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http://dx.doi.org/10.5483/BMBRep.2018.51.4.185

Force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma  

Lim, Eun-Jung (Department of Life Science, Research Institute for Natural Sciences, Hanyang University)
Suh, Yongjoon (Department of Life Science, Research Institute for Natural Sciences, Hanyang University)
Kim, Seungmo (Department of Life Science, Research Institute for Natural Sciences, Hanyang University)
Kang, Seok-Gu (Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine)
Lee, Su-Jae (Department of Life Science, Research Institute for Natural Sciences, Hanyang University)
Publication Information
BMB Reports / v.51, no.4, 2018 , pp. 182-187 More about this Journal
Abstract
In carcinoma, cancer-associated fibroblasts participate in force-mediated extracellular matrix (ECM) remodeling, consequently leading to invasion of cancer cells. Likewise, the ECM remodeling actively occurs in glioblastoma (GBM) and the consequent microenvironmental stiffness is strongly linked to migration behavior of GBM cells. However, in GBM the stromal cells responsible for force-mediated ECM remodeling remain unidentified. We show that tumor-associated mesenchymal stem-like cells (tMSLCs) provide a proinvasive matrix condition in GBM by force-mediated ECM remodeling. Importantly, CCL2-mediated Janus kinase 1 (JAK1) activation increased phosphorylation of myosin light chain 2 in tMSLCs and led to collagen assembly and actomyosin contractility. Collectively, our findings implicate tMSLCs as stromal cells providing force-mediated proinvasive ECM remodeling in the GBM microenvironment, and reminiscent of fibroblasts in carcinoma.
Keywords
Actomyosin contractility; Glioblastoma; Proinvasive extracellular matrix remodeling; Tumor-associated mesenchymal stem-like cells;
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