• Korean Journal of Clinical Pharmacy
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• v.27 no.3
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• pp.161-170
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• 2017

Background: There is recent evidence that insulin resistance is responsible for increasing the risk of developing cognitive dysfunction. To systematically review the influence of intranasal insulin treatment on the cognitive function in Alzheimer's disease patients. Methods: Randomized controlled trials comparing the cognitive effects of intranasal insulin therapy in Alzheimer's disease patients with controlled interventions were retrieved from Pubmed, Medline, Embase and Cochrane library. Meta-analysis was conducted on the cognitive measurements with a subgroup analysis by dose, gender and apolipoprotein E allele 4 (ApoE ${\varepsilon}4$) status. Results: Seven randomized controlled trials were eligible for inclusion. Intranasal insulin had a positive influence on the cognitive function as compared to placebo without a statistical significance (standardized mean difference; SMD = 0.109; 95% confidence interval; CI -0.04 to 0.26; P=0.14). In subgroup analysis, a 20 IU dose of intranasal insulin induced a significant improvement in cognitive function (SMD = 0.14; 95% CI 0.05 to 0.24; P=0.004), but 40 IU did not show this effect (SMD = -0.01; 95% CI -0.11 to 0.09; P=0.82). ApoE ${\varepsilon}4$ positive patients showed a significant decline in cognitive function as compared to ApoE ${\varepsilon}4$ positive patients in the control group (SMD = -0.213; 95% CI -0.38 to -0.04; P=0.015). Such an effect was not apparent in ApoE ${\varepsilon}4$ negative patients. Gender had no influence on the cognitive outcomes. Conclusion: The results indicate that intranasal insulin may have beneficial effect in improving the cognitive function in Alzheimer's disease patients.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.4077-4080
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• 2015

The chemokine receptor 4 (CXCR4) has been widely used in diagnosis and prognosis of colorectal cancer (CRC). However, there is no current consensus on the impact of CXCR4 on CRC patients. The purpose of this study was to evaluate the prognostic and clinicopathological importance of CXCR4 in CRC patients. Databases, such as PubMed, Cochrane library, CBM and EMBASE updated to 2014 were searched to include eligible articles. We analysed correlations between CXCR4 expression and clinicopathological features and overall survival (OS). A total of 1, 055 CRC patients from twelve studies were included in the study. The pooled odds ratios (ORs) which indicated CXCR4 expression was likely to be associated with TNM stage (OR=0.43, CI=0.34-0.55, P<0.00001), lymph node status (OR=2.23, CI=1.23-4.05, P=0.008) and vascular invasion (OR=2.21, CI=1.11-4.39, P=0.02). Poor overall survival of CRC cancer was found to be significantly related to CXCR4 overexpression (hazard ratio (HR) 1.36 CI=1.17-1.59, P<0.0001), whereas combined ORs revealed that CXCR4 expression had no correlation with gender or differentiation. Based on the published studies, CXCR4 overexpression in patients w ith CRC indicates poor survival outcome and clinicopathological factors.

• Proceedings of the IEEK Conference
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• 1998.10a
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• pp.641-644
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• 1998

In this paper, wideband MMIC LNA's were designed using low Q matching network. gains of 23.6~25.4dB $(24.5\pm0.9dB),$ noise figures of 0.9~2.8 dB were obtained from the designed wideband MMIC LNA in the frequency ranges of 1.2~2.8㎓. And, P1dB of 10.13 dBm, IP3 of 12.25 dB were obtained at the center frequency of 2 ㎓. A chip size of the designed wideband MMIC LNA is 1.4mm$\times$1.4mm.

• Journal of Korean Library and Information Science Society
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• v.9
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• pp.241-266
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• 1982

This paper gives a summary and overview of a survey conducted at the catalogues of five universities in Daegu during November 1982. The major objective of this study was to secure information about user needs in order to improve the catalogue in Korean university libraries. Data was collected by a combined method of questionnaire and interview. A total of 379 respondents were taken on a randomly selected sample of catalogue users. Results of the survey can be summarized as follows: 1. Eighty-eight percent of the students answered that they had used the library more than twice a month. Nevertheless the number of students consulting the catalogue with the same frequency was only 220, or a n.0, pproximately 58 percent. Those who used the library most tended to use the catalogue more than those who rarely came to the library. 2. Those who had been shown how to use their own catalogue were only 32.5percent of which the students found the instruction sufficient for them to be able to use the catalogue were only 37.5 percent. In particular, they stated that instructions by printed materials and/or library orientation were so poor that they didn't give much help in using the catalogue. This problem makes many libraries to review their own method of instruction in order to encourage patrons to use the catalogue more effectively. 3. Most of the students consulted the catalogue in order to locate library materials. Known-item searches and subject searches were 84 and 16 percent respectively. While 70.5 percent of the students used the author-title catalogue without any difficulties, only 35.5 percent of those stated that using the classed catalogue was easy. 4. It was surprising that the number of students using title access in the search was far greater than that of students using author access. In contrast with this, other studies conducted by many earlier overseas investigators revealed that the great majority of patrons tended to use the latter first. Therefore, we should put more emphasis on the title entries in the catalogue itself as well as cataloging rules. 5. Most useful bibliographic elements in the entry were author, title, call number, date and publisher whereas edition, series statement and the location of publisher were rarely used compared with the other elements. Content note was the most desirable element in the entry to be involved, for many catalogers were used not to describe it on the note area. 6. The chief reason given for not using the catalogue was "I can manage without it" with "It's difficult to understand contents of the card entry." The other one was "It's useless to search materials by the catalogue because I've failed so many times to obtain them out of the stock." In response to this, circulation and acquisition system should be improved not to make such complaints any more.

