• Biomolecules & Therapeutics
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• 제25권1호
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• pp.80-90
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• 2017

Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G protein-coupled receptors, $S1P_{1-5}$. The molecular identification of S1P receptors opened up a new avenue for pathophysiological research on this lipid mediator. Cellular and molecular in vitro studies and in vivo studies on gene deficient mice have elucidated cellular signaling pathways and the pathophysiological meanings of S1P receptors. Another unexpected finding that fingolimod (FTY720) modulates S1P receptors accelerated drug discovery in this field. Fingolimod was approved as a first-in-class, orally active drug for relapsing multiple sclerosis in 2010, and its applications in other disease conditions are currently under clinical trials. In addition, more selective S1P receptor modulators with better pharmacokinetic profiles and fewer side effects are under development. Some of them are being clinically tested in the contexts of multiple sclerosis and other autoimmune and inflammatory disorders, such as, psoriasis, Crohn's disease, ulcerative colitis, polymyositis, dermatomyositis, liver failure, renal failure, acute stroke, and transplant rejection. In this review, the authors discuss the state of the art regarding the status of drug discovery efforts targeting S1P receptors and place emphasis on potential clinical applications.

• 산업공학
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• 제24권3호
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• pp.231-240
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• 2011

Manufacturing enterprises have been doing their best endeavors to obtain competitiveness using various methodologies, such as information technology. In order to achieve competitiveness, they are adopting manufacturing execution system (MES). MES is a total management system that manages from the beginning of the production by product order until the quality inspection of the finished product. And MES is an inter-mediator for supplementation of information gap between ERP and inspection machine and equipment. This paper describes on establishment of effective strategy based on BPR methodology and implementation of MES small and medium PCB manufacturing company with multiple-types of products and mixed process flows. And then we proposed evaluation model based on balanced score card (BSC) for considering non-finance elements as well as finance elements. With evaluation model, we analyzed benefits and effects of MES.

• 한국생활과학회지
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• 제16권1호
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• pp.183-191
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• 2007

The purpose of this study was to measure the effect of nausea and learned food aversion on relationships linking food neophobia to appetite and food rejection. A total of 250 questionnaires were completed. Path analytic model was used measure the effect of mediator. Results of the study demonstrated that the path analytic result for the data also indicated excellent model fit. The influences of food neophobia on nausea and food rejection were statistically significant. The influences of nausea on learned food aversion and appetite were statistically significant. The influences of food neophobia on learned food aversion and appetite were not statistically significant. The influence of nausea on food rejection was not statistically significant. Moreover, nausea and aversion played a perfectly mediating roles in the relationship between food neophobia and appetite. Aversion also played no mediating role in the relationship between food neophobia and food rejection.

• 경영과학
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• 제29권2호
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• pp.1-20
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• 2012

While feeling anxious about the risk of exposure of personal information and privacy, users of microblogs and social network services are continuously using them. This study aims to develop a model to investigate this phenomenon. Specifically, this study explores the relationship between personal characteristics (represented by privacy concern and self-presentation) and an individual's self-disclosure. An individual's personal belief (represented by perceived risk and perceived trust) is also tested as an mediator between the relationship. Through a questionnaire survey to 183 twitter users in Korea, the results indicate that self-presentation has a direct influence on self-disclosure as well as an indirect influence through perceived trust. In contrast, privacy concern has not a direct but an indirect negative influence on self-disclosure through perceived risk. In conclusion, self-presentation has a stronger influence on self-disclosure then privacy concern to Twitter users. An individual who has a higher propensity for self-presentation will form a stronger perceived trust on Twitter, which in turn, affects the individual's self-disclosure. On the other hand, an individual who is more concerned with personal privacy will feel more serious about perceived risk, which in turn, negatively influences one's perception of the trust in Twitter as well as his desire for self-disclosure.

• 유통과학연구
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• 제11권5호
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• pp.25-31
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• 2013

Purpose - This study aims to determine the effects of marketing factors on the long-term purchasing behavior regarding industrial goods, using data from wholesalers and retailers. Research design, data, and methodology - We used multiple regression analysis and 3-step regressions to investigate causality. We used 177 questionnaires targeting wholesalers and retailers of industrial goods. Results - First, long-term purchasing behavior is positively related only with advertising and marketing factors. Second, the relationship between marketing factors and brand value show that the physical environment, word-of-mouth advertising, and publicity are positively related, except advertising and sales promotion, respectively. Third, brand value and long-term purchasing behavior are positively related. Finally, brand value is not a mediator between marketing factors and long-term purchasing behavior. Conclusion - This study suggests that industrial goods providers should use marketing strategies that are different from those used in the consumer market. Further, if they want to maintain long-term relationships, they should increase their brand value.

