• Nutrition Research and Practice
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• 제8권3호
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• pp.257-266
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• 2014

BACKGROUND/OBJECTIVE: Licorice has been shown to possess cancer chemopreventive effects. However, glycyrrhizin, a major component in licorice, was found to interfere with steroid metabolism and cause edema and hypertension. The roasting process of licorice modifies the chemical composition and converts glycyrrhizin to glycyrrhetinic acid. The purpose of this study was to examine the anti-carcinogenic effects of the ethanol extract of roasted licorice (EERL) and to identify the active compound in EERL. MATERIALS/METHODS: Ethanol and aqueous extracts of roasted and un-roasted licorice were prepared. The active fraction was separated from the methylene chloride (MC)-soluble fraction of EERL and the structure of the purified compound was determined by nuclear magnetic resonance spectroscopy. The anti-carcinogenic effects of licorice extracts and licochalcone A was evaluated using a MTT assay, Western blot, flow cytometry, and two-stage skin carcinogenesis model. RESULTS: EERL was determined to be more potent and efficacious than the ethanol extract of un-roasted licorice in inhibiting the growth of DU145 and MLL prostate cancer cells, as well as HT-29 colon cancer cells. The aqueous extracts of un-roasted and roasted licorice showed minimal effects on cell growth. EERL potently inhibited growth of MCF-7 and MDA-MB-231 breast, B16-F10 melanoma, and A375 and A2058 skin cancer cells, whereas EERL slightly stimulated the growth of normal IEC-6 intestinal epithelial cells and CCD118SK fibroblasts. The MC-soluble fraction was more efficacious than EERL in inhibiting DU145 cell growth. Licochalcone A was isolated from the MC fraction and identified as the active compound of EERL. Both EERL and licochalcone A induced apoptosis of DU145 cells. EERL potently inhibited chemically-induced skin papilloma formation in mice. CONCLUSIONS: Non-polar compounds in EERL exert potent anti-carcinogenic effects, and that roasted rather than un-roasted licorice should be favored as a cancer preventive agent, whether being used as an additive to food or medicine preparations.

• Journal of Korean Neurosurgical Society
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• 제60권6호
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• pp.635-643
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• 2017

Objective : Acute basilar artery occlusion (BAO) is associated with severe neurological dysfunction and high mortality rates. The benefits of mechanical thrombectomy in BAO have not been explored in recent clinical trials. Therefore, we analyzed outcomes of stent retriever mechanical thrombectomy for BAO, and compared with anterior circulation occlusions (ACO). Methods : In total, 161 consecutive patients (24 BAO, 137 ACO) who underwent mechanical thrombectomy with the stent retriever between January 2013 and August 2016 enrolled in our study. All patients underwent clinical assessment with the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin scale (mRS). Radiological results were used to evaluate thrombolysis in cerebral infarction (TICI) scores and successful recanalization was defined by TICI 2b or 3. Results : Mean NIHSS scores at 24 hours and 30 days were significantly higher in the BAO group than the ACO group (p=0.021, p=0.001). mRS at 90 days was significantly higher in the BAO group (4.2) compared with the ACO group (3.0) (p=0.003). The BAO group (2.0) performed fewer stent retriever passages than the ACO group (2.7) (p=0.049). There were no significant differences between the two groups in terms of complications, but the BAO patients experienced a higher mortality (16.6%) rate than ACO patients (5.8%) (p=0.001). In subgroup analysis of BAO, patients with short procedure times achieved successful recanalization (p=0.001) and successfully recanalized patients exhibited more favorable mRS at 90 days (p=0.027). Conclusion : In our study, mechanical thrombectomy of BAO patients showed worse clinical outcome and higher mortality rate than ACO patients. However, mechanical thrombectomy with a stent retriever in BAO is an effective treatment, because successfully recanalized patients showed good clinical outcome in BAO patients.

