• Title/Summary/Keyword: on-off control

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Plasmodium vivax Drug Resistance Genes; Pvmdr1 and Pvcrt-o Polymorphisms in Relation to Chloroquine Sensitivity from a Malaria Endemic Area of Thailand

  • Rungsihirunrat, Kanchana;Muhamad, Poonuch;Chaijaroenkul, Wanna;Kuesap, Jiraporn;Na-Bangchang, Kesara
    • Parasites, Hosts and Diseases
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    • v.53 no.1
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    • pp.43-49
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    • 2015
  • The aim of the study was to explore the possible molecular markers of chloroquine resistance in Plasmodium vivax isolates in Thailand. A total of 30 P. vivax isolates were collected from a malaria endemic area along the Thai-Myanmar border in Mae Sot district of Thailand. Dried blood spot samples were collected for analysis of Pvmdr1 and Pvcrt-o polymorphisms. Blood samples ($100{\mu}l$) were collected by finger-prick for in vitro chloroquine susceptibility testing by schizont maturation inhibition assay. Based on the cut-off $IC_{50}$ of 100 nM, 19 (63.3%) isolates were classified as chloroquine resistant P. vivax isolates. Seven non-synonymous mutations and 2 synonymous were identified in Pvmdr1 gene. Y976F and F1076L mutations were detected in 7 (23.3%) and 16 isolates (53.3%), respectively. Analysis of Pvcrt-o gene revealed that all isolates were wild-type. Our results suggest that chloroquine resistance gene is now spreading in this area. Monitoring of chloroquine resistant molecular markers provide a useful tool for future control of P. vivax malaria.

Applicability Study on Reticulitermes speratus kyushuensis (Isoptera: Rhinotermitidae) Colony Eliminator to Preserve Wooden Cultural Heritage (일본흰개미 아종 모니터링 및 군체제거를 위한 예찰제어기 개발 연구)

  • Chung, Yong Jae;Kim, Si Hyun;Kim, Youn Ju;Yu, Jae Seung
    • Journal of the Korean Wood Science and Technology
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    • v.43 no.6
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    • pp.818-825
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    • 2015
  • This study is conducted to develop new termite colony elimination system that can control termite colony much faster, and to eco-environmentally prevent termite damage occurred in wooden cultural heritage. As a result of laboratory test, we developed a component system, of which fipronil 0.001% (w/w) treated bait was used as a suitable termite colony eliminator. This system can be monitored without taking off underground, and it makes regular monitoring much more efficient. The result of field test showed that 36 termite baiting devices among 367 installed devices were damaged by foraging termites. After baiting, all of termite colonies attracted to devices were eliminated or their activity clearly decreased.

The development of a mobile u-Health program and evaluation for self-diet management for diabetic patients

  • Ahn, Yun;Bae, Jeahurn;Kim, Hee-Seon
    • Nutrition Research and Practice
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    • v.10 no.3
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    • pp.342-351
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    • 2016
  • BACKGROUND/OBJECTIVES: This study aims to develop a mobile nutritional management program for integration into the already developed web-based program, Diabetes Mellitus Dietary Management Guide (DMDMG) for diabetic patients. Further, we aim to evaluate the amended DMDMG program. SUBJECTS/METHODS: The mobile application based on an Android operating system includes three parts: 1) record of diet intake, which allows users to take pictures of the meal and save to later add diet records into DMDMG; 2) an alarm system that rings at each meal time, which reminds users to input the data; 3) displays the diet record and the results of nutrient intake, which can be also viewed through the web program. All three parts are linked to the web-based program. A survey was conducted to evaluate the program in terms of nutrition knowledge, dietary attitude, eating behavior and diet intake by non-equivalent control group design among diabetic patients with 14 DMDMG users and 12 non-user controls after a one-month trial of DMDMG. RESULTS: Non-users did not use the program, but participated in the weekly off-line nutrition classes for one month. The program users showed increased healthful dietary behavior (P < 0.01) and dietary attitude scores (P < 0.05). More DMDMG users had higher nutrition knowledge scores after one-month trial than non-users. However, dietary intake significantly increased in non-user group for calcium and sodium (P < 0.05) while the user group did not show significant changes. CONCLUSIONS: The program has created positive changes in patients' dietary life. All the users were satisfied with the program, although some expressed minor difficulties with an unfamiliar mobile app.

Analysis of Nonlinearity of RF Amplifier and Back-Off Operations on the Multichannel Wireless Transmission Systems. (다 채널 무선 전송 시스템의 RF증폭기의 비선형 및 백-오프 동작 분석)

  • 신동환;정인기;이영철
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.8 no.1
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    • pp.18-27
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    • 2004
  • In this paper, we presents an analytical simulation procedure for evaluation in baseband digital modulated signals distortions in the present of RF power amplifier(SSPA) nonlinear behavior and backoff operations of OFDM wireless transmission system. we obtained the optimum nonlinear transfer function of designed SSPA with the SiGe HBT bias currents of OFDM multi-channel wireless transmission system and compared this transfer function to SSPA nonlinear modeling functions mathematically, we finds optimum bias conditions of designed SSPA. With the derived nonlinear modeling function of SSPA, We analysed the PSD characteristics of in-band and out-band output powers of SSPA EVM measurement results of distorted constellation signals with the input power levels of SSPA. The results of paper can be applied to find the SSPA linearly with optimum bias currents and determine the SSPA input backoff bias for AGC control circuits of SSPA.

