• Journal of Ginseng Research
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• v.44 no.1
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• pp.105-114
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• 2020

Background: Exploring the pharmacokinetic (PK) changes of various active components of single herbs and their combinations is necessary to elucidate the compatibility mechanism. However, the lack of chemical standards and low concentrations of multiple active ingredients in the biological matrix restrict PK studies. Methods: A putative multiple reaction monitoring strategy based on liquid chromatography coupled with mass spectrometry (LC-MS) was developed to extend the PK scopes of quantification without resorting to the use of chemical standards. First, the compounds studied, including components with available reference standard (ARS) and components lacking reference standard (LRS), were preclassified to several groups according to their chemical structures. Herb decoctions were then subjected to ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry analysis with appropriate collision energy (CE) in MS² mode. Finally, multiple reaction monitoring transitions transformed from MS² of ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry were used for ultrahigh-performance liquid chromatography coupled with triple quadrupole mass spectrometry to obtain the mass responses of LRS components. LRS components quantification was further performed by developing an assistive group-dependent semiquantitative method. Results: The developed method was exemplified by the comparative PK process of single herbs Radix Ginseng (RG), Radix Polygala (RP), and their combinations (RG-RP). Significant changes in PK parameters were observed before and after combination. Conclusion: Results indicated that Traditional Chinese Medicine combinations can produce synergistic effects and diminish possible toxic effects, thereby reflecting the advantages of compatibility. The proposed strategy can solve the quantitative problem of LRS and extend the scopes of PK studies.

• Journal of Convergence for Information Technology
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• v.10 no.3
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• pp.104-114
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• 2020

The purpose of this study is to investigate the degree of rude experienced by nursing students during clinical practice and to investigate the impact of incivility and stress coping strategies on nursing professional value formation. Research instrument were measured using incivility, stress coping strategies, and nursing professional value. Data analysis was performed using SPSS WIN 20.0. The results of the study were as follows: First, among general characteristics, there were significant differences in the degree of incivility in cases of gender, grade, satisfaction with clinical practice, satisfaction with clinical practice environment, and experience of incivility among clinical practice. In addition, the difference of nursing professional value showed significant difference according to major satisfaction, clinical practice satisfaction, and clinical practice environment satisfaction. Second, incivility is correlated with problem-solving(r=.36), social support(r=.26), avoidance(r=.25), and nursing professional value(r=-. 16). The results of this study suggest that satisfactory clinical practice environment and clinical practice experience are important for establishing nursing professional value of nursing students.

• Journal of the Korea Society of Computer and Information
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• v.21 no.6
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• pp.9-19
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• 2016

In finance literature, stock liquidity showing how stocks can be cashed out in the market has received rich attentions from both academicians and practitioners. The reasons are plenty. First, it is known that stock liquidity affects significantly asset pricing. Second, macroeconomic announcements influence liquidity in the stock market. Therefore, stock liquidity itself affects investors' decision and managers' decision as well. Though there exist a great deal of literature about stock liquidity in finance literature, it is quite clear that there are no studies attempting to investigate the stock liquidity issue as one of decision making problems. In finance literature, most of stock liquidity studies had dealt with limited views such as how much it influences stock price, which variables are associated with describing the stock liquidity significantly, etc. However, this paper posits that stock liquidity issue may become a serious decision-making problem, and then be handled by using data mining techniques to estimate its future extent with statistical validity. In this sense, we collected financial data set from a number of manufacturing companies listed in KRX (Korea Exchange) during the period of 2010 to 2013. The reason why we selected dataset from 2010 was to avoid the after-shocks of financial crisis that occurred in 2008. We used Fn-GuidPro system to gather total 5,700 financial data set. Stock liquidity measure was computed by the procedures proposed by Amihud (2002) which is known to show best metrics for showing relationship with daily return. We applied five data mining techniques (or classifiers) such as Bayesian network, support vector machine (SVM), decision tree, neural network, and ensemble method. Bayesian networks include GBN (General Bayesian Network), NBN (Naive BN), TAN (Tree Augmented NBN). Decision tree uses CART and C4.5. Regression result was used as a benchmarking performance. Ensemble method uses two types-integration of two classifiers, and three classifiers. Ensemble method is based on voting for the sake of integrating classifiers. Among the single classifiers, CART showed best performance with 48.2%, compared with 37.18% by regression. Among the ensemble methods, the result from integrating TAN, CART, and SVM was best with 49.25%. Through the additional analysis in individual industries, those relatively stabilized industries like electronic appliances, wholesale & retailing, woods, leather-bags-shoes showed better performance over 50%.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.22 no.3
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• pp.225-232
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• 2004

