Browse > Article

Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (II)  

Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Young-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Jong-Min (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Joo-Hwan (Department of Life Science, Daejeon University)
Yoo, Jeong-Lim (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.3, 2008 , pp. 223-227 More about this Journal
Abstract
Advanced glycation end products (AGEs) contribute to the progression of micro and macrovsacular complication of diabetes and therefore present a promising target for therapeutic agents. In this study, 40 Korean herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 21 herbal medicines $(IC_{50}<50{\mu}g/ml)$ exhibited an inhibitory activity against AGEs formation compared with anminoguanidine $(IC_{50}=72.12{\mu}g/ml)$. Particularly, 7 herbal medicines, Actinidia arguta (root and stem), Crataegus pinnatifida (twig), Camellia japonica (whole), Kalopanax pictus (bark), Lagerstroemia indica (leaf-stem), Reynoutria sachalinensis (root) showed more potent inhibitory activity (approximately 3-10 fold) than the positive control aminoguanidine.
Keywords
Advanced glycation end products (AGEs); diabetic complications; herbal medicines;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
Times Cited By SCOPUS : 4
연도 인용수 순위
1 Namba T, Tsunezuka M, Takehana Y, Nunome S, Takeda K, Shu YW, Kakiuchi S, Takigi S and Hattori M (1984) Studies on dental caries prevention by traditional Chinese medicines. IV. Screening of crude drugs for anti-plaque action and effects on Artemisia capollaris spikes on adgerence of Streptociccus mutans to smooth surfaces and synthesis of glucan, Shoyakugaku Zasshi. 38: 263-264
2 Kao ES, Wang CJ, Lin WL, Yin YF, Wang CP, Tseng TH (2005) Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo. J. Agric. Food. Chem. 53: 430-436   DOI   ScienceOn
3 Choi SY, Jung SH, Lee HS, Park KW, Yun BS, Lee KW. (2008) Glycation inhibitory activity and the identification of an active compound in Plantago asiatica extract. Phytother. Res 22: 323-329   DOI   ScienceOn
4 Vinson, J.A. and Howard , T.B. (1996) Inhibition of protein glycation and advanced glycation endproducts by ascorbic acid and other vitamins and nutrients. J. Nutr. Biochem. 7:659-663   DOI   ScienceOn
5 Webby RF. (1991) A flavonol triglycoside from Actinida arguta var. giraldii. Phytochemistry. 30: 2443-2444   DOI   ScienceOn
6 Park H, Kim MS, Jeon BH, Kim TK, Kim YM, Ahnn J, Kwon DY, Takaya Y, Wataya Y, Kim HS. (2003) Antimalarial activity of herbal extracts used in traditional medicine in Korea. Biol Pharm. Bull. 26: 1623-1624   DOI   ScienceOn
7 Min SK, Park YK, Park JH, Jin SH, Kim KW (2004) Screening of Antibacterial Activity from hot Water Extracts of Indigenous Plants J. Life Sci. 14: 956-952
8 Zhang X, Thuong PT, Jin W, Su ND, Sok DE, Bae K, Kang SS (2005) Antioxidant activity of anthraquinones and flavonoids from flower of Reynoutria sachalinensis. Arch. Pharm. Res 28: 22-7   과학기술학회마을   DOI
9 Larkins RG, Dunlop ME. (1992) The link between hyperglycaemia and diabetic nephropathy. Diabetologia 35: 499-504   DOI
10 Huebschmann A.G., Vlassara H, Regensteiner JG, Reusch J.(2007) Diabetes and advanced glycoxidation end products. Annual review of diabetes 51-63
11 Jang DS, Kim JM, Lee YM, Kim YS, Kim JH, Kim JS. (2006) Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata. Chem. Pharm .Bull . 54: 1315-1317   DOI   ScienceOn
12 Lim H-W, Kang SJ, Park M, Yoon JH, Han BH, Choi S-E, Lee M (2006) Antioxidative and nitric oxide production inhibitory activities of pheolic compounds from fruits of Actinidia arguta. Nat. Prod. Sci. 12: 221-225   과학기술학회마을
13 Kim SM, Hwang EJ, Pyo B-S, Lee S-Y (2004) Antioxidant and antimicrobial activities of the extracts from native Camellia japonica in Kore. Korean J. Plant Res. 17: 314-322
14 Jang DS, Lee GY, Kim YS, Lee YM, Kim CS, Yoo JL, Kim JS.(2007) Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase. Biol. Pharm. Bull. 30: 2207-10   DOI   ScienceOn
15 Itokawa H, Nakajima H, Ikuta A, Iitaka Y. (1981) Two teiterpenes from the flowers of Camellia japonica. Phytochemistry. 20: 2539   DOI   ScienceOn
16 Brownlee M. (2005) The Pathobiology of diabetic complications: A unifying mechanism. Diabetes 54: 1615-1625   DOI   ScienceOn
17 Yang S, Litchfield JE, Baynes JW. (2003) AGE-breakers cleave model compounds, but do not break Maillard crosslinks in skin and tail collagen from diabetic rats. Arch Biochem. Biophys. 412: 42-6   DOI   ScienceOn
18 Kim CS, Sohn EJ, Kim YS, Jung DH, Jang DS, Lee YM, Kim DH, Kim JS (2007) Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. J Ethnopharmacol. 111(2): 240-247   DOI   ScienceOn
19 Jang DS, Lee YM, Kim YS, and Kim JS (2006) Screening of Korean traditional herbal medicines with inhibitory activity on advanced glycation end products (AGEs) formation. Kor. J. Pharmacogn. 37: 48-52   과학기술학회마을
20 Kim YS, Lee YM, Kim C-S, Sohn EJ, Jang DS, and Kim JS (2006) Inhibitory effect of KIOM, a new herbal prescription, on AGEs formation and expression of type IV collagen and TGF-$\beta$1 in STZ-induced diabetic rats. Kor. J. Pharmacogn. 37: 103-109   과학기술학회마을
21 Rahbar, S. and Figarola, J.L. (2003) Novel inhibitors of advenced glycation endproducts. Arch. Biochem. Biophys. 419: 63-79   DOI   ScienceOn
22 Peppa M, Brem H, Cai W, Zhang JG, Basgen J, Li Z, Vlassara H, Uribarri J. (2006) Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). Am J Nephrol. 26: 430-6   DOI   ScienceOn
23 Jang DS, Lee GY, Kim J, Lee YM, Kim JM, Kim YS, Kim JS. (2008) A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta. Arch. Pharm. Res. 31: 666-670   과학기술학회마을   DOI
24 Ahmed N. (2005) Advanced glycation endproducts-role in pathology of diabetic complications. Diabetes Res. Clin. Pract. 67: 3-21   DOI   ScienceOn
25 Kim JM, Lee YM, Lee GY, Jang DS, Bae KH, Kim JS. (2006) Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs). Arch. Pharm. Res. 29: 821-825   과학기술학회마을   DOI
26 Wilkinson-Berka JL, Kelly DJ, Koerner SM, Jaworski K, Davis B, Thallas V, Cooper ME. (2002) ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. Diabetes 51: 3283-9   DOI