• Journal of the Korean BIBLIA Society for library and Information Science
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• v.32 no.1
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• pp.59-87
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• 2021

The purpose of this study is to investigate the influence of teacher-librarians' autonomy support on the school library users' satisfaction and continuance intention. Based on SDT(self-determination theory), it focuses on the mediating effect of BPN(basic psychological needs) between the autonomy supports and the satisfaction of the school library users. A survey was administered to 331 middle school students and the research model was examined by using regression analysis and Hayes' parallel multiple mediator model. The findings show that the teacher-librarians' support for autonomy directly and indirectly has a positive effect on the students' satisfaction with the school library, and perceived autonomy and competence among the sub-factors of basic psychological needs are found to have a significant mediating effect between the support of the librarian's autonomy and satisfaction with the school library. In addition, students' satisfaction with the school library shows a significant effect on the continuance intention. This study is meaningful in that it presents the role of teacher-librarians as a factor affecting students' motivation to use school libraries and provides implications for revitalizing school libraries.

• Journal of Convergence for Information Technology
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• v.12 no.4
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• pp.316-327
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• 2022

This study empirically analyzed the effects of beauty service training on customer orientation and job performance of beauty industry workers. First, as a result of the study, there were differences in service training, customer orientation, and job performance according to general characteristics, and service training showed significant differences in age, highest level of education, work experience, and number of employees, job performance in age, work experience, and number of employees, and job performance in age, academic background, work experience, and number of employees. Secondly, it was identified that service training makes a significant effect on customer orientation, the factor that makes the greatest effect on customer orientation among sub-factors of service training is educational content, and it can be seen that customer orientation increases when educational content, educational instructor, and educational environment are higher. Thirdly, it was identified that service training and customer orientation make a significant effect on job performance. hese research results show that the better the educational environment, instructor, and educational content of beauty industry workers, the higher the customer-oriented service, leading to the creation of loyal customers and can improve job performance as well.

• The Journal of the Korea Contents Association
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• v.22 no.4
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• pp.58-69
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• 2022

The purpose of this study is to find a way that companies can use social media trust effectively to increase brand trust and intelligently increase it by linking with brand authenticity. Therefore, the purpose of this study is as follows. First, a conceptual definition of the research variables of trust in social media, trust in information sources, and trust in messages is established, Second, the casual relationship between two conceptually defined independent variables and mediator variables of perceived risk and self-efficacy was verified. Third, the casual relationship was verified on whether it affects brand authenticity and brand trust through perceived risk and self-efficacy, which are mediators of social media trust. Fourth, through the verification result of the casual relationship between the research variables constituting the research model of this study, it was intended to present academic and practical implications on how social media trust can effectively enhance brand trust.

• Korean Journal of Culture and Social Issue
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• v.26 no.3
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• pp.167-194
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• 2020

In this study, we tested the hypothesis that a woman who claims sexual assault would be evaluated more negatively, and the suspected man would be judged more leniently, when the woman is agentic. In addition, we expected that this phenomenon would occur because the agentic accuser does not conform to the 'sexual crime victim' stereotype or feminine norms, and considered these as mediator variables. We also postulated that male (vs. female) participants would have a less positive regard of the agentic accuser and tested participant gender's moderating effects. Contrary to our hypothesis, participants criticized the agentic (vs. non-agentic) woman who claims sexual assault less and perceived her more positively and truthfully, and more likely to judged the suspected man to be guilty and recommended longer sentences. However, we observed the expected moderating effects of participant gender, so that male (vs. female) participants evaluated the agentic accuser more negatively. Mediation analyses yielded results on perceived truthfulness that were consistent with our hypothesis: Participants thought of agentic accuser as less feminine, which predicted less perceived truthfulness. Also, the less the agentic accuser was perceived to be feminine, male participants blamed her more while female participants had more positive impressions of her.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.405-418
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• 2022

