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http://dx.doi.org/10.4162/nrp.2021.15.6.715

Lomens-P0 (mixed extracts of Hordeum vulgare and Chrysanthemum zawadskii) regulate the expression of factors affecting premenstrual syndrome symptoms

Lee, Yoon Seo (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)
Jeon, Hyelin (BioMedical Research Institute, Kyung Hee University)
Her, Yang-Mi (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)
Lee, Da Eun (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)
Jeong, Yong Joon (Research Institute, Genencell Co. Ltd.)
Kim, Eun Jeong (Research Institute, Genencell Co. Ltd.)
Choe, Tae Hwan (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)
Suh, Hee Ju (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)
Shin, Seung-Yeon (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)
Park, Dae Won (BioMedical Research Institute, Kyung Hee University)
Lee, Yeong-Geun (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)
Kang, Se Chan (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)

Publication Information

Nutrition Research and Practice / v.15, no.6, 2021 , pp. 715-731 More about this Journal

Abstract

BACKGROUND/OBJECTIVES: Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal production of estrogen and progesterone, leading to PMS symptoms. Thus, we judged that the inhibition of prolactin hypersecretion could mitigate PMS symptoms. MATERIALS/METHODS: Hordeum vulgare L. extract (HVE), Chrysanthemum zawadskii var. latilobum extract (CZE), and Lomens-P0 the mixture of these extracts were tested in subsequent experiments. The effect of extracts on prolactin secretion at the in vitro level was measured in GH3 cells. Nitric oxide and pro-inflammatory mediator expression were measured in RAW 264.7 cells to confirm the anti-inflammatory effect. Also, the hyperprolactinemic Institute for Cancer Research (ICR) mice model was used to measure extract effects on prolactin and hormone secretion and uterine inflammation. RESULTS: Anti-inflammatory effects of and prolactin secretion suppress by HVE and CZE were confirmed through in vitro experiments (P < 0.05). Treatment with Lomens-P0 inhibited prolactin secretion (P < 0.05) and restored normal sex hormone secretion in the hyperprolactinemia mice model. In addition, extracts significantly inhibited the expression of pro-inflammatory biomarkers, including interleukin-1𝛽, and -6, tumor necrosis factor-𝛼, inducible nitric oxide synthase, and cyclooxygenase-2 (P < 0.01). We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. The Lomens-P0, which includes tricin and chlorogenic acid, is expected to be effective in improving PMS symptoms in the human body. CONCLUSIONS: The Lomens-P0 suppressed the prolactin secretion in hyperprolactinemia mice, normalized the sex hormone imbalance, and significantly suppressed the expression of inflammatory markers in uterine tissue. This study suggests that Lomens-P0 may have the potential to prevent or remedy materials to PMS symptoms.

Keywords

Premenstrual syndrome; medicinal plants; prolactin; hormones; inflammation;

