• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.8
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• pp.5042-5052
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• 2014

This study examined the mediator or moderator role of job embeddedness in the relationship between the nursing performance and turnover intention. Data was collected from 653 nurses in 3 tertiary hospitals, 2 secondary hospitals, and 3 small-medium sized hospitals in Daegu, and analyzed by descriptive statistics, Pearson's correlations, hierarchical multiple regression using the PASW 18.0 program and structural equation model (SEM) using the AMOS 18.0 program. The job embeddedness showed mediating effects between the nursing performance and turnover intention. On the other hand, job embeddedness did not have moderating effects. This study confirmed that job embeddedness had a mediating effect on the relationship between the nursing performance and turnover intention. Enhancing job embeddedness is required to promote nursing performance and reduce turnover intention.

• Human Ecology Research
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• v.56 no.2
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• pp.145-156
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• 2018

This study investigates the effects of over-parenting behavior and peer-alienation on adolescents' school adjustment and explores the mediating effects of smartphone dependency on the above relations. The subjects were 1,882 first grade students in middle school selected from the 7th year data of the 2010 Korea Children and Youth Panel Survey (2010 KCYPS). Data were analyzed by descriptive statistics, Pearson's correlation, structural equational models, and Sobel test with SPSS 21.0 and Amos 18.0. The findings were as follows. First, there was no significant difference in the school adjustment according to gender. However, boys were higher in the perception of over-parenting behavior and peer-alienation, and girls were higher in smartphone dependency. Second, peer-alienation and smartphone dependency had negative impacts on the school adjustment. But over-parenting behavior had no significant effect on school adjustment. Third, smartphone dependency played a mediator role between over-parenting behavior and peer-alienation as well as the school adjustment. Fourth, there were no significant differences between boys and girls in the relations among over-parenting behavior, peer-alienation, smartphone dependency and school adjustment. But there was a slight difference in influence. The findings of this study suggest that interventions on how to use smartphone correctly are important for improving adolescents' school adjustment. In addition, gender differences in school adjustment should be considered for a better understanding.

• Korean Journal of Social Welfare
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• v.60 no.3
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• pp.151-176
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• 2008

The purpose of this study is to see the effects of school climate on school violence and fears of attending school. The direct relationship between school climates and fears of attending school will be examined, as well as the indirect and mediated effects of school violence in that school climates influence the fears of attending school. A theoretical model of the relationships of school climates, school violence, and fears of attending school will be given. The subjects of the surveys were chosen from 12 junior high schools in the Seoul, Gyeonggi area through convenience sampling. 1,317 surveys were then analyzed. School climates directly affect the fear of going to school through the mediums of peer and teacher violence. The derived results stress the necessity of improving school climates in order to reduce violence from peers and teachers and to reduce fear of attending school.

• Safety and Health at Work
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• v.11 no.1
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• pp.88-96
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• 2020

Background: The current lack of the number of nurses and high nurse turnover rate leads to major problems for the health-care system in terms of cost, patient care ability, and quality of care. Theoretically, burnout may help link emotional labor with turnover intention. The purpose of this study was to investigate the mediating effect of burnout in the association between emotional labor and turnover intention in Korean clinical nurses. Methods: Using data collected from a sample of 606 nurses from six Korean hospitals, we conducted a multiple regression analysis to determine the relationships among clinical nurses' emotional labor, burnout, and turnover intention, looking at burnout as a mediator. Results: The results fully and partially support the mediating role of burnout in the relationship between the subfactors of emotional labor and turnover intention. In particular, burnout partially mediated the relationship between emotional disharmony and hurt, organizational surveillance and monitoring, and lack of a supportive and protective system in the organization. In addition, we found that burnout has a significant full mediation effect on the relationship between overload and conflicts in customer service and turnover intention. Although the mediating effect of burnout was significantly associated with the demands and regulation of emotions, no significant effects on turnover intention were found. Conclusion: To reduce nurses' turnover, we recommend developing strategies that target both burnout and emotional labor, given that burnout fully and partially mediated the effects of emotional labor on turnover intention, and emotional labor was directly associated with turnover intention.

