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Meta-Analysis of Effect in Serum Bio-Markers for Early Diagnosis: Rheumatoid Arthritis

  • Woo, Myoung Soo (Department of Biomedical Laboratory Science, Jeonju Kijeon College) ;
  • Mun, Sora (Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University) ;
  • Kang, Hee-Gyoo (Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University)
  • Received : 2021.11.16
  • Accepted : 2021.12.13
  • Published : 2021.12.31

Abstract

Rheumatoid arthritis refers to acute and chronic arthritis due to unexplained autoantibody attack. Rheumatoid arthritis should be accompanied by difficulty in mobility and severe distress due to the progression of systemic arthritis. Therefore, this study early diagnoses the effects of Rheumatoid factor (RF), C-reactive protein (CRP), and Anti-cyclic citrullinated peptide (Anti-CCP), which are typical serum markers for rheumatoid arthritis by meta-analysis. Pubmed and EMBASE, were used as PICO criteria, and two independent researchers selected papers according to the criteria set in this study. The selection criteria was a study of patients with rheumatoid arthritis who developed early onset, and the paper was evaluated using the NCS. Forest plot and Funnel plot graphs for each serum marker were calculated using Revman 5.4. After finding 193 papers on Pubmed and 184 papers on EMBASE and selecting according to the criteria, a total of 41 papers were used for the analysis. The magnitude of the effect that appears in the Forest plot of RF with the Mean differnce value is 134.34, CRP is 21.42 and Anti-CCP is 270.41. The magnitude of the effect of Anti-CCP in meta-analysis was analyzed to be larger than that of RF and CRP, and it is considered that the development of early-diagnosis serum markers using Anti-CCP and additional retrospective studies are highly effective. The combination of RF, CRP, and Anti-CCP as a panel marker is expected to be very efficient.

Keywords

Acknowledgement

This research was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP (Grant No. 2016M3A9B6904241).

