• Archives of Pharmacal Research
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• v.28 no.5
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• pp.604-611
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• 2005

Polyethylene glycol (PEG) 6000-based solid dispersions (SDs), by incorporating various pharmaceutical excipients or microemulsion systems, were prepared using a fusion method, t o compare the dissolution rates and bioavailabilities in rats. The amorphous structure of the drug in SDs was also characterized by powder X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). The ketoconazole (KT), as an antifungal agent, was selected as a model drug. The dissolution rate of KT increased when solubilizing excipients were incorporated into the PEG-based SDs. When hydrophilic and lipophilic excipients were combined and incorporated into PEG-based SDs, a remarkable enhancement of the dissolution rate was observed. The PEG-based SDs, incorporating a self microemulsifying drug delivery system (SMEDDS) or microemulsion (ME), were also useful at improving the dissolution rate by forming a microemulsion or dispersible particles within the aqueous medium. However, due to the limited solubilization capacity, these PEG-based SDs showed dissolution rates, below 50% in this study, under sink conditions. The PEG-based SD, with no pharmaceutical excipients incorporated, increased the maximum plasma concentration (C$_{max}$) and area under the plasma concentration curve (AUC$_{0-6h}$) two-fold compared to the drug only. The bioavailability was more pronounced in the cases of solubilizing and microemulsifying PEG-based SDs. The thermograms of the PEG-based SDs showed the characteristic peak of the carrier matrix around 60$^{\circ}C$, without a drug peak, indicating that the drug had changed into an amorphous structure. The diffraction pattern of the pure drug showed the drug to be highly crystalline in nature, as indicated by numerous distinctive peaks. The lack of the numerous distinctive peaks of the drug in the PEG-based SDs demonstrated that a high concentration of the drug molecules was dissolved in the solid-state carrier matrix of the amorphous structure. The utilization of oils, fatty acid and surfactant, or their mixtures, in PEG-based SD could be a useful tool to enhance the dissolution and bioavailability of poorly water-soluble drugs by forming solubilizing and microemulsifying systems when exposed to gastrointestinal fluid.

• Magazine of the Korean Society of Agricultural Engineers
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• v.41 no.6
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• pp.54-63
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• 1999

Considering that rural village had evolved through a long-sustained effort of harmnization with nature, there should be the wisdom not only to reflect the level of rural resident's housing demand, but also to conserve the traditional characteristics of high-valuation in the modern rural housing. In Korea , standard design proposals of rural houses had been made public three times ; in 1972 , 1984 and 1995. so , firstly, this study analysed the inner-space layouts of design proposals mentioned above, from which changes and problems in the past housing design were derived. And also, through, the positive acceptance of residents' opinion living inthe houses built by standard design proposals in 1970 ~1980's, improved design principles and an alternative model were proposed , finally. The inner-space structed of standard design proposals in 1970s was originated from small-scaled and low-priced one, basically under the " open system". In 1980s, the basic design principle changed to the 'closed system' in which the living room being the focus of indoor family life, and , in 1990s, progressively, therural housing developed to the high qualified type by the spatial enlargement and with increased equipements. However, this structural change of rural house brought about the problem of functional separatioon between farming and daily living activities. In details, limited spaces of multipurpose spaces and sanitary facility would be mentioned as problems for improvement. conclusively in this study, newoly arranged "open system" was recommended , as a basic design principle for theinner space structure formation of rural house, which easily links the constituent inner-house spaces to outer one. Based on this principle, the detailed design criterial was proposed as follows ; 1. The living room be directly linked to the front-yard and centrally placed, the addtional space of which could be secured for the special family events by the flexibleuse of its adjacent room or by the housing of male quarters(separated from main building quarter). 2. The kitchen also be directly linked to side-yard and to livng room , for the convenience of farming activities and the shortening of path flow housewife. 3. The expanded toilet-and-bathroom be placed in the directly connected left-hand side to the living room and also be allowed access through multipurpose spaces to out door. 4. The multipurpose spaces be directly connected to the kitchen and the toilet and-bathroom , of which function would be for undressing of working clothes, quickwashing and ordinary working.nd ordinary working.