• 한국산학기술학회논문지
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• 제17권12호
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• pp.532-541
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• 2016

서울시 도로는 교통하중, 도로포장 노후화 및 잦은 굴착복구 등의 열악한 도로조건으로 인하여 도로포장 수명이 기대수명에 미치지 못하여 효율적 도로포장관리(Pavement Management System, PMS)와 적절한 유지보수 시기가 요구된다. 본 연구에서는 도로의 표면상태조사와 FWD(Falling Weight Deflectometer)기반 조사를 통하여 장기 공용성 구간의 보수우선 순위를 선정하고 각 지수에 따른 우선순위의 상관도를 분석하여 명확한 포장상태 평가와 타당한 공법 및 시기의 선정에 도움이 되고자 한다. 이를 위해 서울특별시의 장기 공용성 구간(Long Term Performance Pavement, LTPP)을 활용하여 표면상태조사를 통해 균열, 소성변형, 종단평단성을 측정하였고 서울포장평가지수인 SPI(Seoul Pavement Index)로 포장상태를 나타내었다. 또한 동일 구간에 대해 FWD시험을 통한 처짐량과 코어채취에 의한 포장두께 자료를 이용하여 포장층의 탄성계수를 역산하고 허용 교통량을 산정하여 실제 교통량과 허용 교통량을 비교 후 잔존수명을 추정하였다. 이를 통하여 도출된 포장상태 지수와 포장지지력에 따른 잔존수명을 비교분석하였다. 결과적으로 표면상태지수인 Crack, Rutting, IRI(International Roughness Index) 값들의 보수 우선순위와 지지력에 의한 보수 우선순위를 분석하여 보수 우선순위에 따른 포장상태지수와 포장지지력의 상관성을 검토하였다. 그 결과, 균열과 소성변형에 대하여 R-square 값이 0.65이상으로 상관도가 높은 반면, 종단평탄성과 그 값을 포함한 SPI와의 상관도는 비교적 낮은 수준을 나타내었다.

• 농촌계획
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• 제21권2호
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• pp.63-77
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• 2015

Improve the rural views of the Government and the municipalities with the intention of rural landscape planning. However, rural scenery evaluation of landscape types and element categories, landscape scenes, such as the valuation of resources selected, form a coherent system and ecological point of view is not only a Visual perspective of evaluation, or evaluation is made. This study evaluates the rural landscape through the rural landscape for rurality is implemented can explain the image. Rural amenity 100 represented the rural landscape in rurality with photos of photos, and scenes, photos, location-based rural Vista rurality landscapes drawn components. Selected landscape photography scenic landscapes in the u.s. survey and image vocabularies through surveys is representative of the landscape in rurality of each Vista location-specific photos and images began extracted factors. As a result, the Distant view is a town and village in the rolling hills of the surrounding environment is an image behind the Vista Skyline, Farmland Rural village forests, Behind the hills, Individual housing roof, Housing arrangement, The number of household includes landscape components. Factor analysis 'openness', 'intimacy', 'activity', 'complexity', 'safety' was down to five factors, such as a description of the overall factors that force was 66.45 percent. Middle distance view is close to being out of town houses and village environment, an image in the skyline hills Vista, farmlands, village forests, rolling hills, behind the scenes of the housing component of the neck, the sperm will honor an individual factor analysis results are 'intimacy', 'safety', 'openness', 'specificity', 'complexity' five factors the whole description of the capacity factors compared to 67.24 percent. Close-range view is mainly in Vista village embraced the individual elements and an image of a harmonious location in the surroundings of the sperm, individual houses, fences, gates, courtyard, Garden, garage, agricultural facilities, including, but not limited to, factors assay but an 'intimacy', 'complexity', 'safety', 'activity', 'openness' five factors, such as a description of the overall factors that force was 65.29%. This research seeks to determine the extent to which rurality of rural landscape Vista by location attributes and elements and representative officer in photo selection and rurality to extract the image. To date, followed by a comprehensive study, which was presented through the readjustment could not overlook the Visual elements. The future rural development officer for the evaluation of rural landscape classification and quantitative and objective assessment will have to come up with ways to do.

• 농촌계획
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• 제21권2호
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• pp.79-90
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• 2015

In empirical studies on rural development projects, differentiation tends to be considered a strategy aimed at increasing the number of visitors. Rural development projects include the improvement of living environment, and the discussion about project goals and evaluation of project results are often focused on the aspect of rural tourism. Thus, subjective benefits of such projects for residents are omitted. This study examines the meaning of differentiation from the perspective of residents and explores the validity of the number of visitors and the possibility of reflecting residents' subjective score as evaluation indicators for a project. To achieve such an objective, this study uses survey data collected from 153 people in 38 comprehensive development projects in areas of Eup and Myeon, Korea. The results of this study show that differentiation is viewed as a by-product of positive improvement from a rural development project, from the perspective of residents. The effects of rural development are classified into two dimensions: socioeconomic effects and living environmental effects. Landscape improvement is included in the dimension of living environmental effects and an increase in the number of visitors is included in the dimension of socioeconomic effects. As such, they are confirmed to be the factors that determine the level of differentiation. For example, the increase in the number of visitors is confirmed to be a valid indicator of project success, in which two-dimensional characters are reflected. The level of differentiation evaluated by residents is a result of the workings of the above two factors. Unlike in previous studies, the possibility of evaluation based on the perception of residents is confirmed in the evaluation of results. When the level of differentiation is interpreted as the direct result of a project, the number of visitors has an impact on socioeconomic effects, and the project content of landscape improvement has an impact on living environmental effects. The goal of policy and residents is the same in terms of the effort residents may make in maximizing results of a project by themselves; thus, the government's goal is achieved even when a project is carried out under the autonomy of residents. Ultimately, the government should focus on providing conditions in which active citizen participation can not only occur but help to establish a policy direction, which subsequently strengthens the substantial rights of residents.

