lim, Hye-Won (Sheba Biotech Inc.)
Sun, Yonghua (Fish Molecular Development & Biotechnology, China Zebrafish Resource Center (CZRC), Institute of Hydrobiology)

Publication Information

Journal of the Korean Applied Science and Technology / v.39, no.3, 2022 , pp. 442-453 More about this Journal

Abstract

Various animal models have been used to study the efficacy and action mechanisms of human diseases and medicines. Zebrafish (Danio rerio) is increasingly and successfully used as a model in translational research on human diseases. We obtained necessary information from original peer reviewed articles published in scientific 54 journals, such as Pubmed, Google Scholar, Scopus scince their inception until Dec, 2020 using the following terms: zebrafish animal models, herbal medicine, in vivo screening. In this review, we discuss the recent contributions of the various zebrafish disease models to study of herbal medicines. We focused on cancer, eye diseases, vascular diseases, diabetes and its complications, and cosmetic dermatology. We also highlight the molecular action mechanisms of medicines against these disease, demonstrated using zebrafish embryo. Zebrafish can be pivotal in bridging the gap from lab to clinical bedside. It is used as a model to understand human diseases pathogenies with further scope for drug development. Furthermore, zebrafish can reduce rat and mouse animals in biomedical research.

Keywords

zebrafish (Danio rerio); disease models; drug development; in vivo screening; translational research;

Citations & Related Records

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