Citations & Related Records

Reference

1	Lennartsson AK, Jonsdottir IH. Prolactin in response to acute psychosocial stress in healthy men and women. Psychoneuroendocrinology 2011;36:1530-9. DOI
2	Braverman PK. Premenstrual syndrome and premenstrual dysphoric disorder. J Pediatr Adolesc Gynecol 2007;20:3-12. DOI
3	Hong JP, Park S, Wang HR, Chang SM, Sohn JH, Jeon HJ, Lee HW, Cho SJ, Kim BS, Bae JN, Cho MJ. Prevalence, correlates, comorbidities, and suicidal tendencies of premenstrual dysphoric disorder in a nationwide sample of Korean women. Soc Psychiatry Psychiatr Epidemiol 2012;47:1937-45. DOI
4	Deuster PA, Adera T, South-Paul J. Biological, social, and behavioral factors associated with premenstrual syndrome. Arch Fam Med 1999;8:122-8. DOI
5	Hofmeister S, Bodden S. Premenstrual syndrome and premenstrual dysphoric disorder. Am Fam Physician 2016;94:236-40.
6	McCallum RW, Sowers JR, Hershman JM, Sturdevant RA. Metoclopramide stimulates prolactin secretion in man. J Clin Endocrinol Metab 1976;42:1148-52. DOI
7	Kim AR, Kim HS, Kim DK, Lee JH, Yoo YH, Kim JY, Park SK, Nam ST, Kim HW, Park YH, Lee D, Lee MB, Kim YM, Choi WS. The extract of Chrysanthemum zawadskii var. latilobum ameliorates collagen-induced arthritis in mice. Evid Based Complement Alternat Med 2016;2016:3915013.
8	Song HS, Kwon JE, Baek HJ, Kim CW, Jeon H, Ra JS, Lee HK, Kang SC. Sorghum fermented by Aspergillus oryzae NK enhances inhibition of vascular inflammation in TNF-α-stimulated human aortic smooth muscle cells. Int J Vitam Nutr Res 2018;88:309-18. DOI
9	Skwarlo-Sonta K. Prolactin as an immunoregulatory hormone in mammals and birds. Immunol Lett 1992;33:105-21. DOI
10	Ben-Jonathan N, Hnasko R. Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 2001;22:724-63. DOI
11	Zamani M, Neghab N, Torabian S. Therapeutic effect of Vitex agnus castus in patients with premenstrual syndrome. Acta Med Iran 2012;50:101-6.
12	Silva LG, Ferguson BS, Faciola AP. Rapid communication: prolactin and hydrocortisone impact TNFα-mediated mitogen-activated protein kinase signaling and inflammation of bovine mammary epithelial (MAC-T) cells. J Anim Sci 2017;95:5524-31. DOI
13	Sharma JN, Al-Omran A, Parvathy SS. Role of nitric oxide in inflammatory diseases. Inflammopharmacology 2007;15:252-9. DOI
14	Pearlstein TB. Hormones and depression: what are the facts about premenstrual syndrome, menopause, and hormone replacement therapy? Am J Obstet Gynecol 1995;173:646-53. DOI
15	Rondeau G, Merouani A, Phan V, Deal C, Robitaille P. Serum prolactin levels in a uremic child: effects of bilateral nephrectomy and kidney transplantation. NDT Plus 2011;4:303-6. DOI
16	Gunin AG, Emelianov V, Tolmachev AS, Tolmacheva A. Effect of prolactin and dopaminergic drugs on uterine response to chronic estrogen exposure. J Endocrinol 2002;172:61-9. DOI
17	Orkhon B, Kobayashi K, Javzan B, Sasaki K. Astragalus root induces ovarian β-oxidation and suppresses estrogen-dependent uterine proliferation. Mol Med Rep 2018;18:5198-206.
18	Sugimoto Y, Narumiya S. Prostaglandin E receptors. J Biol Chem 2007;282:11613-7. DOI
19	Fischer DP, Griffiths AL, Lui S, Sabar UJ, Farrar D, O'Donovan PJ, Woodward DF, Marshall KM. Distribution and function of prostaglandin E2 receptors in mouse uterus: translational value for human reproduction. J Pharmacol Exp Ther 2020;373:381-90. DOI
20	Holm P, Shalmi M, Korsgaard N, Guldhammer B, Skouby SO, Stender S. A partial estrogen receptor agonist with strong antiatherogenic properties without noticeable effect on reproductive tissue in cholesterol-fed female and male rabbits. Arterioscler Thromb Vasc Biol 1997;17:2264-72. DOI