Simotang oral liquid (SMT) is a traditional Chinese medicine (TCM) consisting of four natural plants and is used to alleviate gastrointestinal side effects after chemotherapy and functional dyspepsia (FD). However, the mechanism by which SMT helps cure these gastrointestinal diseases is still unknown. Here, we discovered that SMT could alleviate gastrointestinal side effects after chemotherapy by altering gut microbiota. C57BL/6J mice were treated with cisplatin (DDP) and SMT, and biological samples were collected. Pathological changes in the small intestine were observed, and the intestinal injury score was assessed. The expression levels of the inflammatory factors IL-1β and IL-6 and the adhesive factors Occludin and ZO-1 in mouse blood or small intestine tissue were also detected. Moreover, the gut microbiota was analyzed by high-throughput sequencing of 16S rRNA amplicons. SMT was found to effectively reduce gastrointestinal mucositis after DDP injection, which lowered inflammation and tightened the intestinal epithelial cells. Gut microbiota analysis showed that the abundance of the anti-inflammatory microbiota was downregulated and that the inflammatory microbiota was upregulated in DDP-treated mice. SMT upregulated anti-inflammatory and anticancer microbiota abundance, while the inflammatory microbiota was downregulated. An antibiotic cocktail (ABX) was also used to delete mice gut microbiota to test the importance of gut microbiota, and we found that SMT could not alleviate gastrointestinal mucositis after DDP injection, showing that gut microbiota might be an important mediator of SMT treatment. Our study provides evidence that SMT might moderate gastrointestinal mucositis after chemotherapy by altering gut microbiota.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.264-274
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• 2021

This study aims to analyze the impact of well-being tourism motivation on quality of life through well-being tourism satisfaction, focusing on wellness mediated effects. Recently, despite the growing number of well-being tourism pursuing wellness, the lack of research has led to a close analysis of the impact of well-being tourism motivation on quality of life through well-being tourism satisfaction. For this study, a total of 236 people who have experienced well-being tours in the metropolitan area were surveyed from May 10 to May 21, 2021. First, well-being tourism motivation has a positive effect on well-being tourism satisfaction. Second, well-being tourism satisfaction has a positive impact on the quality of life. Third, Wellness has a positive indirect effect as a partial mediator between well-being tourism satisfaction and quality of life The implications of this study are to demonstrate the impact of well-being tourism on quality of life using Wellness' mediators This study suggests that wellness tourism plays an important role in improving the quality of life. It was analyzed that well-being tourism had a positive effect on improving the quality of life at a time when the fatigue of daily life was increased due to prolonged COVID-19. In addition, Wellis analyzed that it is an important factor in enhancing the quality of life for well-being tourists. This contributes not only to the academic contribution to the revitalization of well-being tourism, but also to the development of stress improvement routes to improve people's lives nationally.

• Journal of Life Science
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• v.32 no.10
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• pp.771-777
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• 2022

Dopaminergic (DA) cell death in Parkinson's disease (PD) has been attributed to multiple, distinct genetic and environmental factors. In rare familial PD loss of parkin function mutations play a key role in nigral DA neuron-specific pathogenesis primarily via endoplasmic reticulum (ER) stress. In more prevalent sporadic PD, environmental exposure to pesticides has a significant epidemiological role. However, it is largely unknown how environmental exposure to xenobiotics is etiologically linked with the known etiology in familial PD. In the present study biochemical evidence for a common pathogenic mechanism between sporadic and familial PD has been identified employing the recently characterized mesencephalic DA cell line, N27-A. Dieldrin, an organochlorine pesticide epidemiologically implicated in sporadic PD, induced the markers of ER stress response such as a chaperone BiP/Grp78, heme oxygenase-1 and especially, parkin. Accordingly, dieldrin activated the ER resident Caspase-12, a mediator of ER stress-specific apoptosis, during cell death of N27-A cells. Of great interest the dieldrin-induced DA neuronal cell death was synergistically rescued by the overexpression of ER resident neuroprotective proteins, parkin and Bcl-2. The present findings implicate that accumulation of ER stress could be one of common pathogenic mechanisms in idiopathic and familial PD, and some ER proteins, such as parkin and Bcl-2 may effectively attenuate ER stress-mediated N27-A DA cell death.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.544-560
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• 2022

