한국약용식물의 최종당화산물 생성저해활성 검색 (II)

Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (II)

  • 이윤미 (한국한의학연구원 한약제제연구부) ;
  • 김영숙 (한국한의학연구원 한약제제연구부) ;
  • 김종민 (한국한의학연구원 한약제제연구부) ;
  • 장대식 (한국한의학연구원 한약제제연구부) ;
  • 김주환 (대전대학교 생명과학부) ;
  • 유정림 (한국한의학연구원 한약제제연구부) ;
  • 김진숙 (한국한의학연구원 한약제제연구부)
  • Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Kim, Young-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Kim, Jong-Min (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Kim, Joo-Hwan (Department of Life Science, Daejeon University) ;
  • Yoo, Jeong-Lim (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine) ;
  • Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
  • 발행 : 2008.09.30

초록

Advanced glycation end products (AGEs) contribute to the progression of micro and macrovsacular complication of diabetes and therefore present a promising target for therapeutic agents. In this study, 40 Korean herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 21 herbal medicines $(IC_{50}<50{\mu}g/ml)$ exhibited an inhibitory activity against AGEs formation compared with anminoguanidine $(IC_{50}=72.12{\mu}g/ml)$. Particularly, 7 herbal medicines, Actinidia arguta (root and stem), Crataegus pinnatifida (twig), Camellia japonica (whole), Kalopanax pictus (bark), Lagerstroemia indica (leaf-stem), Reynoutria sachalinensis (root) showed more potent inhibitory activity (approximately 3-10 fold) than the positive control aminoguanidine.

키워드

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