• Journal of the Korea Society of Computer and Information
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• v.25 no.6
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• pp.109-117
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• 2020

An edutainment system aims to help learners to recognize problems effectively, grasp and classify important information needed to solve the problems and convey the contents of what they have learned. Edutainment contents can be usefully applied to education and training in the both scientific and industrial areas. Our present work proposes an edutainment system that can be applied to a drug discovery process including virtual screening by using intuitive multi-modal interfaces. In this system, a stereoscopic monitor is used to make three-dimensional (3D) macro-molecular images, with supporting multi-modal interfaces to manipulate 3D models of molecular structures effectively. In this paper, our system can easily solve a docking simulation function, which is one of important virtual drug screening methods, by applying gaming factors. The level-up concept is implemented to realize a bio-game approach, in which the gaming factor depends on number of objects and users. The quality of the proposed system is evaluated with performance comparison in terms of a finishing time of a drug docking process to screen new inhibitors against target proteins of human immunodeficiency virus (HIV) in an e-drug discovery process.

• Nutrition Research and Practice
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• v.15 no.6
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• pp.715-731
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• 2021

BACKGROUND/OBJECTIVES: Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal production of estrogen and progesterone, leading to PMS symptoms. Thus, we judged that the inhibition of prolactin hypersecretion could mitigate PMS symptoms. MATERIALS/METHODS: Hordeum vulgare L. extract (HVE), Chrysanthemum zawadskii var. latilobum extract (CZE), and Lomens-P0 the mixture of these extracts were tested in subsequent experiments. The effect of extracts on prolactin secretion at the in vitro level was measured in GH3 cells. Nitric oxide and pro-inflammatory mediator expression were measured in RAW 264.7 cells to confirm the anti-inflammatory effect. Also, the hyperprolactinemic Institute for Cancer Research (ICR) mice model was used to measure extract effects on prolactin and hormone secretion and uterine inflammation. RESULTS: Anti-inflammatory effects of and prolactin secretion suppress by HVE and CZE were confirmed through in vitro experiments (P < 0.05). Treatment with Lomens-P0 inhibited prolactin secretion (P < 0.05) and restored normal sex hormone secretion in the hyperprolactinemia mice model. In addition, extracts significantly inhibited the expression of pro-inflammatory biomarkers, including interleukin-1𝛽, and -6, tumor necrosis factor-𝛼, inducible nitric oxide synthase, and cyclooxygenase-2 (P < 0.01). We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. The Lomens-P0, which includes tricin and chlorogenic acid, is expected to be effective in improving PMS symptoms in the human body. CONCLUSIONS: The Lomens-P0 suppressed the prolactin secretion in hyperprolactinemia mice, normalized the sex hormone imbalance, and significantly suppressed the expression of inflammatory markers in uterine tissue. This study suggests that Lomens-P0 may have the potential to prevent or remedy materials to PMS symptoms.

• The Journal of the Korea Contents Association
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• v.21 no.9
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• pp.632-643
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• 2021

The purpose of this study was to examine how the level of self-compassion of correctional workers influenced depression and the simple and double mediating effects of job stress and job autonomy. Although correctional officers experience high levels of stress and depression, there are limited strategies to protect their job performance. The total of 210 correctional workers in S. Korea were included in the final analysis using SPSS PROCESS Macro model 6. For the analysis, Korean Self-Compassion Scale (K-SCS), Korean occupational stress scale (KOSS), and Center for Epidemiological Studies Depression Scale (CESDS) were used. The results of the study were as follows. First, the correlation analysis showed statistically significant relationships between the variables(p<.01). Second, the simple mediating effect of job autonomy was found in the relationship between the self-compassion and depression as well as the double mediating effect of job stress and job autonomy. The influences of low level of self-compassion on mental health (depression) could be modified by improving the level of work related empowerment (job autonomy) as a protective factor. Based on the results of the study, the further study suggestions and limitations were discussed.