References

  1. Abdul-Maksoud RS, Sediq AM, Kattaia A, Elsayed W, Ezzeldin N, Abdel Galil SM, Ibrahem RA. "Serum miR-210 and miR155 expression levels as novel biomarkers for rheumatoid arthritis diagnosis." Br J Biomed Sci. 2017. 74: 209-213. doi: 210.1080/09674845.09672017.01343545. Epub 09672017 Aug 09674847.
  2. Ahlin E, Elshafie AI, Nur MAM, Ronnelid J. "Anti-Citrullinated Peptide Antibodies in Sudanese Patients with Leishmania donovani Infection Exhibit Reactivity not Dependent on Citrullination." Scandinavian Journal of Immunology. 2015. 81: 201-208. https://doi.org/10.1111/sji.12265
  3. Aiman AQ, Nesrin M, Amal A, Nassar AD. "A new tool for early diagnosis of rheumatoid arthritis using combined biomarkers; synovial MAGE-1 mRNA and serum anti-CCP and RF." Pan Afr Med J. 2020. 36: 270. doi: 10.11604/pamj.12020.11636.11270.21827. eCollection 12020.
  4. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham III CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD. "2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative." Arthritis & Rheumatism. 2010. 62: 2569-2581. https://doi.org/10.1002/art.27584
  5. Anaparti V, Meng X, Hemshekhar M, Smolik I, Mookherjee N, El-Gabalawy H. "Circulating levels of free 25(OH)D increase at the onset of rheumatoid arthritis." PLoS One. 2019. 14: e0219109. doi: 0219110.0211371/journal.pone.0219109. e-Collection 0212019.
  6. Anaparti V, Smolik I, Meng X, O'Neil L, Jantz MA, Fritzler MJ, El-Gabalawy H. "Expansion of Alternative Autoantibodies Does Not Follow the Evolution of Anti-Citrullinated Protein Antibodies in Preclinical Rheumatoid Arthritis: An Analysis in At-Risk First Degree Relatives." Arthritis and Rheumatology. 2021. 73: 740-749. https://doi.org/10.1002/art.41675
  7. Aslanalp Z, Tikiz C, Ulusoy A, Orguc S, Bilgi Yedekci A, Ulman C. "The relationship between serum angiogenic factor levels and disease activity in rheumatoid arthritis." Archives of Rheumatology. 2020. 35: 416-425. https://doi.org/10.46497/ArchRheumatol.2020.7416
  8. Cao G, Chi S, Wang X, Sun J, Zhang Y. "CD4+CXCR5+pd-1+ t follicular helper cells play a pivotal role in the development of rheumatoid arthritis." Medical Science Monitor. 2019. 25: 3032-3040. https://doi.org/10.12659/msm.914868
  9. El Shazly RI, Hussein SA, Raslan HZ, Elgogary AA. "Anti-mutated citrullinated vimentin antibodies in rheumatoid arthritis patients: Relation to disease activity and manifestations." Egyptian Rheumatologist. 2014. 36: 65-70. https://doi.org/10.1016/j.ejr.2013.12.009
  10. El-Banna H, Jiman-Fatani A. "Anti-cyclic citrullinated peptide antibodies and paraoxonase-1 polymorphism in rheumatoid arthritis." BMC Musculoskelet Disord. 2014. 15: 379. doi: 10.1186/1471-2474-1115-1379.
  11. Giles JT, Danielides S, Szklo M, Post WS, Blumenthal RS, Petri M, Schreiner PJ, Budoff M, Detrano R, Bathon JM. "Insulin resistance in rheumatoid arthritis: Disease-related indicators and associations with the presence and progression of subclinical atherosclerosis." Arthritis and Rheumatology. 2015. 67: 626-636. https://doi.org/10.1002/art.38986
  12. Guan SZ, Yang YQ, Bai X, Wang Y, Feng KQ, Zhang HJ, Dong M, Yang HW, Li HQ. "Serum 14-3-3η could improve the diagnostic rate of rheumatoid arthritis and correlates to disease activity." Annals of Clinical and Laboratory Science. 2019. 49: 57-62.
  13. Guo CJ, Lv JH, Niu DS, Ma T, Sun SX, Li LX, Zhao X, Wu L, Jin QH. "Detection of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis patients undergoing total knee arthroplasty." International Journal of Clinical and Experimental Medicine. 2015. 8: 4410.
  14. Hadinedoushan H, Noorbakhsh P, Soleymani-Salehabadi H. "Tumor necrosis factor alpha gene polymorphism and association with its serum level in Iranian population with rheumatoid arthritis." Archives of Rheumatology. 2016. 31: 306-313. https://doi.org/10.5606/ArchRheumatol.2016.5907
  15. Hashemi V, Farrokhi AS, Tanomand A, Babaloo Z, Hojjat-Farsangi M, Anvari E, Tahoori MT, Ezzeddini R, Hosseini A, Gharibi T, Ghalamfarsa G, Jadidi-Niaragh F. "Polymorphism of Foxp3 gene affects the frequency of regulatory T cells and disease activity in patients with rheumatoid arthritis in Iranian population." Immunol Lett. 2018. 204: 16-22. doi: 10.1016/j.imlet.2018.1010.1001. Epub 2018 Oct 1014.
  16. Hernandez-Bello J, Oregon-Romero E, Vazquez-Villamar M, Garcia-Arellano S, Valle Y, Padilla-Gutierrez JR, Roman-Fernandez IV, Palafox-Sanchez CA, Martinez-Bonilla GE, Munoz-Valle JF. "Aberrant expression of interleukin-10 in rheumatoid arthritis: Relationship with IL10 haplotypes and autoantibodies." Cytokine. 2017. 95: 88-96. doi: 10.1016/j.cyto.2017.1002.1022. Epub 2017 Feb 1027.