• Journal of Microbiology and Biotechnology
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• v.18 no.11
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• pp.1862-1867
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• 2008

Streptochlorin is a small molecule isolated from marine Streptomyces sp. that is known to have antiangiogenic and anticancer properties. In this study, we examined the effects of this compound on reactive oxygen species (ROS) production and the association of these effects with apoptotic tumor cell death, using a human hepatocarcinoma Hep3B cell line. The results of this study demonstrated that streptochlorin mediates ROS production, and that this mediation is followed by a decrease in the mitochondrial membrane potential (MMP, ${\Delta}{\Psi}_m$), activation of caspase-3, and downregulation of antiapoptotic Bcl-2 protein. The quenching of ROS generation by N-acetyl-L-cysteine administration, a scavenger of ROS, reversed the streptochlorin-induced apoptosis effects via inhibition of ROS production, MMP collapse, and the subsequent activation of caspase-3. These observations clearly indicate that ROS are involved in the early molecular events in the streptochlorin-induced apoptotic pathway. Taken together, our data imply that streptochlorin-induced ROS is a key mediator of MMP collapse, which leads to the caspase-3 activation, culminating in apoptosis.

• The Journal of the Korea Contents Association
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• v.15 no.5
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• pp.507-514
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• 2015

There is an increasing awareness about the abusive supervision(AS) and organizational silence(OS) in organizations and literature about the relation between organizational commitment(OC). But there is a shortage of studies about the abusive supervision and organizational silence in travel service. The purpose of this study is to research reasons of abuse supervision in organizations, its effects, results and applications which can minimize or remove abusive supervision by discussion. In this sense, Questionnaires were delivered 9 travel agencies in Seoul and 241 of them were taken. Questionnaire data was analyzed, and according to the results, some implications were proposed. Abusive supervision affects on organizational silence and organizational commitment of employee in travel agent. Organizational silence ha positive effects on organizational commitment. Organizational silence plays as a role of mediator variable in proposal research model. It is hoped that the present research will encourage future multi-level theoretical and empirical work on abusive supervision.

• The Korean Journal of Physiology
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• v.30 no.1
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• pp.77-83
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• 1996

Platelet-activating factor(PAF) is a phospholipid mediator of pulmonary inflammation, and immunologic reaction. In this study, the role of PAF on tumor necrosis factor$(TNF_{-{\alpha}})$ production by rat alveolar macrophages(AM) was examined. When PAF $(10^{-12}{\sim}10{-16}\;M)$ alone was added to AM culture, $(TNF_{-{\alpha}})$ production was not significantly increased above the resting level. In contrast, the combined addition of PAF $(10^{-6}\;M)$ and muramyl dipeptide(MDP) $(1.0\;{\mu}g\ml)$ to AM cultures markedly enhanced $(TNF_{-{\alpha}})$ production with 8.2 fold increase compared with AM culture in resting state. This potentiative effect was 313% above the sum of the separate effects of PAF and MDP. To characterize MDP effects on $(TNF_{-{\alpha}})$ production, the dose-response of AM cultured with various concentrations of MDP was tested. High level of MDP $(10\;{\mu}g\ml)$ could not significantly enhance the potentiation effect on $(TNF_{-{\alpha}})$ production compared with AM cultures with low level of MDP $(0.1\;{\mu}g\ml)$, i.e. 112.5% vs 107.8%, respectively when $10^{-10}$ M of PAF was simultaneously added to the cell culture. These data support that the potentiation of TNF. g production in AM culture is mediated by PAF rather than MDf It was also evaluated whether the similar result was obtained in silica, respirable toxic particle-treated AM culture. $(TNF_{-{\alpha}})$ production was also significantly enhanced in the PAF $(10^{-6}\;M)$ and silica $(50\;{\mu}g\ml)$-added cell cultures with 4.7 fold above the value of silica alone-stimulated cells. These results indicate that PAF can potentiate $(TNF_{-{\alpha}})$ production by MDP-or silica- stimulated AM and suggest that PAF may play a potent role in lung inflammation and disease associated with microbe and occupational dust exposures.

