• Structural Engineering and Mechanics
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• v.61 no.1
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• pp.105-116
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• 2017

In this paper, the optimal extended homotopy analysis method (OEHAM) is introduced to deal with the damped Duffing resonator driven by a van der Pol oscillator, which can be described as a complex Multi-Degree-of-Freedom (MDOF) nonlinear coupling system. Ecumenically, the exact solutions of the MDOF nonlinear coupling systems are difficult to be obtained, thus the development of analytical approximation becomes an effective and meaningful approach to analyze these systems. Compared with traditional perturbation methods, HAM is more valid and available, and has been widely used for nonlinear problems in recent years. Hence, the method will be chosen to study the system in this article. In order to acquire more suitable solutions, we put forward HAM to the OEHAM. For the sake of verifying the accuracy of the above method, a series of comparisons are introduced between the results received by the OEHAM and the numerical integration method. The results in this article demonstrate that the OEHAM is an effective and robust technique for MDOF nonlinear coupling systems. Besides, the presented methods can also be broadly used for various strongly nonlinear MDOF dynamical systems.

• Nuclear Engineering and Technology
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• v.26 no.2
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• pp.205-211
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• 1994

The best method is selected among the 3 digital dynamic compensation methods which are developed or applied for the Rhodium self-powered neutron detector. The three digital dynamic compensation methods are the existing Dominant Pol Tustin method of the COLSS(Core Operating Limit Supervisory System), the Direct Inversion method and Kalman Filter method. The Direct Inversion method is an improved method of D. Hoppe and R. Maletti and the Kalman Filter method is developed using the Kalman Filter. Response times of the compensated signals to achieve 90% of a step input are 28.1, 17.2 and 6.5 seconds respectively for the same noise gain telling that the Kalman Filter method is the best amens the 3 methods.

• Korean Journal of Pharmacognosy
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• v.50 no.2
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• pp.102-111
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• 2019

Inflammation that is considered to be mainly related to pathogenesis of atopic dermatitis (AD) is the biological response of a host to stimuli, such as cellular injury or infection. In this study, we investigated the anti-inflammatory and anti-oxidative activities of white ginseng roots by ultra high pressure extraction (Gin-UHP), fermentation followed by ultra high pressure extraction (Gin-UHPF), and polyol extraction (Gin-POL). As a result, ginseng extracts were able to decrease the secretion of pro-inflammatory cytokines (interleukin-8 and tumor necrosis factor-alpha) and immunoglobulin E. Also, Gin-POL had the highest DPPH radical scavenging activity and when we compared the SOD-like activity, Gin-UHP had the highest. Moreover, we looked into the effect of these ginseng extracts on anti-aging to show the possible usefulness as a raw material of cosmetics. As a result, ginseng extracts were able to reduce the production of melanin, and inhibit the tyrosinase and elastase activities in a dose-dependent manner. The extracts also decreased the expression of MMP-1 and had a significant hyaluronidase inhibitory activity. Taken together, these results demonstrate that ginseng extracts may have an improvement effect on AD by using its anti-inflammatory and antioxidant properties.

• The Journal of Korean Society of Virology
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• v.29 no.4
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• pp.271-281
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• 1999

The nested polymerase chain reaction (PCR) assay was used to determine the sequences of reverse transcriptase (RT) codons 41, 67, 70, 210, 215 and 219 of human immunodeficiency virus-1 (HIV-1) pol gene. Template DNA was obtained from uncultured peripheral blood mononuclear cells from 27 Korean HIV-1 infected patients treated with ZDV and Korean red ginseng. The second PCRs were done for 2 separated regions (RT codons $13{\sim}98$ and $152{\sim}259$) with $5\;{\mu}l$ of the first PCR productNucleotide sequences were determined by direct sequencing. In the 27 patients, CD4+ cell count decreased from $230{\pm}117/{\mu}l$ to $152{\pm}162/{\mu}l$ for $46{\pm}26$ months (Mo), and actual duration of ZDV intake was $72{\pm}16$ Mo. In the 16 patients who had been treated with ZDV therapy ${\ge}25$ Mo, the incidences of 70R, 215F/Y, and 41L were 61%, 28% and 22%, respectively and those of 67N, 210W and 219Q were 17%. The incidences of 215F/Y were 6.7% for group ${\le}12$ Mo treatment, 22.7% for group with 13 to 24 Mo, and 27.8% for group ${\ge}25$ Mo. There was no mutation in 9 patients. It might be associated with the interruption of ZDV therapy for more than 6 months in 6 patients. This study shows that the detection of mutation could be useful prognostic marker with other clinical and virological data, and very low mutation rate is dectected compared to overseas reports.

