• Vascular Specialist International
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• 제34권4호
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• pp.83-87
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• 2018

Purpose: Thrombosis of the portal vein, known as pylephlebitis, is a rare and fatal complication caused by intraperitoneal infections. The disease progression of superior mesenteric venous thrombosis (SMVT) is not severe. This study aimed to determine the clinical features, etiology, and prognosis of SMVT. Materials and Methods: We retrospectively reviewed the medical records of 41 patients with SMVT from March 2000 to February 2017. We obtained a list of 305 patients through the International Classification of Disease-9 code system and selected 41 patients with SMVT with computed tomography. Data from the medical records included patient demographics, comorbidities, review of system, laboratory results, clinical courses, and treatment modalities. Results: The causes of SMVT were found to be intraperitoneal inflammation in 27 patients (65.9%), malignancy in 7 patients (17.1%), and unknown in 7 patients (17.1%). Among the patients with intraperitoneal inflammation, 14 presented with appendicitis (51.9%), 7 with diverticulitis (25.9%), and 2 with ileus (7.4%). When comparing patients with and without small bowel resection, the differences in symptom duration, bowel enhancement and blood culture were significant (P=0.010, P=0.039, and P=0.028, respectively). Conclusion: SMVT, caused by intraperitoneal inflammation, unlike portal vein thrombosis including pylephlebitis, shows mild prognosis. In addition, rapid symptom progression and positive blood culture can be the prognostic factors related to extensive bowel resection. Use of appropriate antibiotics and understanding of disease progression can help improve the outcomes of patients with SMVT.

• 비교문화연구
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• 제51권
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• pp.103-131
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• 2018

본 연구는 한국의 대학교에서 유학하고 있는 외국인 유학생들의 동기에 대해서 조사하고자 한다. 질적연구방법과 혼합연구방법을 사용한 본 연구는 6개 과목의 학습 본질을 설명할 수 있는 학생 인터뷰, 에세이, 디지털 스토리텔링 비디오 및 학생 제작 동영상으로부터 얻은 데이터를 근거이론(grounded theory)을 통해 분석하였다. 모든 과목은 2014학년부터 2017학년까지 영어교육 과정에 등록되었다. 본 연구자는 이 과정의 교수자였다. 데이터 분석에서 나타난 주요 범주가 경제력, 문화, 언어학습 및 자기개발이었다는 것이 본 연구의 결과에서 나타났으며, 외국인 유학생의 동기에 관한 대부분의 연구문헌의 결과를 입증한다(OUSO, 2015). 그러나 본 연구와 문헌에서 제시된 동기의 범주가 본질적으로 담론적(discursive)이었다는 것을 전문 문헌과 연구 데이터의 조사가 보여주는데 그 이유는 각 범주가 다른 모든 범주와 연관되어 있을 뿐만 아니라 서로 상호구성주의적(co-constructive)이기 때문이다. 이와 같이 본 연구가 시사하는 바는 유학 관련 문헌에서 발견된 동기의 범주가 본질적으로 담론적이라는 것이며, 이는 부르디외의 경제, 사회 및 문화 자본론(1991)과 유사하다. 본 연구의 결과는 유학의 다양한 동기가 비용과 경력 개발이라는 경제 논리하에 존재한다는 것을 시사한다.

• 근관절건강학회지
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• 제26권1호
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• pp.15-26
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• 2019

Purpose: The purpose of this study was to develop a Dongsasub training applying aroma necklace for nursing students in clinical practicum, and to evaluate the training programs' effects on perceived stress, self-esteem, depression, and clinical competence of the participants. Methods: This study used a cluster-randomized controlled trial design. Participants were 56 nursing students taking clinical practicum courses (26 in the experimental group and 30 in the control group). The training program consisted of four sessions of Dongsasub training and wearing a necklace where a mixture of aroma oils attached. Participants in experimental group were given a necklace with essential oil mixture of lavender, bergamot, and geranium with the ratio of 1:1:1 for 2 weeks. The control group received no intervention. Outcome variables included perceived stress, self-esteem, depression, and clinical competence. Data were analyzed with Fisher's exact test, Chi-square, Independent t-test using the SPSS/WIN 21.0. Results: Independent t-test revealed that perceived stress (t=3.15, p=.003), depression (t=4.62, p<.001) were significantly lower in the experimental group than the control group; self-esteem (t=-3.03, p=.004), clinical competence (t=-2.15, p=.036) scored significantly greater than the control group. Conclusion: The results indicate that the Dongsasub training with application of the aroma necklace can be used as an effective nursing intervention for lowering perceived stress, depression and improving self-esteem, clinical competence of nursing students.

