• The Plant Pathology Journal
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• 제29권3호
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• pp.234-241
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• 2013

Polygalacturonase (PG) gene is a typical gene family present in eukaryotes. Forty-nine PGs were mined from the genomes of Neurospora crassa and five Aspergillus species. The PGs were classified into 3 clades such as clade 1 for rhamno-PGs, clade 2 for exo-PGs and clade 3 for exo- and endo-PGs, which were further grouped into 13 sub-clades based on the polypeptide sequence similarity. In gene structure analysis, a total of 124 introns were present in 44 genes and five genes lacked introns to give an average of 2.5 introns per gene. Intron phase distribution was 64.5% for phase 0, 21.8% for phase 1, and 13.7% for phase 2, respectively. The introns varied in their sequences and their lengths ranged from 20 bp to 424 bp with an average of 65.9 bp, which is approximately half the size of introns in other fungal genes. There were 29 homologous intron blocks and 26 of those were sub-clade specific. Intron losses were counted in 18 introns in which no obvious phase preference for intron loss was observed. Eighteen introns were placed at novel positions, which is considerably higher than those of plant PGs. In an evolutionary sense both intron loss and gain must have taken place for shaping the current PGs in these fungi. Together with the small intron size, low conservation of homologous intron blocks and higher number of novel introns, PGs of fungal species seem to have recently undergone highly dynamic evolution.

• International Journal of Computer Science & Network Security
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• 제24권4호
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• pp.127-134
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• 2024

The article highlights the problems of the digitalization of the educational process, which affect the pedagogical cluster and are of a psychological nature. The authors investigate the transformational changes in education in general and the individual beliefs of each subject of the educational process, caused by both the change in the format of learning (distance, mixed), and the use of new technologies (digital, communication). The purpose of the article is to identify the strategic trend of the educational process, which is a synergistic combination of pedagogical methodology and psychological practice and avoiding dialectical opposition of these components of the educational space. At the same time, it should be noted that the introduction of digital technologies in the educational process allows for short-term difficulties, which is a usual phenomenon for innovations in the educational sphere. Consequently, there is a need to differentiate the fundamental problems and temporary shortcomings that are inherent in the new format of learning (pedagogical features). Based on the awareness of this classification, it is necessary to develop psychological techniques that will prevent a negative reaction to the new models of learning and contribute to a painless moral and spiritual adaptation to the realities of the present (psychological characteristics). The methods used in the study are divided into two main groups: general-scientific, which investigates the pedagogical component (synergetic, analysis, structural and typological methods), and general-scientific, which are characterized by psychological direction (dialectics, observation, and comparative analysis). With the help of methods disclosed psychological and pedagogical features of the process of digitalization of education in a mixed learning environment. The result of the study is to develop and carry out methodological constants that will contribute to the synergy for the new pedagogical components (digital technology) and the psychological disposition to their proper use (awareness of the effectiveness of new technologies). So, the digitalization of education has demonstrated its relevance and effectiveness in the pedagogical dimension in the organization of blended and distance learning under the constraints of the COVID-19 pandemic. The task of the psychological cluster is to substantiate the positive aspects of the digitalization of the educational process.

• 한국문헌정보학회지
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• 제24권
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• pp.73-112
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• 1993

The purpose of this study is to identify what are the common characteristics which enable the information management offices of research institutes to provide information services with their companies in effective ways, and furthur, in other to clarify what factors helf the improvement of effectiveness of information services. I have made on-the-spot investigations for the confirmation of present conditions of information service units of research institutes, their statistic data, and their managerial state. I have restricted my research to 36 information service units, as research targets, which are located in Changwon, Choongchong, and Kyongin areas as the reason mentioned in the introduction, and from their research data they keep, I have classified the top 10 information service units as Group A which show the most frequent use or application frequency of research data per a researcher, where as the lowerest 10 information service units are classified as Group B by the same evaluation of application frequency of their data. Then, the result of the comparision between Group A which provide high information services in effective ways and Group B which provide low information services with poor management leads me to identify the following characteristics in terms of the analyses of utilization of the data they process: 1. Those information service units in Group A have more volumes of books and information data, and annual increasing rates of books and informations are higher than those of Group B. 2. The regulations of book circulation in Group A are prescribed for the benefits of users, and if a long-term loan is not permitted, they are allowed to borrow more books at a time than in Group B. 3. The proportion of librarians to researchers is high, the librarians' career is long and their professional education background (the rate of librarians who majored in library science and information) is high In Group A. 4. Most of the directors of information service units are those who majored library science and information, and for the most part, librarians are promoted to the directors of information service units in Group A. 5. The information service units are managed directly under the directors of research institutes in their organization in Group A. 6. The information service units offer an education for information utilization to researchers as one of their managerial programs, and the contents of education are diverse, rich and informative in Group A. 7. The kinds of informations are various in Group A such as, SDI, prompt reports of contents of new informations, circulation of newly published publications, translation service, information analyses, critical reviews, etc. 8. The information service units in Group A have joined various cooperative systems which are aimed at cooperation, co-ownership of resources and informations. These findings lead me to argue that the hypothesis suggested in the introduction of this thesis has been proved without exception.