• Journal of Life Science
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• v.13 no.4
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• pp.529-534
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• 2003

This study was done to investigated the phytosterol compositions of safflower (Carthamus tinctorius L.) seed. The phytoestrogen activity was also determined using CAT-ELISA Kit in ethanol extract of safflower seed. The phytosterol of safflower seeds was identified using gas chromatography-mass spectrometry after saponification of the oils. The phytosterol content and composition of safflower seed oils were 4% and identified stigmast-5-en-3-ol (3$\beta$, 24S)-form, ${\gamma}$-sitosterol (clionasterol) with Wiley MS spectrum library. The synergistic effect of human estrogen receptor (hER) has been investigated using a minimal chimeric promoters composed of the TATA region of the adenovirus-2 major late promoter (A22MLP) and two consensus perfectly polindromic Xenopus vitellogenin A2 gene estrogen responsive elements (XVEREl19). Transient transfection experiments in tile human breast adenocarcinoma cell line MCF-7, which is known to express the estrogen receptor endogenously, revealed that phytoestrogen from Carthamus tinctorius L. acts as estrogen. We have observed the transcriptional activities stimulated methanol and ethanol extract of safflower seed in MCF-7, were 0.43 and 0.37 respectively, compared to that by $\beta$-estradiol as 1.0. Our data showed that safflower seeds have estrogenic activity methanol and ethanol extracts and ethanol lower than that of $\beta$-estradiol. This result provides the first evidence that the beneficial effect of safflower seeds may be mediated, at least in part, by the stimulating effect of phytoestrogen ell bone-protecting.

• Korean Journal of Clinical Pharmacy
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• v.28 no.1
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• pp.30-39
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• 2018

Background: Clinical Pharmacy Practice Experience (CPPE) is an important curriculum that offers students patient-centered disease prevention and treatment with evidence-based optimal pharmacotherapy for better clinical outcomes. However, few studies have evaluated the perception of pharmacy students regarding CPPE in tertiary and secondary hospitals. This study aimed to evaluate the perception of pharmacy students regarding the learning program of CPPE. Methods: The survey questionnaire consisted of 15 self-administered questions regarding pharmacy practices, barriers, and improvement of practical training. Fourteen institutional pharmacies located in seven regions responded to a survey questionnaire from March 1 to June 30, 2017. The participants were pharmacy students doing clerkship in a hospital setting. Results: The response rate was 73.6%. Thirty-five participants (22.4%) had used a hospital library, but 121 (77.6%) had never used the library for drug information resources. Eighty-one (50.0%) responded that clinical knowledge and drug information was the most beneficial practice. Thirty-seven (31.1%) respondents in the tertiary hospitals and 19 (46.3%) in the secondary hospitals answered that they were filling prescriptions during the daily break. On the other hand, 72 respondents (60.5%) in the tertiary hospitals and 17 (41.5%) in the secondary hospitals did literature research to prepare for presentation. Conclusion: More students in secondary hospitals continue to fill prescriptions during the daily break, as compared to those in tertiary hospitals. Therefore, the authors suggest self-directed learning to improve clinical performance and each institution considers offering onsite or online library service to improve evidence-based CPPE for pharmacy school students.

• Journal of Korean Biological Nursing Science
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• v.21 no.4
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• pp.239-248
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• 2019

Purpose: Postmenopausal women are a unique population with high risk for the degeneration of muscle. The aim of the present meta-analysis was to accurately evaluate the effects of vitamin D on muscular strength in postmenopausal women. Methods: A review was conducted using electronic databases, including PubMed, EMBASE, Ovid Medline, CINAHL complete, and the Cochrane Library from inception through 19 March 2019. Included studies were selected by two independent reviewers. The meta-analysis were performed using Review Manager 5.3 software. Results: A total of nine randomized controlled clinical trials were included in this review. Vitamin D interventions led to no changes in the upper limb muscle strength (mean difference -0.16, 95% CI: -1.09 to 0.77), lower body muscle strength (standard mean difference 0.08, 95% CI: -0.11 to 0.26), and back/hip muscle strength (standard mean difference 0.06, 95% CI: -0.05 to 0.17). Conclusion: Pooled results from eight studies indicated that supplementation of vitamin D did not increase muscle strength in postmenopausal women. Apparently, the present review suggests that supplementation of vitamin D alone had no didn't show any beneficial effects on muscle strength in postmenopausal women.

