• Journal of Gastric Cancer
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• 제13권3호
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• pp.129-135
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• 2013

Gastric cancer is the second leading cause of cancer-related deaths worldwide. In advanced and metastatic gastric cancer, the conventional chemotherapy with limited efficacy shows an overall survival period of about 10 months. Patient specific and effective treatments known as personalized cancer therapy is of significant importance. Advances in high-throughput technologies such as microarray and next generation sequencing for genes, protein expression profiles and oncogenic signaling pathways have reinforced the discovery of treatment targets and personalized treatments. However, there are numerous challenges from cancer target discoveries to practical clinical benefits. Although there is a flood of biomarkers and target agents, only a minority of patients are tested and treated accordingly. Numerous molecular target agents have been under investigation for gastric cancer. Currently, targets for gastric cancer include the epidermal growth factor receptor family, mesenchymal-epithelial transition factor axis, and the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathways. Deeper insights of molecular characteristics for gastric cancer has enabled the molecular classification of gastric cancer, the diagnosis of gastric cancer, the prediction of prognosis, the recognition of gastric cancer driver genes, and the discovery of potential therapeutic targets. Not only have we deeper insights for the molecular diversity of gastric cancer, but we have also prospected both affirmative potentials and hurdles to molecular diagnostics. New paradigm of transdisciplinary team science, which is composed of innovative explorations and clinical investigations of oncologists, geneticists, pathologists, biologists, and bio-informaticians, is mandatory to recognize personalized target therapy.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1693-1698
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• 2015

The heterogeneous nature of lung cancer has become increasingly apparent since introduction of molecular classification. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. Activating alterations in several potential driver oncogenic genes have been identified, including EGFR, ROS1 and ALK and understanding of their molecular mechanisms underlying development, progression, and survival of lung cancer has led to the design of personalized treatments that have produced superior clinical outcomes in tumours harbouring these mutations. In light of the tsunami of new biomarkers and targeted agents, next generation sequencing testing strategies will be more appropriate in identifying the patients for each therapy and enabling personalized patients care. The challenge now is how best to interpret the results of these genomic tests, in the context of other clinical data, to optimize treatment choices. In genomic era of cancer treatment, the traditional one-size-fits-all paradigm is being replaced with more effective, personalized oncologic care. This review provides an overview of lung cancer genomics and personalized treatment.

• International Journal of Contents
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• 제5권1호
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• pp.51-55
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• 2009

In this paper, we present a structure of personalized e-Learning system to study for a test formalized by uniform multiple-choice using on/off line mixed estimations as is the case of Driver :s License Test in Korea. Using the system a candidate can study toward the license through the Internet (and/or mobile instruments) within the personalized concept based on IRT(item response theory). The system accurately estimates user's ability parameter and dynamically offers optimal evaluation problems and learning contents according to the estimated ability so that the user can take possession of the license in shorter time. In order to establish the personalized e-Learning concepts, we build up 3 databases and 2 agents in this system. Content DB maintains learning contents for studying toward the license as the shape of objects separated by concept-unit. Item-bank DB manages items with their parameters such as difficulties, discriminations, and guessing factors, which are firmly related to the learning contents in Content DB through the concept of object parameters. User profile DB maintains users' status information, item responses, and ability parameters. With these DB formations, Interface agent processes user ID, password, status information, and various queries generated by learners. In addition, it hooks up user's item response with Selection & Feedback agent. On the other hand, Selection & Feedback agent offers problems and content objects according to the corresponding user's ability parameter, and re-estimates the ability parameter to activate dynamic personalized learning situation and so forth.

• 한국멀티미디어학회논문지
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• 제8권6호
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• pp.814-826
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• 2005

The user-centric broadcasting environment includes the agent system and personalized broadcasting services for user-adaptive TV watching. In this paper, we propose broadcasting environment consisting of personalized broadcasting services and a multi-agent broadcasting system for the services. The proposed system employs the intelligent agent technology of the Foundation for Intelligent Physical Agents (FIPA) as well as metadata technology of MPEG-7 and TV-Anytime Forum (TVAF). To verify the usefulness of the proposed environment, we implemented a test-bed and demonstrated the proposed agent system with three services including intelligent user-information management service, information mobility service, and content retrieval service.

• Asia pacific journal of information systems
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• 제15권3호
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• pp.223-241
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• 2005

In spite of the rapid growth of mobile multimedia contents market, most of the customers experience inconvenience, lengthy search processes and frustration in searching for the specific multimedia contents they want. These difficulties are attributable to the current mobile Internet service method based on inefficient sequential search. To overcome these difficulties, this paper proposes a MOBIIe COntents Recommender System for Movie(MOBICORS-Movie), which is designed to reduce customers' search efforts in finding desired movies on the mobile Internet. MOBICORS-Movie consists of three agents: CF(Collaborative Filtering), CBIR(Content-Based Information Retrieval) and RF(Relevance Feedback). These agents collaborate each other to support a customer in finding a desired movie by generating personalized recommendations of movies. To verify the performance of MOBICORS-Movie, the simulation-based experiments were conducted. The results from this experiments show that MOBICORS-Movie significantly reduces the customer's search effort and can be a realistic solution for movie recommendation in the mobile Internet environment.

