• Korean Journal of Radiology
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• v.24 no.6
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• pp.564-573
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• 2023

Objective: To investigate the feasibility of assessing the viscoelastic properties of the brain using magnetic resonance elastography (MRE) and a novel MRE transducer to determine the relationship between the viscoelastic properties and glymphatic function in neurologically normal individuals. Materials and Methods: This prospective study included 47 neurologically normal individuals aged 23-74 years (male-to-female ratio, 21:26). The MRE was acquired using a gravitational transducer based on a rotational eccentric mass as the driving system. The magnitude of the complex shear modulus |G^*| and the phase angle 𝛗 were measured in the centrum semiovale area. To evaluate glymphatic function, the Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) method was utilized and the ALPS index was calculated. Univariable and multivariable (variables with P < 0.2 from the univariable analysis) linear regression analyses were performed for |G^*| and 𝛗 and included sex, age, normalized white matter hyperintensity (WMH) volume, brain parenchymal volume, and ALPS index as covariates. Results: In the univariable analysis for |G^*|, age (P = 0.005), brain parenchymal volume (P = 0.152), normalized WMH volume (P = 0.011), and ALPS index (P = 0.005) were identified as candidates with P < 0.2. In the multivariable analysis, only the ALPS index was independently associated with |G^*|, showing a positive relationship (β = 0.300, P = 0.029). For 𝛗, normalized WMH volume (P = 0.128) and ALPS index (P = 0.015) were identified as candidates for multivariable analysis, and only the ALPS index was independently associated with 𝛗 (β = 0.057, P = 0.039). Conclusion: Brain MRE using a gravitational transducer is feasible in neurologically normal individuals over a wide age range. The significant correlation between the viscoelastic properties of the brain and glymphatic function suggests that a more organized or preserved microenvironment of the brain parenchyma is associated with a more unimpeded glymphatic fluid flow.

• Korean Journal of Radiology
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• v.24 no.9
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• pp.849-859
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• 2023

Objective: The prognostic value of the volume and density of skeletal muscles in the abdominal waist of patients with colon cancer remains unclear. This study aimed to investigate the association between the automated computed tomography (CT)-based volume and density of the muscle in the abdominal waist and survival outcomes in patients with colon cancer. Materials and Methods: We retrospectively evaluated 474 patients with colon cancer who underwent surgery with curative intent between January 2010 and October 2017. Volumetric skeletal muscle index and muscular density were measured at the abdominal waist using artificial intelligence (AI)-based volumetric segmentation of body composition on preoperative pre-contrast CT images. Patients were grouped based on their skeletal muscle index (sarcopenia vs. not) and muscular density (myosteatosis vs. not) values and combinations (normal, sarcopenia alone, myosteatosis alone, and combined sarcopenia and myosteatosis). Postsurgical disease-free survival (DFS) and overall survival (OS) were analyzed using univariable and multivariable analyses, including multivariable Cox proportional hazard regression. Results: Univariable analysis showed that DFS and OS were significantly worse for the sarcopenia group than for the non-sarcopenia group (P = 0.044 and P = 0.003, respectively, by log-rank test) and for the myosteatosis group than for the non-myosteatosis group (P < 0.001 by log-rank test for all). In the multivariable analysis, the myosteatotic muscle type was associated with worse DFS (adjusted hazard ratio [aHR], 1.89 [95% confidence interval, 1.25-2.86]; P = 0.003) and OS (aHR, 1.90 [95% confidence interval, 1.84-3.04]; P = 0.008) than the normal muscle type. The combined muscle type showed worse OS than the normal muscle type (aHR, 1.95 [95% confidence interval, 1.08-3.54]; P = 0.027). Conclusion: Preoperative volumetric sarcopenia and myosteatosis, automatically assessed from pre-contrast CT scans using AI-based software, adversely affect survival outcomes in patients with colon cancer.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.11a
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• pp.21-22
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• 2008

• Journal of the Korean Mathematical Society
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• v.51 no.5
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• pp.1029-1044
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• 2014

In this paper we consider a generalization of the Mayer-Erd$\ddot{o}$s phenomenon discussed in [12] to linear forms in a larger number of variables.

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.60.4-60
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• 2002

Nonlinear adaptive control for the laboratory pressure-flow model. Control valves are installed on both sides. The pressure and the outlet flow rate are measured. The pressure and outlet flow rate are controlled variables and the control valve stem positions on both sides are the manipulated variables. The variation in both inputs will influence both controlled variables. The control performance is good, in spite of varying valve coefficients of inlet and outlet.

• 제어로봇시스템학회:학술대회논문집
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• 1989.10a
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• pp.87-92
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• 1989

An autopilot for the class of Bank-To-Turn missiles is developed using a multivariable plant model & control design methodology. The roll-pitch-yaw cross coupling is included in the design considerations. Feedback system is designed using the Linear Quadratic Gaussian with Loop Transfer Recovery (LQG/LTR). Nonlinear simulations are presented to demonstrate the performances of the designed system.

• 제어로봇시스템학회:학술대회논문집
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• 1989.10a
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• pp.907-912
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• 1989

A new procedure is presented for optimally placing closed-loop poles of multivariable continuous-time systems in specified regions via linear-quadratic(LQ) state-feedback design. This method has the advantages of pole-placement and LQ-design. In addition, it provides minimum feedback gains in the control law.

• 제어로봇시스템학회:학술대회논문집
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• 1989.10a
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• pp.467-472
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• 1989

In this study, a design method to obtain a robust optimal regulator for linear multivariable system is presented. When assigning eigenvalues of linear multivatiable system , the feedback gain is not unique. So we can assign robustness index to optimality so that we can fully use the remained degree of freedom.

• Journal of applied mathematics & informatics
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• v.6 no.3
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• pp.799-808
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• 1999

We estimate the speed of convergence of Secant method in one variable and multivariable case with a constant from the coefficients of Taylor series. We present a criterion to confirm that z is close enough to a zero for Secant method and compare with that of newton method.

• 제어로봇시스템학회:학술대회논문집
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• 1987.10b
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• pp.185-189
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• 1987

The controller with robustness described in this paper is designed for processes with variable time-delays. This adaptive mechanism includes servo and stabilizing compensators. In the proposed multivariable controller. knowledge of the system time-delay is not required.