• 제목/요약/키워드: psoriasis

검색결과 187건 처리시간 0.203초

한약으로 치료 받은 건선 환자 107명의 안전성 및 유효성에 대한 고찰 (The Safety and Efficacy of Herbal Medicine for 107 Psoriasis Patients: A Retrospective Chart Review)

  • 이병철;최은지
    • 대한한의학회지
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    • 제37권1호
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    • pp.34-40
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    • 2016
  • Objectives: To observe safety and efficacy of herbal medicine for psoriasis patients. Methods: We did retrospective chart review for 107 psoriasis patients who had been treated by herbal medicine for 2 months, and we analyzed the liver function test (LFT) results and Psoriasis Area and Severity Index (PASI) scores of before and after the treatment. Results: The mean LFT and the number of patients with abnormal LFT decreased after the treatments. More than 95% of patients with normal LFT maintained normal results at after the treatment, and only 2.1% and 4.6% patients with normal LFT showed abnormal Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT) results at after the treatment. Also, both mean PASI scores for all patients and patients with abnormal LFT before the treatment decreased significantly. Conclusions: This study suggest that herbal medicine may be safe and effective treatment for psoriasis.

봉약침료법(蜂藥鍼療法)을 가미(加味)한 건선(乾癬) 치험(治驗) 1례(例) (A Case of Psoriasis Treated with Additional Bee Venom Aqua-acupuncture)

  • 이경민;윤현민;고우신;장경전;하지영;서정철;한상원
    • Journal of Acupuncture Research
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    • 제20권1호
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    • pp.228-235
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    • 2003
  • Objective : Psoriasis is a common skin disease and the difficulty of its medical management is well known. This study was designed to investigate the effect of bee venom aqua-acupuncture on psoriasis. Methods : Bee venom aqua-acupuncture was performed two times a week. The following points were selected: LI-11(曲池), LI-15, K-9(築賓) on both sides of body. For herbal medicine, YanHyulJiHwangTang-gami was given. We checked involvement in plaque, erythematous popules and invasiveness according to psoriasis area severity index(PASI). Results :After 9 weeks of treatment, the patient showed that itching symptoms was disappeared and score of PASI changed from 26.2 to 0. Conclusions : These results suggest that bee venom aqua-acupuncture and herbal medicine has good effect on psoriasis. But further studies are required to concretely prove the effectiveness of bee venom aqua-acupuncture for treating psoriasis.

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The pathophysiological role of dendritic cell subsets in psoriasis

  • Kim, Tae-Gyun;Kim, Dae Suk;Kim, Hyoung-Pyo;Lee, Min-Geol
    • BMB Reports
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    • 제47권2호
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    • pp.60-68
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    • 2014
  • Psoriasis is a chronic inflammatory disorder characterized by an erythematous scaly plaque of the skin and is occasionally accompanied by systemic complications. In the psoriatic lesions, an increased number of cytokine-producing dendritic cells and activated T cells are observed, which indicate that psoriasis is a prototype of an immune-mediated dermatosis. During the last decade, emerging studies demonstrate novel roles for the dendritic cell subsets in the process of disease initiation and maintenance of psoriasis. In addition, recently discovered anti-psoriatic therapies, which specifically target inflammatory cytokines produced by lesional dendritic cells, bring much better clinical improvement compared to conventional treatments. These new therapies implicate the crucial importance of dendritic cells in psoriasis pathogenesis. This review will summarize and discuss the dendritic cell subsets of the human skin and their pathophysiological involvement in psoriasis based on mouse- and patient-oriented studies.

고방(古方)으로 치료한 건선 환자 치험 2례 (Two different Cases of Psoriasis Patients Treated with 2 different Kobangs)

  • 문영호;오재선;김선종
    • 동의생리병리학회지
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    • 제28권6호
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    • pp.650-656
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    • 2014
  • The purpose of this study is to investigate the effect of 2 Kobangs. Daecheongryong-tang and Samhwangsasim-tang on to two psoriasis patients each. The improvement of the skin condition was observed by Psoriasis Area and Severity Index (PASI) score. The patient treated with Daecheongryong-tang showed significant improvement after the patient's state of sweating improved and the PASI score of the patient reduced from 17.6 to 1.8 after five months of treatment. The patient treated with Samhwangsasim-tang showed gradual improvement after the patient's defecation was improved and the PASI score of the patient reduced from 27.3 to 3.6 after three months of treatment. According to the results, we obtained clinically positive effects from 2 Kobangs applied on 2 psoriasis cases respectively. Although there were few reports on psoriasis treated with Kobang, we can suggest effective treatment on psoriasis.

