• Archives of Pharmacal Research
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• v.20 no.6
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• pp.566-571
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• 1997

To gain further insight into how estrogens modulate cell function, the effects of estrogen on cell proliferation were studied inhuman breast cancer cells. We examined the effects of estrogen on the proliferation of three human breast cancer cell lines that differed in their estrogen receptor contents. Ten nM estradiol markedly stimulated the proliferation of MCF-7 human breast cancer cells that contained high levels of estrogen receptor $1.15{\pm}0.03 pmole/mg protein)$(over that of control. In T47D cells that contained low levels of estrogen receptor $0.23{\pm}0.05 pmole/mg protein)$, Ten nM estrogen slightly stimulated the proliferation over that of control. MDA-MB-231 cells, that contained no detectable levels of estrogen receptors, had their growth unaffected by estrogen. These results showed their sensitivity to growth stimulation by estrogen correlated well with their estrogen receptor content. Also we examined the effect of estrogen on cellular progesterone receptor level as well as plasminogen activator activity in MCF-7 cells. Ten nM estradiol showed maximal stimulation of progesterone receptor level as well as plasminogen activator activity in MCF-7 cells. It is not clear whether these stimulations of progesterone receptor and plasminogen activator activity by estrogen are related to the estrogen stimulation of cell proliferation of MCF-7 cells. Studies with estrogen in human breast cancer cells in culture indicate that sensitivity to growth stimulation by estrogen correlates well with estrogen receptor contents.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.10
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• pp.879-882
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• 2021

The telemetry standard adopts SOQPSK-TG with excellent power and bandwidth efficiency as a modulation technique, and LDPC code with excellent performance as an error correction code. The SOQPSK-TG transmitter consists of a precoder and a CPM modulator. Rather than implementing each receiver separately, the reception performance is improved by combining the trellis and implementing it as a Viterbi decoder. In this paper, the reception performance of LDPC-encoded SOQPSK-TG was evaluated by replacing the Viterbi decoder with a max-log-map decoder capable of soft metric output. As a result of computer simulation in AWGN channel, there is an Eb/No performance gain of about more than 0.7~0.8dB compared to the conventional method.

• Journal of Korea Society of Digital Industry and Information Management
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• v.15 no.1
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• pp.67-76
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• 2019

Despite attractive advantages such as good time-frequency localization and improved spectral efficiency, filter bank multicarrier with offset quadrature amplitude modulation (FBMC/OQAM) suffers from multipath fading. In highly frequency-selective channels, the effect of multipath interference can significantly distort the FBMC/OQAM signal due to the absence of cyclic prefix. To resolve the problem of the multipath interference in FBMC/OQAM, this paper proposes applying an antenna array that provides well shaped beam pattern for each multipath. To evaluate the performance of the proposed array system, various computer simulations have been conducted. The accuracy of direction of arrival estimation is demonstrated through spatial spectrum for a different number of antennas in a sub-array. The performance improvement is presented in terms of bit error rate. We found that the proposed array system mitigate the multipath interferences in Extended Typical Urban model with 12 antennas in a sub-array. Moreover, as the number of antennas in a sub-array increases, the system provides a signal-to-noise ratio gain.

• ETRI Journal
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• v.46 no.2
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• pp.184-193
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• 2024

This paper presents the performance evaluation of an amplify-and-forward (AF) relay-assisted multiuser multiple input-multiple output (MU-MIMO) downlink transmission system for correlated fading channels. The overall system performance was improved by incorporating a double-quadrature spatial modulation (DQSM) scheme. The bit error rate (BER) performance and detection complexity of the AF-MU-MIMO-DQSM system were analyzed and compared with those of a conventional AF-MU-MIMO system under the same conditions and parameters. The results showed that the correlated fading channel severely affected the performance of systems with higher spectral efficiency (SE). Considering an SE of 12 bpcu/user, the AF-MU-MIMO-DQSM system yielded a gain of up to 3 dB in BER performance compared with that of its conventional counterpart for the analyzed cases. In terms of detection complexity, the AF-MU-MIMO-DQSM system showed a reduction of up to 56 % compared with that of the conventional system for the optimal maximum likelihood detection criterion.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.7C
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• pp.706-714
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• 2009

