• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.3
• /
• pp.137-146
• /
• 2020

Syrup agents are often used after opening, and therefore, there is a high possibility of decreased quality. The Ministry of Food and Drug Safety (MFDS) published guideline on stability testing for pharmaceuticals after opening in December, 2016. We compared guidelines related to the period of use after opening between the United States of America (USA), Europe (EU), and Korea, and we analyzed whether the period of use or storage conditions is stated based on the data of drug approval for 4 dry syrups and 3 large packing syrups before and after the introduction of the guideline. First, in USA and EU, the period of use and storage conditions after opening should be listed on the label on the packaging container (as well as the expiration date), while in Korea, those are included in the area of precautions for use. Second, all of the analyzed drugs were not changed by the guidelines for establishing the new post-opening period of use, and they were only presented for the existing expiration date prior to the establishment of the guideline. Medicines that are used for multiple uses after opening may need improved instructions to ensure that the period of use and storage conditions are listed on the packaging according to stability evaluation after opening.

• Journal of Digital Convergence
• /
• v.18 no.2
• /
• pp.351-360
• /
• 2020

This study was designed to develop an online education program of elderly care service for the senior caregivers. Online survey was conducted senior caregivers who attended K cyber university from November 28, to December 15, 2019. Data were analyzed using chi-square, ANOVA and post test by scheffe method. The results showed that needs of the online education program for senior caregivers were significantly higher than nursing assistants. Social workers were significantly higher than the nursing assistants in the elderly care service online education demand. In terms of performance, 'understanding and counseling for the elderly' and 'practice of the elderly play program' were social workers, senior caregivers and nursing assistants. In conclusion, it is necessary to develop a specialized online education contents for each group according to the necessity of elderly professional care and the demand of online education for elderly care service.

• Journal of Digital Convergence
• /
• v.18 no.10
• /
• pp.51-58
• /
• 2020

This study redesigned the Korean speaking classes to foreign undergraduate students as flipped learning classes and verified their effect on speaking-related emotional variables. In addition, international students' perceptions of what experiences are needed to improve speaking efficacy in Korean were examined. For this purpose, the 'Creative speaking' subject for freshmen was redesigned to flipped learning class and operated for one semester. To analyze the effect of speech-related emotions, a paired t-test was conducted on 26 foreign students' pre-post scores of speech efficacy and anxiety. Also awareness of experiences needed to improve speech efficacy was surveyed and content analysis was conducted. As the result, the speaking efficacy of students after flipped-learning has been significantly improved. This means that flipped learning classes for the Korean speaking are effective for the positive emotions of foreign students speaking Korean. In addition, international students perceived that Korean speaking efficacy can be improved by practicing speaking in Korean, learning with Korean colleagues. Based on these results, several discussions and suggestions were presented.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.23 no.4
• /
• pp.346-355
• /
• 2020

Purpose: Peroxisome proliferator-activated receptor gamma (PPAR-γ) has a key role in hepatic fibrogenesis by virtue of its effect on the hepatic stellate cells (HSCs). Although many studies have shown that PPAR-γ agonists inhibit liver fibrosis, the mechanism remains largely unclear, especially regarding the cross-talk between PPAR-γ and other potent fibrogenic factors. Methods: This experimental study involved 25 male Wistar rats. Twenty rats were subjected to bile duct ligation (BDL) to induce liver fibrosis, further divided into an untreated group (BDL; n=10) and a group treated with the PPAR-γ agonist thiazolidinedione (TZD), at 14 days post-operation (BDL+TZD; n=10). The remaining 5 rats had a sham operation (sham; n=5). The effect of PPAR-γ agonist on liver fibrosis was evaluated by histopathology, protein immunohistochemistry, and mRNA expression quantitative polymerase chain reaction. Results: Histology and immunostaining showed markedly reduced collagen deposition, bile duct proliferation, and HSCs in the BDL+TZD group compared to those in the BDL group (p<0.001). Similarly, significantly lower mRNA expression of collagen α-1(I), matrix metalloproteinase-2, platelet-derived growth factor (PDGF)-B chain, and connective tissue growth factor (CTGF) were evident in the BDL+TZD group compared to those in the BDL group (p=0.0002, p<0.035, p<0.0001, and p=0.0123 respectively). Moreover, expression of the transforming growth factor beta1 (TGF-β1) was also downregulated in the BDL+TZD group (p=0.0087). Conclusion: The PPAR-γ agonist inhibits HSC activation in vivo and attenuates liver fibrosis through several fibrogenic pathways. Potent fibrogenic factors such as PDGF, CTGF, and TGF-β1 were downregulated by the PPAR-γ agonist. Targeting PPAR-γ activity may be a potential strategy to control liver fibrosis.

• Journal of Mushroom
• /
• v.18 no.1
• /
• pp.115-119
• /
• 2020

This study was conducted to investigate the effect of post-harvest CO₂ treatment on the quality of the 'Gonji-7ho' oyster mushroom. The harvested mushrooms were pre-cooled at 3℃ for 1 day and placed in a gas-tight chamber with 0%, 30%, or 50% of CO₂ concentration for 3 hours at 3℃. Next, 400 g of the oyster mushroom sample was packaged into 20-㎛ thick oriented polypropylene (OPP) film bags and stored at 4℃ for 21 days. Treatment with 30% of CO₂ treatment maintained the highest stipe firmness of the oyster mushrooms during storage. The stipe lightness (CIE L^⁎) was the highest at 14 and 21 days, while the stipe yellowness (CIE b^⁎) was the lowest at 2 and 7 days of storage. Therefore, we concluded that the 30% CO₂ treatment maintained the overall visual quality of the 'Gonji-7ho' oyster mushroom until 17 days of storage at 3℃. Our results suggest that the shelf life of 'Gonji-7ho' oyster mushroom could be extended by the postharvest application of 30% CO₂ for 3 hours during low temperature storage.

