• Journal of Microbiology and Biotechnology
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• v.32 no.12
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• pp.1506-1514
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• 2022

Allergic contact dermatitis (ACD) is an allergen-specific T-cell-mediated inflammatory response, albeit with unclear pathogenesis. Exosomes are nanoscale extracellular vesicles secreted by several cell types and widely distributed in various biological fluids. Exosomes affect the occurrence and development of ACD through immunoregulation among other ways. Nevertheless, the role of exosomes in ACD warrants further clarification. This review examines the progress of research into exosomes and their involvement in the pathogenesis, diagnosis, and treatment of ACD and provides ideas for exploring new diagnostic and treatment methods for this disease.

• Tuberculosis and Respiratory Diseases
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• v.41 no.2
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• pp.73-86
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• 1994

In addition to classic cholinergic and adrenergic pathways, the existence of a third division of autonomic control in the human airways has been proved. It is called a nonadrenergic noncholinergic(NANC) nervous system, and difficult to study in the absence of specific blockers. Neuropeptides are certainly suggested to be transmitters of this NANC nervous system. It is very frustrating to understand the pathophysiologic role of these peptides in the absence of any specific antagonists. However, further studies of neuropeptides might eventually lead to novel forms of treatment for bronchial asthma. Another study of the interaction between different components of the autonomic nervous system, either in ganglionic neurotransmission or by presynaptic modulation of neurotransmitters at the end-organ will elute neural control in airway disease, particularly in asthma. Studies of how autonomic control may be disordered in airway disease should lead to improvements in clinical management. Epithelial damage due to airway inflammation in asthma may induce bronchial hyperresponsiveness. Axon reflex mechanism is one of possible mechanisms in bronchial hyperresponsiveness. Epithelial damage may expose sensory nerve terminals and C-fiber nrve endings are stimulated by inflammatory mediators. Bi-directional communication between the nerves and mast cells may have important roles in allergic process. The psychological factors and conditioning of allergic reactions is suggested that mast cell activation might be partly regulated by the central nervous system via the peripheral nerves. Studies in animal models, in huamn airways in vitro and in patients with airway disease will uncover the interaction between allergic disease processes and psychologic factors or neural mechainsms.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.1
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• pp.1-10
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• 2013

We can understand "Shanghanlun(傷寒論)" and "Wenbingtiaobian(溫病條辨)" which are major books on externally contracted diseases well by making a comparative study of their similarities and differences. After studying etiological causes and characteristics of disease, disease pattern, syndrome differentiation, transmutation rules, following conclusions are derived. While cold is an etiological cause of Cold damage and harms Yang qi, heat is an etiological cause of Warm disease and harms Yin qi. Cold damage and Warm disease have something in common in the respect of damage to fluid and humor and Yang qi. Exuberant heat symptom of Yang brightness disease and lesser yin heat transformation pattern have similar damage to fluid and humor as Warm disease does. Warm disease can reach qi collapse syndrome through damage to Yang qi following fluid and humor damage. In the respect of water qi, as Cold damage makes water-dampness retain easily due to cold congealing, dampness-draining diuretic medicinal and warm yang medicinal are used together. As warm disease damages fluid and humor, yin-tonifying medicinal is used and dampness-draining diuretic medicinal can be used in the case of Warm disease with dampness. In the respect of disease pattern, cold syndromes arise mostly by Cold damage except heat syndrome of grater yang disease, chest bind syndrome, stuffiness syndrome, reverting yin disease and yang brightness disease. Warm disease is classified as pure heat syndrome and heat syndrome with bowel excess, damage to yin, qi collapse or damage to blood.

• Herbal Formula Science
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• v.9 no.1
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• pp.11-34
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• 2001

1. Crinical applicational of Sagoonjatang are frequently used in internal disease, G.I.T(Gastro Intestianl Tract) disease, chronical fatigue, athma, etc. 2. Sagoonjatang adjacent prescriptions in pathological organs are the stomach, the spleen, the kidneys, the heart, the lungs. 3. Sagoonjatang partake chronic fatigue disease, G.I.T disease, pulmonary disease, brain blood barrier disease, infertility, vomiting of pregnancy, sedation of brain, healing mechanism, sweating regulation, urination, peripheral blood ciraculation, electrolyte blance, etc.

