• Journal of Positioning, Navigation, and Timing
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• v.10 no.2
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• pp.145-151
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• 2021

According to the Korea Augmentation Satellite System (KASS) system milestone, Site Acceptance Test (SAT) has three steps test until the end of the project. SAT#1 is the first time of SAT steps and verify the KASS Reference Station (KRS) and Sub System (S/S) for the monitoring and controllable. After the equipment and software were installed at the Mission Control Center (MCC) with Central Monitoring and Control Simulator (CMS) for the SAT#1, the 1:1 test was progressed when the KRS and S/S are ready to test. SAT#1 has a 10 steps test case and it was progressed each KRS sites. The test was finished throughout the real-time monitoring and the data collection including the data analysis all of the 7 KRS sites. Finally SAT#1 was completed on December 2020 with successfully.

• Proceedings of the Korean Society of Computer Information Conference
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• 2014.01a
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• pp.307-308
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• 2014

본 논문은 대학에서의 팀 프로젝트 학습이 어떻게 수행되고 있는지를 고찰한 것이다. 논의된 결과, 학생들은 조별 활동을 함에 있어서 SNS를 적극 활용함을 알 수 있었다. 이는 주제의 선정이라든지 각자의 역할을 수행하기 위해서는 시공간의 제약을 극복해야 하기 때문이다. 또한 팀 프로젝트를 발표하는 과정에서 학생들은 주제에 맞는 다양한 시청각 자료들을 활용함을 알 수 있었다. 이는 팀 프로젝트를 수행하는 과정에서 요청되는 커뮤니케이션의 극대화를 위한 최선의 전략이기 때문이다.

• 한국IT서비스학회:학술대회논문집
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• 2003.11a
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• pp.657-665
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• 2003

ERP 시스템은 전사 통합 관점에서 기업 전체의 업무를 관리하기 때문에, 업무 집중도가 높고, 처리량이 많으며, 업무가 Waterfall 모델로 설계된 부분이 많은 특성이 있어, 어느 한 부분의 성능 문제가 전체 시스템 운영의 중대한 Issue로 확대될 가능성이 크다. 본 논문을 통해서 ERP 시스템의 성능 Issue를 사전에 점검할 수 있는 성능 테스트(Performance Testing) 방법을 연구했고, 실제 ERP 시스템 구축 Project에 투입되어 성능 테스트를 진행한 사례를 고찰하여, 발견된 Issue를 토대로 ERP 시스템의 성능을 최적화하고 시스템을 안정적으로 운영할 수 있는 방안을 연구해 보았다.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.102-112
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• 2001

It has been passed $5\~6$ years since Construction Management introduced in Korea, but a few government projects have been presented as CM instances. We performed CM service, on behalf of the foreign Client, in the Insa-dong construction, I-Project. Even though there were many limits in cost, time and other aspects, we have attained satisfaction of the Client and successful businesses of all the construction parties as adopting the advanced management methods. Many advanced construction methods have been applied for the purpose of time reduce, cost save and quality assurance as well as to the webbased project management has been imported to overcome the limits of time and place. They have actualized to increase the productivity of the project by managing the floor to floor cycle and quality systemically pursuant to ISO 9002, and by adopting Real-name construction and completion system (or individual activity. While carrying out this project, it is possible to establish mutual reliability and understanding enable to resolve the issues occurring in the early stage due to insufficient understanding of CM, lack of communications and team work, indistinct work scope through continuos training and conferences. Additionally, we became to share business targets among the parties and promoted the project in confidence. We wish that the success of I- project to be rated as a standard model of CM in Korea.

