• Journal of Mushroom
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• v.16 no.3
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• pp.140-146
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• 2018

Pleurotus eryngii is one of the most commercially important mushrooms cultivated in Korea. However, the shelf-life of the fruiting body is short, limiting its export. A new hybrid strain H17 of P. eryngii was developed to extend the shelf-life by mono-mono crossing between monokaryotic strains derived from DanBi and KNR2774. Although the cultivation period of H17 was slightly longer than that of the reference cultivar Kenneutari No.2, the quality did not change and remained normal after a period of 65.0 days at $4^{\circ}C$. This result was significantly different from that of the reference cultivar Kenneutari No.2. Analysis of the genetic characteristics of the new hybrid strain H17 revealed a different profile from that of the parental and reference cultivars when random amplification of polymorphic DNA (RAPD) primers was used. These results demonstrate that H17 is a new cultivar with improved storability after harvesting.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.5 no.1
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• pp.116-125
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• 2005

Orthotopic liver transplantation is the treatment of choice for inherited metabolic diseases. However, the supply of donor organs is limiting and therefore many patients cannot benefit from this therapy. In contrast, hepatocytes can be isolated from a single donor liver. They can be transplanted into several recipients, and this procedure may help overcome the shortage of donor livers. A great deal of work with animal models indicates that hepatocytes transplanted into the liver or spleen can survive, function, and participate in the normal regenerative process. Recent clinical studies suggest that hepatocyte transplantation may be useful for bridging patients to whole organ transplantation and for providing metabolic support during liver failure and for replacing whole organ transplantation in certain inherited metabolic diseases. Nowadays, hepatocytes from various stem cells have been regarded as an another cell source for treatment of inherited metabolic diseases. Although cell therapy using stem cells for inherited metabolic disease patient has been accepted only as an experimental trial yet, hepatocytes from stem cells can solve a lot of obstacles in the treatment of inherited metabolic diseases.

• The Korean Journal of Applied Statistics
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• v.22 no.5
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• pp.1047-1057
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• 2009

The nonparametric bivariate two-sample test of Bennett (1967) is extended to the multivariate k sample test. This test has been easily modified for a monotone trend among k samples. Often in applications it is important to consider a set of multivariate response variables simultaneously, rather than individually, and also important to consider testing k samples altogether. Different approaches of estimating the null covariance matrices of the test statistics resulted in the same limiting form. The multivariate k sample test is applied to the non-normal data of a randomized trial conducted for a period of four weeks in mental hospitals. The purpose of the trial is to compare the efficacy of three different interventions for a relief of the frequently occurring problems of constipation, caused as a side effect of antipsychotic drugs during hospitalization. The bowel movement status of patient for a week is summarized into a single severity score, and severity scores of four weeks comprise a four-dimensional multivariate variable. It is desirable with this trial data to consider a multivariate testing among k samples.

• Nuclear Engineering and Technology
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• v.37 no.6
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• pp.587-594
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• 2005

In an effort to develop a thermal-hydraulic (TH) safety analysis code for Gas-cooled Reactors (GCRs), the MARS code, which was primarily developed for TH analysis of water reactor systems, has been extended here for application to GCRs. The modeling requirements of the system code were derived from a review of major processes and phenomena that are expected to occur during normal and accident conditions of GCRs. Models fur code improvement were then identified through a review of existing MARS code capability. Among these, the following priority models necessary fur the analysis of limiting high and low pressure conduction cooling events were evaluated and incorporated in MARS-GCR/V1 : 1) Helium (He) and Carbon Dioxide ($CO_2$) as main system fluids, 2) gas convection heat transfer, 3) radiation heat transfer, and 4) contact heat transfer models. Each model has been assessed using various conceptual problems for code-to-code benchmarks and it was demonstrated that MARS-GCR/V1 is capable of capturing the relevant phenomena. This paper describes the models implemented in MARS-GCR/V1 and their verification and validation results.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.1
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• pp.33-40
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• 2001

The aim of present study was to define the cellular mechanisms underlying changes in delayed rectifier $K^+\;(K_{DR})$ channel function in isoproterenol-induced hypertrophy. It has been proposed that $K_{DR}$ channels play a role in regulation of vascular tone by limiting membrane depolarization in arterial smooth muscle cells. The alterations of the properties of coronary $K_{DR}$ channels have not been studied as a possible mechanism for impaired coronary reserve in cardiac hypertrophy. The present study was carried out to compare the properties of coronary $K_{DR}$ channels in normal and hypertrophied hearts. These channels were measured from rabbit coronary smooth muscle cells using a patch clamp technique. The main findings of the study are as follows: (1) the $K_{DR}$ current density was decreased without changes of the channel kinetics in isoproterenol-induced hypertrophy; (2) the sensitivity of coronary $K_{DR}$ channels to 4-AP was increased in isoproterenol-induced hypertrophy. From the above results, we suggest for the first time that the alteration of $K_{DR}$ channels may limit vasodilating responses to several stimuli and may be involved in impaired coronary reserve in isoproterenol-induced hypertrophy.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.11
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• pp.2128-2135
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• 2009

