• Journal of Microbiology and Biotechnology
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• v.31 no.11
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• pp.1508-1518
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• 2021

Hsa_circ_0001947 is associated with multiple cancers, but its function in non-small cell lung cancer (NSCLC) is ambiguous and needs further research. The targeting relationship among circ_0001947, miR-661, and downstream of tyrosine kinase 7 (DOK7) was predicted by database and further verified by dual-luciferase reporter assay, while their expressions in cancer tissues and cells were detected by quantitative real-time polymerase chain reaction (qRT-PCR). After transfection, cell biological behaviors and expressions of miRNAs, miR-661 and DOK7 were determined by cell function experiments and qRT-PCR, respectively. Circ_0001947 was low-expressed in NSCLC tissues and cells. Circ_0001947 knockdown intensified cell viability and proliferation, induced cell cycle arrest at S phase, suppressed apoptosis and evidently enhanced miR-510, miR-587, miR-661 and miR-942 levels, while circ_0001947 overexpression did the opposite. MiR-661 was a target gene of circ_0001947 that participated in the regulation of circ_0001947 on cell biological behaviors. Furthermore, DOK7, the target gene of miR-661, partly participated in the regulation of miR-661 on cell viability. Hsa_circ_0001947 acts as a sponge of miR-661 to repress NSCLC development by elevating the expression of DOK7.

• Journal of Korean Neurosurgical Society
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• v.65 no.4
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• pp.499-506
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• 2022

Objective : We conducted this study with the aim of predicting the biological behavior of meningiomas, and determining the benefits of associating histological subtype and grade with the expression of proliferative markers and tumor suppressor proteins. Methods : The study included 29 patients with primary intracranial and intraspinal meningioma diagnosed in the pathology laboratory of Konya City Hospital between January 2014 and December 2020. Clinicopathological characteristics of the patients including parameters such as age and gender were obtained from the hospital records. Histopathological findings were obtained by re-evaluating the preparations stained with Hematoxylin-Eosin, which were extracted from the archive, and by evaluating new sections obtained from paraffin blocks of patients stained with Ki67, p53, and p57 immunohistochemical stains. Results : A moderate correlation was found between tumor size and Ki67 proliferation index (PI) (p=0.003, r=0.530). There was no significant difference between grade I and grade II tumors in terms of p53 (p=0.184) and p57 (p=0.487) expressions. There were higher levels of Ki67 PI in grade II tumors. The histological subtypes of the tumor had no significant difference with Ki67 PI (p=0.018), p53 (p=0.662), and p57 (p=0.368) expressions. Conclusion : In order to obtain more definitive results, there is a need for studies, which are conducted with a greater number of patients and in multiple centers, and in which a long prospective follow-up is planned. The combination of histological, surgical, and imaging markers could make a more sensitive tool for predicting recurrence, and this could also be tested in future studies.

• Journal of Intelligence and Information Systems
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• v.20 no.1
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• pp.1-14
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• 2014

Both researchers and practitioners are showing an increased interested in interactive exhibition services. Interactive exhibition services are designed to directly respond to visitor responses in real time, so as to fully engage visitors' interest and enhance their satisfaction. In order to install an effective interactive exhibition service, it is essential to adopt intelligent technologies that enable accurate estimation of a visitor's emotional state from responses to exhibited stimulus. Studies undertaken so far have attempted to estimate the human emotional state, most of them doing so by gauging either facial expressions or audio responses. However, the most recent research suggests that, a multimodal approach that uses people's multiple responses simultaneously may lead to better estimation. Given this context, we propose a new multimodal emotional state estimation model that uses various responses including facial expressions, gestures, and movements measured by the Microsoft Kinect Sensor. In order to effectively handle a large amount of sensory data, we propose to use stratified sampling-based MRA (multiple regression analysis) as our estimation method. To validate the usefulness of the proposed model, we collected 602,599 responses and emotional state data with 274 variables from 15 people. When we applied our model to the data set, we found that our model estimated the levels of valence and arousal in the 10~15% error range. Since our proposed model is simple and stable, we expect that it will be applied not only in intelligent exhibition services, but also in other areas such as e-learning and personalized advertising.