• 약학회지
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• 제50권6호
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• pp.386-392
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• 2006

Pramlintide, a synthetic analogue of human hormone amylin, is the first of a new class of amylinomimetic compounds. Present study was undertaken to compile and analyze the clinical trials of pramlintide, and thereby to facilitate the design of the bridging study for the earlier introduction of the drug, which might be needed by diabetes patients in Korea. Sixty-two articles from Pubmed and MEDLINE search were used to analyze the trials of pramlintide along with prescribing information and New Drug Application packet obtained form the manufacturer. The efficacy of the new drug was attributed to three mechanisms: delay of gastric emptying time, inhibition of post-prandial glucagon secretion, and reduction of food intake by enhanced satiety. Clinical trials consistently identified the effectiveness of the drug for the treatment of type 1and type 2 diabetes who have failed to achieve glycemic control despite optimal therapy with insulin. However, the six pivotal Phase III clinical trials were peformed with mostly caucasian and some black and hispanic people. None of the trials documented the proportion of either Asian or Korean participants. Since Korean diabetes patients show different epidemiology and characteristics in their disease state, it appears that the bridging study of pramlintide should be designed in the level of full scale Phase III clinical trial along with pharmacokinetic and pbarmacodynamic studies.

• Macromolecular Research
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• 제14권2호
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• pp.179-186
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• 2006

In the present work, low density polyethylene (LDPE)/aliphatic polyester (APES)/organoclay ternary nanocomposites were prepared. In particular, the effect of a compatibilizer, polyethylene-graft-maleic anhydride (PE-g-MAH), on the morphology and properties of the ternary nanocomposites was investigated. LDPE/APES/organoclay nanocomposites were prepared through melt intercalation method using two different kinds of organoclay. The dispersibility of silicate clays in the nanocomposites was investigated by X-ray diffraction and atomic force microscopy. The ternary nanocomposites showed higher tensile properties than the LDPE/APES blend did. The dispersibility and properties of nanocomposites containing Cloisite 30B were better than those of the nanocomposites containing Cloisite 20A. Unlike Cloisite 20A, hydroxyl groups in the intercalants in Cloisite 30B interlayer underwent a certain polar interaction with the carboxyl group of APES, favoring the intercalation of APES chains and the formation of LDPE/APES/Closite 30B nanocomposites. However, the introduction of the polar hydroxyl groups also enhanced the interaction with the silicate surface at the same time, thereby rendering somewhat difficult the replacement of the surface contacts by LDPE chains, and impeding the extensive intercalation and further exfoliation of Cloisite 30B in the LDPE/APES matrix. The compatibilizer enhanced the intercalation of the polymer chain inside the clay gallery and thus improved the mechanical properties of the ternary nanocomposites. Rheological measurements of the nanocomposites via frequency sweep experiment indicated a certain interaction between the clay platelet and the polymer molecules in the melted state.

• 한국전기전자재료학회논문지
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• 제35권4호
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• pp.407-411
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• 2022

Bulk-sized PbTiO₃ (PT), which is widely known as a high-performance ferroelectric oxide but cannot be fabricated into a monolithic ceramic due to its high c/a ratio, was successfully prepared with a high tetragonality by partially substituting Ni ions for Pb ions using a solid-state reaction method. We found that Ni-doped PT was well-fabricated as a bulk monolith with a significant c/a ratio of ~1.06. X-ray diffraction on as-sintered and crushed samples revealed that NiTiO₃ secondary phase was present at the doping level of more than 2 at.%. Scanning electron microscopic study showed that NiTiO₃ secondary phase grew on the surface of PT specimens regardless of the doping level possibly due to the evaporation of Pb during sintering. We demonstrated that an unconventional introduction of Ni ions into A-site plays a key role on the fabrication of bulk PT, though how Ni ion functions should be studied further. We expect that this study contributes to a further development of displacive ferroelectric oxides with a high c/a ratio.

• 한국분말재료학회지
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• 제9권6호
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• pp.441-448
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• 2002

Dispersions of non-soluble ceramic particles in a metallic matrix can enhance the strength and heat resistance of materials. With the advent of mechanical alloying it became possible to put the theoretical concept into practice by incorporating very fine particles in a flirty uniform distribution into often oxidation- and corrosion- resistant metal matrices. e.g. superalloys. The present paper will give an overview about the mechanical alloying technique as a dry, high energy ball milling process for producing composite metal powders with a fine controlled microstructure. The common way is milling of a mixture of metallic and nonmetallic powders (e.g. oxides. carbides, nitrides, borides) in a high energy ball mill. The heavy mechanical deformation during milling causes also fracture of the ceramic particles to be distributed homogeneously by further milling. The mechanisms of the process are described. To obtain a homogeneous distribution of nano-sized dispersoids in a more ductile matrix (e.g. aluminium-or copper based alloys) a reaction milling is suitable. Dispersoid can be formed in a solid state reaction by introducing materials that react with the matrix either during milling or during a subsequent heat treatment. The pre-conditions for obtaining high quality materials, which require a homogeneous distribution of small dis-persoids, are: milling behaviour of the ductile phase (Al, Cu) will be improved by the additives (e.g. graphite), homogeneous introduction of the additives into the granules is possible and the additive reacts with the matrix or an alloying element to form hard particles that are inert with respect to the matrix also at elevated temperatures. The mechanism of the in-situ formation of dispersoids is described using copper-based alloys as an example. A comparison between the in-situ formation of dispersoids (TiC) in the copper matrix and the milling of Cu-TiC mixtures is given with respect to the microstructure and properties, obtained.