• The Korean journal of internal medicine
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• v.33 no.6
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• pp.1194-1202
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• 2018

Background/Aims: This study evaluated the role of hypomethylating agents (HMA) compared to best supportive care (BSC) for patients with high or very-high (H/VH) risk myelodysplastic syndrome (MDS) according to the Revised International Prognostic Scoring System. Methods: A total of 279 H/VH risk MDS patients registered in the Korean MDS Working Party database were retrospectively analyzed. Results: HMA therapy was administered to 205 patients (73.5%), including 31 patients (11.1%) who then received allogeneic hematopoietic cell transplantation (allo-HCT), while 74 patients (26.5%) received BSC or allo-HCT without HMA. The 3-year overall survival (OS) rates were $53.1%{\pm}10.7%$ for allo-HCT with HMA, $75%{\pm}21.7%$ for allo-HCT without HMA, $17.3%{\pm}3.6%$ for HMA, and $20.8%{\pm}6.9%$ for BSC groups (p < 0.001). In the multivariate analysis, only allo-HCT was related with favorable OS (hazard ratio [HR], 0.356; p = 0.002), while very poor cytogenetic risk (HR, 5.696; p = 0.042), age ${\geq}65years$ (HR, 1.578; p = 0.022), Eastern Cooperative Oncology Group performance status (ECOG PS) 2 to 4 (HR, 2.837; p < 0.001), and transformation to acute myeloid leukemia (AML) (HR, 1.901; p = 0.001) all had an adverse effect on OS. Conclusions: For the H/VH risk group, very poor cytogenetic risk, age ${\geq}65years$, ECOG PS 2 to 4, and AML transformation were poor prognostic factors. HMA showed no benefit in terms of OS when compared to BSC. Allo-HCT was the only factor predicting a favorable long-term outcome. The use of HMA therapy did not seem to have an adverse effect on the transplantation outcomes. However, the conclusion of this study should be carefully interpreted and proven by large scale research in the future.

• 한국노년학
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• v.38 no.1
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• pp.225-241
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• 2018

Self-driving is meaningful activity for older persons because it enlarges the range of activity and provides opportunities for social participation. Driving is a complex activity that requires integration of physical, cognitive and sensory functions and is influenced by human and psychological factors. Age related functional deterioration affects the driving ability of older drivers. The purpose of this study is to investigate the factors affecting the risk of accidents and driving cessation of elderly drivers through systematic literature review. MEDLINE, EMBASE, Cochrane Library, KoreaMed, Pubmed were used for searching articles published from 2007 to 2017. 'aged', 'aging', 'automobile driving', 'age factors' were used as search terms and 18 articles were finally selected for analysis among 1,458 articles. In result of the study, the most significant effect showed in the physical domain, the driving habit and the performance function. The most frequent used tools evaluated driving habit and the cognitive function. In demographic characteristics, there was a correlation with the driving discontinue according to sex and age. This study emphasizes the necessity of preparing measures for safety driving with elderly. In addition, it suggests the necessity of systematically services such as individual education programs based on various driving cessation related factors of the elderly.

• Journal of dental hygiene science
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• v.18 no.6
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• pp.374-379
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• 2018

This study attempted to identify factors work environment that affect job satisfaction in dental hygienists. This study was conducted between August 29 and September 28, 2017, as part of an in-depth study of the 'Survey on the Working Environment of Clinical Dental Hygienists' of the Korean Dental Hygienists Association. To get the responses, the questionnaire was posted on the website of the Korean Dental Hygienists Association, and of the respondents, 4,663 were selected and analyzed. An independent t-test and one way ANOVA analysis were used to make a comparison of job satisfaction according to the general characteristics, salary, and tasks. Logistic regression analysis was conducted to identify factors affecting job satisfaction. The significance level was 0.05. In regard to salary information, the job satisfaction was found to be high (p<0.001) in cases where the salary was considered appropriate, when incentives were provided, when rewards or vacation expenses were supported, and when overtime and nightly work allowances were paid. In regard to job information, the job satisfaction was found to be high (p<0.001) when the volume of work was considered appropriate, when there were sufficient numbers in the workforce, and when the division of labor among the other personnel was clear. As a factor affecting job satisfaction of dental hygienists, the case of thinking that 'workload is appropriate' was found to be 2.052 times, showing the highest score. Job satisfaction in dental hygienists affects the turnover and has a significant effect on the performance of the organization. Therefore, it is believed, that it is urgent to improve the working environment such as salary and clear division of duties affecting job satisfaction of dental hygienists.

