• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2453-2457
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• 2016

Background: Dysregulation of HSP90 gene expression is known to take place in breast cancer. Here we used D,L-lactic-co-glycolic acid-polyethylene glycol-17-dimethylaminoethylamino-17-demethoxy geldanamycin (PLGA-PEG-17DMAG) complexes and free 17-DMAG to inhibit the expression of HSP90 gene in the T47D breast cancer cell line. The purpose was to determine whether nanoencapsulating 17DMAG improves the anti-cancer effects as compared to free 17DMAG. Materials and Methods: The T47D breast cancer cell line was grown in RPMI 1640 supplemented with 10% FBS. Encapsulation of 17DMAG was conducted through a double emulsion method and properties of copolymers were characterized by Fourier transform infrared spectroscopy and H nuclear magnetic resonance spectroscopy. Assessment of drug cytotoxicity was by MTT assay. After treatment of T47D cells with a given amount of drug, RNA was extracted and cDNA was synthesized. In order to assess HSP90 gene expression, real-time PCR was performed. Results: Taking into account drug load, IC50 was significant decreased in nanocapsulated 17DMAG in comparison with free 17DMAG. This finding was associated with decrease of HSP90 gene expression. Conclusions: PLGA-PEG-17DMAG complexes can be more effective than free 17DMAG in down-regulating of HSP90 expression, at the saesm time exerting more potent cytotoxic effects. Therefore, PLGA-PEG could be a superior carrier for this type of hydrophobic agent.

• Journal of Advanced Research in Ocean Engineering
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• v.3 no.1
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• pp.41-52
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• 2017

This paper presents a numerical and experimental study of sloshing loads on liquefied natural gas (LNG) vessels. Conventional LNG carriers with membrane-type cargo systems have filling restrictions from 10% to 70% of tank height. The main reason for such restrictions is high sloshing loads around these filling depths. However, intermediate filling depths cannot be avoided for most LNG vessels except the LNG carrier. This study attempted to design a membrane-type LNG tank with a modified lower-chamfer shape that allows all filling operations. First, numerical sloshing analysis was carried out to find an efficient height of the lower-chamfer that can reduce sloshing pressure at partially filled conditions. The numerical sloshing analysis program SHI-SLOSH was used for numerical simulation; this program is based on SOLA-VOF. The effectiveness of the newly designed tanks was validated by 1:50-scale three-dimensional tank tests. A total of three different tanks were tested: a conventional tank and two modified tanks. As test conditions, various filling depths and wave periods were considered, and the same test conditions were applied to the three tanks. During the test, slosh-induced dynamic pressures were measured around the corners of the tank wall. The measured pressure data were post-processed and the pressures of the three different tanks were statistically compared in several ways. Experimental results show that the modified tanks were quite effective in reducing sloshing loads at low filling conditions. This study demonstrated the possibility of all filling operations for LNG cargo containment systems.

• Journal of Advanced Navigation Technology
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• v.21 no.6
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• pp.572-578
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• 2017

As the demand of high accuracy positioning for dynamic users increases, Network RTK is actively researched for dynamic users. Network RTK is a system which provides precise positioning in the range of about 50 to 70km radius using carrier phase measurements from several reference stations. By configuring multiple clusters, which provide Network RTK corrections independently, as a single system, it could provide precise positioning for a wider area. In this paper, we have studied how to efficiently operate multiple clusters in the Korean Peninsula. We analyzed the computational load according to the configuration of a multi-cluster system and proposed a method of selecting the main reference station and system infrastructure configuration for efficient operation. In order to analyze the effects of each proposed method, 71 clusters were constructed using the reference stations of the National Geographic Information Institute and simulations were conducted. As a result of the simulation, system computation amount was reduced by 66 % and system configuration cost was reduced by 90 %.

• Proceedings of the KIEE Conference
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• 2001.07b
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• pp.1020-1022
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• 2001

because the output of solar cell is direct, it is necessary to install D/A converter system for A.C load, and in case of driving utility line system, it is possible to drive system relation when the system supplies sinusodal current ant voltage having unit power factor. As the characteristics of the soar cell output the is influenced by dailysunight charge, for more electric power it is essential to control the direction toward the san so that the driving point of solar cell can always operate near maximum output point. PWM modulation device among electric power converters must have stable modulation at anytime when it includes noise-factors such as noise-wave and noises on electric voltage wave, a synchronous signal system. In dealing with synchronous signal for control and control signal by microprocessor, it is necessary to compensate it because there is time difference between sample paint and carrier wave. On this papers, single phase PWM current type invertor controled the solar cell having typical voltage dropping character has optimun short current in short, reduces D.C reactance, composes controller for modulation and keeps lower harmonic and high power factor keeping maximum output of solar cell according daily sunlight charge variation.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.11
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• pp.29-34
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• 2004