• 한국체육학회지인문사회과학편
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• v.51 no.3
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• pp.437-445
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• 2012

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and manganese superoxide dismutase (MnSOD) has been hypothesized as a mediator in the activation of multiple pathways implicated in the pathogenesis of diabetic disease. The objective of this study was to understand the mechanism that aerobic exercise activate GAPDH and MnSOD in pancreatic cells. To achieve the purpose of this study, thirty male Sprague-Dawley rats were assigned to control group, diabetic group and diabetic exercise group. 10 rats were forced to exercise according to exercise protocol for 8weeks and 20 rats were untrained for control and diabetic group. Pancreatic tissue were extracted from the each. Expressions of GAPDH and MnSOD in diabetic pancreatic tissues were significantly decreased compare to control group. However, swimming (trained diabetic group) significantly increased expressions of GAPDH and MnSOD compare to diabetic group, respectively. In hyperglycemia, GAPDH and MnSOD in pancreatic cells is activated by aerobic exercise, and this inactivates multiple pathways implicated in the pathogenesis of diabetic disease. In conclusion, these findings suggest that increased activity of GAPDH and MnSOD by exercise have beneficial effects on mitochondrial dysfunction and arresting the progression of diabetic disease.

• Journal of the Korean association of regional geographers
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• v.16 no.1
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• pp.1-15
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• 2010

A feng-shui map(山圖) represents the most ideal natural landform on a map of feng-shui space model, highlighting propitious spots and grave sites in terms of feng-shui. This study made an analysis into feng-shui maps featured in the Chinese feng-shui manual Jiriinjasuji published in the Ming dynasty of China and did research on the following points regarding the traits of landform expressions: viewpoints of feng-shui maps, perspective points, center-oriented maps, double map scales, mountain theories, detailed expressions of propitious spots, etc. The major characteristics of landform expressions in the Chinese feng-shui manual Jiriinjasuji are as follows: the viewpoint technique was aerial one; the maps were center-oriented, that is to say, the center of grave sites or propitious spot was depicted in detail; and often the important terrains around grave sites were exaggerated or delete compared with real landforms. In addition, other vital landforms not observed from grave sites were depicted with viewpoints moved and were represented in greater details' The part of mountain theories had the following points as their main subject matter: geographical locations, overall orientations of mountain ranges, topographical traits, grave seat directions, surrounding terrains and extent of fortune-bringing. The directions of the maps were relative and there was no definite concept of scales. But, there are many cases where the maps made use of the double scale technique when expressing the terrains that have propitious space, logistical cities or directional importance. Furthermore, they often utilized multiple scale in expressing near views, mid-range views and distant views.

• Journal of dental hygiene science
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• v.15 no.2
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• pp.113-118
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• 2015

This study was conducted to develop a plan for emotional labor of clinical dental hygienists by understanding the factors affecting their emotional labor. Self-administered questionnaires were distributed to 293 dental hygienists who worked in dental hospitals and clinics located in Busan and Gyeongsangnam-do from June to September in 2013. The questionnaire items used in this study consisted of 5 items of general characteristics, 2 items of characteristics related to turnover, and 9 items of emotional labor. t-test, ANOVA, and multiple regression analysis were performed using the SPSS Statistics ver. 17.0 for Windows program for data analysis. The average level of the study subjects was $69.85{\pm}12.82$. With regard to the emotional labor according to the general characteristics, the frequency of emotional expressions (p<0.037) showed significant differences in the marital status. The workplace showed significant differences in the frequency of emotional expressions (p<0.001), attentiveness of emotional expressions (p<0.002), emotional dissonance (p<0.032), and total (p<0.001). The turnover intentions showed significant differences in the frequency of emotional expressions (p<0.001), attentiveness of emotional expressions (p<0.001), emotional dissonance (p<0.001), and total (p<0.001). As a factor affecting emotional labor, turnover intention (p<0.001) and workplace (p<0.001) had an effect on emotional labor. The results showed that turnover intention and workplace were associated with the emotional labor of dental hygienists. There is a need to develop an emotional education program to make it possible to effectively manage emotional labor of dental hygienists for providing high-quality medical services of dental institutions.

• Culinary science and hospitality research
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• v.20 no.2
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• pp.152-164
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• 2014

This research attempts to analyze the significant factors that affect the level of expectation and satisfaction of parents on cooking activities for their child(ren) by comparing the levels of their original expectation and satisfaction; based on the understanding of the educational values and effects of cooking activities for children. To conduct the empirical studies, 254 survey samples were collected from the parents who have had their child(ren) participate in cooking activities; in addition, the data was processed and analyzed by using various comparative statistical analysis; including t-test, IPA analysis, regression analysis, one-way ANOVA. And Duncan's multiple test was added to verify the outcome afterwards. As the result of the research, the expectation and satisfaction of parents who let their child(ren) participate in cooking activities were significantly different by such variables as 'improvement of linguistic expression,' 'development of understanding numbers and scientific concepts,' 'extension of capability to give his/her emotional expressions,' 'assistance in soothing his/her psychological stresses.' Besides, 'educational contents and methods' were revealed as another factor that influenced parents' satisfaction, and it is clarified that the level of satisfaction is significantly different according to the organizations offering activity programs.