  17. Hussein MS, El-Barbary AM, Nada DW, Gaber RA, Elkolaly RM, Aboelhawa MA. "Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease." International Journal of Rheumatic Diseases. 2021. 24: 591-598. https://doi.org/10.1111/1756-185X.14084
  18. Iranshahi N, Assar S, Amiri SM, Zafari P, Fekri A, Taghadosi M. "Decreased Gene Expression of Epstein-Barr Virus-Induced Gene 3 (EBI-3) may Contribute to the Pathogenesis of Rheumatoid Arthritis." Immunol Invest. 2019. 48: 367-377. doi: 310.1080/08820139.08822018.01549066. Epub 08822018 Dec 08820134.
  19. Janssen KM, de Smit MJ, Brouwer E, de Kok FA, Kraan J, Altenburg J, Verheul MK, Trouw LA, van Winkelhoff AJ, Vissink A, Westra J. "Rheumatoid arthritis-associated autoantibodies in non-rheumatoid arthritis patients with mucosal inflammation: a case-control study." Arthritis Res Ther. 2015. 17: 174. doi: 110.1186/s13075-13015-10690-13076.
  20. Khan MA, Dixit K, Uddin M, Malik A, Alam K. "Role of peroxynitrite-modified H2A histone in the induction and progression of rheumatoid arthritis." Scandinavian Journal of Rheumatology. 2012. 41: 426-433. https://doi.org/10.3109/03009742.2012.698300
  21. Konda Mohan V, Ganesan N, Gopalakrishnan R, Venkatesan V. "HLA-DRB 1 shared epitope alleles in patients with rheumatoid arthritis: relation to autoantibodies and disease severity in a south Indian population." International Journal of Rheumatic Diseases. 2017. 20: 1492-1498. https://doi.org/10.1111/1756-185X.12948
  22. Lazm AM, Alomashi GB, Jebur MS. "Potential association of proteus mirabilis and strongyloides stercoralis among rheumatoid arthritis patients." Biochemical and Cellular Archives. 2018. 18: 109-114.
  23. Lee CH, Lee KH. "Surgical Treatment for Hand and Wrist Problems in Rheumatoid Arthritis." J Korean Orthop Assoc. 2020. 55: 472-486. https://doi.org/10.4055/jkoa.2020.55.6.472
  24. Li W, Liu Y, Zheng X, Gao J, Wang L, Li Y. "Investigation of the potential use of sialic acid as a biomarker for rheumatoid arthritis." Annals of Clinical and Laboratory Science. 2019. 49: 224-231.
  25. Liao J, Ip WS, Cheung KY, Wan WM, Cautherley GWH, Cai X, Lin X, Renneberg R, Chan CPY. "Diagnostic utility of an anti-CCP point-of-care immunotest in Chinese patients with rheumatoid arthritis." Clinica Chimica Acta. 2011. 412: 778-781. https://doi.org/10.1016/j.cca.2011.01.013
  26. Maksymowych WP, Naides SJ, Bykerk V, Siminovitch KA, Van Schaardenburg D, Boers M, Landewe R, Van Der Heijde D, Tak PP, Genovese MC, Weinblatt ME, Keystone EC, Zhukov, OS, Abolhosn RW, Popov JM, Britsemmer K, Van Kuijk AW, Marotta A. "Serum 14-3-3η is a novel marker that complements current serological measurements to enhance detection of patients with rheumatoid arthritis." Journal of Rheumatology. 2014. 41: 2104-2113. https://doi.org/10.3899/jrheum.131446
  27. Meyer PWA, Ally MTM, Hodkinson B, Anderson R, Tikly M. "Comparison of the diagnostic potential of three anti-citrullinated protein antibodies as adjuncts to rheumatoid factor and CCP in a cohort of South African rheumatoid arthritis patients." Rheumatol Int. 2018. 38: 993-1001. doi : 1010.1007/s00296-00018-04036-y. Epub 02018 Apr 00230.
  28. Mimori T. "Clinical significance of anti-CCP antibodies in rheumatoid arthritis." Internal Medicine. 2005. 44: 1122-1126. https://doi.org/10.2169/internalmedicine.44.1122
  29. Mohamed A, Enein A, Abdelsalam N, Balata M, Abdellatif S, Rizk E, Fathy A. "Utility of anti-carbamylated protein antibodies in the diagnosis of early rheumatoid arthritis." Indian Journal of Rheumatology. 2019. 14: 37-41. https://doi.org/10.4103/injr.injr_110_18
  30. Mun S, Lee J, Lim MK, Lee YR, Ihm C, Lee SH, Kang HG. "Development of a novel diagnostic biomarker set for rheumatoid arthritis using a proteomics approach." BioMed Research International. 2018. 2018.
  31. Mun S, Lee J, Park M, Shin J, Lim MK, Kang HG. "Serum biomarker panel for the diagnosis of rheumatoid arthritis." Arthritis Research & Therapy. 2021. 23: 1-10. https://doi.org/10.1186/s13075-020-02389-4
  32. Narayan V, Pallinti V, Ganesan N. "A study of serum YKL-40 and its correlation with traditional biomarkers in rheumatoid arthritis patients." Indian Journal of Rheumatology. 2019. 14: 200-205. https://doi.org/10.4103/injr.injr_44_19
