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The Korean Association of Immunobiologists (대한면역학회)
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Association of KIR (Killer Cell Immunoglobulin-like Receptor) Genotype with Psoriasis in Korean Population

한국인에서 건선과 KIR (Killer Cell Immunoglobulin-like Receptor) 유전자형 사이의 연관성

  • Choi, Eun-Jung (Department of Microbiology, The Catholic University of Korea College of Medicine) ;
  • Choi, Hee-Baeg (Catholic Hematopoietic Stem Cell Bank, The Catholic University of Korea College of Medicine) ;
  • Kim, Su-Yeon (Department of Microbiology, The Catholic University of Korea College of Medicine) ;
  • Yoon, Ho-Yeul (Department of Microbiology, The Catholic University of Korea College of Medicine) ;
  • Park, Min-Ji (Department of Microbiology, The Catholic University of Korea College of Medicine) ;
  • Kim, Tae-Yoon (Department of Dermatology, The Catholic University of Korea College of Medicine) ;
  • Kim, Tai-Gyu (Department of Microbiology, The Catholic University of Korea College of Medicine)
  • 최은정 (가톨릭대학교 의과대학 미생물학교실) ;
  • 최희백 (가톨릭대학교 의과대학 조혈모세포은행) ;
  • 김수연 (가톨릭대학교 의과대학 미생물학교실) ;
  • 윤호열 (가톨릭대학교 의과대학 미생물학교실) ;
  • 박민지 (가톨릭대학교 의과대학 미생물학교실) ;
  • 김태윤 (가톨릭대학교 의과대학 피부과학교실) ;
  • 김태규 (가톨릭대학교 의과대학 미생물학교실)
  • Published : 2005.09.30
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Abstract

Background: Psoriasis is a multifactorial autoimmune skin disease with a pathogenesis that has remained obscure. Recently, T cells bearing natural killer receptors (NKRs) were precisely and strongly targeted as new putative pathogenic immunocytes in psoriasis. Among NKRs, killer cell immunoglobulin-like receptor (KIR) is the major molecule recognizing HLA class I allotypes and might be closely related to psoriasis. Methods: To investigate the association of KIR genotype and patients with psoriasis in Korean, we defined the 14 KIR genotypes in 96 patients with psoriasis and 86 healthy controls using PCR-SSP methods. Results: The frequencies of KIR2DS4 and KIR3DL1 were significantly decreased in psoriasis compared with controls (RR=0.21, p<0.02). When patients were divided into two subgroups at the age of onset, type I (<30 years) and type II ($({\geq}30$ years) respectively, these phenomena were similarly observed independent of groups divided (type I: RR=0.26, p<0.005; type II: RR=0.14, p<0.0006). When the patients were divided into subgroups according to the age of onset and family history, the frequencies of KIR2DS4, KIR3DL1, and KIR2DS3 were significantly decreased in type I compared with type II psoriasis (3DL1, 2DS4: p<0.004; 2DS3: p<0.04) and were significantly decreased in psoriasis without family history compared to with family history (3DL1, 2DS4: p<0.007; 2DS3: p<0.05). The frequency of haplotype combination BB was significantly increased in psoriasis compared with controls (RR=2.74, p<0.009). Conclusion: These results suggest that KIR genotype is a factor for the occurrence and development of psoriasis and in future how combinations of HLA and KIR genes influence psoriasis needs to be defined.

Keywords

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