Adaptive Rate-Distortion Optimized Multiple Loop Filtering Algorithm (적응적 율-왜곡 최적 다중 루프 필터 기법)

  • Hong, Soon-Gi;Choe, Yoon-Sik;Kim, Yong-Goo
    • Journal of Broadcast Engineering
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    • v.15 no.5
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    • pp.617-630
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    • 2010
  • At 37th VCEG meeting in Jan. 2009, Toshiba proposed Quadtree-based Adaptive Loop Filter (QALF). The basic concept of QALF is to apply Wiener filter to decoded image after the conventional deblocking filter and to represent the filter on/off flag data for each basic filtering unit in a more efficient way of quadtree structure. QALF could enhance the compression performance of around more than 9%, but the structure of one filter for a decoded frame leaves room for further improvement in the sense that optimal filter for one region of a frame could quite different from the optimal filter for other parts of a picture. This paper proposes multiple adaptive loop filters for better utilization of local characteristics of decoded frame to optimize the region-based Wiener filters. Additional filters, proposed in this paper, cover separate spatial area of each decoded frame according to the performance of previously designed filter(s) to provide the flexibility of rate-distortion based selection of the number of filters.

Improvement of Naval Combat System UPS under Abnormal Transients (비정상 과도상태에서의 해군 전투체계 UPS 개선)

  • Kim, Sung-Who;Choi, Han-Go
    • Journal of the Institute of Convergence Signal Processing
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    • v.19 no.3
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    • pp.97-103
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    • 2018
  • This paper addresses an improved naval combat UPS(Uninterruptable Power Supply) system under abnormal transients. Previously, thermistor and varistor elements were used to cope with transient overvoltage and overcurrent, however the UPS was frequently unavailable because it was vulnerable to abnormal transient voltage generated during system operation. In order to overcome this problem and protect UPS system, this paper proposes an input power cut-off circuit that detects the initial input power and abnormal transient voltage generated during operation, improvement of power control sequence, and a method to prevent malfunction of an inverter and CPU. The UPS system implementing the proposed method was simulated by input power variable test using programmable AC/DC generator, and finally validated its reliability and stability through field tests by mounting on multifunctional console of naval combat system.

One-Step Simultaneous Immunochromatographic Strip Test for Multianalysis of Ochratoxin A and Zearalenone

  • Shim, Won-Bo;Dzantiev, Boris B.;Eremin, Sergei A.;Chung, Duck-Hwa
    • Journal of Microbiology and Biotechnology
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    • v.19 no.1
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    • pp.83-92
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    • 2009
  • Individual immunochromatographic assays (ICG) for ochratoxin A (OTA) and zearalenone (ZEA) were optimized and used in the development of a one-step simultaneous immunochromatographic assay (OS-ICG) for the rapid multianalysis of two mycotoxins in corn samples. The nitrocellulose membrane of the OS-ICG was treated with OTA-bovine serum albumin (BSA), ZEA-ovalbumin (OVA), and anti-mouse IgG in the OTA test, ZEA test, and control zones, respectively. Monoclonal antibody-gold conjugates (OTA3 MAb-gold and ZEA2C5 MAb-gold) were sprayed onto the conjugate pad. The visual detection limits were 2.5 and 5 ng/ml for OTA and ZEA, respectively, and the results were obtained within 15 min after starting the analysis. An efficient, simple, and rapid extraction method using 30% MeOH/PBS was established and validated by analyzing the corn samples spiked with OTA/ZEA mixtures (0/0, 5/10, 10/20, and $20/30\;{\mu}g/kg$). The cut-off values of the OS-ICG for the spiked corn were 5 and $10\;{\mu}g/kg$ for OTA and ZEA, respectively. Natural corn samples were analyzed by OS-ICG, direct competitive enzyme-linked immunosorbent assay (DC-ELISA), and HPLC. Results of the OS-ICG were in good agreement with those obtained by DC-ELISA and HPLC. The developed OS-ICG offers a rapid, easy-to-use, and portable analytical system and can be used as a convenient qualitative tool for the on-site simultaneous determination of OTA and ZEA in cereals, food, and agricultural products in one analytical cycle.