In this paper, we proposed a burst mode AGC loop and preamble detector applicable for VDL(VHF Digital Link) mode-2 using D8PSK modulation scheme and the performance analysis of proposed schemes is described. Generally the AGC scheme can be divided into two types, continuos and burst mode AGC. The continuos mode is performed well only with an analog feedback AGC loop. But the analog feedback AGC loop is not suitable for burst mode since its gain lock time is more than preamble duration, which causes the preamble detector misses preamble. Hence a fast digital AGC loop is required for burst mode. Also the AGC loop has to be designed with full gain during idle time to detect bursts although the signal level is very low. If the time to acquire gain lock is slow, the preamble detector fail to detect burst due to saturation of a lot of preamble samples. The receiver performance might be down even if the burst was detected because the preamble is used to estimate several parameters need to demodulation at receiver. In this paper we analysed relationships between the AGC loop and preamble detector. we present an AGC loop and preamble detector in burst mode.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.12
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• pp.1742-1750
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• 2015

As a novel approach for disease control and prevention, nutritional modulation of the intestinal health has been proved. However, It is still unknown whether branched-chain amino acid (BCAA) is needed to maintain intestinal immune-related function. The objective of this study was to determine whether BCAA supplementation in protein restricted diet affects growth performance, intestinal barrier function and modulates post-weaning gut disorders. One hundred and eight weaned piglets ($7.96{\pm}0.26kg$) were randomly fed one of the three diets including a control diet (21% crude protein [CP], CON), a protein restricted diet (17% CP, PR) and a BCAA diet (BCAA supplementation in the PR diet) for 14 d. The growth performance, plasma amino acid concentrations, small intestinal morphology and intestinal immunoglobulins were tested. First, average daily gain (ADG) (p<0.05) and average daily feed intake (ADFI) (p<0.05) of weaned pigs in PR group were lower, while gain:feed ratio was lower than the CON group (p<0.05). Compared with PR group, BCAA group improved ADG (p<0.05), ADFI (p<0.05) and feed:gain ratio (p<0.05) of piglets. The growth performance data between CON and BCAA groups was not different (p>0.05). The PR and BCAA treatments had a higher (p<0.05) plasma concentration of methionine and threonine than the CON treatment. The level of some essential and functional amino acids (such as arginine, phenylalanine, histidine, glutamine etc.) in plasma of the PR group was lower (p<0.05) than that of the CON group. Compared with CON group, BCAA supplementation significantly increased BCAA concentrations (p<0.01) and decreased urea concentration (p<0.01) in pig plasma indicating that the efficiency of dietary nitrogen utilization was increased. Compared with CON group, the small intestine of piglets fed PR diet showed villous atrophy, increasing of intra-epithelial lymphocytes (IELs) number (p<0.05) and declining of the immunoglobulin concentration, including jejunal immunoglobulin A (IgA) (p = 0.04), secreted IgA (sIgA) (p = 0.03) and immunoglobulin M (p = 0.08), and ileal IgA (p = 0.01) and immunoglobulin G (p = 0.08). The BCAA supplementation increased villous height in the duodenum (p<0.01), reversed the trend of an increasing IELs number. Notably, BCAA supplementation increased levels of jejunal and ileal immunoglobulin mentioned above. In conclusion, BCAA supplementation to protein restricted diet improved intestinal immune defense function by protecting villous morphology and by increasing levels of intestinal immunoglobulins in weaned piglets. Our finding has the important implication that BCAA may be used to reduce the negative effects of a protein restricted diet on growth performance and intestinal immunity in weaned piglets.

• The Korea Journal of Herbology
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• v.25 no.3
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• pp.1-9
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• 2010

Objectives : This study was undertaken to verify the effects of Gyeongshingangjeehwan18 (GGEx18) on obesity using ob/ob male mice. Methods : Eight-week old mice (wild-type C57BL/6J and ob/ob) were used for all experiments. Wild-type C57BL/6J mice were used as lean control and obese ob/ob mice were randomly divided into 5 groups: obese control, GGEx15, GGEx16, GGEx17, and GGEx18. After mice were treated with several kinds of GGEx for 11 weeks, body weight gain, feeding efficiency ratio, plasma lipid and glucose metabolism. Results : 1. Compared with obese controls, GGEx-treated mice had lower body weight gain and feeding efficiency ratio, the magnitudes of which were prominent in GGEx16 and GGEx18. 2. Consistent with their effects on body weight gain, GGEx16 and GGEx18 not only decreased plasma triglycerides levels, but also increased HDL-cholesterol concentration. 3. CT analysis revealed that visceral fat areas were decreased in all treatment groups compared with obese control mice. The decrease in visceral fat area was prominent in GGEx16 and GGEx18, although they were not statistically significant. 4. The size of adipocytes were significantly decreased by GGEx18, whereas the adipocyte number per unit area was significantly increased, suggesting that GGEx18 decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by GGEx16 and GGEx18, and the inhibitory effect was most effective in GGEx18. 5. Plasma GOT and GPT concentrations were significantly lower following GGEx16 and GGEx18 treatment compared with obese controls. Organ weights were not changed by GGEx treatment, indicating GGEx do not show any toxic effects. Conclusions : These results suggest that GGEx may regulate obesity. Of the 4 compositions, GGEx18 seems to be most effective in improving obesity and lipid disorders.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.1
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• pp.109-115
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• 2004