• 사상체질의학회지
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• 제23권3호
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• pp.351-360
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• 2011

1. Objective: This study was designed to analyze the characteristics of each Sasang constitutional type using the Temperament and Character Inventory (TCI). 2. Methods: A total of 135 healthy subjects (age 19-30) participated in this study, consisting of 35 Soyang-type, 66 Taeeum-type, 30 Soeum-type, and 4 Taeyang-type subjects. A Sasang Constitutional Medicine specialist determined each subject's Sasang constitutional type based on the Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD) and comprehensive constitutional assessment. The subjects were also asked to complete the TCI. 3. Results: Among the four temperament dimensions, the Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Novelty Seeking (NS). The Soeum-type subjects showed significantly higher scores than the Taeum- and Soyang-type subjects in Harm Avoidance (HA) (Soeum type > Taeeum type > Soyang type). The Soyang-type subjects showed significantly higher scores than the Soeum-type subjects in Reward Dependence (RD). The Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Persistence (P). Among the three character dimensions, the Soyang-type subjects showed significantly higher score than the Taeeumand Soeum-type subjects in Self-Directedness (SD) (Soyang type > Taeeum type > Soeum type). The Soyang-type showed significantly higher scores than the Taeeum-type in Cooperativeness (C). 4. Conclusions: Differences in temperament and character were discovered across the Sasang constitutional types. The Sasang constitutional characteristics should be investigated in larger studies in the future. Similar studies could add to the growing knowledge of Sasang constitutional typology and contribute to a more accurate Sasang constitutional diagnosis.

• 한국수자원학회논문집
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• 제44권9호
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• pp.721-730
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• 2011

본 연구는 기상청에서 실시간으로 생산하고 있는 레이더-AWS 강우강도(RAR) 자료의 유출모의 적용성을 평가하고자 하는데 그 목적이 있다. 춘천댐 상류유역(4859.73 $km^2$)을 대상유역으로 선정하고 5개소유역에 대한시단위 AWS와 RAR 유역평균강우량을 산정하였다. 미계측 유역에서는 AWS와 RAR의 상관성이 낮고 계측유역에서는 높은 것으로 나타났다. 시단위 AWS와 RAR 유역평균 강우량은 강우분포형태에 따라차이가 크게 발생하는 것으로 나타났다. 두 자료의 유역평균 강우량을 이용하여 2006∼2009년의 홍수기간에 대해 모의유량을 평가하였다. 계측유역에 해당하는 춘천댐에서는 RAR 모의유량이 AWS 결과에 비해 정확도가 낮게 나타나나 미계측유역이 존재하는 화천댐과 평화의댐에서 AWS 모의유량이 과대추정되는 경우에 한해서 RAR 모의유량은 정확하게 모의하는 것으로 나타났다. 따라서 시단위 RAR 자료는 미계측 유역의 실시간 유량예측을 위한 강우자료로 활용이 가능할 것으로 판단된다.

• 한국수자원학회논문집
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• 제43권9호
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• pp.789-799
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• 2010

본 연구의 목적은 GCM으로부터 생산된 기후시나리오자료를 이용하여 미래 확률강우량을 산정하는 방법을 제안하고 미래기간의 확률강우량, 홍수량, 홍수위 산정을 통해 기후변화로 인한 홍수특성변화를 정량적으로 분석하는데 있다. 대상유역으로 남한강 상류유역을 선정하였으며, 기후시나리오자료는 13개 GCMs으로부터 IPCC SRES A2 기후시나리오 자료를 구축하였고 자료기간은 총 130년(1971~2100년)이다. 확률강우량은 4개 자료기간(S0: 1971~2000년; S1: 2011~2040년; S2: 2041~2070년; S3: 2071~2100년)으로 구분하여 강우지속기간 1440분의 100년 빈도 확률강우량을 산정하였다. 또한 17개 소유역에 대해 확률홍수량을 산정하고 충주댐 직하류부터 팔당댐 직상류까지의 주하도 구간에 대해 홍수위 분석을 수행하였다. 남한강유역은 과거기간의 확률강우량 142.1mm에 비해 13.0~15.1% 증가, 첨두홍수량은 $20,708.0\;m^3/s$에 비해 29.1~33.5% 증가, 홍수위는 구간평균 12.6~13.6% 증가하는 것을 확인하였다.

