• Journal of Korean Society of Transportation
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• v.4 no.1
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• pp.3-11
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• 1986

One important element of a systematic approach to the management and control of the flow of people over an urban street network is the monitoring and evaluation of system performance. The nature of TSM strategies that, in part, differentiates them from traditional long-range transportation improvement alternatives is that they are less costly, are more quickly implemented and modified, and are often oriented toward sub-area problems which must be addressed at a more microscopic level of analysis. These factors suggest that pre-implementation evaluations of alternative TSM actions will often have to rely on quick-turn around, manual methods of analysis to guide the choice of which management action should be implemented. This paper was prepared to focus on the definition and importance of TSM, specifically associated with monitoring and evaluating traffic performance in the context of TSM startegies. A simple case study of reversible lane technique was presented. The purposes of the case study is to illustrate the methodology of evaluating TSM strategies and demonstrate to identify the benefit from the reversible lane technique, which may otherwise be overlooked in real world. Applying the reversible lane technique to Sam-Il elevate highway, it was found to be a very promising low cost alternative to reduce total travel time(or delay) and fuel consumption.

• Journal of the Korean Wood Science and Technology
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• v.42 no.5
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• pp.523-532
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• 2014

This study was done to evaluate the antioxidant effect of oak hot water extracts on the oxidative stress induced by reactive oxygen species (ROS). The cytotoxicity of $H_2O_2$-induced oxidative stress was performed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay for the cell viability according to the dose-dependent treatment. Oak extracts demonstrated a dose-dependent ability to inhibit $H_2O_2$-induced apoptosis in cultured tenofibroblasts, as assessed by MTT assay and FACS analysis. $H_2O_2$ increased the phosphorylation of extracellular regulated kinase1/2 (ERK1/2) and of c-Jun N-terminal kinase (JNK) and the production of reactive oxygen species (ROS). In contrast, treatment with oak extracts was decreased this activation of ERK1/2 and JNK, as confirmed by western blot analysis, and reduced the production of ROS, as verified by fluorescent microscopic and flow cytometry (FACS) analyses. These findings suggest that oak extracts, by suppressing JNK, ERK1/2, and intracellular ROS production, have a concentration-dependent antiapoptotic effect on achilles tenofibroblasts exposed to an oxidative stressor, and may have therapeutic potential.

• Computers and Concrete
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• v.20 no.1
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• pp.39-47
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• 2017

In this paper, mode I fracture toughness of rock was determined by direct and indirect methods using Particle Flow Code simulation. Direct methods are compaction tension (CT) test and hollow centre cracked quadratic sample (HCCQS). Indirect methods are notched Brazilian disk (NBD) specimen, the semi-circular bend (SCB) specimen, hollow centre cracked disc (HCCD), the single edge-notched round bar in bending (SENRBB) specimen and edge notched disk (END). It was determined that which one of indirect fracture toughness values is close to direct one. For this purpose, initially calibration of PFC was undertaken with respect to data obtained from Brazilian laboratory tests to ensure the conformity of the simulated numerical models response. Furthermore, the simulated models in five introduced indirect tests were cross checked with the results from direct tests. By using numerical testing, the failure process was visually observed. Discrete element simulations demonstrated that the macro fractures in models are caused by microscopic tensile breakages on large numbers of bonded discs. Mode I fracture toughness of rock in direct test was less than other tests results. Fracture toughness resulted from semi-circular bend specimen test was close to direct test results. Therefore semi-circular bend specimen can be a proper test for determination of Mode I fracture toughness of rock in absence of direct test.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.10
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• pp.1541-1550
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• 2001

This paper describes experimental investigations in the direct extrusion of copper clad aluminum rods through conical dies. Composite materials consist of two or more different material layers. Copper clad aluminum composite materials are being used fur economic and structural purposes and the development of an efficient production method of copper clad aluminum composite material rods by extrusion is very important, It is necessary to know the conditions in which successful uniform extrusion ,and sound cladding may be carried out without any defects in the direct extrusion. There are several variables that have an influence on determining a sound clad extrusion. In order to investigate the influence of these parameters on the hot direct extrudability of the copper clad aluminum composite material rods, the experimental study have been performed with various extrusion temperatures, extrusion ratios and semi-cone angles of die. Subsequently, the microscopic inspection of interface bonding is carried out for extruded products. By measuring hardness, along extrusion way of products, a variation of hardness has been discussed. Proportional flow state has been considered by measuring radius ratio of Cu sleeve and Al core before and after extrusion.

• Journal of Microbiology
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• v.40 no.3
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• pp.224-229
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• 2002

The effect of human cytomegalovirus (HCMV) on three human monocyte cell lines at different stages of differentiation was investigated. While the viability of HL-60 cells or U-937 cells was not significantly affected by HCMV infection, the viability of THP-1 cells was reduced. Acridine orange/ethidiurn bromide staining revealed that the reduction of THP-1 cell viability was due to increased apoptotic death following HCMV infection. Apoptosis in HL-60 cells was not affected by HCMV infection, and induction of apoptosis of U-937 cells by HCMV was intermediate between HL-60 and THP-1 cells. Since HL-60 cells are the least differentiated and THP-1 cells are the most differentiated, the induction of apoptosis of human monocytes appears to be related to the degree of cell differentiation. Flow cytometric and confocal microscopic studies using fluorescent calcium indicator Fluo-3 suggested a significant increase in intracellular free calcium concentration (［Ca$\^$2+/］i) in THP-1 cells undergoing apoptosis by HCMV infection. Again ［Ca$\^$2+/］i in HCMV-infected HL-60 cells was not critically altered, and that in HCMV-infected U-937 cells was intermediate between THP-1 cells and HL-60 cells. Calcium influx blockers such as verapamil and nifedipine partially reversed HCMV-induced apoptosis in THP-1 cells.