In order to verify the effect of job-esteem attitude on the empowerment of social service workers on service orientation, this study conducted a questionnaire survey on manpower providing local autonomous social service investment projects in Chungcheongbuk-do through analyzing 329 copies of data. The main research results show that, work performance relationship and personal work orientation have a significant effect on job esteem among the sub-factors of empowerment, it was found that the work environment control had a significant effect on all of the service-oriented sub-factors (trust-oriented, sincerity-oriented, and type-oriented). In addition, personal work-oriented empowerment was found to have a significant effect on sincerity-oriented and type-oriented among the service-oriented sub-factors, and it was confirmed that the empowerment of social service workers had a positive effect on service orientation through employee appreciation as a medium. It was confirmed that job-esteem, which is a mediator, affects sincerity and type orientation, which are sub-variables of service orientation. In order to improve the service orientation of social service workers, it is necessary to develop a manual for a clear understanding of their work and to provide continuous and practical maintenance education so workers can develop their own abilities.

• BMB Reports
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• v.54 no.5
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• pp.266-271
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• 2021

Estrogen-related receptor γ (ERRγ), a member of the orphan nuclear receptor family, is a key mediator in cellular metabolic processes and energy homeostasis. Therefore, ERRγ has become an attractive target for treating diverse metabolic disorders. We recently reported that ERRγ acts as a negative regulator of osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand (RANKL). In the present study, we explored the effects of an ERRγ-specific modulator, GSK5182, on ERRγ-regulated osteoclast differentiation and survival. Interestingly, GSK5182 increased ERRγ protein levels much as does GSK4716, which is an ERRγ agonist. GSK5182 inhibited osteoclast generation from bone-marrow-derived macrophages without affecting cytotoxicity. GSK5182 also attenuated RANKL-mediated expression of cFos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), pivotal transcription factors for osteoclastogenesis. Arrested osteoclast differentiation was associated with reduced RANK expression, but not with the M-CSF receptor, c-Fms. GSK5182 strongly blocked the phosphorylation of IκBα, c-Jun N-terminal kinase, and extracellular signal-regulated kinase in response to RANKL. GSK5182 also suppressed NF-κB promoter activity in a dose-dependent manner. In addition to osteoclastogenesis, GSK5182 accelerated osteoclast apoptosis by caspase-3 activation. Together, these results suggest that GSK5182, a synthetic ERRγ modulator, may have potential in treating disorders related to bone resorption.

• Korean Journal of Biological Psychiatry
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• v.28 no.1
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• pp.13-22
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• 2021

Objectives Despite growing attention to anxiety in bipolar disorder (BD), little research has assessed anxiety symptoms in the course of BD. The current prospective follow-up study examines the influence of subjectively and objectively measured anxiety symptoms on the course of BD. Methods A total of 49 patients with BD were followed-up prospectively for average of one year at an average of four months interval. The Korean version of the Beck Anxiety Inventory (K-BAI), the Hamilton Anxiety Rating Scale, heart rate variability (HRV) were used to measure anxiety subjectively, objectively and physiologically. Participants were divided into high and low anxiety groups based on their K-BAI scores. Kaplan-Meier survival analysis was performed to compare the recurrence of mood episode, suicide attempt, emergency room visit, and psychiatric hospitalization between two groups. Mediators were investigated with Cox proportional hazards models. Results Compared to the low anxiety group, the high anxiety group reported significantly higher impulsiveness (p = 0.016) and lower high frequency component on HRV (p = 0.007) after controlling for severity of BD. Regarding survival analysis, the high anxiety group showed hastened depressive episode recurrence (p = 0.048) and suicidal ideation was the mediator of the hazard ratio (HR) 1.089 (p = 0.029) in the Cox model. Moreover, the high anxiety group showed a tendency of accelerated suicide attempt (p = 0.12) and impulsivity was the risk factor of suicide attempt (HR = 1.089, p = 0.036). Conclusions This interim analysis of prospective study suggests that high anxiety level in BD may anticipate unfavorable course. Further studies are needed to understand the multifactorial mechanism of anxious bipolar patients.