• Korean Journal of Oriental Medicine
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• v.8 no.1
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• pp.109-126
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• 2002

The herbal extract (YMT_02) is a modified herbal extracts from Yukmijihwangtang (YMJ) to promote memory-enhancing. The YMJ extracts has been widely used as an anti-aging herbal medicine for hundred years in Asian countries. The purpose of this study is to; 1) quantitatively evaluate the memory-enhancing effect of YMT_02 by hehavior task, 2) identify candidate genes responsible for enhancing memory by cDNA microarray and 3) assess the anti-oxidant effect of YMT_02 on PC12 cell. Memory retention abilities are addressed by passive avoidance task with Sprague-Dawley (SD) male rat. Before the training session, the rats are subdivided into four groups and administrated with YMT_02, Ginkgo biloba, Soya lecithin and normal saline for 10 days. The retention test was performed. 24 hours after the training session. The retention time of the YMT_02 group was significantly (p<0.05) delayed $({\sim}100%)$, whereas Ginkgo biloba and Soya lecithin treatment delayed 20% and 10% respectively. The hippocampi of YMT_02 and control group were dissected and mRNA was further purified. After synthesizing cDNA using oligo-dT primer, the cDNA were applied and mRNA was further purified. After synthesizing cDNA using oligo-dT primer, the cDNA were applied to Incyte rat GEMTM 2 cDNA microarray. The microarray results show that prealbumin(transthyretin), phosphotidy lethanolamine N-methyltransferase, and PEP-19 are expressed abundantly in the YMT_02 treated group. Especially, PEP-19 is a neuron-specific protein, which inhibits apoptotic processes in neuronal cell. On the other hand, transcripts of RAB15, glutamate receptor subunit 2 and CDK 108 are abundant in control group. Besides, neuronal genes involved in neuronal death or neurodegeneration such as neuronal-pentraxin and spectrin are abundantly expressed in control group. Additionally, the YMT_02 shows an anti oxidative effect in the PC12 cell. The list of differentially expressed genes may implicate further insight on the action and mechanism behind the memory-enhancing effect of herbal extracts YMT_02, for example, anti-apoptotic, anti-oxidative, and neuroprotective effects.

• Proceedings of the KSR Conference
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• 2006.11b
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• pp.225-230
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• 2006

We have investigated mechanical behaviors of composite materials containing Ni-Ti shape memory alloy(SMA) wires by performing several experimental methods. In this study, several sample specimens were fabricated in order to perform photo-elasticity tests and impact tests under various test conditions for investigating the mechanical behaviors of the SMA composite materials. From the test results, the shape memory effect of SMA in composite materials can be considered as one of possible ways in controlling crack growth in the materials.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2003.06a
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• pp.256-261
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• 2003

A memory industry is developing rapidly according to the period of the ubiquitous to approach. According to the development of a memory industry, the efficiency of the manufacture is becoming the serious consideration. DC parameter test system was a development low in this research for an efficiency increase of the manufacture. DC parameter test system increase of the manufacture. In the method to measure the output after permit volt and current at element.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.5
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• pp.876-880
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• 2011

Gammakdaejo-Tang (GMT) is a traditional oriental medicinal formula, a mixture of 3 crude drugs, and it has been clinically used for treating mild depressive disorders. The purpose of the study was to examine the effect of Gammakdaejo-Tang (GMT) on repeated stress-induced alterations of learning and memory on a passive avoidance test (PAT) test and also the anxiety-related behavior on the elevated pulse maze (EPM) in ovariectomized female rats. We assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) in the hippocampus after behavioral testing. The rats were exposed to the immobilization (IMO) stress for 14 days (2hours/day), and Gammakdaejo-Tang (400 mg/kg, p.o.) was administered 30 min before IMO stress. Treatments with GMT caused significant reversals of the stress-induced deficits in learning and memory on a working memory test, and it also produced an anxiolytic-like effect on the EPM, and increased the ChAT reactivities (p<0.001, respectively). These results suggest that Gammakdaejo-Tang might prove to be an effective antidepressant agent.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.39 no.11
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• pp.44-52
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• 2002