• Journal of Mushroom
• /
• v.18 no.1
• /
• pp.95-99
• /
• 2020

The trade deficit in mushrooms has continued to increase in recent years. This study explored major issues and challenges faced by the mushroom industry to increase export, and to prioritize the current issues and challenges based on their relative importance. 11 major issues and challenges in the mushroom industry were highlighted in focus group interviews. Best-worst scaling analysis prioritized these major issues and challenges, and questionnaire surveys were completed by 31 mushroom industry experts. The results revealed that strengthening the mushroom quality and price competitiveness were the main priorities, followed sequentially by a diversification of the overseas export markets and stabilization of the domestic mushroom price.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.38 no.4
• /
• pp.327-343
• /
• 2020

This study proposes a method to improve the geometric quality of KOMPSAT (Korea Multi-Purpose Satellite)-3/3A Level 1R imagery, particularly for efficient disaster damage analysis. The proposed method applies a novel grid-based SIFT (Scale Invariant Feature Transform) method to the Planetscope ortho-imagery, which solves the inherent limitations in acquiring appropriate optical satellite imagery over disaster areas, and the KOMPSAT-3/3A imagery to extract GCPs (Ground Control Points) required for the RPC (Rational Polynomial Coefficient) bias compensation. In order to validate its effectiveness, the proposed method was applied to the KOMPSAT-3 multispectral image of Gangnueng which includes the April 2019 wildfire, and the KOMPSAT-3A image of Daejeon, which was additionally selected in consideration of the diverse land cover types. The proposed method improved the geometric quality of KOMPSAT-3/3A images by reducing the positioning errors(RMSE: Root Mean Square Error) of the two images from 6.62 pixels to 1.25 pixels for KOMPSAT-3, and from 7.03 pixels to 1.66 pixels for KOMPSAT-3A. Through a visual comparison of the post-disaster KOMPSAT-3 ortho-image of Gangneung and the pre-disaster Planetscope ortho-image, the result showed appropriate geometric quality for wildfire damage analysis. This paper demonstrated the possibility of using Planetscope ortho-images as an alternative to obtain the GCPs for geometric calibration. Furthermore, the proposed method can be applied to various KOMPSAT-3/3A research studies where Planetscope ortho-images can be provided.

• Ecology and Resilient Infrastructure
• /
• v.7 no.2
• /
• pp.90-96
• /
• 2020

Recently, a method that applies laser scanning (LS) that acquires vegetation information such as the vegetation habitat area and the size of vegetation in a point cloud format has been proposed. When LS is used to investigate the physical shape of vegetation, it has the advantage of more accurate and rapid information acquisition. However, to examine uncertainties that may arise during measurement or post-processing, the process of adjusting the data by the actual data is necessary. Therefore, in this study, the physical structure of stems, branches, and leaves of woody vegetation in an artificially formed river channel was manually investigated. The obtained results then compared with the information acquired using the three-dimensional terrestrial laser scanning (3D TLS) method, which repeatedly scanned the target vegetation in various directions to obtain relevant information with improved precision. The analysis demonstrated a negligible difference between the measurements for the diameters of vegetation and the length of stems; however, in the case of branch length measurement, a relatively more significant difference was observed. It is because the implementation of point cloud information limits the precise differentiation between branches and leaves in the canopy area.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.6
• /
• pp.563-573
• /
• 2020

This study aimed to provide basic data to assist in developing programs to improve the quality of life after identifying the factors affecting aging anxiety among middle-aged women. The subjects were 256 middle-aged women in Korea. Data were collected from March 8 to April 11, 2019, and analyzed using descriptive statistics, independent t-test, One-way ANOVA, Pearson correlation, and stepwise multiple regression with SPSS/WIN 18.0. This study found that the aging anxiety of the subjects differed significantly according to job and marriage satisfaction. Aging anxiety had a negative correlation with health perceived health (r=-.300, p<.001), resilience (r=-.537, p<.001), satisfaction of married life (r=-.316, p<.001), and self-esteem (r=-.424, p<.000). The factors affecting aging anxiety were as follows: resilience (β=-.47, p<.001), occupation (β=-.19, p=.003), and self-esteem (β=-.19, p=.014) with 36.9% explanatory power (F=14.34, p<.001). To reduce the aging anxiety of middle-aged people, programs will be needed to improve participation in post-middle-aged jobs or social activities and resilience, self-esteem, thereby providing education and mediation that can allow middle-aged women to accept aging positively.

• The Journal of the Korea Contents Association
• /
• v.20 no.3
• /
• pp.671-677
• /
• 2020

The number one female cancer in Korea is breast cancer, and the incidence rate continues to increase. There are many opinions that this is due to the impact of increased sedentary life along with economic growth. In this study, the international standard exercise status questionnaire was administered to patients and normal group who visited to the specialized cancer hospital in Korea, and to standardized scores of the exercise status (MET score) obtained from questionnaire were used to compare the impaction on breast cancer risk and difference of the MET score between the patients and control group. The ages of the study subjects were selected as subjects without statistical differences between the patients group and the normal group. also done with survey the family history, BMI, the menarche, age at birth of first child, the degree of education to exclude impaction on breast cancer risk depending on physical activity. In general, the breast cancer patients showed lower MET scores than the normal group, and the effect of activity on breast cancer was greater in post-menopausal women than in pre-menopausal women. Also BMI was similar to breast cancer risk. Maintaining proper weight through exercise can reduce the accumulation of carcinogens in breast cancer in the body, thereby reducing the incidence of breast cancer.