• 한국수자원학회논문집
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• 제47권10호
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• pp.891-906
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• 2014

본 연구는 수계관리 측면에서 물 공급의 기준이 되는 하류 제어지점에서 발생할 수 있는 물 부족을 최소 허용하면서 저수지군 최적 운영방안을 제공할 수 있도록 위험도 평가기준을 목적함수 및 제약조건에 반영한 hedging rule을 혼합정수계획법(MIP, Mixed Integer Programming)으로 구성하고 이에 대한 이행도를 분석함으로써 기존의 용수공급 신뢰도에 중점을 두었던 저수지군 최적 운영 분석기법을 개선하고자 하였다. 이를 위해 한강수계 5개 저수지(소양강댐, 충주댐, 화천댐, 청평댐, 팔당댐)군을 대상으로 수계관리를 위한 모형을 구축하였으며, 한강수계 내에 총 8개의 가상 제어지점을 구성하여 댐 하류 제어지점에서의 물 부족에 대해 위험도를 평가하였으며, 개발된 hedging rule의 적정성을 검증하기 위하여 2개의 유입량 계열('93. 1월~'97. 12월, '99. 1월~'03. 12월)에 대하여 적용 검토하였다. 팔당댐 하류 제어지점의 월별 최소유량을 비교하면 '93. 1월~'97. 12월의 모의기간에서는 hedging rule 적용 시 $317.5{\times}10^6m^3$으로 단독운영의 $310.6{\times}10^6m^3$, 연계운영의 $56.3{\times}10^6m^3$ 보다 많은 유량을 보였으며, '99. 1월~'03. 12월의모의기간에서도 hedging rule 적용시 $243.7{\times}10^6m^3$ 으로 단독운영의 $204.2{\times}10^6m^3$, 연계운영의 $111.2{\times}10^6m^3$에 비해 최소 유량이 많은 것을 확인하였으며, 이는 제안한 hedging rule에 의해 하류 제어지점에서의 최대 물 부족량이 감소하는 결과를 보여주고 있다.

• Journal of Korean Neurosurgical Society
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• 제50권4호
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• pp.332-340
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• 2011

Objective : Pyogenic spondylitis often results in acute neurological deterioration requiring adequate surgical intervention and appropriate antibiotic treatment. The purpose of this study was to conduct an analysis of the clinical effect of continuous irrigation via laminotomy in a series of patients with pyogenic spondylitis in thoracic and lumbar spine. Methods : The authors conducted a retrospective investigation of 31 consecutive patients with pyogenic thoracic and lumbar spondylitis who underwent continuous irrigation through laminotomy from 2004 to 2008. The study included 22 men and 9 women, ranging in age from 38 to 78 years (mean 58.1 years). The average follow-up duration was 13.4 months (range, 8-34 months). We performed debridement and abscess removal after simple laminotomy, and then washed out epidural and disc space using a continuous irrigation system. Broad spectrum antibiotics were administered empirically and changed according to the subsequent culture result. Clinical outcomes were based on the low back outcome scale (LBOS), visual analogue scale (VAS) score, and Frankel grade at the last follow-up. Radiological assessment involved plain radiographs, including functional views. Results : Common predisposing factors included local injection for pain therapy, diabetes mellitus, chronic renal failure, and liver cirrhosis. Causative microorganisms were identified in 22 cases (70.9%) : Staphylococcus aureus and Streptococcus spp. were the main organisms. After surgery, LBOS, VAS score, and Frankel grade showed significant improvement in most patients. Spinal stability was maintained during the follow-up period, making secondary reconstructive surgery unnecessary for all patients, except one. Conclusion : Simple laminotomy with continuous irrigation by insertion of a catheter into intervertebral disc space or epidural space was minimally invasive and effective in the treatment of pyogenic spondylitis. This procedure could be a beneficial treatment option in patients with thoracolumbar spondylitis combined with minimal or moderate destructive change of vertebrae.