• Title/Summary/Keyword: oriental herbal medicine

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Observation of Microorganism in Herbal Decoction mafactured by Korean Medical Clinic (한약 탕전 팩의 미생물 연구)

  • Yu, Young-Beob;Ma, Jin-Yeul;Ha, Hye-Kyung;Huang, Dae-Sun;Kim, Bok-Kyu;Shin, Kwang-Soo;Shin, Hyun-Kyoo
    • Herbal Formula Science
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    • v.15 no.2
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    • pp.119-126
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    • 2007
  • Objectives: This study presents observation of microorganism such as total aerobic bacteria, total fungus, E. coli, Pseudonomas aerugjnosa, Staphylococcus aureus, and Salmonella typhimurium in herbal decoction manufactured by Korean medical clinic. Methods: We examined to observe microorganism using the requirements for the experimental methods recommended by FDA. For the identification, we observed microscopic methods and carried out polymerase chain reaction (PCR) and DNA purification. The purified DNA samples were analyzed by DNA sequencer. As compared with NCBI database. the results were identified by sequences similarity. Results and conclusion: 26 (55%) of 46 decoctions observed positive for microbial test. 12 (46 %) of 26 positive decoctions exceed requirement of microbial limit test. These microbial colony identified genus of Bacillus using microscopic and DNA sequencing methods.

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Analysis of Studies on Guibi-tang(Guipitang) for Fundamental Establishment of Evidence Based Medicine(EBM) (EBM 기반구축을 위한 귀비탕(歸脾湯) 연구 문헌 분석)

  • Kim, Jung-Hoon;Lee, Jun-Kyoung;Ha, Hye-Kyoung;Seo, Chang-Seob;Lee, Mi-Young;Lee, Ho-Young;Jung, Da-Young;Lee, Nam-Hun;Lee, Jin-Ah;Huang, Dae-Sun;Shin, Hyun-Kyoo
    • Journal of Oriental Neuropsychiatry
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    • v.20 no.3
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    • pp.205-216
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    • 2009
  • Objectives : To establish the fundaments for EBM of Traditional Korean Medicine, the papers on Guibi-tang(Guipitang) which were frequently used in medical institutions of Traditional Korean Medicine were analyzed through researching domestic and international literatures. Methods : The papers were classified by the year of publishment, by experimental methods, by laboratory animals used in biological experiment and by the kinds of studies on biological efficacy. Results : Of total 39 papers were registered in domestic journals. Since 1980, publishments of papers have continuously increased. The papers on biological studies were 34 volumes, clinical studies were 5 volumes. Biological studies mainly showed the effects of anti-stress, anti-oxidant, hemostasis, anti-osteoporosis, gastroprotection, reproductive ability, brain cell activity, radioprotection. And clinical studies showed improvements of fearful throbbing, memory and orientation, insomnia, vericose vein, schizophrenia. Conclusions : Guibi-tang(Guipitang) could be used to fortify the spleen, nourish the heart and then control the blood. However biological studies need to be conducted in accordance with clinical study and further clinical studies on randomized controlled trials should be proceeded.

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Equivalence of Traditional and Individual Preparation of Ssanghwa-tang in terms of Polyphenol Contents and Radical Scavenging Activity (폴리페놀 및 항산화 관점에서의 쌍화탕 및 단미혼합쌍화탕의 동등성)

  • Kim, Dong-Seon;Um, Young-Ran;Yang, Min-Cheol;Yun, Na-Young;Lee, Jae-Hoon;Ma, Jin-Yeul
    • Korean Journal of Oriental Medicine
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    • v.17 no.2
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    • pp.169-172
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    • 2011
  • Traditional medicines usually use combinational formula that is prepared by mixing different varieties of medicinal herbs and boiling them in water to yield a decoction. In recent years a modified method has been proposed and practiced wherein the individual herbs are boiled with water separately and later these extracts are mixed together for use. This practice has lead to a constant controversy concerning the chemical and biological equivalence between the preparations arriving out of these two methodologies. In this research, we attempted to study the effects of traditional and individual preparation of Ssanghwa-tang (ST) to evaluate their equivalence in terms of its antioxidant activity and polyphenol content. The study results indicate that the polyphenol contents as well as the extraction yields of these two preparations were very similar to each other.