한국인에서 건선과 KIR (Killer Cell Immunoglobulin-like Receptor) 유전자형 사이의 연관성 (Association of KIR (Killer Cell Immunoglobulin-like Receptor) Genotype with Psoriasis in Korean Population)

  • 최은정;최희백;김수연;윤호열;박민지;김태윤;김태규
    • IMMUNE NETWORK
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    • 제5권3호
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    • pp.179-185
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    • 2005
  • Background: Psoriasis is a multifactorial autoimmune skin disease with a pathogenesis that has remained obscure. Recently, T cells bearing natural killer receptors (NKRs) were precisely and strongly targeted as new putative pathogenic immunocytes in psoriasis. Among NKRs, killer cell immunoglobulin-like receptor (KIR) is the major molecule recognizing HLA class I allotypes and might be closely related to psoriasis. Methods: To investigate the association of KIR genotype and patients with psoriasis in Korean, we defined the 14 KIR genotypes in 96 patients with psoriasis and 86 healthy controls using PCR-SSP methods. Results: The frequencies of KIR2DS4 and KIR3DL1 were significantly decreased in psoriasis compared with controls (RR=0.21, p<0.02). When patients were divided into two subgroups at the age of onset, type I (<30 years) and type II ($({\geq}30$ years) respectively, these phenomena were similarly observed independent of groups divided (type I: RR=0.26, p<0.005; type II: RR=0.14, p<0.0006). When the patients were divided into subgroups according to the age of onset and family history, the frequencies of KIR2DS4, KIR3DL1, and KIR2DS3 were significantly decreased in type I compared with type II psoriasis (3DL1, 2DS4: p<0.004; 2DS3: p<0.04) and were significantly decreased in psoriasis without family history compared to with family history (3DL1, 2DS4: p<0.007; 2DS3: p<0.05). The frequency of haplotype combination BB was significantly increased in psoriasis compared with controls (RR=2.74, p<0.009). Conclusion: These results suggest that KIR genotype is a factor for the occurrence and development of psoriasis and in future how combinations of HLA and KIR genes influence psoriasis needs to be defined.

乾癬患者의 治驗 3例 (Three Cases of Psoriasis)

  • 김중호;채병윤
    • 한방안이비인후피부과학회지
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    • 제3권1호
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    • pp.127-134
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    • 1990
  • Psoriasis is a common chronic recurrent inflammatory disease of the skin characterized by round, circumscribed, erythematous dry scaling patches of various sizes, covered by grayish white or silvery white. imbricated and lamella scales. Three cases of psoriasis has onset from 6 months to 35 years. These patients has been treated with western medicine. But they could not expect to improve condition. We experienced three cases of psoriasis that have a result of effect with Oriental Herb medicine.

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乾癬에 對한 東.西醫 文獻的 硏究 (The Oriental and Occidental bibliographic Study of Psoriasis)

  • 김남권;황충연;임규상
    • 한방안이비인후피부과학회지
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    • 제12권1호
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    • pp.154-178
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    • 1999
  • Psoriasis is the recurrent disease of skin and till now its mechanism, pathogenesis and treatment are not clearly discovered. So, like these papers, we must investigate more safety and effective treatment of psoriasis. And I obtained the following condusions from the Oriental and Occidental bibliographic investigation. 1. In Oriental medicine. Baikbi, Pungsun, Eunselbyong, Songpisun, Baikselpung were the other names of Psoriasis. 2. In Occidental medicine, genetic factors, aggravation and inducible factors, biochemical factors, immunologic factors, disorder of epidermal kinetics, vascular malformation of dermis were cosidered to the pathogenic factors of psoriasis. 3. In Oriental medicine, the pathogenic factors of psoriasis were divided two parts. One is exogenous pathogenic factors which including the blood-heat, blood dryness, blood stasis, deficiency of liver and kidney, inharmony of impulsive and appointed pulsation, deficiency of blood. The other is exogenous pathogenic factors which including the wind-evil, wind-wetness, wind-heat, wind-cold, wetness-heat, cold-wetness, heat-evil. 4. In Occidental medicine, external applicative medicine, internal medicine, ultraviolet therapy, ultraviolet - external applicative medicine compound therapy and etc. were used the therapy of psoriasis. 5. In Oriental medicine, clean away heat and cooling blood, aliment the blood and moisturize, activating blood and expelling blood stasis, harmonize and invigorate the liver and kidney, invigorate the kidney, aliment the blood and moisturize the skin, aliment the blood and expelling the wind, expelling the wind and wetness, clean away heat and expelling wind, expelling the wind and scatter the cold, clean away heat and expelling the wetness, heat up the meridian and scatter the cold, clean away heat and remove the toxin and etc. were used the method of internal therapy of psoriasis. 6. Until Qing dynasty, wind expelling effective prescriptions like Bangpungtongsungsan, Sopungsan. Supungsunkisan and etc. were used and recently Yanghyelgeupungtang, Hwalhyelgeupungtang, Samultanggagam and etc. were used the internal therapy of psoriasis. 7. In the external therapy of psoriasis, Yuhonggo, Pungyugo, Sekryupiyeongo were used the plaster therapy and Folium Rerillae, Camphora, Fructus, Xanthii, Herba Spirodelae compound prescription were used the cleansing therapy, Okgisan, Chiunsan, Galmyogo, Hobunsan, Muisan, Madugo, Jeyugohengin were used the rubbing skin therapy. Rangdok Radix Aconiti, Bijeonilchoalkwang were used the attaching therapy, the extract of Rhizoma Et Radix Veratri was used the spreading pouder therapy. 8. In the acupuncture therapy of psoriasis, the Jelgol, chok Samni(S36), Kansa(P5), Haegye(S41), Wijung(B40) and etc. were used the acupuncture point, and the angle of helix incision threapy that disinfect and cut the angle of helix and plaster the Semen Glycine and Squama Manitis were used.

