• 동의생리병리학회지
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• 제28권1호
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• pp.16-21
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• 2014

Micro needle roller therapy has been used for cosmetic purposes, such as reducing skin winkles and improving elasticity of skin. It is claimed that micro needle roller therapy has potentials for connective tissue regeneration by facilitating collagen synthesis. Therefore, there seems to be a possibility that connective tissue regenerating potential of micro needle roller therapy could influence the hair growth cycle. This study, we investigated the hair growth-promoting effects of micro needle roller therapy. C57BL/6 mice were devided into three groups as follows: normal saline-treated, minoxidil-treated, and micro needle roller therapy-received group. Hair growth activity was evaluated by handscopic and microscopic observations. Sections of dorsal skin were stained with hematoxylin and eosin. Expression of BrdU, FGF, and VEGF was detected by immunohistochemical staining. Micro needle roller therapy enhanced the development of hair follicle during anagen. Immunohistochemical analysis revealed that micro neeld roller therapy incresed the expression of BrdU and FGF in the hair follicles of C57BL/6 mice. Furthermore, micro needle roller therapy upregulated mRNA expression of VEGFR-2, FGF-2, EGF - growth factors that play a central role in hair follicle development during anagen. These results suggest that Micro needle roller therapy can potentially be used for the treatment of alopecia.

• Design & Manufacturing
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• 제10권3호
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• pp.25-29
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• 2016

Recently, a hyaluronic acid micro needle patch for therapeutic and cosmetic purposes has been used by attaching directly to the skin with a pattern having a micro needle shape of 1/3 thickness of hair. These products are attracting attention as an innovative product that maximizes the effect by activating the active ingredient in the skin in the deep skin without blocking the horny layer because the micro needle shape exists on the patch surface so that it can penetrate effectively to the skin. Currently, DAB (droplet air blowing) or MEMS technology is used to make pattern shapes for patches. Because of this technology, manufacturing time is long and manufacturing cost is high, so we tried to develop the mold technology to machine the microneedle shape directly to the metal. In this study, we first fabricated a needle pattern with a quadrangular pyramid shape and finally produced a conical needle pattern.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2004년도 춘계학술대회 논문집
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• pp.250-253
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• 2004

Sharpness of the tip of micro needle is very Important quality that should be controlled in the manufacturing processes. Acupuncture needle is one of the most widely used micro-needle. And the tip sharpness of acupuncture needle Is usually checked by the magnitude of resisting force obtained through sharpness test. In this study, some sharpness tests of acupuncture needle were done and the relationship between the misalignment of specimen and the magnitude of resisting force. The diameter of the needle used in the test was $250\;{\mu}m$ and the length of it was 40 mm.

• 한국생산제조학회지
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• 제26권3호
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• pp.285-291
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• 2017

Micro-needles are used as transferring devices for sampling of tiny constitute substances from biological bodies. Typically, nickel is used as a coating to improve the rigidity of micro-needles. This study introduces the methodology to manufacture a WC needle with very high hardness and toughness. Micro-EDM technology was used to manufacture micro-needles with holes $130{\mu}m$ in diameter and $2300{\mu}m$ in length. A micro-needle was aligned to the micro-EDM electrode using a custom two degree-of-freedom alignment system. A three-step manufacturing technique was developed to drill a micro-hole using a WC electrode. In the first process, an electrode $105{\mu}m$ in diameter was used to make a hole. Electrodes of 90 and $105{\mu}m$ diameters were used in the second and third process, respectively. Consequently, a WC micro-needle with an inner hole of $135{\mu}m$ diameter, length of $2300{\mu}m$, and outer diameter of $300{\mu}m$ was developed.

• 대한의용생체공학회:의공학회지
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• 제33권4호
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• pp.202-206
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• 2012

In this study, we developed transdermal direct drug delivery device using micro-needle painlessly. We has fabricated micro-needle that is 130 ${\mu}m$ thickness and 250 ${\mu}m$length with 10 ${\mu}m$ spiral groove for rolling down drug. Head part of micro-needle device is composed of 20ea micro-needles, an on-off valve and a protective cap. Glass bottle for containing drug is connected to head part of micro-needle device. We examined the puncture characteristic testing using porcine skin and drug delivery testing using porcine, rat skin with Indian Ink.

• KSBB Journal
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• 제25권2호
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• pp.116-122
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• 2010

Fermented materials have been used for long time around the world and have been researched according to the excellent effect in the part of medical and food industry. However, when such materials are applied on skin, because of the skin barrier, the most effective ingredients are poorly absorbed. The absorption of the skin is exceedingly limited and the method of increasing skin absorption needs special procedures. The micro-needle therapy is a method used to improve the absorption of drug (solution) in the skin which is called "natural skin rejuvenation therapy". This therapy uses micro-needle which is equipped with very thin, delicate needles smaller than a 0.07 mm thick hair. During this therapy, the micro-needle makes small holes and helps absorb the solution into the skin. This is a very excellent therapy in skin absorption. It can be used in wide regions of the skin without any side effects and no recovery time. In 2007, the micro-needle is permitted to personal care. However, the solutions have not yet been developed professionally, and such skill is needed.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 추계학술대회 논문집 Vol.21
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• pp.152-152
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• 2008

Micro probe with Ni-Co tip was designed. Unit processes for fabricating the micro probe were developed. We are investigated the micro probe tip using by Ni-Co alloy. One-step and three-step needle was fabricated by plating process, CMP, and photolithography process. The plating thickness was varied by current density and time. Futher data will be extract by different process conditions.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 추계학술대회 논문집
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• pp.207-208
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• 2006

• Journal of Acupuncture Research
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• 제29권4호
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• pp.81-91
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• 2012

Objectives : There are numerous methods in treating acne scar. On the contrary there are hardly any cases on treating acne scars through Korean medicine. By observing we compared how much acne scar was treated by scar regeneration acupuncture therapy and micro-needle therapy treatment through observing pre and post case photos, KAGS, KCADI and patient satisfaction. Results : By comparing pre and post procedure through acne scar grade criteria, total of 5 patients showed improvement and could see distinct change in skin comparing case photos. After comparing pre and post procedures, total of 5 patients showed improvements in figures of Korean acne index. 4 patients replied very satisfied and 1 replies satisfied on patient satisfaction survey. Conclusions : After observing patients satisfaction, and comparing case photos, acne scar grade criteria, korean acne index, it can be considered that scar regeneration acupuncture therapy and micro-needle therapy done in our clinic to be valid treatment.

• 전자공학회논문지SC
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• 제45권6호
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• pp.16-25
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• 2008

미세 탐침이란 프로브 카드(Probe Card)를 구성하는 초미세탐침을 의미한다. 이러한 미세 탐침은 그 크기가 상당히 미세하기 때문에 외관 이상 유무를 사람의 눈으로 검사하기가 상당히 어렵다. 반면, 프로브카드를 구성하는 미세 탐침의 이상 유무는 상당히 중요한 요소라고 볼 수 있다. 이에 본 연구에서는 사람의 눈으로 검사하기 어려운 미세 탐침의 불량 상태를 자동화된 비전 시스템으로 검사할 수 있는 방법을 개발하였다. 즉 탐침의 구부러진 각도, Tip Length, 종단 직경을 고속으로 자동 검사할 수 있는 비전 기술을 개발한 것이다 제안한 방법에 의한 실험결과, 사람의 육안에 위한 검사보다 검사의 정확도와 속도가 향상되었으며, 또한 조명환경에 대해서도 강건성(robustness)이 향상되었음을 알 수 있었다.