ELECTRICAL GROUND SUPPORT EQUIPMENT (EGSE) DESIGN FOR SMALL SATELLITE

  • Park, Jong-Oh;Choi, Jong-Yoen;Lim, Seong-Bin;Kwon, Jae-Wook;Youn, Young-Su;Chun, Yong-Sik;Lee, Sang-Seol
    • Journal of Astronomy and Space Sciences
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    • v.19 no.3
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    • pp.215-224
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    • 2002
  • This paper describes EGSE design for the small satellite such like KOMPSAT-2 satellite. Recent design trend of small satellite and EGSE is to take short development time and less cost. For this purpose, the design for KOMPSAT-2 satellite and EGSE are not much modified from KOMPSAT-1 heritage. It means that it is able to be accommodated the verified hardware and software modules used in KOMPSAT-1 satellite program if possible. The objective of EGSE is to provide hardware and software for efficient electrical testing of integrated KOMPSAT-2 satellite in three general categories. (1) Simulators for ground testing (e.g. solar-simulation power, earth scenes, horizons and sun sensor). (2) Ground station type satellite data acquisition and processing test sets. (3) Overall control of satellite using hardline datum. In KOMPSAT (KOrea Multi-Purpose SATellite) program, KOMPSAT-2 EGSE was developed to support satellite integration and test activities. The KOMPSAT-2 EGSE was designed in parallel with satellite design. Consequently, the KOMPSAT-2 EGSE was based on the KOMPSAT-1 heritage since the spacecraft design followed the heritage. The KOMPSAT-2 baseline was elaborated by taking advantage of experience from KOMPSAT-1 program. The EGSE of KOMPSAT-2 design concept is generic modular design with preference in part selection with commercial off-the-shelf which were proven from KOMPSAT-1 programs, flexible/user friendly operational environment (graphical interface preferred), minimized new design and self test capability.

The Effect of Repetitive Magnetic Stimulation in an SCI Rat Model with Stem Cell Transplantation (줄기세포를 이식한 척수손상 흰쥐에서 반복자기자극의 효과)

  • Bae, Young-Kyung;Park, Hea-Woon;Cho, Yun-Woo;Kim, Su-Jeong;Lee, Joon-Ha;Kwon, Jung-Gu;Ahn, Sang-Ho
    • The Journal of Korean Physical Therapy
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    • v.22 no.1
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    • pp.67-73
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    • 2010
  • Purpose: We tested whether repetitive transcranial magnetic stimulation (rTMS) improved recovery following spinal cord injury (SCI) in rats with transplantation of adipose tissue-derived stromal cells (ATSCs). Methods: Twenty Sprague-Dawley rats (200-250 g, female) were used. Moderate spinal cord injury was induced at the T9 level by a New York University (NYU) impactor. The rat ATSCs (approximately $5{\times}10^5$ cells) were injected into the perilesional area at 9 days after SCI. Starting four days after transplantation, rTMS (25 Hz, 0.1 Tesla, pulse width=$370{\mu}s$, on/off time=3 sec/3 sec) was applied daily for 7 weeks. Functional recovery was assessed using the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale as well as pain responses for thermal and cold stimuli. Results: Both groups showed similar, gradual improvement of locomotor function. rTMS stimulation decreased thermal and cold hyperalgesia after 7 weeks, but sham stimulation did not. Conclusion: rTMS after transplantation of ATSCs in an SCI model may reduce thermal hyperalgesia and cold allodynia, and may be an adjuvant therapeutic tool for pain control after stem cell therapy in SCI.

Optimization of Thermal-alkaline Pre-treatment for Anaerobic Digestion of Flotation Scum in Food Waste Leachate Using Box-Behnken Design and Response Surface Methodology (Box-Behnken 및 반응표면 분석법을 이용한 음식물류 폐수 부상 스컴의 혐기성 소화를 위한 열-알칼리 전처리 최적화)

  • Lee, Dong-Young;Choi, Jae-Min;Kim, Jung-Kwang;Han, Sun-Kee;Lee, Chae-Young
    • Journal of Korean Society of Water and Wastewater
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    • v.29 no.2
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    • pp.183-192
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    • 2015
  • Response surface methodology (RSM) based on a Box-Behnken Design (BBD) was applied to optimize the thermal-alkaline pre-treatment operating conditions for anaerobic digestion of flotation scum in food waste leachate. Three independent variables such as thermal temperature, NaOH concentration and reaction time were evaluated. The maximum methane production of 369.2 mL $CH_4/g$ VS was estimated under the optimum conditions at $62.0^{\circ}C$, 10.1% NaOH and 35.4 min reaction time. A confirmation test of the predicted optimum conditions verified the validity of the BBD with RSM. The analysis of variance indicated that methane production was more sensitive to both NaOH concentration and thermal temperature than reaction time. Thermal-alkaline pretreatment enhanced the improvement of 40% in methane production compared to the control experiment due to the effective hydrolysis and/or solubilization of organic matters. The fractions with molecular weight cut-off of scum in food waste leachate were conducted before and after pre-treatment to estimate the behaviors of organic matters. The experiment results found that thermal-alkaline pre-treatment could reduce the organic matters more than 10kD with increase the organic matters less than 1kD.