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Hair-growth Promoting Effect of Microneedle Roller Therapy  

Lee, Chang Hyun (Department of Anatomy, College of Korean Medicine, Woosuk University)
Lee, Ji Yeon (Division of Applied Medicine, School of Korean Medicine, Pusan National University)
Shin, Hyun Jong (Department of Pathology, College of Korean Medicine, Woosuk University)
Ha, Ki Tae (Division of Applied Medicine, School of Korean Medicine, Pusan National University)
Seo, Hyung Sik (Department of Ophthalmology, Otolaryngology and Dermatology, Korean Medicine Hospital of Pusan National University)
Jeong, Han Sol (Division of Applied Medicine, School of Korean Medicine, Pusan National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.28, no.1, 2014 , pp. 16-21 More about this Journal
Abstract
Micro needle roller therapy has been used for cosmetic purposes, such as reducing skin winkles and improving elasticity of skin. It is claimed that micro needle roller therapy has potentials for connective tissue regeneration by facilitating collagen synthesis. Therefore, there seems to be a possibility that connective tissue regenerating potential of micro needle roller therapy could influence the hair growth cycle. This study, we investigated the hair growth-promoting effects of micro needle roller therapy. C57BL/6 mice were devided into three groups as follows: normal saline-treated, minoxidil-treated, and micro needle roller therapy-received group. Hair growth activity was evaluated by handscopic and microscopic observations. Sections of dorsal skin were stained with hematoxylin and eosin. Expression of BrdU, FGF, and VEGF was detected by immunohistochemical staining. Micro needle roller therapy enhanced the development of hair follicle during anagen. Immunohistochemical analysis revealed that micro neeld roller therapy incresed the expression of BrdU and FGF in the hair follicles of C57BL/6 mice. Furthermore, micro needle roller therapy upregulated mRNA expression of VEGFR-2, FGF-2, EGF - growth factors that play a central role in hair follicle development during anagen. These results suggest that Micro needle roller therapy can potentially be used for the treatment of alopecia.
Keywords
Micro needle roller therapy; Hair follicle; Anagen; Alopecia;
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