• 실천공학교육논문지
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• 제9권2호
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• pp.133-137
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• 2017

본 논문에서는 전기전자공학전공의 필수과목 중의 하나인 전기회로교과를 이러닝 컨텐츠로 개발하고 이를 실제 수업에 활용한 사례에 대한 연구 결과를 제시한다. 전기회로 이러닝 컨텐츠를 이론학습은 멀티미디어형을 기반으로 하였으며 실습부분은 동영상을 기반으로 하여 개발하였다. 이러닝 컨텐츠는 실제 오프라인 수업에 블랜디드 수업 형태로 활용하였다. 이러닝 컨텐츠의 구성요소별 학습효과에 대한 조사를 수행하였으며 전기회로에 적합한 이러닝 컨텐츠의 유형에 대한 조사 및 분석을 수행하였다. 또한 이러닝 컨텐츠를 오프라인 수업에 활용할 때 효과적인 활용방법에 대해 조사 분석하였다. 본 논문에서는 이와 같은 이러닝 컨텐츠의 사례조사를 통해 공학교육에 있어서 효과적인 컨텐츠의 회차구성, 회차당 길이 및 유형과 활용방법을 제시하였다.

• Perspectives in Nursing Science
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• 제16권1호
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• pp.1-11
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• 2019

Purpose: This study was conducted to identify the perceptions toward school forest programs related to forest welfare services in elementary schools and suggest strategies to activate new programs. Methods: A mixed method research was performed. Four teachers and one forest therapist participated in a focus group interview; 162 teachers answered a survey. Results: The teachers were aware of the effects of the forest program, but there were some barriers, including the question of whether there was an accessible forest, school forest management problems, the risk of teachers' work overload, and the lack of program diversification for elementary students. Solutions included the expansion of school forests and forest facilities available to students, development of a variety of programs, provision of appropriate information on available facilities, and cooperation with educational institutions for institutionalization and increased effectiveness of school-based forest utilization programs. In addition, a scientific basis for data accumulation is needed. Conclusion: The Ministry of Forestry is cooperating with the Ministry of Education and local education offices to activate a forest-use health promotion program for elementary school students. Additionally, to utilize the forests in regular education courses, teachers should strive to spread positive awareness of forests.

• Journal of Gastric Cancer
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• 제18권4호
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• pp.400-408
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• 2018

Purpose: This study aimed to evaluate immediate outcomes and clinical courses of patients with early gastric carcinoma with lymphoid stroma (GCLS) who underwent endoscopic resection. Materials and Methods: We retrospectively reviewed the medical records of 40 patients (mean age, 56.9 years; 90.0% male) who underwent endoscopic resection and were pathologically diagnosed with GCLS confined to the mucosa or to the submucosa between March 1998 and December 2017. Results: Forty GCLS lesions in 40 patients were treated using endoscopic resection. Only 4 (10%) patients received diagnosis of GCLS before endoscopic resection. Fourteen (35.0%) lesions were intramucosal cancers and 26 (65.0%) exhibited submucosal invasion. En bloc resection (97.5%) was achieved for all lesions except one, with no significant complications. The complete resection rate was 85.0% (34 of 40 lesions). After endoscopic resection, 17 patients were referred for surgery and underwent gastrectomy with lymph node (LN) dissection because of deep submucosal invasion (n=16) and misclassification as undifferentiated cancer (n=1). No LN metastasis was determined in the specimens obtained during surgery. During a mean follow-up period of 49.7 months for 23 patients without surgical treatment, no regional LN enlargements, distant metastases, or gastric cancer-related deaths were found, although 1 metachronous lesion (undifferentiated adenocarcinoma, follow-up duration: 7 months) was observed. Conclusions: In patients with early GCLS, endoscopic resection is technically feasible and has favorable clinical outcomes. Therefore, endoscopic resection might represent an alternative treatment modality in patients with early GCLS with a low likelihood of LN metastasis.

• 정보교육학회논문지
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• 제23권3호
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• pp.229-235
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• 2019

게이미피케이션은 수업에 게임의 요소나 게임을 접목함으로서 학생의 흥미도를 향상시키고, 직접 참여할 수 있는 환경을 조성함으로서 보다 뛰어난 학업성취도 향상을 도우며, 이와 같은 게이미피케이션을 인공지능이라는 IT기술에 융합함으로서 초등 과정을 대상으로 핵심원리를 학습할 수 있는 교육과정을 제안한다. 제안된 교육과정은 인공지능의 학습방법에 대해 보드 게임형식으로 학습함으로서 초등 과정의 피학습자에 수준에 맞추어 원리를 이해할 수 있도록 돕는다. 이와 같은 게임의 요소를 접목한 학습방법은 피학습자에게 IT원리를 학습할 수 있도록 함으로서 다양한 관점에서 대상을 이해하는 능력을 키우고, 컴퓨팅 사고력을 강화한다. 제안된 게이미피케이션을 접목한 초등 인공지능 교육과정은 최근 2015 교육과정에서부터 크게 부각되고 있는 정보과학 교육과정의 발전에 이바지 할 수 있을 것으로 예상된다.

