• 한국산업보건학회지
• /
• 제30권4호
• /
• pp.376-386
• /
• 2020

Objectives: This study identifies the trend of possible occupational disease and probable occupational disease in lead or cadmium workers. It is also required to check the usefulness of follow-up management in lead or cadmium workers by reviewing the relevance between the results of follow-up management and the trend of possible occupational disease and probable occupational disease. Methods: From 2009 to 2018, the results of the Ministry of Employment and Labor's special health-screening program for hazard agents for workers were used. The correlation between the ratio of possible occupational disease and probable occupational disease of lead or cadmium workers and the ratio of those who observed were and underwent observed follow-up management was analyzed to confirm the usefulness of follow-up management. Results: Over the past decade, the average annual proportion of possible occupational disease and probable occupational disease among lead workers has been on the decline. Among cadmium workers, it has generally shown a trend of increasing and decreasing. After the implementation of follow-up management, possible occupational disease in lead workers showed significant relevance to work prohibitions and restrictions, and probable occupational disease in lead workers showed significant relevance to the work prohibitions and restrictions, on-duty treatment, and boundary lines. However, there was no significant correlation between persons involved in cadmium workers. Conclusion: In this study, more active managements such as work ban and restrictions, on-duty treatment among follow-up management of possible occupational disease and probable occupational disease of lead worker and observers are related to a decrease in the ratio of those who have been diagnosed with possible occupational disease and probable occupational disease.

• Nuclear Engineering and Technology
• /
• 제53권1호
• /
• pp.273-281
• /
• 2021

The radiological safety of the spent resin treatment facility with a¹⁴C treatment capacity of 1 ton/day was evaluated in terms of the external and internal exposure of worker according to operation scenario. In terms of external dose, the annual dose for close work for 1 h/day at a distance of more than 1 m (19.8 mSv) satisfied the annual dose limit. For 8 h of close work per day, the annual dose exceeded the dose limit. For remote work of 2000 h/year, the annual dose was 14.4 mSv. Lead shielding was considered to reduce exposure dose, and the highest annual dose during close work for 1 h/day corresponded to 6.75 mSv. For close work of 2000 h/year and lead thickness exceeding 1.5 cm, the highest value of annual dose was derived as 13.2 mSv. In terms of internal exposure, the initial year dose was estimated to be 1.14E+03 mSv when conservatively 100% of the nuclides were assumed to leak. The allowable outflow rate was derived as 7.77E-02% and 2.00E-01% for the average limit of 20 mSv and the maximum limit of 50 mSv, respectively, where the annual replacement of the worker was required for 50 mSv.

• 환경위생공학
• /
• 제16권1호
• /
• pp.91-101
• /
• 2001

In order to propose a optimum method increasing accuracy and reproducibility in analysis of urine lead levels, we compared matrix modifier addition method and microwave digestion method. The results were as follows ; 1. Where the concentration of $Pd(NO_3)_2$(matrix modifier) was $50mg/{\ell}$, and ashing temperature was $900^{\circ}C$, the results were optimum. In case of matrix modifier addition method, the average coefficient of variation (CV) of normal man was 24.1%, and lead worker was 7.9%. The average urine lead levels of standard were $10.42\mu{g}/{\ell}$ and $19.89\mu{g}/{\ell}$ , the accuracies compared to reference values were 97.0% and 92.6%, respectively. 2. Microwave digestion temperature($160~180^{\circ}C$), time(15~25min) and the ratio of urine/ashing acid(1:1~4:1) did not significantly affect lead absorbance and background absorbance. Therefore we set up a optimum analytical conditions as follows: temperature, $160^{\circ}C$; time, 15min; the ratio of urine/ashing acid, 4:1. after samples were digested by the above analytical conditions, lead absorbance and background absorbance was measured at $450^{\circ}C$ as ashing temperature. The average coefficient of variation (CV) of normal man was 12.4%, and lead worker was 6.2%. The average urine lead levels of standard urine were $10.66\mu{g}/{\ell}$ and $23.31\mu{g}/{\ell}$, the accuracies compared to reference values were 99.3% and 103.9%, respectively. From the results, we suggest that microwave digestion method is a more favorable method than matrix modifier addition method because of easiness to reduce organic matter, possibility to analysis at low temperature and accuracy.