This paper reports the RF dispersion and linearity characteristics of unpassivated AlGaN/InGaN/GaN high electron-mobility transistors (HEMTs) grown by molecular beam epitaxy (MBE). The devices with a 0.5 ${\mu}{\textrm}{m}$ gate-length exhibited relatively good DC characteristics with a maximum drain current of 730 mA/mm and a peak g$_{m}$ of 156 mS/mm. Highly linear characteristic was observed by relatively flat DC transconductance (g$_{m}$) and good inter-modulation distortion characteristics, which indicates tight channel carrier confinement of the InGaN channel. Little current collapse in pulse I-V and load-pull measurements was observed at elevated temperatures and a relatively high power density of 1.8 W/mm was obtained at 2 GHz. These results indicate that current collapse related with surface states will not be a power limiting factor for the AlGaN/InGaN HEMTs.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.12A
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• pp.1340-1348
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• 2004

In this paper, we propose a PAPR-minimized sequence mapping scheme that achieves the minimum Peak-to-Average Power Ratio (PAPR) and the minimum amount of computations for the OFDM system. To reduce the PAPR, the mapping table is created with information about block index and symbol patterns of the lower signal power. When the input data sequence comes, it performed division by the block length to find the quotient and remainder. The symbol pattern of the lower signal power can be found in terms of the block index as the quotient in the mapping table and transmitted with remainder as the side information to distinguish and recover the original data sequence in the receiver. The two methods with the proposed mapping scheme are proposed in this paper. One is with mapping table to recover the O%M signal in both transmitter and receiver. The other is with mapping table only in transmitter to reduce the load and the complexity in the mobile system. We show that this algorithm provides the PAPR reduction, the simple processing and less computational complexity to be implemented for the multi-carrier system.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.3
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• pp.253-261
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• 2014

In this paper, vibration analysis of power differential gear train for 2.5MW wind turbine system is analyzed. which system is composed of two planetary gear set, one helical gear set and main shaft that connected by flange. Planetary gear set, helical gear set, main shaft are modeled in MASTA program and housing, torque arm, carrier, flange components are modeling by finite element method. Each models are combined by component mode superposition. To analysis of natural vibration characteristic about 2.5MW wind turbine gear train was performed and check about critical speed with wind load, mass unbalance, angle misalignment excitation frequency.

• Proceedings of the Korea Society of Design Studies Conference
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• 2001.10a
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• pp.9.1-9
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• 2001

Concerning the development of suitable healthcare equipment for a aged people at their homes in order to reduce the labor and increase the efficiency in the homehelpers' work, we conducted a study on the actual conditions of healthcare in Kyoto city (healthcare in taking a meal and excretion, moving and taking a bath by using a hand-powered lift, moving by a wheelchair, shower carrier healthcare, assistance in body care and housework) by digital video filming, interviews and layout investigations. On the base of those investigations by using methods for analysis of video pictures, we divided the healthcate work into scenes and e exctracted the main problems in terms of health care equipment, information, environment, healthcare skills, mental burden, social s system, family burden, ete. Furthermore the questionnaire survey of home helpers (18 persons - 50% answers) clarified that more than half of them have lumbago pains and the biggest load in the everyday healthcare c comes from moving the patients or getting them into or out of t the equipment for moving. Finally we considered concrete proposals appropriate for each h healthcare scene image, based on evaluation toward efficiency (design guidelines) for suitable healthcare equipment for aged people at their homes: 1) Design toward a proper posture 2) Design toward self-help possibility 3) Design toward patient active participation 4) Design toward rationality of the whole process 5) Design toward place-appropriate healthcare equipment 6) Design toward healing of mind 7) Good level of healthcare skills 8) Economic, systematic rationality

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.27 no.1
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• pp.50-59
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• 2016

This work shows that the design and test results of a power amplifier(PA) with broadband and high linearity for 4G applications in $0.11{\mu}m$ CMOS process. A 1:2-transformer is designed for load impedance matching of PA and a inter-stage matching is implemented for a linearity. A designed PA achieves more than 27.3 dBm of linear output power and 26.1 % of power-added efficiency(PAE) under an adjacent channel leakage ratio(ACLR) of -30 dBc for a LTE 16-QAM 10 MHz signal with a carrier frequency range of 1.8 to 2.3 GHz.

• Journal of Power System Engineering
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• v.22 no.1
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• pp.48-55
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• 2018

It has recently been reported that methanol fuel has been used in the product carrier with established duel fuel engine, which has been greatly reducing emissions of $CO_2$, NOx and SOx from the engine. However, to use methanol alone as fuel oil in a general diesel engine, design modification of cylinder head is needed because the ignition aid device or the duel fuel injection system is needed. On the other hand, only if the mixer is installed on the fuel oil supply line, diesel oil - methanol blending oil can be used as fuel oil for the diesel engine, but there is a problem of the phase separation when two fuels are mixed. In this study, diesel oil and methanol were blended compulsorily in preventing the phase separation with installing agitators and a fuel oil boost pump on fuel line of a test engine. Also, cylinder pressure and fuel consumption quantity were measured according to engine load and methanol blending ratio, and indicated mean effective pressure, heat release rate and combustion temperature obtained from the single zone combustion model were analyzed to investigate the effects of latent heat of vaporization of methanol on combustion stability and characteristics. As a result, the combustion stability and characteristics of 10% methanol blending oil are closest to the those of diesel oil, and it could be used as fuel oil in existing diesel engines without deterioration of engine performance and combustion characteristics.