Since memory technology has been developed fast, test complexity and test time have been increased simultaneously. In practice, March algorithms are used widely for detecting various faults. However, March algorithms cannot detect NPSFs(Neighborhood Pattern Sensitive Faults) which must be considered for DRAMs. This paper proposes an effective algorithm for high fault coverage by modifying the conventional March algorithms.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.2 s.332
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• pp.57-64
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• 2005

In this paper, we develop the common CAD tool that creates the automatically BIST IP by user settings for the convenient test of embedded memory. Previous tools have defect that when memory model is changed, BIST IP must re-designed depending on memory model because existing tools is limited the widely used algorithms. We develop the tool that is created automatic BIST IP. It applies the algorithm according to the memory model which user requests We usually use the multi-port asynchronous SRAM needless to refresh as the embedded memory. However, This work researches on the dual-port SRAM.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.5
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• pp.345-352
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• 2010

The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, $i.p.$) and intracerebroventricular streptozotocin (i.c.v STZ, 3 mg/kg, $10{\mu}l$, $1^{st}$ and $3^{rd}$ day) in separate groups of animals. Morris water-maze test was employed to assess learning and memory. The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative stress. Brain acetylcholinesterase enzyme (AChE) activity was also measured. Scopolamine/streptozotocin administration induced significant impairment of learning and memory in mice as indicated by marked decrease in Morris water-maze performance. Scopolamine/streptozotocin administration also produced a significant enhancement of brain AChE activity and brain oxidative stress (an increase in TBARS and a decrease in GSH) levels. Treatment of erythropoietin (500 and 1,000 IU/Kg i.p.) significantly reversed scopolamine- as well as streptozotocin-induced learning and memory deficits along with attenuation of those-induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that erythropoietin exerts a beneficial effect in memory deficits of mice possibly through its multiple actions including potential anti-oxidative effect.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.1
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• pp.36-45
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• 2002

This paper introduces the design and implementation of a flash memory simulator to emulate a real flash memory. Since this simulator provides exact execution time information and parameter testing functions as well as the type, total capacity, block size, and page size of flash memory, it can be used as a real flash memory as viewed by the operating system. Furthermore, the simulator provides time logging functions of the internal routines of the flash memory management software allowing the monitoring of bottlenecks within the software. Finally, we show the performance measurements of applications under the Linux operating systems on both the simulator and a test board verifying the simulator's use as a replacement for real flash memory.

• Natural Product Sciences
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• v.16 no.2
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• pp.93-98
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• 2010

The Chongmyung-tang (CMT) has been used as an oriental herbal medicine for the purpose of enhanced learning and memory. Recently, since fermentation may give a positive effect on pharmacological actions of herbal medicine, many studies are focused to find fermented medicinal herbs with improved bioactivity. In the present study, memory enhancing, antioxidant and reducing power activity of CMT and fermented CMT with Aspergillus oryzae (FCMT-A) or Saccharomyces cerevisiae (FCMT-S) were determined. To evaluate the memory enhancing activities of CMT, FCMT-A and FCMT-S, we performed passive avoidance test using scopolamine induced amnesia model. Administration of CMT, FCMT-A and FCMT-S showed a significant memory enhancing effect about 72.5, 78.3, 71.8% of the normal group respectively. CMT, FCMT-A and FCMT-S also exhibited strong $DPPH{\bullet}$, ${\bullet}{O_2}^-$, $NO^{\codt}$, $ABTS^{{\cdot}+}$ scavenging activities and reducing ower. It was also found that fermented CMT has slightly higher scavenging activities on $DPPH{\bullet}$, $ABTS^{{\cdot}+}$ radicals compared to CMT. These results revealed that CMT, FCMT-A and FCMT-S had memory enhancing and radical scavenging activities. In addition, the fermentation of CMT was more or less important for elevated memory enhancing and antioxidant activities of CMT.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.32 no.3
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• pp.477-486
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• 2022

This study aims to present a method using event sourcing patterns and blockchain as a way to cope with vulnerabilities in memory manipulation at the client level. To verify the plan, the method of running the memory operation application was analyzed, and the performance was compared and analyzed when the memory operation prevention plan was applied by fabricating a test application. As a result of the analysis, the usage of memory increased compared to the method of XOR operation by storing major data in one memory, but it was possible to prevent the operation of the memory operation program without significantly affecting the performance of the game.