• The Journal of Korean Medical History
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• v.24 no.1
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• pp.73-96
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• 2011

The BianMaiFa chapter, which is the first chapter of SongBon ShangHanLun, is the scholarly description(專論) of the pulse and pathological mechanism but has not been studied and published yet. This study is about article 11-23 which is the second part of The BianMaiFa chapter. We compared the original texts within the editions, comparing and analyzing the annotations of successive dynastic medical group. The articles of The SongBon ShangHanLun BianMaiFa chapter 11-23 is consisted as is shown: article 11 12 13 state about a dignosis of yin-yang, deficiency-excess, fluid-humor from difference of a pulse shape and a sign of recovery from a disease, article 14 states about a prognosis of a disease according to a pulse, article 15 states about a pulse from which we predict a recovery, article 16 states about normal pulse according to season, article 17 states about ups and downs of a disease according to yin-yang of day and night, article 18 states about a location of a disease in connection with a pulse, article 19 states about a pathological mechanism of a diarrhea through a anterior tibial pulse(趺陽脈), a lesser yin pulse(少陰脈), article 20 states about a cause of disease, a symptom, a therapy about a floating and tight pulse(浮緊脈), article 21 states about a pathological mechanism of symptoms through a anterior tibial pulse(趺陽脈), article 22 states about a pulse, a pathological mechanism, symptoms caused by erroneous treatment, article 23 states about a pulse, a symptom, a therapy with internal heat. The BianMaiFa chapter 11-23 discussed a diagnosis, a prognosis of a disease, understanding of pathological mechanism through pulse. And The BianMaiFa suggests a various use of pulse.

• Journal of Sasang Constitutional Medicine
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• v.16 no.2
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• pp.44-51
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• 2004

1. Objectives This paper is written for clear understanding on the concepts of 'Deep adherence of the Nature' and 'Sudden explosion of the Emotion' and for intensive comprehension of Mechanism of 'The Exterior Disease' and 'The Interior Disease' by The Nature and the Emotion. 2. Methods The study mainly based on "The exterior disease injured by the Nature, the interior disease injured by the Emotion" and deals with 'Seongmyungron, Sadanron, Hwarkchungron and Jangburon'. 3. Results and conclusions The conclusions as follows (1) Exterior Disease in each constitution breaks out by deep adherence of the Nature. Interior Disease brings out with sudden explosion of the Emotion. (2) 'Deep adherence of the Nature' is the state that the Ear, Eye, Nose, Mouth taking care of environmental frames can't work enoughly because of wrong minds on the Jaw, Breast, Umbilicus, Abdment. 'Sudden explosion of the Emotion' is the state that the Lung, Spleen, Liver, Kidney doing human affairs doesn't do appropriately for each constitution due to negative minds on the Head, Shoulder, Waist, Hip. (3) The result that the Ear, Eye, Nose, Mouth doesn't extract the clear energy from 'Jin, Go, You, Yaek sea' so they are lack of 'Shin, Qi, Hyul, Jeong' causes exterior disease in each constitution. (4) In each constitution, Interior disease results from that the Lung, Spleen, Liver, Kidney fails to bring on the clear juice from 'Lee, Mak, Hyul, Jeong sea', so shortage of 'Jin, go, You, Yaek' results in it.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.5
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• pp.606-612
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• 2005

This study was performed to provide basic data that predict the application of Saengmaegsan(SMS) as medicinal food. SMS has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. We examined the effects of SMS on physiological function in isolated abdominal aorta and femoral artery from rabbit and measured the changes of regional cerebral hood flow(rCBF), which was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Spargue-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The contraction forces by injection of norephinephrine in isolated abdominal aorta and femoral artery were significantly decreased in each concentration of SMS treatment compared with control. rCBF was increased by SMS in a dose-dependent manner. These results suggest that SMS causes a diverse response of rCBF and arterial diameter. These mechanism in rCBF increase may be mediated by prostaglandis, cyclic GMP and adrenergic $\beta-receptor$. Also mechanism in artery contraction decrease is also mediated by prostaglandis and cyclic GMP. These results indicate that SMS can be nsed as a safe and clinically applicable as a supplementation of diet therapy for cerebral cardiovascular disease patients.