• Journal of Legislation Research
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• no.44
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• pp.655-688
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• 2013

Most of all the transfer of undertakings in such a service provision business as labour-intensive operation creates uncertainty of employment, aggravates terms of employment and breaks a trade union. However there are no regulations in Korea to protect employees from these undesirable situations. On the other hand Great Britain has introduced the concept of a transfer of undertakings by service provision change in 2006. It was intended to remove or at least alleviate the uncertainties and difficulties created by the need under TUPE 1981 and EU Directive to establish a transfer of a stable economic identity which retained its identity in the hands of the alleged transferee. In contrast to the words used to define transfer in the 1981 Regulations 'service provision change' is a wholly new statutory concept and distinguished from the economic entity. The new provisions seems to be straightforwards and the circumstances in which service provision change is established are clearly set out in Regulations. In this context there is no need for a judicially prescribed multi-factorial approach, as advanced by European Court of Justice like Spijkers test. The new concept of service provision change apply even though there are some minor difference or differences between the nature of the tasks carried on after service provision change as compared with before it. A commonsense and pragmatic approach is required and It is enough only to ask whether the activities carried on by the alleged transferee are fundamentally or essentially the same as those carried out by the alleged transfer. TUPE 2006 of Great Britain far exceeding the scope of the Acquired Rights Directive is full of suggestions as a model of legislation to secure a stable employment itself and favorable and fair conditions of employment. More active efforts are needed for lawmaking to prohibit a dismissal and vary conditions of employment for the reason of the transfer of undertakings itself.

• Journal of The Korean Society of Agricultural Engineers
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• v.61 no.4
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• pp.23-32
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• 2019

Increasing crop production with the same amount of resources is essential for enhancing the economy in agriculture. The first prerequisite is to understand relationships between the resources. The concept of WEF (Water-Energy-Food) nexus analysis was first introduced in 2011, which helps to interpret inter-linkages among the resources and stakeholders. The objective of this study was to analyze energy-water nexus in greenhouse cultivation by estimating reference evapotranspiration and heating load. For the estimation, this study used the physical model to simulate the inside temperature of the agricultural greenhouse using heating, solar radiation, ventilated and transferred heat losses as input variables. For estimating reference evapotranspiration and heating load, Penman-Monteith equation and seasonal heating load equation with HDH (Heating Degree-Hour) was applied. For calibration and validation of simulated inside temperature, used were hourly data observed from 2011 to 2012 in multi-span greenhouse. Results of the simulation were evaluated using $R^2$, MAE and RMSE, which showed 0.75, 2.22, 3.08 for calibration and 0.71, 2.39, 3.35 for validation respectively. When minimum setting temperature was $12^{\circ}C$ from 2013 to 2017, mean values of evapotranspiration and heating load were 687 mm/year and 2,147 GJ/year. For $18^{\circ}C$, Mean values of evapotranspiration and heating load were 707 mm/year and 5,616 GJ/year. From the estimation, the relationship between water and heat energy was estimated as 1.0~2.6 GJ/ton. Though additional calibrations with different types of greenhouses are necessary, the results of this study imply that they are applicable when evaluating resource relationship in the greenhouse cultivation complex.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.22 no.4
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• pp.81-86
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• 2022

In this work, we propose a method for automatically determining the domain of columns of file data structured by csv format. New data can be generated through convergence between data and data, and the consistency of the joined columns must be maintained in order for these new data to become an important resource. One of the methods for measuring data quality is a domain-based quality diagnosis method. Domain is the broadest indicator that defines the nature of each column, so a method of automatically determining it is necessary. Although previous studies mainly studied domain automatic discrimination of relational databases, this study developed a model that can automate domains using the characteristics of file data. In order to specialize in the domain discrimination of file data, the data were simplified and patterned using a regular expression, and the contents of the data header corresponding to the column name were analyzed, and the suffix used was used as a derived variable. When derivatives of regular expressions and suffixes were added, the result of automatically determining the domain with an accuracy of 95% greater than the existing method of 87% was derived. This study is expected to reduce the quality measurement period and number of people by presenting an automation methodology to the quality diagnosis of public data.