The human history has progressed closely related to land. Mankind started land administration as a tool of governance to make land the object of imposing taxation as well as developing the land administration as a concept of securing property rights. People have drawn boundary lines on the ground to form a land parcel according to the usage and/or ownership. Furthermore, the land administration has been developed as a registering system of cadastral records fer the public announcement of fixed boundary instead of changeable ground boundary. Currently the citizens demand the provision of accurate and diverse information on the land which is assessed to has high property value encouraged by the rapid development in the post-industrial society today. However, even though the fact that the Korean cadastral registers produced during the Land Investigation Project are still practically in use causes land-related disputes and promotes public mistrust because of the changed boundaries by parcel mutation, the expansion and contraction of map sheets and the quality deterioration and damage of map paper, but the ultimate resolution is not yet made so far. The distance difference between boundary points are compared and analyzed using TS surveying method in the research as a methodology to resolve the boundary inconsistency, the current problem of cadastral records. Consequently, I'd say that the new surveying method of registering the coordinates of real ground boundary has been regarded as more efficient than considering the matter on the map regardless of urban or rural areas.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.38 no.3
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• pp.211-222
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• 2020

The purpose of this study is to derive a plan to improve the standard of survey cost, which is a system for estimating survey cost operated by the National Geographic Information Institute. The current standard has not been revised significantly since the initial enactment. However, in the situation where the survey industry is getting worse, the actualization of the standard is an urgent task for training engineers and industrial development. In this study, in order to break the problems of the standard and to derive improvement plan, we analyzed the outline, basic characteristics, and history of the standard and compared it with similar domestic ones. We collected opinions from the government and the industry through a survey, and verified labor cost and overhead rates. The conclusions are as follows. First, it is necessary to complement standard for production rate that directly affects direct cost, and to compensate for the missing items in the direct cost. Second, when compared with cost standards in foreign countries and cadastre field, the labor cost in survey field was found to be very low and improvement is needed. Third, the overhead rates were assessed to be appropriate, and the problem of improper overhead design should be coped with by strengthening education and promotion. Fourth, it is necessary to consider the introduction of deliberation committee or standard market price system for rapid response to new technologies.

• Journal of Life Science
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• v.16 no.7 s.80
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• pp.1158-1163
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• 2006

Bisphenol A (BPA), 2,2-bis(4-hydroxyphenyl) propane, has been widely used as a monomer for production of epoxy resins and polycarbonate plastics, and final products of BPA include adhesives, protective coatings, paints, optical lens, building materials, compact disks and other electrical parts. Since BPA is a toxic chemical to elicit acute cell cytotoxicity and chronic endocrine disrupting activity, the degradation of BPA has been focused during last decades. To overcome the problem of photo-, and chemical-degradation of BPA, in this study, a bacterium that is able to biodegrade BPA, was isolated. The bacterium, isolated froln the soil of plastic factory, was identified as Acinetobacter calcoaceticus (strain BP-2) based on physiological and 16S rDNA sequencing analysis. A. calcoaceticus BP-2 was able to grow in the presence of $1140{\mu}g\;ml^{-1}$ BPA. Biodegradation experiments showed that BP-2 mineralized BPA via 4-hydroxybenzoic acid and 4-hydroxyacetophenone, and average degradation rate was $53.3{\mu}g\;ml^{-1}\;day^{-1}$ under optimal conditions (pH 7 and $30^{\circ}C$). In high density resting cell $(3.5g-dcw.1^{-1})$ experiments, the maximal degradation rate was increased to $89.7{\mu}g\;ml^{-1}\;h^{-1}$. Our results suggest that BP-2 has high potential as a catalyst for practical BPA bioremediation.