• The Journal of the Korea Contents Association
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• v.15 no.10
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• pp.160-172
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• 2015

The purposes of this study was to examine the relationship between social capital of social welfare workers and organizational citizenship behavior, and investigate mediated effects of job satisfaction. For the research, social capital was consisted of trust, norms and networks. Survey were collected for 278 social workers in social welfare organization located in Kangwon-do. Regression analysis were conducted with SPSS program. Sobel Test was added in 3-stage multiple regression analysis of Baron and Kenny. Social capital made a positive effect on organizational citizenship behavior. In factors of social capital, trust and network made a significant effect on organizational citizenship behavior, but norms didn't show a significant effect on organizational citizenship behavior. As the results of verifying mediator effects of job satisfaction in the relationship between social capital and organizational citizenship behavior, social capital made a direct effect on organizational citizenship behavior of workers and indirect effect on it through the job satisfaction.

• Journal of Family Relations
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• v.22 no.3
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• pp.29-46
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• 2017

Objectives: The purpose of this study was to investigate a role of self-compassion in conflict resolution strategies among dating couples. Further, we examined conflict resolution strategies as mechanisms to explain in the relationship between self-compassion and relationship satisfaction. Method: Two hundred forty two dating couples were recruited. Actor and Partner Independence Model(APIM) was used to examine actor and partner effects of self-compassion on relationship satisfaction as well as conflict resolution strategies. The total of 4 APIMs, two positive conflict resolution strategies(i.e., positive emotional reactions, active coping) and two negative conflict resolution strategies(i.e., negative emotional reactions and hostility, avoidance) were analyzed. Positive conflict resolution strategies had only actor effect in the link between self-compassion and relationship satisfaction. That is, self-compassionate men and women were more likely to use positive conflict resolution strategies and, in turn, led to their higher relationship satisfaction. Both actor and partner effects were found in the negative conflict resolution strategy models. In terms of actor effect self-compassionate men and women were less likely to use negative conflict resolution strategies and that, in turn, led to their higher relationship satisfaction. In terms of partner effects we found that women's negative emotional reactions and hostility mediated the link between women's self-compassion and their male partners' relationship satisfaction. Men's avoidance mediated the link between men's self-compassion and their female partners' relationship satisfaction.

• Journal of Microbiology and Biotechnology
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• v.32 no.9
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• pp.1186-1194
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• 2022

The intake of probiotic lactic acid bacteria not only promotes digestion through the microbiome regulated host intestinal metabolism but also improves diseases such as irritable bowel syndrome and inflammatory bowel disease, and suppresses pathogenic harmful bacteria. This investigation aimed to evaluate the immunomodulatory effects in intestinal epithelial cells and to study the clinical efficacy of the selected the Bifidobacterium breve and Bifidobacterium longum groups. The physiological and biochemical properties were characterized, and immunomodulatory activity was measured against pathogenic bacteria. In order to find out the mechanism of inflammatory action of the eight viable and sonicated Bifidobacterium spp., we tried to confirm the changes in the pro-inflammatory cytokines (TNF-α, interleukin (IL)-6, IL-12) and anti-inflammatory cytokine (IL-10), and chemokines, (monocyte chemoattractant protein-1, IL-8) and inflammatory enzymatic mediator (nitric oxide) against Enterococcus faecalis ATCC 29212 infection in Caco-2 cells and RAW 264.7 cells. The clinical efficacy of the selected B. breve and B. longum group was studied as a probiotic adjuvant for acute diarrhea in children by oral administration. The results showed significant immunomodulatory effects on the expression levels of TNF-α, IL-6, IL-12, MCP-1, IL-8 and NO, in sonicated Bifidobacterium extracts and viable bifidobacteria. Moreover, each of the Bifidobacterium strains was found to react more specifically to different cytokines. However, treatment with sonicated Bifidobacterium extracts showed a more significant effect compared to treatment with the viable bacteria. We suggest that probiotics functions should be subdivided according to individual characteristics, and that personalized probiotics should be designed to address individual applications.