• Korean Institute of Interior Design Journal
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• v.26 no.2
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• pp.83-91
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• 2017

This study was conducted by the awareness that although interior spaces using the techniques and characteristics of assemblage are excellent means to reveal distinctiveness and identity with preeminent originality which are different from other spaces, there are few domestic studies and literatures on them. The results analyzed by preceding studies and cases on the characteristics of expression of assemblage which appear in the interior spaces of commercial areas can be summarized as follows; First, assemblage expresses identity of spaces with symbols capable of multiple interpretations through the method of integration and repetition of the materials used. Second, it strongly reminds visitors of memories on spaces by producing odd and unfamiliar scenes with such designs as installation art. Third, when it uses ordinary materials, it adds combination, integration, transformation or colors to the materials for extraordinary traits. Fourth, it pursues sustainability through recycling or upcycling by using wastes or natural materials. Fifth, in order to express materials to fit the purposes of spaces, it formulates outcomes with intentional plans. To sum up above analysis results, expressions of assemblage which appear in modern commercial spaces are characterized by expression of symbols with multiple meanings, purse formativeness which fit the purposes and meanings of spaces, play the role of reminding memories on places by producing extraordinary spaces with strangeness and unfamiliarity such as installation art and sometimes show sustainability by using recyclable materials. The results of this study are expected to be utilized as reference materials which suggest directions of approach to interior spaces through assemblage techniques and materials which can be used in various design terms by domestic designers.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.3
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• pp.580-584
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• 2008

In the present study, Radix clematidis extract (RCE) was evaluated to determine if it could protect pancreatic ${\beta}$ cells against multiple low dose streptozotocin (MLDS)-induced diabetes. Injection of mice with MLDS resulted in hyperglycemia and hypoinsulinemia, which was confirmed by immunohistochemical staining. However, the induction of diabetes by MLDS was completely prevented when mice were pre-administrated with RCE. Generation of oxidative stress is implicated in MLDS, a ${\beta}$ cell specific toxin-induced islet cell death. In this context, to elucidate the mechanisms of protective effects in RCE pre-administrated diabetic mice, we investigated the expression of heme oxygenase-1 (HO-1), which is one of the anti-oxidant enzymes. MLDS-induced HO-1 expressions were significantly reduced in MLDS-treated mice. However, the decrease of HO-1 by MLDS were protected by pretreatment of RCE. The molecular mechanism by which RCE inhibits diabetic conditions by MLDS appears to involve inhibition of HO-1 expression. Taken together, these results reveal the possible therapeutic value of RCE for the prevention of type 1 diabetes progression.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.12
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• pp.5862-5887
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• 2019

In this paper, we propose a two-way relaying scheme using non-orthogonal multiple access (NOMA) technology. In this scheme, two sources transmit packets with each other under the assistance of the decode-and-forward (DF) relays, called as a TWDFNOMA protocol. The cooperative relays exploit successive interference cancellation (SIC) technique to decode sequentially the data packets from received summation signals, and then use the digital network coding (DNC) technique to encrypt received data from two sources. A max-min criterion of end-to-end signal-to-interference-plus-noise ratios (SINRs) is used to select a best relay in the proposed TWDFNOMA protocol. Outage probabilities are analyzed to achieve exact closed-form expressions and then, the system performance of the proposed TWDFNOMA protocol is evaluated by these probabilities. Simulation and analysis results discover that the system performance of the proposed TWDFNOMA protocol is improved when compared with a conventional three-timeslot two-way relaying scheme using DNC (denoted as a TWDNC protocol), a four-timeslot two-way relaying scheme without using DNC (denoted as a TWNDNC protocol) and a two-timeslot two-way relaying scheme with amplify-and-forward operations (denoted as a TWANC protocol). Particularly, the proposed TWDFNOMA protocol achieves best performances at two optimal locations of the best relay whereas the midpoint one is the optimal location of the TWDNC and TWNDNC protocols. Finally, the probability analyses are justified by executing Monte Carlo simulations.