Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Lomens-P0 (mixed extracts of Hordeum vulgare and Chrysanthemum zawadskii) regulate the expression of factors affecting premenstrual syndrome symptoms

  • Lee, Yoon Seo (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Jeon, Hyelin (BioMedical Research Institute, Kyung Hee University) ;
  • Her, Yang-Mi (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Lee, Da Eun (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Jeong, Yong Joon (Research Institute, Genencell Co. Ltd.) ;
  • Kim, Eun Jeong (Research Institute, Genencell Co. Ltd.) ;
  • Choe, Tae Hwan (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Suh, Hee Ju (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Shin, Seung-Yeon (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Park, Dae Won (BioMedical Research Institute, Kyung Hee University) ;
  • Lee, Yeong-Geun (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University) ;
  • Kang, Se Chan (Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University)
  • Received : 2020.12.11
  • Accepted : 2021.04.08
  • Published : 2021.12.01
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Abstract

BACKGROUND/OBJECTIVES: Premenstrual syndrome (PMS) is a disorder characterized by repeated emotional, behavioral, and physical symptoms before menstruation, and the exact cause and mechanism are uncertain. Hyperprolactinemia interferes with the normal production of estrogen and progesterone, leading to PMS symptoms. Thus, we judged that the inhibition of prolactin hypersecretion could mitigate PMS symptoms. MATERIALS/METHODS: Hordeum vulgare L. extract (HVE), Chrysanthemum zawadskii var. latilobum extract (CZE), and Lomens-P0 the mixture of these extracts were tested in subsequent experiments. The effect of extracts on prolactin secretion at the in vitro level was measured in GH3 cells. Nitric oxide and pro-inflammatory mediator expression were measured in RAW 264.7 cells to confirm the anti-inflammatory effect. Also, the hyperprolactinemic Institute for Cancer Research (ICR) mice model was used to measure extract effects on prolactin and hormone secretion and uterine inflammation. RESULTS: Anti-inflammatory effects of and prolactin secretion suppress by HVE and CZE were confirmed through in vitro experiments (P < 0.05). Treatment with Lomens-P0 inhibited prolactin secretion (P < 0.05) and restored normal sex hormone secretion in the hyperprolactinemia mice model. In addition, extracts significantly inhibited the expression of pro-inflammatory biomarkers, including interleukin-1𝛽, and -6, tumor necrosis factor-𝛼, inducible nitric oxide synthase, and cyclooxygenase-2 (P < 0.01). We used high-performance liquid chromatography analyses to identify tricin and chlorogenic acid as the respective components of HVE and CZE that inhibit prolactin secretion. The Lomens-P0, which includes tricin and chlorogenic acid, is expected to be effective in improving PMS symptoms in the human body. CONCLUSIONS: The Lomens-P0 suppressed the prolactin secretion in hyperprolactinemia mice, normalized the sex hormone imbalance, and significantly suppressed the expression of inflammatory markers in uterine tissue. This study suggests that Lomens-P0 may have the potential to prevent or remedy materials to PMS symptoms.

Keywords

Acknowledgement

This work was supported by the Korean Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET) through the High Value-added Food Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (317041-5).

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