• Journal of Pharmaceutical Investigation
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• 제41권2호
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• pp.59-65
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• 2011

Nanotechnology for cancer therapy is playing a pivotal role in dramatically improving current approaches to cancer detection, diagnosis, and therapy while reducing toxic side effects associated with previous cancer therapy. A widespread understanding of these new technologies will lead to develop the more refined design of optimized nanoparticles with improved selectivity, efficacy and safety in the clinical practice of oncology. This review provides an integrated overview of applications and advances of nanotechnology in cancer therapy, based on molecular diagnostics, treatment, monitoring, target drug delivery, approved nanoparticle-based chemotherapeutic agents, and current clinical trials in the development of nanomedicine and ultimately personalized medicine.

• 한국컴퓨터산업학회논문지
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• 제2권8호
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• pp.1109-1116
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• 2001

본 논문에서는 사용자의 행동과 웹상에서 지능형 에이전트를 활용하여 계층적 아키텍처 아래 수행되는 행동을 모니터링 하는데 관점을 두며, 개인화 된 정보 서비스를 쉽게 개발할 수 있는 메커니즘을 제시하고자 한다. 지능형 에이전트는 모니터링 기법을 포함하여, 사용자의 행동을 기록, 프로파일에 기반 한 행동 분석, 사용자의 브라우저나 혹은 메일에 지능적 에이전트에 의해 전달되는 맞춤화 된 컨텐츠의 선택 및 구성 등과 같은 일련의 과정을 포함한 개인화 된 서비스를 제공하는 자동화된 프로세스 기법 중의 하나이다. 모니터링 기술은 개인화 된 지능적 서비스를 제공하는 프로세스를 구성하는데 활용될 수 있다. 결국, 효과적인 개인화 된 서비스의 수행은 다양한 고객의 관심 및 니즈를 정의하고 정확하게 알아내며 고객이 수행한 행동들을 기록하는 것에 달려있다.

• International Journal of Fuzzy Logic and Intelligent Systems
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• 제3권2호
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• pp.215-221
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• 2003

Generally, we want to be searched the newest as well as some appropriate personalized information from the internet resources. However, it is a complex and repeated procedure to search some appropriate information. Moreover, because the user's interests are changed as time goes, the real time modeling of a user's interests should be necessary. In this paper, I propose PREA system that can search and filter documents that users are interested from the World Wide Web. And then it constructs the user's interest model by a modified spreading neural network. Based on this network, PREA can easily produce some queries to search web documents, and it ranks them. The conventional spreading neural network does not have a visualization function, so that the users could not know how to be configured his or her interest model by the network. To solve this problem, PREA gives a visualization function being shown how to be made his interest user model to many users.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2021년도 추계학술발표대회
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• pp.1160-1163
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• 2021

DOOH(Degital Out of Home) advertisement market is developing steadily, and the case of use is also increasing, In advertisement market, personalized services is actively being provided with technological development. On the other hand, personalized services are difficult to be provided in DOOH and are p rovided by only personal information, not feelings. This study aims to construct personalized DOOH se rvices by using AI facial expression recognition and suggesting a solution optimized for interaction bet ween user and services by providing healing and advertisement.

• 정보처리학회논문지B
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• 제13B권5호
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• pp.533-540
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• 2006

웹에 분산된 모든 윈 페이지는 구조가 서로 다르다. 시멘틱 웹 환경은 이형적인 구조를 갖는 웹 페이지들의 메타데이터 바탕으로 시멘틱 검색이 가능하다. 그러나 일반적으로 사용자의 요구에 따른 시멘틱 김색은 상황에 따라 엄청난 수의 검색 결과를 내놓는다. 따라서 검색 결과에 대해 각 사용자에 맞는 검색 결과 순위를 적용할 필요가 있다. Culture Finder는 시멘틱 웹 검색 에이전트들이 개인화 된 문화 정보를 검색할 수 있도록 도움을 준다. Culture Finder는 웹에 존재하는 각 웹 페이지에 대한 메타 데이터를 작성하고, 시멘틱 검색을 이행하며 사용자 프로파일을 기반으로 삼아 검색 결과에 대한 순위 점수를 계산한다. Culture Finder에는 개인화 된 시멘틱 검색을 효율적으로 실행하기 위해 중요한 5가지 기법이 적용되었다. 사용자의 검색 행위로부터 사용자 프로파일을 생성하기 위한 기계 학습기법, 시멘틱 웹 검색 에이전트를 위한 효율적인 시멘틱 검색 기법, 사용자 질의의 효과적인 파악을 위한 질의 분석 기법, 각 사용자에게 적합한 검색 결과를 제공하기 위한 순위 적용 기술, 메타데이터를 생성하기 위한 상위 온톨로지 표현 방법, 본 논문에서는 Culture Finder의 구조를 통해서 시멘틱 개인화 검색에 대한 기법을 제안한다.