• Korean Journal of Environmental Biology
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• v.37 no.3
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• pp.351-361
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• 2019

To investigate the temporal distribution of planktonic larvae of Tegillarca granosa and Anadara kagoshimensis in the Boseong coastal waters of South Korea, samples of planktonic bivalve larvae were taken from the coastal waters from June to September 2018 (this consisted of monthly sampling in June, July, and September with three- or four-day interval sampling in August). The samples were analyzed using metagenomic next-generation sequencing methods (target gene: mitochondria cytochrome c oxidase 1 region). In this study, a total of 21 bivalve operational taxonomic units (OTUs) were detected with the most abundant bivalve OTUs (relative mean abundance >1%) belonging to Magallana sikamea, Xenostrobus atratus, Musculista senhousia, Magallana gigas, Sinonovacula constricta, Anadara kagoshimensis, Kurtiella aff. bidentata, and Tegillarca granosa. In particular, Tegillarca granosa and Anadara kagoshimensis (the main fishery resources on the Boseong coast) accounted for 0.51-12.50% (average 4.00%) and 0.01-12.50% (1.92%), respectively. The planktonic bivalve larvae were most abundant from July to August. Anadara kagoshimensis was most abundant in early August but rare in the other investigated periods, whereas Tegillarca granosa was more abundant in late August. Bivalve larvae monitoring is important to predict the production of bivalve fisheries. Therefore, intensive monitoring is needed to understand the changes in planktonic bivalve larvae because potentially rapid turnover can respond to the ecological interaction of spawning bivalves.

• The Korean Journal of Pharmacology
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• v.24 no.1
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• pp.1-10
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• 1988

To obtain information about the structure of the human phenylethanolamin N-methyltransferase (PNMT) and to further define the extent of the evolutionary relationships among PNMT molecules of several spesies, a full length cDNA clone for bovine adrenal PNMT was used to screen a charon 4A genomic library. One phage was isolated and identified, which included the entire PNMT gene. The length of inserted genomic DNA was 13.1-Kilobase (Kb) containing two internal EcoRI sites. Construction of a restriction map and subsequent Southern and dot blot analysis with 5'-and3'-specific cDNA probes allowed the identification of exon-containing fragments. This is the first report of the cloning of gene for human epinephrine synthesizing enzyme.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.2 no.1
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• pp.178-210
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• 1974

It needs to put into practice the systems analysis in the analysis of some operations and status of library for the purpose of systematizing the work of reforming in the new easier form to process, to storage, to retrieve and to make use of the increasing informations and data of library. In this study, some of systems which are generally using in every library was caught in the case study of K university library. Having analyzed them with the two methods of the flowcharting and mathematical analysis, we found the obstructive factors in operation. As the result of this research, it was gained the new system as the alternative one. A. Alternative System B. Advantages of alternative systems 1. In the reference room When it converts the present system into the new system, it can profit 6.771 won/user (13.815won-7.044won=6.771 won). Therefore, a half the average required cost of the present system can be saved. If this saving would be alloted for the cost 33,000won required to make the cataloging cards, it would be taken for 94 days (33,000 won ${\div}$ 6,771 won/user=4,874users. 4,874users ${\div}$ 52users/day=94days) to get it. The saving cost/year by the new system will be 95,417 won, and in the first year the initial cost (33,000won) reduces the saving cost to 62,417won. 2. In the periodical room The average required time for using the materials of the present system is 17 minutes/user and the average required cost/user is 23.775won, while the average required time of the new system is 4 minutes and the average required cost/user is 5.33won. Therefore, the new system has profit 4 times of the present system. Accordingly, it occurs when the dispersed periodical materials get together. 3. In the classification and cataloging When one processes - the oriental books - by the Linear Programming Technique, the maximum of the process can be increased from 11.6 volumes per librarian of the present system to 12 volumes per librarian of the new system increased 0.4 volume in a day, and cataloging by the manual printer can be shorten from 3 minutes per card of the present system to 1.5 minutes per card of the new system. Consequently, we can complete the other operations (books equipment, updating of cataloging cards, etc.) with 141 minutes which are saved in the course of the afore-mentioned works. 4. In the status of collections The average growth rate of 4 years from 1968 to 1971 is 9.825 %, and that of the purchased materials is 6.2% similar to the advanced nations, but it has the different position from 215,000 volumes by the Standard Degree for Establishment of College and University, and the difference between the total collections 151,671 volumes and Dunns' growth model ($N_t=N_oe^{-at}$) claimed by Leimkuhler 155,297 volumes in 1971 is 3,626 volumes, and for the purpose of compensation the difference, we found the fact that it needs to have the increased budget of 24~30% per year, Thus, if the budget of 24~30 % per year. Thus, if the budget would be increased per year as the rate of the afore-mentioned figure, it would be reached at the Standard Degree for Establishment of College and University in 1975, and thereafter, it can be decreased to the lebel which is able to maintain the growth rate of 5~6% per year.