Acute Toxicity Study on Gumiganghwal-tang(Jiuweiqianghuo-tang) in Sprague-Dawley Rats (Spargue-Dawley 랫드를 이용한 구미강활탕의 급성독성 연구)

  • Shin, In-Sik;Kim, Jung-Hoon;Ha, Hye-Kyung;Seo, Chang-Seob;Lee, Mi-Young;Lee, Ho-Young;Lee, Jun-Kyoung;Lee, Nam-Hun;Lee, Jin-Ah;Lee, Sul-Lim;Huh, Jung-Im;Shin, Hyeun-Kyoo
    • Herbal Formula Science
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    • v.18 no.1
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    • pp.79-85
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    • 2010
  • Objectives : This study was conducted to evaluate the acute toxicity and safety of Gumiganghwal-tang (Jiuweiqianghou-tang) in Sprague-Dawley rats though the current regulatory guideline. Methods : The preliminary study showed that the single oral administration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Results : Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Conclusions : These results showed that the single oral adminstration of Gumiganghwal-tang(Jiuweiqianghou-tang) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the $LD_{50}$ of Gumiganghwal-tang (Jiuweiqianghou-tang) was considered to be over 2000 mg/kg body for both sexes.

The Current State of Clinical Studies for Herbal Medicine of Attention Deficit Hyperactivity Disorder (ADHD) -Focusing on Chinese Journals- (ADHD의 한약물 치료에 대한 최신 임상연구 동향 -2007년부터 2012년까지 중국 논문을 중심으로-)

  • Ryu, Chun-Gil;Cho, A-Ram;Seo, Joo-Hee;Jeong, Seong-Sik;Lee, Ji-Su;Sung, Woo-Yong
    • Journal of Oriental Neuropsychiatry
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    • v.24 no.1
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    • pp.1-12
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    • 2013
  • Objectives : The purpose of this study was to take around herbal medicine for Attention Deficit Hyperactivity Disorder in China. Methods : A journal search was performed using China National Knowledge Infrastructure (CNKI) from 2007 to 2012. Key words searched were 'ADHD'. Results : 25 studies were selected. Case control studies showed that herbal medicine treatment reported better results than the western medicine treatment group. 12 case reports reported a significant improvement in herbal medicine treatment for patients with ADHD. Frequently used herbal materials were Rhizome of Polygalae Radix and Rhizome of Acori Gramineri Rhizoma (16 times), Root of Glycyrrhiza uralensis Fisch (14 times), Root of Rehmanniae Radix et Rhizoma Preparata and Sclerotium of Poria cocos Wolf (12 times). Conclusions : There have been many studies regarding herbal medicine for Attention Deficit Hyperactivity Disorder in China, and these studies can be applied to the clinical practices in Korea.

Clinical Case Report of Polyneuritis : With Cervus Elaphus Herbal-Acupuncture (녹용약침요법을 병행한 다발성 신경염 환자 치험 1례)

  • Sul, Jae-Uk;Kim, Sun-Jong;Sin, Mi-Suk;Choi, Jin-Bong;Kim, Se-Jin
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.1 no.1
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    • pp.35-43
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    • 2006
  • Objectives : This study was performed to evaluate the effect of Cervus elaphus herbal-acupuncture on patient with polyneuritis, who shows sensory disorder on both hands, severe pain on left foot and ambulation difficulty due to weakness on left leg. Methods : We treated the patient by Cervus elaphus Herbal-acupuncture. Other treatments were acupunture, herbal medication, several rehabilitative therapies without western medication. We used evaluation scale including VAS(Visual Analogue Scale), MRC(Medicak Research Council) and Thermological Difference of between hand and foot. Results and Conclusions : In the results, the symptoms were improved gradually, and VAS and MRC were also numerically improved. Thermological Difference of between feet was decreased from$4.40^{\circ}C\;to\;0.26^{\circ}C$. In this case, a patient was treated by oriental medical treatments without western medication, and relatively the relatively the result was more effective.

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Quality Monitoring of Distributed Schizandra chinensis (Turcz.) Baill in Korea

  • Choo, Byung-Kil;Kim, Hong-Jun;Lee, A-Yeong;Chun, Jin-Mi;Lee, Hye-Won;Woo, Myeong-Ji;Kim, Sun-Hee;Kim, Ho-Kyoung
    • The Journal of Korean Medicine
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    • v.27 no.4
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    • pp.150-155
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    • 2006
  • Object : This study investigated the quality inspection of Schizandra chinensis (Turcz.) Bail distributed in Korea. Methods: To evaluate the quality of these herbal medicines, we carried out TLC pattern analysis, purity, loss on drying, ash, acid-insoluble ash, essential oil contents, dilute ethanol-soluble, water-soluble, ether-soluble extracts and HPLC analysis. Results : As a result, TCL pattern analysis of schizandrin and gomisin A showed Rf=0.64 and 0.74, respectively. To measured content of schizandrin and gomisin A, we quantitatively analyzed using HPLC. The average contents of schizandrin and gomisin A were detected to be 0.60 (${\pm}$0.02)% and 0.12 (${\pm}$0.004)%, respectively. Discussion : As a result of this study, we suggest that the minimum content of schizandrin and gomisin A should be 0.5% and 0.1%, respectively. We could suggest that the minimum of essential oil content should be 0.6 ml.