• Transactions of the Korean hydrogen and new energy society
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• v.6 no.2
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• pp.53-63
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• 1995

A 100kW class stack consisting of 10 molten carbonate fuel cells has been fabricated. Internally manifold stack has been tested for endurance. Each cell in the stack had an electrode area of $100cm^2$ and reactant gases were distributed in each cells in a cross-flow configuration. Initial and long term operation performance of the stack was investgated as a function of gas utilization using a specially designed small scale stack test facility. It was possible to have a stack with an output of more than 100W using an anode gas of 72% $H_2/18%$ $CO_2/10%H_2O$ and cathode gas of 33% $O_2/67%$ $CO_2$ and 70% Air 30% $CO_2$. The output and voltage of the stack at a current 15A($150mA/cm^2$) and gas utilization of 0.4 showed 125.8W and 8.39V respectively by elapsed time of 310 hours operation. In long term operation characteristics, the voltage drop of 52.4mV/1000hour was observed after more than 1,840 hours operation. Among the voltage drop, the OCV loss was highest than other voltage loss such as internal resistance and electrode polarization. Non uniformity of 2voltages and degradation of cell voltage in the stack was observed in according to changing the utilization rate after a long term operation. Further work for increasing the performance prolonging the life of the stack are required.

• Molecules and Cells
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• v.41 no.5
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• pp.454-464
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• 2018

Crosstalk between G-protein signaling and glutamatergic transmission within the brain reward circuits is critical for long-term emotional effects (depression and anxiety), cravings, and negative withdrawal symptoms associated with opioid addiction. A previous study showed that Regulator of G-protein signaling 4 (RGS4) may be implicated in opiate action in the nucleus accumbens (NAc). However, the mechanism of the NAc-specific RGS4 actions that induce the behavioral responses to opiates remains largely unknown. The present study used a short hairpin RNA (shRNA)-mediated knock-down of RGS4 in the NAc of the mouse brain to investigate the relationship between the activation of ionotropic glutamate receptors and RGS4 in the NAc during morphine reward. Additionally, the shRNA-mediated RGS4 knock-down was implemented in NAc/striatal primary-cultured neurons to investigate the role that striatal neurons have in the morphine-induced activation of ionotropic glutamate receptors. The results of this study show that the NAc-specific knock-down of RGS4 significantly increased the behaviors associated with morphine and did so by phosphorylation of the GluR1 (Ser831) and NR2A (Tyr1325) glutamate receptors in the NAc. Furthermore, the knock-down of RGS4 enhanced the phosphorylation of the GluR1 and NR2A glutamate receptors in the primary NAc/striatal neurons during spontaneous morphine withdrawal. These findings show a novel molecular mechanism of RGS4 in glutamatergic transmission that underlies the negative symptoms associated with morphine administration.

• Korean Journal of Food Science and Technology
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• v.46 no.4
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• pp.410-417
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• 2014

Berries and green tea are underutilized in the food industry despite their great potential as a functional food ingredients. The purpose of this study was to determine the extraction conditions under which total phenolic contents and antioxidant activities of berry and green tea extracts are maximized. Extracts produced using 0-80% ethanol and temperatures ranging from $5-65^{\circ}C$ were evaluated for total phenolic content (TP), as well as for DPPH and ABTS radical-scavenging activities by using response surface methodology. Both ethanol and temperature had significant effects (p<0.05). Ogaja extract produced at $67^{\circ}C$ by using 33% ethanol yielded maximum TP, ABTS, and DPPH values of 23.74 mg GAE/g, 19.77, and 25.04 mg VCE/g, respectively. Optimum conditions for mulberry and raspberry extraction were found to be $65^{\circ}C$ by using 69% and 40% ethanol, respectively. Mulberry and raspberry extracts had TP, DPPH, and ABTS values of 20.74 mg GAE/g, 23.55, and 35.44 mg VCE/g, and 26.08 mg GAE/g, 39.93, and 55.60 mg VCE/g, respectively. Green tea extraction at $57^{\circ}C$ by using 43% ethanol was found to be optimal, yielding TP, ABTS, and DPPH values of 101.15 mg GAE/g, 171.38, and 177.56 mg VCE/g, respectively.