Three experiments were conducted to evaluate the effects of taurine (Tau) supplements on broiler growth performance, serum constituents and antibody production. In Exp. 1, 3 day old chicks received a basal diet supplemented with Tau at 0, 0.10, 0.20, 0.30 or 0.40% for 6 weeks. Although dietary Tau supplementing at 0.30 or 0.40% enhanced feed conversion and reduced feed consumption during 0 to 3 weeks (p<0.05), neither serum total cholesterol or anti-Newcastle disease virus (NDV) titer were affected. In Exp. 2, dietary Tau supplement at 0.25-0.75% enhanced feed conversion of broilers during 0 to 3 weeks, but daily gain and feed consumption were not affected. The 0.75% Tau supplement group displayed lower serum total cholesterol at 6 weeks (p<0.05) comparing with the control group but no difference in anti-NDV titers. In Exp. 3, broilers were treated with dietary Tau of 0 or 0.50% combined with low (0/0%), medium (0.18/0.08%), or high (0.36/0.16%) methionine (Met) levels for 6 weeks (0 to 3/3 to 6 weeks). The addition of Met significantly improved daily gain and feed conversion of broilers during 0 to 3 weeks (p<0.01). Dietary Tau interacted significantly with Met on daily gain and feed consumption. Broiler serum amino acids revealed that Met supplements only increased serum Met level, but only serum Tau level was enhanced as given dietary Tau supplementation. The broilers receiving Tau normalized serum triglycerides level by feeding with the low Met diet and tended to display higher anti-NDV titers (p<0.10). The experimental results suggest that the growth response obtained by Tau supplements results partly from interactions with sulfur amino acids. However, the modulation of the broiler lipid metabolism may be responsible for dietary Tau.

• Herbal Formula Science
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• v.16 no.2
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• pp.205-217
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• 2008

Objectives : We investigated the effects of Herba Ephedrae and Rhizoma Amorphophalli on high fat diet induced obese male mice. Methods : 8 weeks old, high fat diet induced obese male mice were divided into 5 groups: C57BL/6 normal control, obese vehicle control, GGEx55 (Herba Ephedrae), GGEx61 (Rhizoma Amorphophalli), GGEx62 (Herba Ephedrae + Rhizoma Amorphophalli). After mice were treated with GGEx for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, rectal temperature, fat weight, plasma leptin and lipid levels. We also took micro-computerized axial tomography (micro-CT) on the mice. Results : 1. GGEx55 and GGEx62 groups significantly decreased body weight gain and feeding efficiency ratio compared with vehicle control. But they significantly increased rectal temperature. 2. Plasma total cholesterol and LDL-cholesterol concentrations were significantly increased by GGEx55 groups, whereas were significantly decreased by GGEx62 groups compared with vehicle control. 3. GGEx55 and GGEx62 groups significantly decreased total, subcutaneous and visceral fat as well as fat areas in micro-CT analysis of abdomen compared with vehicle control. 4. Plasma GOT and GPT concentrations were significantly increased by GGEx55 groups compared with vehicle control. Conclusions : These results demonstrate that GGEx55 and GGEx62 effectively reduces body weight gain, feeding efficiency ratio in high fat diet induced obese mice, leading to the modulation of obesity. In addition, GGEx55 and GGEx62 decreases visceral adipose tissue mass and improves plasma lipids, suggesting that GGEx55 and GGEx62 may act as a therapeutic agent for obesity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.2A
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• pp.172-178
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• 2011

In this paper, the performance of bit interleaved of coded and modulation(BICM) module of the second generation of digital terrestrial television broadcasting system(DVB-T2) is evaluated with the help of computer simulation. The frame error rate performance is studied in AWGN, Rayleigh fading and 15% erasure channels. In addition, iterative receiver is considered that exchanges extrinsic information between the rotated demapper and the LDPC decoder. Through the simulation it is observed that under the flat fading Rayleigh channel, about 1.2dB gain at FER of $10^{-4}$ is introduced when rotated constellation and iterative demapping and decoding are employed. Under the 15% earasure channel, rotated constellation gives performance gain of about 5dB at BER of $10^{-4}$ and when IDD is applied, additional performance gain of about 3dB can be achieved.