• Journal of the Korea Convergence Society
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• v.10 no.1
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• pp.163-176
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• 2019

The purpose of this study is to examine the impact of PM consultant leadership competence on consulting repurchase intention and the impact of SME CEO participation on consulting repurchase intention. The validity of the measurement model was secured through CFA (Confirmative Factor Analysis) for the questionnaire data, and consistency was secured through the same method convenience, and significant results were obtained. In other words, not only the ability of PM consultant in repurchase of consulting is important, but also confirms that repurchase intention differs according to the participation of manager. Therefore, the performance that manager feels depends on the degree of manager's interest in repurchase and plays an important role in repurchase. As a result, it is important for PM to report to manager and / or make the manager participate in consulting process so that manager can be interested. In this study, it is difficult to generalize the relationship between PM's leadership role and manager's involvement in the repurchase intention. However, it is meaningful that PM's competence as well as management's participation are very important, and that this study figured out which drection PM's leadership should focus on. The purpose of this study is to investigate the effect of the variables on the repurchase intention.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.8
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• pp.207-215
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• 2019

This study was conducted to identify key success factors of the Agricultural Cooperative Federation. We classified the divisions of regional agricultural cooperatives into high performers and low performers to investigate differences in environmental stability, resource capacity, resource flexibility, differentiation strategy, and low-cost strategies between high and low performers. Empirical analyses revealed that high performers are superior to low performers in resource capacity, resource flexibility, differentiation, and low-cost, but there was no difference in environmental stability between high performers and low performers. Internal factors including resource and strategy attributes affect business performance, but external factors such as environmental attributes do not. Moreover, resource flexibility generates the broadest gap between high performers and low performers. These results indicate that resource flexibility is the key factor leading to success of organizations with greater competitors because it enables them to overcome their disadvantageous competitive position in size and resources through complete exploitation of resources across divergent business areas owing to its flexibility. Our contribution is that we draw the key success factors of the Agricultural Cooperative Federation through an empirical approach.

• Journal of the Korean Geotechnical Society
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• v.35 no.6
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• pp.17-26
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• 2019

In this study, the statistical characteristics of the resistance bias factors were analyzed using a high-quality field load test database, and the total resistance bias factors were estimated considering the soil uncertainty and construction errors for the application of the limit state design of aggregate pier foundation. The MLR model by Bong and Kim (2017), which has a higher prediction performance than the previous models was used for estimating the resistance bias factors, and its suitability was evaluated. The chi-square goodness of fit test was performed to estimate the probability distribution of the resistance bias factors, and the normal distribution was found to be most suitable. The total variability in the nominal resistance was estimated including the uncertainty of undrained shear strength and construction errors that can occur during the aggregate pier construction. Finally, the probability distribution of the total resistance bias factors is shown to follow a log-normal distribution. The parameters of the probability distribution according to the coefficient of variation of total resistance bias factors were estimated by Monte Carlo simulation, and their regression equations were proposed for simple application.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.30 no.3
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• pp.181-189
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• 2019

In this study, a triple-band antenna that can be used in WLAN(Wireless Local Area Network) at 2.4 GHz, 5.8 GHz, and 5G at 3.5 GHz is fabricated. The proposed antenna uses a parasitic element to show the triple band, and the reflector is used at a distance of ${\lambda}/4$ from the antenna to reduce the Specific Absorption Rate(SAR). Its dimensions are $100{\times}75{\times}1.6mm^3$ and each parameter value is optimized for better performance and a lower SAR value. As a result, we obtained a bandwidth of 540 MHz(2.02~2.56 GHz), 390 MHz(3.39~3.78 GHz), and 1,210 MHz(5.56~6.77 GHz) based on the reflection loss factor of -10 dB. In addition, the SAR values of the antenna with reflector are observed to reduce below the SAR value of international standard.