The estrogen-related receptor γ modulator, GSK5182, inhibits osteoclast differentiation and accelerates osteoclast apoptosis |
Kim, Hyun-Ju
(Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Korea Mouse Phenotyping Center, KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University)
Yoon, Hye-Jin (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Korea Mouse Phenotyping Center, KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University) Lee, Dong-Kyo (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Korea Mouse Phenotyping Center, KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University) Jin, Xian (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Korea Mouse Phenotyping Center, KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University) Che, Xiangguo (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Korea Mouse Phenotyping Center, KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University) Choi, Je-Yong (Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Korea Mouse Phenotyping Center, KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University) |
1 | Cardelli M, Zirngibl RA, Boetto JF et al (2013) Cartilage-specific overexpression of ERRgamma results in Chondrodysplasia and reduced chondrocyte proliferation. PLoS One 8, e81511 DOI |
2 | Jeong BC, Lee YS, Park YY et al (2009) The orphan nuclear receptor estrogen receptor-related receptor gamma negatively regulates BMP2-induced osteoblast differentiation and bone formation. J Biol Chem 284, 14211-14218 DOI |
3 | Kim HJ, Kim BK, Ohk B et al (2019) Estrogen-related receptor gamma negatively regulates osteoclastogenesis and protects against inflammatory bone loss. J Cell Physiol 234, 1659-1670 DOI |
4 | Kim DK, Kim JR, Koh M et al (2011) Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling. J Biol Chem 286, 38035-38042 DOI |
5 | Kim DK, Ryu D, Koh M et al (2012) Orphan nuclear receptor estrogen-related receptor gamma (ERRgamma) is key regulator of hepatic gluconeogenesis. J Biol Chem 287, 21628-21639 DOI |
6 | Bianco S, Lanvin O, Tribollet V, Macari C, North S and Vanacker JM (2009) Modulating estrogen receptor-related receptor-alpha activity inhibits cell proliferation. J Biol Chem 284, 23286-23292 DOI |
7 | Wang ZQ, Ovitt C, Grigoriadis AE, Mohle-Steinlein U, Ruther U and Wagner EF (1992) Bone and haematopoietic defects in mice lacking c-fos. Nature 360, 741-745 DOI |
8 | Jung YK, Han SW, Kim GW, Jeong JH, Kim HJ and Choi JY (2012) DICAM inhibits osteoclast differentiation through attenuation of the integrin alphaVbeta3 pathway. J Bone Miner Res 27, 2024-2034 DOI |
9 | Teitelbaum SL (2000) Bone resorption by osteoclasts. Science 289, 1504-1508 DOI |
10 | Tsukasaki M and Takayanagi H (2019) Osteoimmunology: evolving concepts in bone-immune interactions in health and disease. Nat Rev Immunol 19, 626-642 DOI |
11 | Lacey DL, Timms E, Tan HL et al (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165-176 DOI |
12 | Kim DK, Gang GT, Ryu D et al (2013) Inverse agonist of nuclear receptor ERRgamma mediates antidiabetic effect through inhibition of hepatic gluconeogenesis. Diabetes 62, 3093-3102 DOI |
13 | Boyle WJ, Simonet WS and Lacey DL (2003) Osteoclast differentiation and activation. Nature 423, 337-342 DOI |
14 | Kim DK, Jeong JH, Lee JM et al (2014) Inverse agonist of estrogen-related receptor gamma controls Salmonella typhimurium infection by modulating host iron homeostasis. Nat Med 20, 419-424 DOI |
15 | Johnson RS, Spiegelman BM and Papaioannou V (1992) Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71, 577-586 DOI |
16 | Wong BR, Rho J, Arron J et al (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem 272, 25190-25194 DOI |
17 | Lee ZH and Kim HH (2003) Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts. Biochem Biophys Res Commun 305, 211-214 DOI |
18 | Park JH, Lee NK and Lee SY (2017) Current understanding of RANK signaling in osteoclast differentiation and maturation. Mol Cells 40, 706-713 DOI |
19 | Kim JH and Kim N (2014) Regulation of NFATc1 in osteoclast differentiation. J Bone Metab 21, 233-241 DOI |
20 | Nakashima T, Hayashi M and Takayanagi H (2012) New insights into osteoclastogenic signaling mechanisms. Trends Endocrinol Metab 23, 582-590 DOI |
21 | Giguere V, Yang N, Segui P and Evans RM (1988) Identification of a new class of steroid hormone receptors. Nature 331, 91-94 DOI |
22 | Hong H, Yang L and Stallcup MR (1999) Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem 274, 22618-22626 DOI |
23 | Chao EY, Collins JL, Gaillard S et al (2006) Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett 16, 821-824 DOI |
24 | Son YO, Park S, Kwak JS et al (2017) Estrogen-related receptor gamma causes osteoarthritis by upregulating extracellular matrix-degrading enzymes. Nat Commun 8, 2133 DOI |
25 | Vernier M, Dufour CR, McGuirk S et al (2020) Estrogenrelated receptors are targetable ROS sensors. Genes Dev 34, 544-559 DOI |
26 | Cardelli M and Aubin JE (2014) ERRgamma is not required for skeletal development but is a RUNX2-dependent negative regulator of postnatal bone formation in male mice. PLoS One 9, e109592 DOI |
27 | Takayanagi H, Kim S, Koga T et al (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3, 889-901 DOI |
28 | Kim JH, Choi YK, Do JY et al (2015) Estrogen-related receptor gamma plays a key role in vascular calcification through the upregulation of BMP2 expression. Arterioscler Thromb Vasc Biol 35, 2384-2390 DOI |
29 | Kong YY, Yoshida H, Sarosi I et al (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397, 315-323 DOI |
30 | Yasuda H, Shima N, Nakagawa N et al (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A 95, 3597-3602 DOI |
31 | Giguere V (2008) Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev 29, 677-696 DOI |
32 | Asagiri M, Sato K, Usami T et al (2005) Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med 202, 1261-1269 DOI |
33 | Franzoso G, Carlson L, Xing L et al (1997) Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev 11, 3482-3496 DOI |
34 | Iotsova V, Caamano J, Loy J, Yang Y, Lewin A and Bravo R (1997) Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 3, 1285-1289 DOI |
35 | Kim HJ, Lee DK, Jin X, Che X and Choi JY (2020) Oleoylethanolamide exhibits GPR119-dependent inhibition of osteoclast function and GPR119-independent promotion of osteoclast apoptosis. Mol Cells 43, 340-349 DOI |
36 | Takeshita S, Kaji K and Kudo A (2000) Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res 15, 1477-1488 DOI |
37 | Misra J, Kim DK and Choi HS (2017) ERRgamma: a junior orphan with a senior role in metabolism. Trends Endocrinol Metab 28, 261-272 DOI |