• 의학교육논단
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• 제21권3호
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• pp.143-149
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• 2019

In 2018, The Ministry of Health and Welfare announced its first comprehensive plan for patient safety, which included the imperative to develop a patient safety curriculum for students studying to become health professionals. The aim of this study is to assess current patient safety education and points of consideration for introducing new curriculum. An online survey was used to understand the status of patient safety education in medical schools, and key informant interviews and focus group interviews were used to collect qualitative data on the experience of patient safety education. The results of the online survey from 16 out of 40 medical schools (40% response rate) and the qualitative data analysis were integrated and analyzed. Twelve schools (75%) had established courses related to patient safety. The qualitative responses suggest that patient safety education is appropriate both before and after clinical training through a variety of educational methods, and that the topics should be linked with clinical training. The challenge of securing lecture time to address patient safety was mentioned as a realistic obstacle. When patient safety education is integrated in future curriculum, it is necessary to consider it as a priority. Moreover, in the early stages of introducing patient safety education, a step-by-step, policy-based approach is required for seamless adoption and settlement.

• Clinical and Experimental Pediatrics
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• 제64권7호
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• pp.355-363
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• 2021

Background: Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity. Purpose: This study aimed to explore the molecular responses of podocytes to nephrotic plasma to identify specific genes and signaling pathways differentiating various clinical NS groups as well as biological processes that drive injury in normal podocytes. Methods: Transcriptome profiles from immortalized human podocyte cell line exposed to the plasma of 8 subjects (steroid-sensitive nephrotic syndrome [SSNS], n=4; steroid-resistant nephrotic syndrome [SRNS], n=2; and healthy adult individuals [control], n=2) were generated using microarray analysis. Results: Unsupervised hierarchical clustering of global gene expression data was broadly correlated with the clinical classification of NS. Differential gene expression (DGE) analysis of diseased groups (SSNS or SRNS) versus healthy controls identified 105 genes (58 up-regulated, 47 down-regulated) in SSNS and 139 genes (78 up-regulated, 61 down-regulated) in SRNS with 55 common to SSNS and SRNS, while the rest were unique (50 in SSNS, 84 genes in SRNS). Pathway analysis of the significant (P≤0.05, -1≤ log2 FC ≥1) differentially expressed genes identified the transforming growth factor-β and Janus kinase-signal transducer and activator of transcription pathways to be involved in both SSNS and SRNS. DGE analysis of SSNS versus SRNS identified 2,350 genes with values of P≤0.05, and a heatmap of corresponding expression values of these genes in each subject showed clear differences in SSNS and SRNS. Conclusion: Our study observations indicate that, although podocyte injury follows similar pathways in different clinical subgroups, the pathways are modulated differently as evidenced by the heatmap. Such transcriptome profiling with a larger cohort can stratify patients into intrinsic subtypes and provide insight into the molecular mechanisms of podocyte injury.

• Journal of Gastric Cancer
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• 제20권4호
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• pp.395-407
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• 2020

Purpose: A phase II study was conducted to evaluate the safety and efficacy of preoperative, intra-arterial perfusion of epirubicin, etoposide, and oxaliplatin combined with oral chemotherapy S-1 (SEEOX) for the treatment of type 4 gastric cancer. Materials and Methods: A single-center, single-arm phase II trial was conducted on 36 patients with histologically proven type 4 gastric cancer without distant peritoneal or organ metastasis. Patients received 3, 21-day courses of SEEOX preoperative chemotherapy. The primary endpoint was overall survival (OS) and the secondary outcomes assessed were chemotherapeutic response, radical resection rate, pathological regression, toxicities, postoperative morbidity, and mortality. Results: All patients were at an advanced stage of cancer (stage III or IV) and completed the entire course of treatment. Based on changes in tumor volume and peritoneal metastasis, the objective response rate was 55.6% (20/36; 95% confidence interval [CI], 38.5%-72.6%) and the disease control rate was 69.4% (25/36; 95% CI, 53.6%-85.3%). The radical resection rate was 75% (27/36; 95% CI, 60.1%-89.9%) and the proportion of R0 resections was 66.7% (21/36; 95% CI, 50.5%-82.8%). The pathological response rate was 33.3%, of which 13.9% showed complete pathological regression. The median survival was 27.1 months (95% CI, 22.24-31.97 months), and the 2-year OS was 48.5% (95% CI, 30.86%-66.1%). Conclusions: Preoperative SEEOX is a safe and effective treatment for type 4 gastric cancer. Based on these preliminary data, a phase III study will be conducted to confirm the superiority of this regimen over standard treatment.