• Tunnel and Underground Space
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• v.29 no.6
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• pp.542-557
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• 2019

The behavior of rock mass is influenced by its microscopic feature of internal structure generating from forming and metamorphic process. This study investigated a new methodology for characterization of rock based on the X-ray CT (computed tomography) images reflecting the spatial distribution characteristics of internal constituent materials. The X-ray image based analysis is capable of quantification of heterogeneity and anisotropy of rock fabric, size distribution and shape parameter analysis of rock mineral grains, fluid flow simulation based on pore geometry image and roughness evaluation of unexposed joint surface which are hardly acquired by conventional rock testing methods.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.31 no.3 s.258
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• pp.225-233
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• 2007

The growth of GaN on the patterned substances has proven favorable to achieve thick, crack-free GaN layers. In this paper, numerical modeling of transport and reaction of species is performed to estimate the growth rate of GaN from tile reaction of TMG(trimethly-gallium) and ammonia. GaN growth rate was estimated through the model analysis including the effect of species velocity, thermal convection and chemical reaction, and thermal condition for the uniform deposition was to be presented. The effect of shape and construction of microscopic pattern was also investigated using a simulator to perform surface analysis, and a review was done on the quantitative thickness and shape in making GaN layer on the pattern. Quantitative analysis was especially performed about the shape of reactor geometry, periodicity of pattern and flow conditions which decisively affect the quality of crystal growth. It was found that the conformal deposition could be obtained with the inclination of trench ${\Theta}>125^{\circ}$. The aspect ratio was sensitive to the void formation inside trench and the void located deep in trench with increased aspect ratio.

• Journal of the Korean Society for Precision Engineering
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• v.13 no.1
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• pp.53-61
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• 1996

A clear understanding of the surface formation mechanism due to cutting is very important to help produce a good quality surface. Much of the roughness along the length of a bar being cut in a lathe can be explained in terms of macroscopic tool shape and feed rate. However, the roughness along the direction of cutting requires a different explanation. The formation of surface roughness is a problem in flow and fracture of materials in the vicinity of the tool edge. On a microscopic scale the cutting edge is rounded because it is impossible to grind a perfectly sharp cutting edge. Even if a perfectly sharp cutting edge were obtained it would soon become dull as a result of rapid breakdown and wear of the cutting edge. A research project is proposed in which in the main object is to model the surface formation mechanism due to cutting. The tool was assumed to be dull, that is, its edge has a finite radius. In order to study the effect of the radius of cutting edge on the surface formation, tools having different cutting edges were used. For orthogonal cutting experiment, cast iron and glass were chosen as brittle materials. Plowing forces acting in the cutting edge were estimated and its effect on the surface roughness was studied by observing the machined surface using optical microscope.

• International Journal of Highway Engineering
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• v.15 no.2
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• pp.159-167
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• 2013

PURPOSES : In this study, the effects of when median exclusive bus lanes were applied to Daejeon trunk road (Wolpyeng crossway~Seodaejeon crossway, 6.3km) and (Daeduck Bridge 4~Kyeryong 4, 2.6km) by Microscopic Simulation VISSIM (5.0) was studied. The median exclusive bus lanes are one of the measures of transportation system manage techniques that can especially improve the efficiency of public transportation facilities. METHODS : According to the analysis of VISSIM on the Gyerong mainroad and Daedeok mainroad, when the median exclusive bus lanes were applied unlike when the roadside bus-only lanes were applied, the average travel speed of vehicles decreased but the average delay time and travel time increased. This arised from the changes in the geometric structure of the road which occurred the reduction of vehicle lane in the center of the road. RESULTS : In the case of bus, on the other hand, the average travel speed increased but the average delay time and travel time decreased. This is because the problems such as illegal parking and stopping, secondary road in out vehicle, and conflict of intersection right turn that roadside bus-only lanes occurred was solved. CONCLUSIONS : Although the introduction of median exclusive bus lanes will have a negative effect on general traffic flow due to the aggravation of travel, decrease of passenger car usage will lead to decrease of traffic volume. Therefore, smooth vehicle travel is expected.

• Korean Journal of Veterinary Research
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• v.58 no.1
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• pp.27-31
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• 2018

Canine coronavirus is a single-stranded RNA virus that causes enteritis in dogs of any age. Coronaviral enteritis is seldom definitively diagnosed, since it is usually much less severe than many other types of enteritis and is self-limiting. Conventional diagnostics for the canine coronaviral enteritis such as polymerase chain reaction (PCR), virus isolation, and electron microscopic examination are inappropriate for small animal clinics due to the complicated experimental processes involved. Therefore, a commercially available lateral flow test kit based on chromatographic immunoassay techniques was tested to evaluate its performance as a first-line diagnostic test kit that could be used in clinics. The coronavirus antigen test kit detected canine coronavirus-infected dogs with 93.1% sensitivity and 97.5% specificity. The detection limit of the test kit was between $1.97{\times}10^4/mL$ and $9.85{\times}10^3/mL$ for samples with a 2-fold serial dilution from $1.25{\times}10^6\;TCID_{50}$ ($TCID_{50}$, 50% tissue culture infectious dose). Additionally, the test kit had no cross-reactivity with canine parvovirus, distemper virus, or Escherichia coli. Overall, the commercially available test kit showed good diagnostic performance in a clinical setting, with results similar to those from PCR, confirming their potential for convenient and accurate use in small animal clinics.