• Journal of Korea Water Resources Association
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• v.53 no.3
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• pp.201-214
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• 2020

This study proposes a bias correction method of dual-pol radar rain rate in real time using the dual Kalman filter. Unlike the conventional Kalman filter, the dual Kalman filter predicts state variables with two systems (state estimation system and model estimation system) at the same time. Bias of rain rate is corrected by applying the bias correction ratio to the rain rate estimate. The bias correction ratio is predicted from the state-space model of the dual Kalman filter. This method is applied to a storm event with long duration occurred in July 2016. Most of the bias correction ratios are estimated between 1 and 2, which indicates that the radar rain rate is underestimated than the ground rain rate. The AR (1) model is found to be appropriate for explaining the time series of the bias correction ratio. The time series of the bias correction ratio predicted by the dual Kalman filter shows a similar tendency to that of observation data. As the variability of the bias correction increases, the dual Kalman filter has better prediction performance than the Kalman filter. This study shows that the dual Kalman filter can be applied to the bias correction of radar rain rate, especially for long and heavy storm events.

• Toxicological Research
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• v.33 no.4
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• pp.265-272
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• 2017

Aryl hydrocarbons such as 3-nitrobenzanthrone (NBA), 4-aminobiphenyl (ABP), acetylaminofluorene (AAF), benzo(a)pyrene (BaP), and 1-nitropyrene (NP) form bulky DNA adducts when absorbed by mammalian cells. These chemicals are metabolically activated to reactive forms in mammalian cells and preferentially get attached covalently to the $N^2$ or C8 positions of guanine or the $N^6$ position of adenine. The proportion of $N^2$ and C8 guanine adducts in DNA differs among chemicals. Although these adducts block DNA replication, cells have a mechanism allowing to continue replication by bypassing these adducts: translesion DNA synthesis (TLS). TLS is performed by translesion DNA polymerases-Pol ${\eta}$, ${\kappa}$, ${\iota}$, and ${\zeta}$ and Rev1-in an error-free or error-prone manner. Regarding the NBA adducts, namely, 2-(2'-deoxyguanosin-$N^2$-yl)-3-aminobenzanthrone (dG-$N^2$-ABA) and N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone (dG-C8-ABA), dG-$N^2$-ABA is produced more often than dG-C8-ABA, whereas dG-C8-ABA blocks DNA replication more strongly than dG-$N^2$-ABA. dG-$N^2$-ABA allows for a less error-prone bypass than dG-C8-ABA does. Pol ${\eta}$ and ${\kappa}$ are stronger contributors to TLS over dG-C8-ABA, and Pol ${\kappa}$ bypasses dG-C8-ABA in an error-prone manner. TLS efficiency and error-proneness are affected by the sequences surrounding the adduct, as demonstrated in our previous study on an ABP adduct, N-(2'-deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-ABP). Elucidation of the general mechanisms determining efficiency, error-proneness, and the polymerases involved in TLS over various adducts is the next step in the research on TLS. These TLS studies will clarify the mechanisms underlying aryl hydrocarbon mutagenesis and carcinogenesis in more detail.

• Proceedings of the KIEE Conference
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• 2005.07d
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• pp.2849-2851
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• 2005

본 논문에서는 소형 카오스 무인 비행체에서의 장애물 회피 기법과 목표물 탐지 기법을 제안하였다. 장애물은 불안정한 VDP(van der Pol) 방정식을 이용하였으며 목표물은 안정한 VDP 방정식을 이용하였다. UAV가 장애물과 목표물에 접근하게 되면 불안정 또는 안정한 VDP 방정식이 UAV를 밀어내거나 끌어들임으로서 장애물을 피해가거나 목표물 탐색할 수 있는 알고리즘을 제시하고 컴퓨터 시뮬레이션으로 그 결과를 검증하였다.

• Proceedings of the KIEE Conference
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• 2005.07d
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• pp.2852-2854
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• 2005

In this paper, we propose a method to a synchronization of chaotic mobile robots that have unstable limit cycles in a chaos trajectory surface. We assume all obstacles in the chaos trajectory surface have a VDP (Van der Pol) equation with an unstable limit cycle. The proposed methods are assumed that if one of two chaotic mobile robot receives the synchronization command, the other robot also follows the same trajectory during the chaotic robot search on the arbitrary surface.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.121-121
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• 2003

The purpose of this study is to investigate the effect of mucosal vaccine delivery vehicles and adjuvants on the local and systemic antibody responses following mucosal immunization of mice with hepatitis B surface antigen (HBsAg). Mice were immunized on days 0 and 21 by administration of hepatitis B surface antigen B (HBsAg) into the vagina. HBsAg was delivered in saline or poloxamer(Pol)-based vehicle containing mucoadhesive polycarbophil (PC). (omitted)

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2004.10a
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• pp.7-10
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• 2004

In this paper, we propose a method to avoid obstacles that have unstable limit cycles in a chaos trajectory surface. We assume all obstacles in the chaos trajectory surface have a Van der Pol equation with an unstable limit cycle. When a chaos UAVs meet an obstacle in an Arnold equation or Chua's equation trajectory, the obstacle reflects the UAV