• Integrative Medicine Research
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• v.6 no.2
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• pp.165-178
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• 2017

Background: Traditional Korean Sasang constitutional (SC) medicine categorizes individuals into four constitutional types [Tae-eum (TE), So-eum (SE), Tae-yang (TY), or So-yang (SY)] based on biological and physiological characteristics. As these characteristics are closely related to the bioenergetics of the human body, we assessed the correlation between SC type and energy metabolism features. Methods: Forty healthy, young ($22.3{\pm}1.4$ years) males volunteered to participate in this study. Participants answered an SC questionnaire, and their face shape, voice tone, and body shape were assessed using an SC analysis tool. Thirty-one participants (10 TE, 10 SE, 3 TY, and 8 SY) were selected for further analysis. Collected blood samples were subjected to blood composition analysis, mitochondrial function analysis, and whole-exome sequencing. Results: The SY type showed significantly lower total cholesterol and high-density lipoprotein cholesterol levels than the SE type. Cellular and mitochondrial Adenosine triphosphate (ATP) levels were similar across types. All types showed similar basal mitochondrial oxygen consumption rates, whereas the TE type showed a significantly lower ATP-linked oxygen consumption rate than the other types. Whole-exome sequencing identified several genes variants that were exclusively detected in particular SC types, including 19 for SE, seven for SY, 11 for TE, and six for TY. Conclusion: SC type-specific differences in mitochondrial function and gene mutations were detected in a small group of healthy, young Korean males. These results are expected to greatly improve the accurate screening and utilization of SC medicine.

• The Korea Journal of Herbology
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• v.36 no.5
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• pp.101-108
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• 2021

Objectives : A root of Dipsacus asperoides C. Y. Cheng et T. M. Ai (D. asperoides) has been traditionally used as a medicinal resource in several Asian countries, including Korean and traditional Chinese medicine that has been traditionally used for treating several medical conditions including pain, arthritis, and bone fractures in Korea. In the present study, we investigated potential subacute toxicities of D. asperoides extract. Methods : C57BL/6 mice (male, 7weeks) were randomly divided into 4 groups of 5 mice. Except for the control group, the mice were orally administrated D. asperoides extract at doses of 50, 150, or 450 mg/kg/day for 2 weeks. At the end of the treatment period, all mice were euthanized, and the following parameters were examined: mortality, body weight, clinical signs, gross findings, hematology, serum biochemistry, organ weight, and histopathology. Results : There were no abnormalities in mortality, clinical signs, body weight, gross findings, or organ weight after repeated administration of D. asperoides extract for 2 weeks, compared with the control group. In addition, there were no significant changes in hematological, serum biochemical, and histopathological parameters between the control group and D. asperoides extract administrated groups with doses of up to 450 mg/kg/day. Conclusion : In this study, D. asperoides extract showed no significant toxicities at a dose of up to 450 mg/kg/day in mice. Although we could not confirm the toxic dose of D. asperoides extract, it can be considered safe for further pharmacological use.

• The Korea Journal of Herbology
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• v.36 no.6
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• pp.1-8
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• 2021

Objectives : Atractylodis rhizoma Alba has been traditionally used as a medicinal resource that is used for enhancing Qi (氣) in traditional medicine in Korea, China, and Japan. This study investigated the protective effects of Atractylodis rhizoma Alba extract (ARE) against trimethyltin (TMT), a neurotoxin that causes selective hippocampal injury, using both in vitro and in vivo models. Methods : We investigated the effects of ARE on TMT- (5mM) induced cytotoxicity in primary cultures of mouse hippocampal cells (7 days in vitro ) and on hippocampal injury in C57BL/6 mice injected with TMT (2.6 mg/kg). Results : We observed that ARE treatment (0 - 50 ㎍/mL) significantly reduced TMT-induced cytotoxicity in cultured hippocampal neurons in a dose-dependent manner, based on results of lactate dehydrogenase and 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assays. Additionally, this study showed that orally administered ARE (5 mg/kg; between -6 and 0 days before TMT injection) significantly attenuated seizures in adult mice. Furthermore, quantitative analysis of allograft inflammatory factor-1 (Iba-1)- and glial fibrillary acidic protein (GFAP)- positive cells showed significantly reduced levels of Iba-1- and GFAP-positive cell bodies in the dentate gyrus of mice treated with ARE prior to TMT injection. These findings indicate the significant protective effects of ARE against the TMT-induced massive activation of microglia and astrocytes in the hippocampus. Conclusions : We conclude that ARE minimizes the detrimental effects of TMT-induced hippocampal neurotoxicity, both in vitro and in vivo . Our findings may serve as useful guidelines to support ARE administration as a promising pharmacotherapeutic approach to hippocampal degeneration.