• 제목/요약/키워드: optimality theory

검색결과 89건 처리시간 0.027초

Optimal Scheduling of Drug Treatment for HIV Infection: Continuous Dose Control and Receding Horizon Control

  • Hyungbo Shim;Han, Seung-Ju;Chung, Chung-Choo;Nam, Sang-Won;Seo, Jin-Heon
    • International Journal of Control, Automation, and Systems
    • /
    • 제1권3호
    • /
    • pp.282-288
    • /
    • 2003
  • It is known that HIV (Human Immunodeficiency Virus) infection, which causes AIDS after some latent period, is a dynamic process that can be modeled mathematically. Effects of available anti-viral drugs, which prevent HIV from infecting healthy cells, can also be included in the model. In this paper we illustrate control theory can be applied to a model of HIV infection. In particular, the drug dose is regarded as control input and the goal is to excite an immune response so that the symptom of infected patient should not be developed into AIDS. Finite horizon optimal control is employed to obtain the optimal schedule of drug dose since the model is highly nonlinear and we want maximum performance for enhancing the immune response. From the simulation studies, we found that gradual reduction of drug dose is important for the optimality. We also demonstrate the obtained open-loop optimal control is vulnerable to parameter variation of the model and measurement noise. To overcome this difficulty, we finally present nonlinear receding horizon control to incorporate feedback in the drug treatment.

Optimal Scheduling of Drug Treatment for HIV Infection;Continuous Dose Control and Receding Horizon Control

  • Shim, H.;Han, S.J.;Jeong, I.S.;Huh, Y.H.;Chung, C.C.;Nam, S.W.;Seo, J.H.
    • 제어로봇시스템학회:학술대회논문집
    • /
    • 제어로봇시스템학회 2003년도 ICCAS
    • /
    • pp.1951-1956
    • /
    • 2003
  • It is known that HIV (Human Immunodeficiency Virus) infection, which causes AIDS after some latent period, is a dynamic process that can be modeled mathematically. Effects of available anti-viral drugs, which prevent HIV from infecting healthy cells, can also be included in the model. In this paper we illustrate control theory can be applied to a model of HIV infection. In particular, the drug dose is regarded as control input and the goal is to excite an immune response so that the symptom of infected patient should not be developed into AIDS. Finite horizon optimal control is employed to obtain the optimal schedule of drug dose since the model is highly nonlinear and we want maximum performance for enhancing the immune response. From the simulation studies, we find that gradual reduction of drug dose is important for the optimality. We also demonstrate the obtained open-loop optimal control is vulnerable to parameter variation of the model and measurement noise. To overcome this difficulty, we finally present nonlinear receding horizon control to incorporate feedback in the drug treatment.

  • PDF

영어의 모음체계 연구 (A study of English vowel system)

  • 이재영
    • 대한음성학회지:말소리
    • /
    • 제38호
    • /
    • pp.71-97
    • /
    • 1999
  • In this paper I have surveyed vowel phonemes in a variety of English accents and have proposed the vowel systems of English. The English accents covered in this paper include General American English, Northeastern American English, Western American English, Southern British English, Northern British English, Scottish English, Southern Irish English, Northern Irish English, Australian English, and New Zealand English. The vowel systems proposed here reflect the acoustic information of vowels and phonological aspects of English. This paper offers an Optimality Theory-based analysis of the English vowel systems by appealing to independently motivated constraints. This paper, following Flemming(1995), makes an assumption that the vowel system in question is selected in output as an optimal candidate by a given constraint ranking, the assumption which is different from the view that the vowel system is fixed in input. The analysis proposed here gives an answer to why a specific vowel system is selected and why dialectal variations come about. It is shown in this paper that the vowel system selected in a specific dialect comes from an optimal satisfaction of a given constraint ranking and that dialectal differences result from dynamic permutations of the same constraints. The constraint-based analysis proffered here accounts well for the similarities and differences among dialects in regard to the vowel system.