In this paper, current limiter using a magnetic switching which is based on magnetic flux change in the case of fault is proposed. This current limiter consists of iron-core and three parts of coils. One is the primary coil connected to the power system. Another is the secondary coil wound to the opposite direction of the primary coil's winding. The other is the secondary of the secondary coil which is a movable copper plate winding and located below the secondary coil. In the normal state, the magnetic flux produced in the primary and secondary coils flows to the opposite directions each other and becomes to be canceled out. Therefore the voltages induced between the coils are zero. In the case of a fault, at the moment of a fault occurrence recognition, the switch connected to a secondary coil is opened and the secondary of the secondary coil is pulled out to the outside of the iron-core. Then, magnetic flux becomes to flow through the iron-core. Accordingly, the voltage is induced between the both ends of the primary coil and makes the current reduced. Therefore it is possible to cut off the circuit breaker easily with the proposed current limiter. This paper analyzes the current limiting effects and the detailed results are given.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.11a
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• pp.255-258
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• 2003

The hysteresis characteristics of flux-lock reactor, which is an essential component of flux-lock type superconducting fault current limiter (SFCL), was investigated. The hysteresis loss of iron core in flux-lock type SFCL does not happen due to its winding's structure especially in the normal state. From the equivalent circuit for the flux-lock type SFCL and the fault current limiting experiments, the hysteresis curves could be drawn. Through the hysteresis curves together with the fault current level due to the inductance ratio for the 1st and 2nd winding, the increase of the number of turns in the 2nd winding of the flux-lock type SFCL had a role to prevent the iron core from saturation.

• Nuclear Engineering and Technology
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• v.50 no.5
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• pp.709-716
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• 2018

A criticality safety analysis was performed for the APR-1400 spent fuel pool region-II to ensure the safe storage of spent fuel, with credit taken for depletion and in-rack neutron absorbers (Metamic panels). PLUS7 fuel assembly was modeled using TRITON-NEWT of SCALE-6.1. The burnup-dependent cross-section library was generated under limiting core-operating conditions with 5%-w U-235 initial enrichment. MCNP5 was used to evaluate the neutron multiplication factor in an infinite array of rack cells with the axially nonuniformly burnt PLUS7 assemblies under normal, abnormal, and accident conditions; including all biases and uncertainties. The main purpose of this study is to investigate reactivity variations due to the critical depletion and reactor operation parameters. The approach, assumptions, and modeling methods were verified by analyzing the contents of the most important fissile and the associated reactivity effects. The Nuclear Regulatory Commission (NRC) guidance on k-eff being less than 1.0 for spent fuel pools filled with unborated water was the main criterion used in this study. It was found that assemblies with 49.0 GWd/MTU and 5.0 w/o U-235 initial enrichment loaded in Region-II satisfy this criterion. Moreover, it was found that the end effect resulted in a positive bias, thus ensuring its consideration.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.2
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• pp.113-119
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• 2006

Coronary artery disease is a loading cause of morbidity and mortality across the world. Percutaneous coronary intervention has become the major technique of revascularization. However, restenosis remains a major limitation of this procedure. Recently the need for repeat intervention due to restenosis, the most vexing long-term failure of percutaneous coronary intervention, has been significantly reduced owing to the introduction of two major advances, intracoronary brachytherapy and the drug-eluting stents. Intracoronary brachytherapy has been employed in recent years to prevent restenosis lesions with effective results, principally in in-stent restenosis. Restenosis is generally considered as au excessive form of normal wound healing divided up in precesses: elastic recoil, neointimal hyperplasia, and negative vascular remodeling. Restenosis has previously been regarded as a proliferative process in which neointimal thickening, mediated by a cascade of inflammatory mediators and other factors, is the key factor. Ionizing radiation has been shown to decrease the proliferative response to injury in animal models of restenosis. Subsequently, several randomized, double blind trials have demonstrated that intracoronary brachytherapy can reduce the rates of both angiographic restenosis and clinical event rates in patients undergoing percutaneous coronary intervention for in stent restenosis. Some problems, such as late thrombosis and edge restenosis, have been identified as limiting factors of this technique. Brachytherapy is a promising method of preventing and treating coronary artery restenosis.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.19 no.5
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• pp.93-103
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• 2009

Since message forgery or alteration in VANET may cause severe consequences, authentication of critical messages must be provided. However, using normal digital signature may infringe privacy of drivers. Therefore, VANET requires authentication systems that provide conditional anonymity. In this paper, we propose a new authentication system for VANET. In our proposed system, each vehicle can update its pseudonym using re-encryption technique and digitally sign messages using representation problem on the pseudonym. By limiting the usage period, revocation of individual pseudonym is not required. Moreover, we also provide a way to revoke the vehicle itself. Secureness of our system partially rely on the usage of tamper-resistance hardware.