21	Yen JY, Wang PW, Su CH, Liu TL, Long CY, Ko CH. Estrogen levels, emotion regulation, and emotional symptoms of women with premenstrual dysphoric disorder: the moderating effect of estrogen receptor 1α polymorphism. Prog Neuropsychopharmacol Biol Psychiatry 2018;82:216-23. DOI
22	Majumdar A, Mangal NS. Hyperprolactinemia. J Hum Reprod Sci 2013;6:168-75. DOI
23	Palubska S, Adamiak-Godlewska A, Winkler I, Romanek-Piva K, Rechberger T, Gogacz M. Hyperprolactinaemia - a problem in patients from the reproductive period to the menopause. Przegl Menopauz 2017;16:1-7.
24	Wang X, Ma L, Zhang EJ, Zou JL, Guo H, Peng SW, Wu JH. Water extract of Fructus Hordei Germinatus shows antihyperprolactinemia activity via dopamine D2 receptor. Evid Based Complement Alternat Med 2014;2014:579054.
25	Osorio FL, de Paula Cassis JM, Machado de Sousa JP, Poli-Neto O, Martin-Santos R. Sex hormones and processing of facial expressions of emotion: a systematic literature review. Front Psychol 2018;9:529. DOI
26	Kim KY, Oh TW, Yang HJ, Kim YW, Ma JY, Park KI. Ethanol extract of Chrysanthemum zawadskii Herbich induces autophagy and apoptosis in mouse colon cancer cells through the regulation of reactive oxygen species. BMC Complement Altern Med 2019;19:274. DOI
27	Pereira Suarez AL, Lopez-Rincon G, Martinez Neri PA, Estrada-Chavez C. Prolactin in inflammatory response. Adv Exp Med Biol 2015;846:243-64. DOI
28	Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev 2000;80:1523-631. DOI
29	Verkaik S, Kamperman AM, van Westrhenen R, Schulte PF. The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis. Am J Obstet Gynecol 2017;217:150-66. DOI
30	Schmidt PJ, Martinez PE, Nieman LK, Koziol DE, Thompson KD, Schenkel L, Wakim PG, Rubinow DR. Premenstrual dysphoric disorder symptoms following ovarian suppression: triggered by change in ovarian steroid levels but not continuous stable levels. Am J Psychiatry 2017;174:980-9. DOI
31	Wira CR, Rodriguez-Garcia M, Patel MV. The role of sex hormones in immune protection of the female reproductive tract. Nat Rev Immunol 2015;15:217-30. DOI
32	Seidlova-Wuttke D, Wuttke W. The premenstrual syndrome, premenstrual mastodynia, fibrocystic mastopathy and infertility have often common roots: effects of extracts of chasteberry (Vitex agnus castus) as a solution. Clin Phytoscience 2017;3:6. DOI
33	Borba VV, Zandman-Goddard G, Shoenfeld Y. Prolactin and autoimmunity. Front Immunol 2018;9:73. DOI
34	Li MX, Liu H, Li Y, Wang F, Zhang PR, Zang P. Anti-hyperprolactinemic effect of formula malt decoction, a Chinese herbal cocktail. Trop J Pharm Res 2015;14:263-9. DOI
35	Koshikawa N, Tatsunuma T, Furuya K, Seki K. Prostaglandins and premenstrual syndrome. Prostaglandins Leukot Essent Fatty Acids 1992;45:33-6. DOI
36	Klein-Laansma CT, Jong M, von Hagens C, Jansen JP, van Wietmarschen H, Jong MC. Semi-individualized homeopathy add-on versus usual care only for premenstrual disorders: a randomized, controlled feasibility study. J Altern Complement Med 2018;24:684-93. DOI
37	Cerqueira RO, Frey BN, Leclerc E, Brietzke E. Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review. Arch Women Ment Health 2017;20:713-9. DOI
38	Moreno-Carranza B, Bravo-Manriquez M, Baez A, Ledesma-Colunga MG, Ruiz-Herrera X, Reyes-Ortega P, de Los Rios EA, Macotela Y, Martinez de la Escalera G, Clapp C. Prolactin regulates liver growth during postnatal development in mice. Am J Physiol Regul Integr Comp Physiol 2018;314:R902-8.