  • PDF

MNO와 MVNO 사이의 무선 채널 공유를 위한 게임이론적 모델 (Game Theoretic Model for Radio Channel Sharing between MNO and MVNO)

  • 박재성;김범준
    • 한국정보과학회논문지:정보통신
    • /
    • 제37권4호
    • /
    • pp.312-316
    • /
    • 2010
  • 본 논문에서는 기지국 채널 자원을 MNO(Mobile Network Operator)와 MVNO(Mobile Virtual Network Operator)가 공유할 경우 사업자들에게 채널 자원을 공정하고 효율적으로 할당하기 위한 게임 이론적 모델을 제안한다. 제안 모델은 협상(Bargaining) 게임 이론을 이용하며 MNO와 MVNO의 입력 부하를 고려하여 이들 사이의 기지국 채널 자원을 할당한다. 제안 기법은 사업자별 입력 부하가 비대칭적인 경우 입력 부하가 낮은 사업자보다 입력 부하가 높은 사업자에게 보다 많은 양의 채널을 할당하여 기지국의 채널 이용율을 증가시키며 또한 한 사업자의 과도한 입력 부하로 인해 타 사업자의 서비스 품질이 저하되는 것을 방지한다.

처리(處理)들과 대조(對照)와의 비교(比較)를 위한 부분(部分)BTIB실험계획모형(實驗計劃模型) (Partially BTIB Designs for Comparing Treatments with a Control)

  • 김광훈
    • Journal of the Korean Data and Information Science Society
    • /
    • 제1권
    • /
    • pp.7-33
    • /
    • 1990
  • Bechhofer and Tamhane(1981) developed a theory of optimal incomplete block designs for comparing several treatments with a control. This class of designs is appropriate for comparing simultaneously $p{\geq}2$ test treatments with a control treatment (the so-called multiple comparisons with a control (MCC) problem) when the observations are taken in incomplete blocks of common size $K{\<}p+1$. In this paper we want to extend to partially BTIB designs with two associate classes for the MCC problem. We propose a new class of incomplete block designs that are partially balanced with respect to test treatments. Because the class of designs that we consider is larger than the class of designs in Bechhofer and Tamhane and provides us with designs that improve on the optimal designs in their class. We shall use the abbreviation PBTIB to refer to such designs. We study their structure and give some methods of construction. Also we describe a procedure for making exact joint confidence statements for the MCC problem in PBTIB Designs with two associate classes. We study Optimality, Admissibility considerations in PBTIB designs with two associate classes.

  • PDF

모음 약화 현상의 세분화 (Vowel Reduction in Russian)

  • 이성민
    • 비교문화연구
    • /
    • 제30권
    • /
    • pp.97-124
    • /
    • 2013
  • For a long period, vowel reduction has been accepted as one of the most common pronunciation rules in Russian phonology. However, since the rules have been modified in many ways after the influx of loanwords, [a, e, i, o, u, ${\star}$]-including [e, o]-can now be pronounced in unstressed position, obeying the rule of vowel reduction. Especially in Modern Russian, along with the destruction of the consonant pronunciation norm due to some relatively complex changes it underwent palatalization, consonant pronunciation has been simplified, and as a response to such a phenomenon, the specialization of vowel pronunciation rule is now occurring. In other words, in the interrelation between consonants and vowels, as the pronunciation rules for consonants are simplified and thus the contrast between consonants is weakened, the degree of dependence on pronunciation of segment in the vowel pronunciation rule has been elevated. Therefore, the analysis says that the degree of vowel reduction depends on a vowel's distance from a stressed syllable is not enough; the influence of surrounding phonemes-including consonants-or the formative characteristics of words themselves should also be considered. The introduction of Max-noncorner/UnderLex, a/an Licence constraint that is related to non-declension nouns, and that of IdentC[back] and ShareCV[back], which are faithfulness constraint and share constraint respectively that are related to the nature of consonants stresses that vowel pronunciation rules should not be simply viewed as rules for vowels; The rules should be analyzed with emphasis on their correlation with surrounding phonemes.