• Journal of Plant Biotechnology
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• v.32 no.2
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• pp.73-83
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• 2005

Disease resistance in plants is often controlled by gene-for-gene mechanism in which avirulence (avr) gene products encoding by pathogens are specifically recognized, either directly or indirectly by plant disease resistance (R) gene products and sequential signal transduction pathways activating defense responses are rapidly triggered. As a results, not only exhibit a resistance against invading pathogens but also plants maintain the systemic acquired resistance (SAR) to various other pathogens. This molecular interaction between pathogen and plant is commonly compared to innate immune system of animal. Recent studies arising from molecular characterization of a number of R genes from various plant species that confer resistance to different pathogens and corresponding avr genes from various pathogens resulted in the accumulation of a wealth of knowledge on molecular mechanism of gene-for-gene interaction. Furthermore, new technologies of genomics and proteomics make it possible to monitor the genome-wide gene regulation and protein modification during activation of disease resistance, expanding our ability to understand the plant immune response and develop new crops resistant to biotic stress.

• Journal of Sasang Constitutional Medicine
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• v.23 no.1
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• pp.44-52
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• 2011

1. Objectives: This research was proposed to find out how the recognition on Mangeum-syndrome(亡陰證) of Soyangin in Sasang Constitutional Medicine(SCM) evolved from "Donguisusebowon-GabObon(東醫壽世保元甲午本)"(DGO) to "Donguisusebowon-ShinChukbon(東醫壽世保元辛丑本)"(DSC). 2. Methods: We compared "Donguisusebowon-GabObon(東醫壽世保元甲午本)"(DGO) with "Donguisusebowon-ShinChukbon(東醫壽世保元辛丑本)"(DSC) to know how the symptom, mechanism, treatment principle and treatment methods on Mangeum-syndrome(亡陰證) of Soyangin in Sasang Constitutional Medicine(SCM). 3. Results and Conclusions: (1) The way to categorize the Exterior Disease and Interior Disease was different between DSC and DGO. (2) There was only a fundamental mechanism about the Boktongseolsa-syndrome(gastralgia and diarrhea) and no treatment principles and treatment methods about it in DGO. But the Boktongseolsa-syndrome was evolved into Mangeum-syndrome(亡陰證) in DSC with a detailed mechanism and treatment principles of it. (3) The evolution of Mangeum-syndrome(亡陰證) in DSC from Boktongseolsa-syndrome in DGO was attributed to the experience of treatment on Seomeo-syndrome(譫語證).

• BMB Reports
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• v.48 no.1
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• pp.13-18
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• 2015

Alzheimer's disease severely compromises cognitive function. One of the mechanisms to explain the pathology of Alzheimer's disease has been the hypotheses of amyloid-pore/channel formation by complex $A{\beta}$-aggregates. Clinical studies suggested the moderate alcohol consumption can reduces probability developing neurodegenerative pathologies. A recent report explored the ability of ethanol to disrupt the generation of complex $A{\beta}$ in vitro and reduce the toxicity in two cell lines. Molecular dynamics simulations were applied to understand how ethanol blocks the aggregation of amyloid. On the other hand, the in silico modeling showed ethanol effect over the dynamics assembling for complex $A{\beta}$-aggregates mediated by break the hydrosaline bridges between Asp 23 and Lys 28, was are key element for amyloid dimerization. The amyloid pore/ channel hypothesis has been explored only in neuronal models, however recently experiments suggested the frog oocytes such an excellent model to explore the mechanism of the amyloid pore/channel hypothesis. So, the used of frog oocytes to explored the mechanism of amyloid aggregates is new, mainly for amyloid/pore hypothesis. Therefore, this experimental model is a powerful tool to explore the mechanism implicates in the Alzheimer's disease pathology and also suggests a model to prevent the Alzheimer's disease pathology.