  33. Nass FR, Skare TL, Goeldner I, Nisihara R, Messias-Reason IT, Utiyama SRR. "Analysis of four serum biomarkers in rheumatoid arthritis: association with extra articular manifestations in patients and arthralgia in relatives." Rev Bras Reumatol Engl Ed. 2017. 57: 286-293. doi: 210.1016/j.rbre.2016.1003.1001. Epub 2016 Mar 1022.
  34. Nell V, Machold KP, Stamm TA, Eberl G, Heinzl H, Uffmann M, Smolen JS, Steiner G. "Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis." Annals of the Rheumatic Diseases. 2005. 64: 1731-1736. https://doi.org/10.1136/ard.2005.035691
  35. Okada M, Kobayashi T, Ito S, Yokoyama T, Komatsu Y, Abe A, Murasawa A, Yoshie H. "Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adults." J Periodontol. 2011. 82: 1433-1441. doi: 1410.1902/jop.2011.110020. Epub 112011 Feb 110022.
  36. Otterness IG. The value of C-reactive protein measurement in rheumatoid arthritis. Seminars in arthritis and rheumatism, Elsevier, 1994.
  37. Ozkan Y, Mete G, Sepici-Dincel A, Sepici V, Simsek B. "Tryptophan degradation and neopterin levels in treated rheumatoid arthritis patients." Clinical Rheumatology. 2012. 31: 29-34. https://doi.org/10.1007/s10067-011-1767-5
  38. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE. "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews." Bmj. 2021. 372.
  39. Ramwadhdoebe TH, Ramos MI, Maijer KI, van Lienden KP, Maas M, Gerlag DM, Tak PP, Lebre MC, van Baarsen LGM. "Myeloid dendritic cells are enriched in lymph node tissue of early rheumatoid arthritis patients but not in at risk individuals." Cells. 2019. 8.
  40. Reyes-Perez IV, Sanchez-Hernandez PE, Munoz-Valle JF, Martinez-Bonilla GE, Garcia-Iglesias T, Gonzalez-Diaz V, Garcia-Arellano S, Cerpa-Cruz S, Polanco-Cruz J, Ramirez-Duenas MG. "Cytokines (IL-15, IL-21, and IFN-γ) in rheumatoid arthritis: association with positivity to autoantibodies (RF, anti-CCP, anti-MCV, and anti-PADI4) and clinical activity." Clinical Rheumatology. 2019. 38: 3061-3071. https://doi.org/10.1007/s10067-019-04681-4
  41. Rykova E, Sizikov A, Roggenbuck D, Antonenko O, Bryzgalov L, Morozkin E, Skvortsova K, Vlassov V, Laktionov P, Kozlov V. "Circulating DNA in rheumatoid arthritis: Pathological changes and association with clinically used serological markers." Arthritis Research and Therapy. 2017. 19.
  42. Shakiba Y, Koopah S, Jamshidi AR, Amirzargar AA, Masoud A, Kiani A, Niknam MH, Nazari B, Nikbin B. "Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in iranian patients with rheumatoid arthritis: Evaluation of clinical value and association with disease activity." Iranian Journal of Allergy, Asthma and Immunology. 2014. 13: 147-156.
  43. Shen C, Sun XG, Liu N, Mu Y, Hong CC, Wei W, Zheng F. "Increased serum amyloid A and its association with autoantibodies, acute phase reactants and disease activity in patients with rheumatoid arthritis." Molecular Medicine Reports. 2014. 11: 1528-1534. https://doi.org/10.3892/mmr.2014.2804
  44. Shen R, Ren X, Jing R, Shen X, Chen J, Ju S, Yang C. "Rheumatoid factor, anti-cyclic citrullinated peptide antibody, C-reactive protein, and erythrocyte sedimentation rate for the clinical diagnosis of rheumatoid arthritis." Laboratory Medicine. 2015. 46: 226-229. https://doi.org/10.1309/LMZYTSO5RHIHV93T
  45. Shrivastava AK, Singh HV, Raizada A, Singh SK, Pandey A, Singh N, Yadav DS, Sharma H. "Inflammatory markers in patients with rheumatoid arthritis." Allergol Immunopathol (Madr). 2015. 43: 81-87. doi: 10.1016/j.aller.2013.1011.1003. Epub 2014 Mar 1020.
  46. Tuncer T, Kaya A, Gulkesen A, Kal GA, Kaman D, Akgol G. "Matrix metalloproteinase-3 levels in relation to disease activity and radiological progression in rheumatoid arthritis." Advances in Clinical and Experimental Medicine. 2019. 28: 665-670. https://doi.org/10.17219/acem/94065
  47. Wei Y, Peng L, Li Y, Zhang N, Shang K, Duan L, Zhong J, Chen J. "Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis." Journal of Immunology Research. 2020. 2020.
  48. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses, Oxford, 2000.
  49. Yan S, Wang P, Wang J, Yang J, Lu H, Jin C, Cheng M, Xu D. "Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis." Frontiers in Immunology. 2019. 10.
  50. Yang L, Zhang J, Tao J, Lu T. "Elevated serum levels of Interleukin-37 are associated with inflammatory cytokines and disease activity in rheumatoid arthritis." APMIS. 2015. 123: 1025-1031. https://doi.org/10.1111/apm.12467
  51. Zeng T, Tan L, Wu Y, Yu J. "14-3-3η protein in rheumatoid arthritis: Promising diagnostic marker and independent risk factor for osteoporosis." Lab Medicine. 2020. 51: 529-539. https://doi.org/10.1093/labmed/lmaa001