POLLUTION DETECTION FOR THE SINGULAR LINEAR PARABOLIC EQUATION

  • IQBAL M. BATIHA;IMAD REZZOUG;TAKI-EDDINE OUSSAEIF;ADEL OUANNAS;IQBAL H. JEBRIL
    • Journal of applied mathematics & informatics
    • /
    • 제41권3호
    • /
    • pp.647-656
    • /
    • 2023
  • In this work, we are concerned by the problem of identification of noisy terms which arise in singular problem as for remote sensing problems, and which are modeled by a linear singular parabolic equation. For the reason of missing some data that could be arisen when using the traditional sentinel method, the later will be changed by a new sentinel method for attaining the same purpose. Such new method is a particular least square-like method which permits one to distinguish between the missing terms and the pollution terms. In particular, a sentinel method will be given here in its more realistic setting for singular parabolic problems, where in this case, the observation and the control have their support in different open sets. The problem of finding a new sentinel is equivalent to finding singular optimality system of the least square control for the parabolic equation that we solve.

한국어 화자의 영어 어말 폐쇄음 파열의 인지와 발음 연구 (Korean speakers' perception and production of English word-final voiceless stop release)

  • 이보림;이숙향;박천배;강석근
    • 대한음성학회지:말소리
    • /
    • 제38호
    • /
    • pp.41-70
    • /
    • 1999
  • Researches on perception have, in recent years, been increasingly popular as a means of accounting for cross-linguistic sound patterns (Ohala, 1992; Hemming, 1995; Jun, 1995; Steriade, 1997 among others). In loanword phonology, Silverman(1990, 1992) argues that words from a source language are scanned through the perceptual level and that the features perceived by a speaker are stored in the input to be processed according to his/her native language's phonological constraints. The purpose of this paper is to test the validity of Silverman's proposal by examining the correlation between perception and production of Korean learners of English. We specifically focussed on perception and production of stop release by contrasting English loanwords with English words loarned through education to see if there were any significant differences. The results showed that there was no substantive correlation between the Korean speakers' perception of the loanwords pronounced by English speakers and their own production of those words. In the case of English words, however, the Korean speakers' production was closely related with their perception, although some inter-speaker variations were observed. With Optimality Theory (Prince & Smolenksy, 1993) as a theoretical framework of analysis, it was shown that the theory is a useful means of implementing a phonetics-phonology interface and relating perceptual processes with speech production. Specifically, under the assumption that loanwords with [t]~[t/sup h/] alternation (e.g.,'cut') are originally borrowed into Korean as two different input forms, all the alternations could be straightforwardly accounted for in terms of a unified ranking of constraints.

  • PDF

비대칭 층을 가지는 인공재료모델을 이용한 일반 평판구조물의 위상최적화 (Topology Optimization of General Plate Structures by Using Unsymmetric Layered Artificial Material Model)

  • 박경임;이상진
    • 한국공간구조학회논문집
    • /
    • 제7권5호
    • /
    • pp.67-74
    • /
    • 2007
  • 본 연구에서는 판 구조물의 최적위상을 찾기 위한 비대칭 층을 가지는 인공재료모델을 이용한 위상최적화기법을 제시하였다. 구절점 판요소를 형성하기 위하여 판의 일차전단변형을 고려하는 Reissner-Mindlin 판이론이 도입되었다. 최소화하고자 하는 변형에너지를 목적함수로 하고 구조물의 초기부피를 제약함수로 채택하였다 인공재료모델에 존재하는 다공성물질의 구멍의 크기를 조절하기 위하여 최적정기준법을 바탕으로 하는 크기조절알고리듬을 도입하였다. 제시된 위상최적화 기법의 성능을 조사하기 위하여 수치예제를 수행하였다. 수치해석결과로부터 제시된 위상최적화기법은 판구조물의 최적위상을 도출하는데 매우 효과적인 것으로 나타났다. 특히 제시된 비대칭 층모델은 판구조물의 보강재를 보다 실제적으로 도출하는데 유용할 것으로 나타났다.

  • PDF