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Persicaria senticosa Ameliorates Imiquimod-induced Psoriasis-like Skin Lesions in Mice via Suppression of IL-6/STAT3 Expression and Proliferation of Keratinocytes

  • Jung, Sangmi;Park, Jeong-Ran;Ra, Moonjin;Kim, Young Han;Yu, Ji Hoon;Lee, Yongjun
    • Natural Product Sciences
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    • 제26권2호
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    • pp.136-143
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    • 2020
  • Psoriasis is one of the most common inflammatory skin disorders, with a global prevalence of 2% - 3%. It is an autoimmune skin disorder characterized by excessive generation of plaques on the skin with typical long-lasting red, itchy, and scaly lesions. In this study, we aimed to elucidate the anti-psoriatic effect of the methanolic extract of Persicaria senticosa (PS), a bioactive edible plant extract used in traditional medicine, using a mouse model of imiquimod (IMQ)-induced psoriasis. The daily topical application of IMQ could induce human psoriasis-like lesion. The extract ameliorated IMQ-induced psoriasis. Furthermore, hematoxylin and eosin staining and the Psoriasis Area and Severity Index (PASI) scores indicated that topical application of PS led to an improvement in erythema, scaling, and thickness scores of the mouse dorsal skin and a considerable decrease in the epidermal thickness of the ear and dorsal skin in the IMQ-induced psoriatic mouse model. We also studied the effect of PS on the proliferation of keratinocytes using HaCaT cells. The extract inhibited cell proliferation and IL-6 and pSTAT3 expression induced by M5 cocktail (comprising interleukin [IL]-1α, IL-17A, IL-22, oncostatin M, and tumor necrosis factor-α) in HaCaT cells. Thus, PS might serve as a potential therapeutic agent for the treatment of psoriasis.

홍피성 건선 환자의 한방 치험 1례 (A Case of Erythrodermic Psoriasis)

  • 유승민;손병국;윤영희;최인화
    • 대한한의학회지
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    • 제31권5호
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    • pp.179-187
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    • 2010
  • 임상에서 치료가 어려운 건선을 오래 앓아온 환자가 홍피성 건선이 발생하여 집중적인 입원치료 후 꾸준한 외래진료를 거쳐 호전된 경과를 볼 수 있었기에 보고하는 바이다. 상기 환자는 심장 질환을 동반하고 있었으며 그와 관련된 부종 등의 증상에도 한방치료로 긍정적인 효과를 얻었다. 앞으로 홍피성 건선의 한방치료에 대한 치료의 기준을 마련할 필요가 있을 것으로 생각된다.

N,N,N-Trimethylphytosphingosine (TMP)의 염증성 피부질환 치료제 가능성에 관한 연구 (Study for Possibility of N,N,N-Trimethylphytosphingosine (TMP) for Management of Chronic Skin Diseases)

  • 서원상;오한나;박우정;엄상용;강상모
    • KSBB Journal
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    • 제29권1호
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    • pp.36-41
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    • 2014
  • Skin disease is one of the most common diseases and its incidence is increasing dramatically in modern society. Specially, many attempts have been made to treat chronic skin inflammation diseases, such as psoriasis and atopic dermatitis, but effective therapies for the immune cell-mediated skin diseases, including psoriasis and atopic dermatitis have not been developed. Until recently, several drug candidates which were claimed to be effective for skin diseases have been reported, but most of them are not used to treat chronic skin disease. Especially, Psoriasis is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells and various immune-related cytokines. Formation of new blood vessels starts with early psoriatic changes and disappears with disease clearance. Several angiogenic mediators are up-regulated in psoriasis development. Contact- and mediator-dependent factors derived from keratinocytes, mast cells and immune cells may contribute to the strong blood vessel formation of psoriasis. New technologies and experimental models provide new insights into the role of angiogenesis in psoriasis pathogenesis. TMP and its derivatives themselves effectively inhibited in vitro cell migration, tube formation, and the expression of angiogenic factors. However, TMP and its derivatives induced side effects including hemolysis and local side effects. Therefore, in an attempt to reduce the toxicity and the undesirable side effects of TMP and derivatives, a liposomal formulation was prepared and tested for its effectiveness. TMP and derivatives liposomes retained the effectiveness of TMP in vitro while side effects were reduced. These results support the conclusion that TMP effectively inhibits in vitro angiogenesis, with the possibility that use as a psoriasis relief agent.