• Korean Journal of Social Welfare
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• v.35
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• pp.85-105
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• 1998

This article examined the trend of 125 empirical researches which were published in Jr. of Korean Social Welfare from the first issue to no. 33. in terms of theoretical and methodological orientations. The content analysis was employed for the purpose of the study. Since 1979, the number of empirical researches was in the trend of increasing. The findings from this research were as follows. 1) Among 166 authors, 96.4% were majored in social welfare. Also 6.0% were practitioners and the rest of them were in the position of professors or researchers. The outcome of lack of interdisciplinary co-work and researcher-practitioner co-work led the article to conclude that the nature of applied social science of social welfare was not so actively pursued in Korea. 2) It was almost impossible to find researches which studied same theme or employed same analytical framework. This meant that the work of re-verifying and proving the contray could not be done although it was essential for theory-building. In other words, the disciplinary of social welfare was far behind in the process of theory-building. 3) The methodology upon which most of researches were relied was quantitative methodology(92.8%). The article concluded 'paradigm shift' was not begun in the disciplinary of social welfare yet. 4) The study concluded that the particularity of empirical researches of social welfare in Korea was descriptive-configurative study. Whereas 65.5% of 125 empirical studies were descriptive-configurative, 25% were hypothesis - model test and only 6% causal analysis. 5) The most applied statistic models through the period from 1979 to 1997 were descriptive statistics such as frequency, chi square test, Pearson's r. More advanced statistics such as logit regression, probit regression, path analysis, covariance structure analysis were shown since 1990.

• Journal of Environmental Science International
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• v.25 no.10
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• pp.1349-1368
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• 2016

Concentrations of fine particulate matter ($PM_{2.5}$) and several of its particle constituents measured outside homes in Houston, Texas, and Los Angeles, California, were characterized using multiple regression analysis with proximity to point and mobile sources and meteorological factors as the independent variables. $PM_{2.5}$ mass and the concentrations of organic carbon (OC), elemental carbon (EC), benzo-[a]-pyrene (BaP), perylene (Per), benzo-[g,h,i]-perylene (BghiP), and coronene (Cor) were examined. Negative associations of wind speed with concentrations demonstrated the effect of dilution by high wind speed. Atmospheric stability increase was associated with concentration increase. Petrochemical source proximity was included in the EC model in Houston. Area source proximity was not selected for any of the $PM_{2.5}$ constituents' regression models. When the median values of the meteorological factors were used and the proximity to sources varied, the air concentrations calculated using the models for the eleven $PM_{2.5}$ constituents outside the homes closest to influential highways were 1.5-15.8 fold higher than those outside homes furthest from the highway emission sources. When the median distance to the sources was used in the models, the concentrations of the $PM_{2.5}$ constituents varied 2 to 82 fold, as the meteorological conditions varied over the observed range. We found different relationships between the two urban areas, illustrating the unique nature of urban sources and suggesting that localized sources need to be evaluated carefully to understand their potential contributions to $PM_{2.5}$ mass and its particle constituents concentrations near residences, which influence baseline indoor air concentrations and personal exposures. The results of this study could assist in the appropriate design of monitoring networks for community-level sampling and help improve the accuracy of exposure models linking emission sources with estimated pollutant concentrations at the residential level.

• Molecules and Cells
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• v.38 no.8
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• pp.685-696
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• 2015

Rice is a model plant widely used for basic and applied research programs. Plant cell wall proteins play key roles in a broad range of biological processes. However, presently, knowledge on the rice cell wall proteome is rudimentary in nature. In the present study, the tightly-bound cell wall proteome of rice callus cultured cells using sequential extraction protocols was developed using mass spectrometry and bioinformatics methods, leading to the identification of 1568 candidate proteins. Based on bioinformatics analyses, 389 classical rice cell wall proteins, possessing a signal peptide, and 334 putative non-classical cell wall proteins, lacking a signal peptide, were identified. By combining previously established rice cell wall protein databases with current data for the classical rice cell wall proteins, a comprehensive rice cell wall proteome, comprised of 496 proteins, was constructed. A comparative analysis of the rice and Arabidopsis cell wall proteomes revealed a high level of homology, suggesting a predominant conservation between monocot and eudicot cell wall proteins. This study importantly increased information on cell wall proteins, which serves for future functional analyses of these identified rice cell wall proteins.