• 유통과학연구
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• 제18권2호
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• pp.5-15
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• 2020

Purpose : Today's retailers are integrating new VR technology into their new marketing strategies. Thus, this research aims to understand the role of virtual experiences in the circumstance of sales channels. Research design, data and methodology : Our model hypothesizes that five key factors determine the consumer experience of VR in the virtual retailing context: smartness, vividness, interactivity, playfulness, escape. Information access and flow are mediating variables that connect key drivers and VR satisfaction. Information access and flow then give influence to satisfaction towards VR. Satisfaction serves as a mediator that determines changes in consumer's dual intention: intention to revisit VR and intention to visit the real site. Results : According to the test results, every path except the relationship between information access and satisfaction of VR is accepted as expected at the significance level of 0.05. Conclusions : This research emphasizes the potential importance of VR and continue VR marketing research as an advent research area. Through the dual-path model, this study found that the primary function of VR is information access and flow experience. This result shows that most VR users value emotional benefits rather than rational benefits provided by VR. Finally, the satisfaction of VR can stimulate both the intention to use the VR and the intention to visit real mall.

• 산업경영시스템학회지
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• 제35권1호
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• pp.132-139
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• 2012

The purpose of this study is to examine the effects of transformational leadership and organizational citizenship behavior. It also investigated the mediating effect of self leadership on the causal relationship between transformational leadership and organizational citizenship behavior. Research results, transformational leadership had a positive affected on the self leadership, The self leadership had a positive affected on organizational citizenship behavior. And transformational leadership did not make a significant impact on organizational citizenship behavior. Finally, the self leadership was a full mediator on the relationships between the transformational leadership and the organizational citizenship behavior. Based on these findings, the implications and the limitations of the study were presented including some directions for future studies.

• 대한안전경영과학회지
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• 제20권2호
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• pp.45-53
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• 2018

The purpose of this study is to examine the mediating effect of the organizational trust, acceptance of organizational change on the relationship between job characteristics and organizational commitment. For this study, data were collected from convenient sample of 241 employees at small and medium enterprises in Ulsan city and Gyeongju city. All data collected from the survey were analyzed using with SPSS 18.0 and AMOS 18.0. This study reports findings as followed: 1. The relationship between the job characteristics and the organizational trust is positively related. 2. There was a positive correlation between the job characteristics and the acceptance of organizational change. 3. There was a positive correlation between the job characteristics and the organizational commitment. 4. The relationship between the organizational trust and the acceptance of organizational change is positively related. 5. There was a positive correlation between the organizational trust and the organizational commitment. 6. There was a positive correlation between the acceptance of organizational change and the organizational commitment. Finally, the organizational trust and acceptance of organizational change played as a partial mediator on the relationship between job characteristics and organizational commitment.

• 한국학교ㆍ지역보건교육학회지
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• 제14권1호
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• pp.37-47
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• 2013

Objectives: A descriptive correlational study was designed to examine the relationship of anger to psychosomatic symptoms. In addition, this study investigated the mediating effect of parental attachment in relation to anger and other variable. Methods: Data were collected from 112 subjects in grade 4 or 6, and descriptive statistics, Pearson correlation coefficient, and hierachical multiple regression were used with SPSS/PC 18.0 program to analyze the data. Results: There was a significantly positive effects between state-trait anger and psychosomatic symptoms. Father attachment negatively correlated state-trait anger and psychosomatic symptoms. Also, mother attachment negatively correlated state anger and psychosomatic symptoms. However, maternal attachment was not significantly associated with trait anger. Parental attachment had a significant mediating effect in relation to state-trait anger and psychosomatic symptoms. Conclusions: For the effective management of multi-cultural children's psychosomatic symptoms, programs including parental attachment increasing strategies should be established. These programs can increase parental attachment security which is mediator role between anger and psychosomatic symptoms.

• International Journal of Industrial Entomology and Biomaterials
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• 제35권1호
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• pp.39-44
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• 2017

The venome of Phoneutria nigriventer spider has been shown to have side effects including severe painful erections that last for hours. PnTx2-6, a toxin from P. nigriventer spider venom, modulates voltage gated $Na^+$ channels and activation of nitric oxide (NO) production. NO is essential for the regulation of blood flow and pressure. Therefore, PnTx2-6 is expected to be effective not only for erectile dysfunction but also for cardiovascular diseases. A previously has reported cDNA clone for PnTx2-6 toxin, which was expressed in E. coli cytoplasm. We created the same clone and expressed it in a bacterial expression system. PnTx2-6 increased the genes expression of superoxide dismutase 1, glutathione peroxidase 1, and sulfiredoxin 1. We hypothesized that recombinant PnTx2-6 may indirectly regulate blood flow and pressure, resulting in NO production in human umbilical vein endothelial cells (HUVEC). These data suggest differential regulation of the vascular ageing process, which may contribute to the anatomic heterogeneity of atherosclerosis. The results of this study may be used for the emergency treatment of sudden cardiovascular disease caused by ageing.