• Proceedings of the KIPE Conference
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• 2007.07a
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• pp.129-131
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• 2007

In this paper, a single phase matrix converter circuit with novel commutation technique is proposed. With commercial IGBT modules, the proposed converter is quite compact in structure and easy to build. The applied commutation strategy introduces a simple RC circuit as commutation aid without need for sensing information, leading to stable and reliable operation. The modulation method is explained; the detailed commutation procedure is illustrated. Finally, the simulation results show the validity and verification of the proposed single phase matrix converter.

• Journal of the Korean School Mathematics Society
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• v.7 no.2
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• pp.81-97
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• 2004

This paper is a study on the understanding process of「Matrix and Graph」on discrete mathematics using TI-92 calculator. For this purpose, we investigated the understanding process of two middle school students learning the concepts of matrix and graph using TI-92 calculator. In this process, we collected qualitative data using recorder and video camera. Then we categorized these data as follows: students' attitude related to using technology, understanding process of meaning, expression and operation of matrix and graph, mathematical communication, etc. From this, we have the following conclusions: First, students inquired out the meaning and role of matrix by themselves using calculator. We could see that calculator can do the role of good learning partner to them. Second, students realized their own mistakes when they used calculator on the process of learning matrix. So we found that calculator could form the self-leading learning circumstance on learning matrix. Third, calculators reinforce the mathematical communication in learning matrix and graph. That is, calculator could be a good mediator to reinforce mathematical communication between teacher and students, among students on learning matrix and graph.

• Nutrition Research and Practice
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• v.1 no.4
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• pp.279-284
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• 2007

Solar ultraviolet (UV) irradiation leads to distinct changes in the skin connective tissues by degradation of collagen, which is a major structural component in the extracellular matrix. UV irradiation induces the production of matrix metalloproteinases (MMP) capable of attacking native fibrillar collagen and responsible for inhibiting the construction of collagenous extracellular matrix. In this study, we attempted to investigate the protective actions of Rubus coreanus ethanol extract (RCE) on the MMP production and the consequent procollagen/collagen degradation in UV-B-irradiated human dermal fibroblasts. The analytical data showed that Rubus coreanus ethanol extract was mostly comprised of cyanidin 3-rutinoside. Pre-treatment of fibroblasts with this extract inhibited UV-B-induced production of MMP-1, MMP-8 and MMP-13 in dose-dependent manners. In addition, Western blot analysis and immunocytochemical staining assay revealed that RCE markedly augmented the cellular levels of procollagen/collagen declined in UV-B-exposed dermal fibroblasts. These results demonstrate that RCE blocks UV-B-induced increase of the collagen degradation by inhibiting MMP production. Thus, RCE may act as an agent inhibiting excessive dermal collagen degradation leading to the skin photoaging.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.590-600
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• 2003

The matrix metalloproteinases (MMPs) are a family of enzymes responsible for degrading connective tissue. MMPs catalyze the breakdown of collagen from the extracellular matrix, leading to wrinkle formation and accelerated skin aging. Furthermore, ultraviolet irradiation causes increased expression of certain MMPs. In the extracellular matrix turnover, MMPs are interacting with endogenous regulators named tissue inhibitors of metalloproteinases (TIMPs). Using peptide substrate assays, it has been demonstrated that TIMP-MMP complexes interact highly specifically with $K_{i}$ values of 10$^{-9}$ -10$^{-16}$ M. Therefore applications for TIMP as inhibitor of collagen degradation are suggested for cosmetic anti-aging products to prevent wrinkle formation and loss of elasticity. To date four TIMP proteins (TIMP-1, TIMP-2, TIMP-3 and TIMP-4) have been identified which show a high degree in sequence similarity. The production of human TIMP-2, a 194-residue nonglycosylated protein, was performed by fed-batch culture of Escherichia coli. TIMP-2 accumulated in the bacterial cells in an insoluble form as inclusion bodies. The inclusion bodies were solubilized and the protein refolded to yield the native TIMP-2 in the active form. The integrity of the protein was confirmed by mass analysis, Edman sequencing and gel shift experiments with authentic samples. The inhibitory activity of the refolded and purified TIMP-2 was demonstrated with MMP-1 and MMP-2 assays using synthetic fluorogenic peptide substrates.s.