• Journal of Korean Philosophical Society
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• v.105
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• pp.269-290
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• 2008

The purpose of this paper is to explore the possibility of backwards causation. For study, this paper was divided into four views as follows: The first view was sometimes suggested by the people such as M. Dummett who distinguished observers from behaviors. According to observers' view, backwards causation is impossible, whereas behaviors' view possible. However, in a real or genuine sense, it is incorrect for us to argue for impossibility of backwards causation from the observer aspect. The second view was supported by J. H. Schmidt. He analyzed the possibility of backwards causation in terms of macro and micro level analysis about the causal events. According to micro level analysis, backwards causation is possible, but macro level analysis impossible. Usually the latter makes the former something miraculous. Under the macro level analysis, backwards causation, at first, seems to be miraculous phenomena which belongs to the micro level analysis. The third view had to do with physical equation, and the fourth view physical phenomena, respectively. John Earman argued for the backwards causation by the transformation from Lorentz­-Dirac equation to a second-order integro-differential one in the field of electrodynamic acceleration. His argument was criticized because of his misunderstanding about the relationship between two equations. On the other hand, Phil Dowe defended a version of Reichenbach's own theory about the direction of causation founded on the fork asymmetrical causal relation. However his view was different from Reichenbach's because the former defended the backwards causation model of Bell phenomena in quantum mechanics. On the contrary, Reichenbach put stressed on the priority of cause in the causal process. Subjectivism has recently been defended by H. Price, under the label of perspectivism. According to him, in a certain sense causal asymmetry is not in the world, but is rather a product of our own asymmetric perspective on the world. He also suggested causal net, the symmetry of microphysics, and so on. As mentioned above, there are many kind of suggestions of backwards causation. However none of them replaced objectively the main streams of the direction of causal process. The main stream has been usually defended by pragmatical ground. That is, effects do not precede their causes although causes cannot be without their effects.

• Journal of Pharmaceutical Investigation
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• v.39 no.3
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• pp.185-199
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• 2009

Using a strain-controlled rheometer [Advanced Rheometric Expansion System (ARES)], the steady shear flow properties and the dynamic viscoelastic properties of $Antiphlamine-S^{(R)}$ lotion have been measured at $20^{\circ}C$ (storage temperature) and $37^{\circ}C$ (body temperature). In this article, the temperature dependence of the linear viscoelastic behavior was firstly reported from the experimental data obtained from a temperature-sweep test. The steady shear flow behavior was secondly reported and then the effect of shear rate on this behavior was discussed in detail. In addition, several inelastic-viscoplastic flow models including a yield stress parameter were employed to make a quantitative evaluation of the steady shear flow behavior, and then the applicability of these models was examined by calculating the various material parameters. The angular frequency dependence of the linear viscoelastic behavior was nextly explained and quantitatively predicted using a fractional derivative model. Finally, the strain amplitude dependence of the dynamic viscoelastic behavior was discussed in full to elucidate a nonlinear rheological behavior in large amplitude oscillatory shear flow fields. Main findings obtained from this study can be summarized as follows : (1) The linear viscoelastic behavior is almostly independent of temperature over a temperature range of $15{\sim}40^{circ}C$. (2) The steady shear viscosity is sharply decreased as an increase in shear rate, demonstrating a pronounced Non-Newtonian shear-thinning flow behavior. (3) The shear stress tends to approach a limiting constant value as a decrease in shear rate, exhibiting an existence of a yield stress. (4) The Herschel-Bulkley, Mizrahi-Berk and Heinz-Casson models are all applicable and have an equivalent validity to quantitatively describe the steady shear flow behavior of $Antiphlamine-S^{(R)}$ lotion whereas both the Bingham and Casson models do not give a good applicability. (5) In small amplitude oscillatory shear flow fields, the storage modulus is always greater than the loss modulus over an entire range of angular frequencies tested and both moduli show a slight dependence on angular frequency. This means that the linear viscoelastic behavior of $Antiphlamine-S^{(R)}$ lotion is dominated by an elastic nature rather than a viscous feature and that a gel-like structure is present in this system. (6) In large amplitude oscillatory shear flow fields, the storage modulus shows a nonlinear strain-thinning behavior at strain amplitude range larger than 10 % while the loss modulus exhibits a weak strain-overshoot behavior up to a strain amplitude of 50 % beyond which followed by a decrease in loss modulus with an increase in strain amplitude. (7) At sufficiently large strain amplitude range (${\gamma}_0$>100 %), the loss modulus is found to be greater than the storage modulus, indicating that a viscous property becomes superior to an elastic character in large shear deformations.