• Communications of Mathematical Education
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• v.23 no.1
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• pp.145-174
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• 2009

Based on the thinking that people can understand more clearly when the problem is related with their prior knowledge, the Purpose of this study was to analysis students' informal knowledge, which is constructed through their mathematical experience in the context of real-world situations. According to this purpose, the following research questions were. 1) What is the characteristics of students' informal knowledge about fraction before formal fraction instruction in school? 2) What is the difference of informal knowledge of fraction according to reasoning ability and grade. To investigate these questions, 18 children of first, second and third grade(6 children per each grade) in C elementary school were selected. Among the various concept of fraction, part-whole fraction, quotient fraction, ratio fraction and measure fraction were selected for the interview. I recorded the interview on digital camera, drew up a protocol about interview contents, and analyzed and discussed them after numbering and comment. The conclusions are as follows: First, students already constructed informal knowledge before they learned formal knowledge about fraction. Among students' informal knowledge they knew correct concepts based on formal knowledge, but they also have ideas that would lead to misconceptions. Second, the informal knowledge constructed by children were different according to grade. This is because the informal knowledge is influenced by various experience on learning and everyday life. And the students having higher reasoning ability represented higher levels of knowledge. Third, because children are using informal knowledge from everyday life to learn formal knowledge, we should use these informal knowledge to instruct more efficiently.

• Journal of Preventive Medicine and Public Health
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• v.37 no.3
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• pp.267-273
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• 2004

Objectives : This study was aimed at investigating the medical service utilization pattern of patients who use public medical aid compared to those who have health insurance. Methods : We selected every patient between the age of 18 and 69 who used public medical aid from January 1, 1999, to December 31, 2001, in Gwangju metropolitan city, South Korea. For comparison, a list of patients with health insurance was gathered for same period. Then the medical records of those who had been hospitalized for acute appendicitis were selected among both groups. Of those records, we compared the number of cases of ruptured appendicitis to cases of whole acute appendicitis in both groups. Regarding coding for ruptured appendicitis, International Classification of Diseases - 10 (ICD-10) was used. Multiple logistic regression was used as a statistical tool to determine the effectiveness of risk factors. Results : Even after adjusting for risk factors, such as age and sex, the proportion of perforation of acute appendicitis among public medical aid patients was found to be significantly higher than among insured patients. Conclusions : This comparative study on ruptured appendicitis among public medical aid patients and insured patients, indicates that the proportion of perforation of acute appendicitis could be an index showing that these types of patients utilize medical services differently than insured patients. We know that when abdominal pain is not properly treated at the outset, it easily develops into ruptured appendicitis complicated with peritonitis. Considering this data analysis, we guess the public medical aid system to have significant problem with medical accessibility. So additional and systematic research on the pattern of utilization of medical services of public medical aid patients is needed.

• Journal of the Korean Society for Railway
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• v.19 no.2
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• pp.170-186
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• 2016

This paper introduces a multi-phase fuzzy risk graph model, representing a method for determining for SIL values for railway industry systems. The purpose of this paper is to compensate for the shortcomings of qualitative determination, which are associated with input value ambiguity and the subjectivity problem of expert judgement. The multi-phase fuzzy risk graph model has two phases. The first involves the determination of the conventional risk graph input values of the consequence, exposure, avoidance and demand rates using fuzzy theory. For the first step of fuzzification this paper proposes detailed input parameters. The fuzzy inference and the defuzzification results from the first step will be utilized as input parameters for the second step of the fuzzy model. The second step is to determine the safety integrity level and tolerable hazard rate corresponding to be identified hazard in the railway industry. To validate the results of the proposed the multi-phase fuzzy risk graph, it is compared with the results of a safety analysis of a level crossing system in the CENELEC SC 9XA WG A0 report. This model will be adapted for determining safety requirements at the early concept design stages in the railway business.

• Journal of the Korean Society for Railway
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• v.19 no.2
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• pp.145-158
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• 2016

This paper introduces a risk graph which is one method for determining the SIL as a measure of the effectiveness of signaling system. The purpose of this research is to make up for the weakness of the qualitative determination, which has input value ambiguity and a boundary problem in the SIL range. The fuzzy input valuable consists of consequence, exposure, avoidance and demand rate. The fuzzy inference produces forty eight fuzzy rule by adapting the calibrated risk graph in the IEC 61511. The Max-min composition is utilized for the fuzzy inference. The result of the fuzzy inference is the fuzzy value. Therefore, using the de-fuzzification method, the result should be converted to a crisp value that can be utilized for real projects. Ultimately, the safety requirement for hazard is identified by proposing a SIL result with a tolerable hazard rate. For the validation the results of the proposed method, the fuzzy risk graph model is compared with the safety analysis of the signaling system in CENELEC SC 9XA WG A10 report.