• BMB Reports
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• v.51 no.4
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• pp.182-187
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• 2018

In carcinoma, cancer-associated fibroblasts participate in force-mediated extracellular matrix (ECM) remodeling, consequently leading to invasion of cancer cells. Likewise, the ECM remodeling actively occurs in glioblastoma (GBM) and the consequent microenvironmental stiffness is strongly linked to migration behavior of GBM cells. However, in GBM the stromal cells responsible for force-mediated ECM remodeling remain unidentified. We show that tumor-associated mesenchymal stem-like cells (tMSLCs) provide a proinvasive matrix condition in GBM by force-mediated ECM remodeling. Importantly, CCL2-mediated Janus kinase 1 (JAK1) activation increased phosphorylation of myosin light chain 2 in tMSLCs and led to collagen assembly and actomyosin contractility. Collectively, our findings implicate tMSLCs as stromal cells providing force-mediated proinvasive ECM remodeling in the GBM microenvironment, and reminiscent of fibroblasts in carcinoma.

• Journal of the Society of Naval Architects of Korea
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• v.56 no.1
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• pp.1-10
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• 2019

Naval ship design and related other activities can be characterized by the complexity of the interactions among products, activities, and disciplines. Such complexities often result in inferior designs, cost overrun, and late-delivery. Hence there exist tremendous interests in both improving the design process itself and optimizing the interactions among design activities. This paper looks at the complexity of designing naval ships thereby leading to the innovation of current ship design practices using design structure matrix. It can be used to induce the optimal ordering of design activities as well as identify sources of complexities. The method presented here identifies coupled design activities useful for reducing the complexity of naval ship design as well as optimally reordering design activities. This paper recommends the use of design structure matrix method suitable for numerically optimizing the concept design process of naval ship, and reducing cost and time required in designing naval ships by modeling and analyzing the design activities and engineering tasks, defined in systems engineering planning documents.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.11
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• pp.28-35
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• 2013

The Krylov-Schur algorithm has been applied to reveal the eigen-properties of the wave guide having the square cross section. The eigen-matrix equation has been constructed from FEM with the basis function of the tangential edge-vectors of the triangular element. This equation has been treated firstly with Arnoldi decomposition to obtain a upper Hessenberg matrix. The QR algorithm has been carried out to transform it into Schur form. The several eigen values satisfying the convergent condition have appeared in the diagonal components. The eigen-modes for them have been calculated from the inverse iteration method. The wanted eigen-pairs have been reordered in the leading principle sub-matrix of the Schur matrix. This sub-matrix has been deflated from the eigen-matrix equation for the subsequent search of other eigen-pairs. These processes have been conducted several times repeatedly. As a result, a few primary eigen-pairs of TE and TM modes have been obtained with sufficient reliability.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.10a
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• pp.156-159
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• 2013

The ICT technology by using smartphone is leading the world. Apple opened the smart age with its smartphone on the first place in the world. In 2013, Samsung of Korea is spotlighted in the world, but China will run after Samsung with medium- and low-priced smartphones equipped with functionality and low and medium prices after 2014. That is, the life cycle of ICT technology gets shorter, and the volume of investment is increased. There is increasing uncertainty of enterprises and nations because the expanded volume of investment. Therefore, it is very important to predict emerging ICT technology, and investment development. Korea based on the creative economy is at the point of strengthening ICT. Therefore, this study aims to analyze intellectual property rights (patent) and the ICT market environment for the emerging ICT technology. The result of analysis will contribute to studying the intellectual property rights (patent) and the R&D matrix module in the ICT market environment for discovering and predicting national emerging ICT technology.

• 한국방재학회:학술대회논문집
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• 2007.02a
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• pp.181-185
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• 2007

A free-surface correction(FSC) method is presented to solve the 3-D shallow water equations. Using the mode splitting process, FSC method can simulate shallow water flows under the hydrostatic assumption. For the hydrostatic pressure calculation, the momentum equations are firstly discretized using a semi-implicit scheme over the vertical direction leading to the tri-diagonal matrix systems. A semi-implicit scheme has been adopted to reduce the numerical instability caused by relatively small vertical length scale compare to horizontal one. and, as the free surface correction step the final horizontal velocity fields are corrected after the final surface elevations are obtained. Finally, the vertical final velocity fields can be calculated from the continuity equation. The numerical model is applied to the calculation of the simulation of flow fields in a rectangular open channel with the tidal influence. The comparisons with the analytical solutions show overall good agreements between the numerical results and analytical solutions.

• Journal of the Korean Society of Safety
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• v.13 no.4
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• pp.131-136
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• 1998

The creep behavior and failure mechanism of the 30 vol% hot-pressed $SiC_t/Si_3N_4$ ceramic composite was experimentally investigated at $1200^{\circ}C$ and at various stress levels in air. The creep threshold stress for zero creep rate after 100 hr was found to be approximately 60 MPa. The stress exponent was estimated to be n~1, which suggests that fiber-reinforcement reduced the stress sensitivity of the HPSN matrix with the stress exponent of 2. The tertiary stage leading to creep rupture was found at 250 MPa but was very short. The microstructure of the crept specimen showed random fiber fracture and no matrix cracking. Interfacial debonding was absent.