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A Clinical Case of Liver Injury Induced by Chungsim Yeonja-tang (청심연자탕 투여후 발생한 약물 유인성 간손상 치험 1례)

  • Sun, Teh-Cheng;Jang, Hae-Jin;Song, Woo-Sup;Yoon, Yeo-Kwang
    • The Journal of Internal Korean Medicine
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    • v.25 no.3
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    • pp.539-544
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    • 2004
  • Herbal medicine has been used in the Eastern world for 2,000 years, and is beneficial for numerous diseases. There have been reports pertaining to the safety of herbal medicine, but there have been few reports about herbal medicine induced liver injury in Eastern or Western medicine. Most are descriptions of hepatotoxicity of certain toxic herbs. We experienced one case of drug induced liver injury in the treatment of cerebral infarction with Chungsim Yeonja-tang. Although the patient had not used medication and Chungsim Yeonja-tang has no toxic herbs in it. patient's ALP, AST, ALT, GGT was twice elevated after 20 days on medication. This was diagnosed as drug induced liver injury, possibly due to incorrect diagnosis of Sasang constitution. So no herbal medicine was given for seven days. Then Gagam Saeng Gan-tang was given. Gagam Saeng Gan-tang have been used to treat hepatic disease and have been known to have beneficial effects. After 25 days on medication, the clinical symptoms and liver function improved. So, this case is presented to bring more attention to the toxicity of herbal medicines.

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The Clinical Study for Peripheral Facial Paralysis Treated with Herbal Stream Therapy (구안와사에 대한 훈증요법 복합치료 효과)

  • Kim, Ji-Soo;Park, Soo-Yeon;Choi, Chang-Won;Kim, Kyeong-Soo;Kim, Kyeong-Ok;Wei, Tung-Shuen;Yang, Seung-Joung
    • Herbal Formula Science
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    • v.23 no.1
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    • pp.151-159
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    • 2015
  • Objectives : This study was performed to investigate the effect of herbal steam therapy on peripheral facial paralysis. Methods : 55 patients with peripheral facial paralysis were treated with Korean Medicine therapy including herbal steam therapy. We evaluated the effect of Korean Medicine therapy including herbal steam therapy by Yanagihara grading system. Results : 1. 55 patients were treated with Korean Medicine therapy and 23.27±14.11 times of herbal steam therapy. 2. After treatment, Y-system score was significantly increased(p-value<0.001) from 18.00±6.5514 to 35.00±6.3404. Conclusions : Herbal stream therapy seem to be effective to improve symptoms of peripheral facial paralysis. Further studies will be needed to identify the beneficial of herbal steam therapy on peripheral facial paralysis.

Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (II) (한국약용식물의 최종당화산물 생성저해활성 검색 (II))

  • Lee, Yun-Mi;Kim, Young-Sook;Kim, Jong-Min;Jang, Dae-Sik;Kim, Joo-Hwan;Yoo, Jeong-Lim;Kim, Jin-Sook
    • Korean Journal of Pharmacognosy
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    • v.39 no.3
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    • pp.223-227
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    • 2008
  • Advanced glycation end products (AGEs) contribute to the progression of micro and macrovsacular complication of diabetes and therefore present a promising target for therapeutic agents. In this study, 40 Korean herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 21 herbal medicines $(IC_{50}<50{\mu}g/ml)$ exhibited an inhibitory activity against AGEs formation compared with anminoguanidine $(IC_{50}=72.12{\mu}g/ml)$. Particularly, 7 herbal medicines, Actinidia arguta (root and stem), Crataegus pinnatifida (twig), Camellia japonica (whole), Kalopanax pictus (bark), Lagerstroemia indica (leaf-stem), Reynoutria sachalinensis (root) showed more potent inhibitory activity (approximately 3-10 fold) than the positive control aminoguanidine.