• 대한방사선기술학회지:방사선기술과학
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• 제28권2호
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• pp.129-135
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• 2005

현대사회의 IT 정보통신 인터넷 관련 산업은 눈부신 발전을 거듭하여 초고속 인터넷 보급률이 세계 1위를 차지하고 있으며, 이동통신의 종주국을 자랑이라도 하듯이 단말기의 관련기술 및 생산도 세계의 상위를 차지하고 있다. 이처럼 IT 분야는 하루가 다르게 빠르게 변화하고 있으나, 방사선학과의 학부로서 정보통신 관련교육은 이에 부응하지 못하는 실정이다. 학부로서의 인격 및 지식교육과 방사선사로서의 기술 및 직업교육의 교과 과정은 현재의 IT 환경과 실제 임상의 디지털 관련 장비의 인터페이스에 적응하기는 다소 힘들다. 특히 의료 디지털 환경 및 병원의 정보화로 방사선과에서의 방사선사의 역할이 증대되고 있는 상황에서의 정보 통신영역의 교육과정의 개선 및 새로운 과정의 제안은 디지털 사회의 변화에 적응할 뿐만 아니라 방사선사의 자질 및 위상을 높일 수 있는 계기로 생각된다. 따라서 본 논문에서는 디지털 방사선 환경에서의 방사선학과의 교육과정에 대한 각 대학 및 대학교별 현황과 문제점을 제시하며, 그 현황을 바탕으로 새로운 교육과정의 도입을 위한 개선 방향을 제안하고자 한다.

• 한국재료학회지
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• 제22권10호
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• pp.499-503
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• 2012

The present study is intended to comparatively investigate the changes in microstructure and tensile properties at room and elevated temperatures in commercial AM50(Mg-5%Al-0.3%Mn) and 0.3 wt%CaO added ECO-AM50 alloys produced by permanent mould casting. The typical microstructure of AM50 alloy was distinctively characterized using two intermetallic compounds, ${\beta}(Mg_{17}Al_{12})$ and $Al_8Mn_5$, along with ${\alpha}$-(Mg) matrix in an as-cast state. The addition of a small amount of CaO played a role in reducing dendrite cell size and quantity of the ${\beta}$ phase in the AM50 alloy. It is interesting to note that the added CaO introduced a small amount of $Al_2Ca$ adjacent to the ${\beta}$ compounds, and that inhomogeneous enrichment of elemental Ca was observed within the ${\beta}$ phase. The ECO-AM50 alloy showed higher hardness and better YS and UTS at room temperature than did the AM50 alloy, which characteristics can be mainly ascribed to the finer-grained microstructure that originated from the CaO addition. At $175^{\circ}C$, higher levels of YS and UTS and higher elongation were obtained for the ECO-AM50 alloy, demonstrating that even 0.3 wt%CaO addition can be beneficial in promoting the heat resistance of the AM50 alloy. The combinational contributions of enhanced thermal stability of the Ca-containing ${\beta}$ phase and the introduction of a stable $Al_2Ca$ phase with high melting point are thought to be responsible for the improvement of the high temperature tensile properties in the ECO-AM50 alloy.

• 대한금속재료학회지
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• 제46권3호
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• pp.125-130
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• 2008

Conventional plasma carburizing or nitriding for austenitic stainless steels results in a degradation of corrosion resistance. However, a low temperature plasma surface treatment can improve surface hardness without deteriorating the corrosion resistance. The 2-step low temperature plasma processes (the combined carburizing and post nitriding) offers the increase of both surface hardness and thickness of hardened layer and corrosion resistance than the individually processed low temperature nitriding and low temperature carburizing techniques. In the present paper, attempts have been made to investigate the influence of the introduction of Ar gas (0~20%) in nitriding atmosphere during low temperature plasma nitriding at $370^{\circ}C$ after low temperature plasma carburizing at $470^{\circ}C$. All treated specimens exhibited the increase of the surface hardness with increasing Ar level in the atmosphere and the surface hardness value reached up to 1050 HV0.1, greater than 750 $HV_{0.1}$ in the carburized state. The expanded austenite phase (${\gamma}_N$) was observed on the most of the treated surfaces. The thickness of the ${\gamma}_N$ layer reached about $7{\mu}m$ for the specimen treated in the nitriding atmosphere containing 20% Ar. In case of 10% Ar containing atmosphere, the corrosion resistance was significantly enhanced than untreated austenitic stainless steels, whilst 20% Ar level in the atmosphere caused to form CrN in the N-enriched layer (${\gamma}_N$), which led to the degradation of corrosion resistance compared with untreated austenitic stainless steels.