• 대한안전경영과학회지
• /
• 제8권3호
• /
• pp.67-75
• /
• 2006

Scheduling of dismantling old research reactor need to consider time, cost and safety for the worker. The biggest issue when dismantling facility for research reactor is safety for the worker and cost. Large portion of a budget is spending for the labor cost. To save labor cost for the worker, reducing a lead time is inevitable. Several algorithms applied to reduce read time, and safety considered as the most important factor for this project. This research presents three different dismantling scheduling scenarios. Best scenario shows the specific scheduling for worker and machine, so that it could save time and cost.

• 산업보건소식
• /
• 제46호
• /
• pp.3-13
• /
• 1987

For the purpose of investigating the effect of occupational health service in terms of environmental control and health provision of workers on the improvement of worker's health, authors analysed the data of environmental measurement and health check-up of one lead using industry who started his investment to environmental improvement from 1980. Six hundred million won was invested for environmental improvement from 1980 to 1986. This investment brought about apparent improvement of working conditions of all of the workplaces from mean concentration of lead in air over 0.15mg/$m^3$ 1981 to mean concentration of lead in air less than 0.15mg/$m^3$. Environmental control reduced mean blood lead level from 51.2 $\pm$ 11.5ug/이 in 1983 to 39.2 $\pm$ 16.0ug/dl in 1986, and delta-aminolevulinic acid concentration 3.15 $\pm$ 2.1mg/l in 1982 to 1.96 $\pm$ 1. 7mg/l in 1986, respectively. Blood ZPP levels were decreased from 76.1 $\pm$ 58.9ug/dl in 1983 to 42.23 $\pm$ 30.3ug/dl in 1986. If 150ug/dl of blood ZPP is considered as unacceptable limit of lead intoxication, more than 10 percent of workers belonged to this category in 1983, but only 0.5 of workers showed their blood ZPP level over the 150ug/dl in 1986 It was observed that no workers whose work duration were less than one year showed their blood ZPP level over 100ug/dl, but there were high percentages of lead workers with high blood ZPP (over 150 ug/dl) who were working in uncontrolled had working condition and whose work duration were less than one year.

• 한국산업보건학회지
• /
• 제21권4호
• /
• pp.193-200
• /
• 2011

Objectives: Blood lead and hyperhomocysteinemia have been found to be associated with cardiovascular disease. The objective of the present study was to assess the relationship of lead biomarkers on plasma homocysteine and blood pressure. Methods: To evaluate the effect of lead biomarkers including blood lead on plasma homocysteine and blood pressure in retired lead workers, 66 retired lead workers without any occupational exposure to organic solvent, mercury and arsenic were agreed to participate this study. For the control subjects 42 controls were recruited from same area of retired lead workers with consideration of demographic characteristics. Results: The mean levels of blood lead and ZPP of retired lead workers were significantly higher than control group. There were positive significant correlations between blood lead and plasma homocysteine, also systolic and diastolic blood pressure. The multiple linear regression analysis also reveled that plasma homocysteine was significantly associated with blood lead after adjusting for age, gender, body mass index, lead exposure, smoking and drinking. Diastolic blood pressure was significantly associated with blood lead, plasma homocysteine, and total cholesterol; whereas, systolic blood pressure was significantly associated with plasma homocysteine only. Conclusions: Blood lead showed significant association with plasma homocysteine and blood pressure even after more than mean 10 years from their retirements.

• 한국산업보건학회지
• /
• 제11권2호
• /
• pp.111-117
• /
• 2001

A cross-sectional study was performed to evaluate associations between lead biomarkers, lead-related symptoms, and ${\delta}$-aminolevulinic acid dehydratase (ALAD) genotype among 598 lead workers and 144 control office workers in storage battery industries, secondary smelting and litharge making industries. Lead inhibits the second enzymes, ALAD, in the heme synthesis pathway. ALAD gene, which codes for one of three isozymic proteins (termed ALAD1-1, ALAD1-2, and ALAD2-2), seems to modify the toxicokinetics of lead. The result as follows; The percents of total workers whose genotype of ALAD1-1 and ALAD1-2 were 88.4% and 11.6%, respectively. The zinc protoporphyrin in blood (ZPP) and ${\delta}$-aminolevulinic acid in urine (ALAU) of lead workers with ALAD1-2 were significantly lower than those of lead workers with ALAD1-1, but there were no significant difference between two genotype for blood lead, age, and work duration. The proportion of ALAD1-2 genotype in control office workers was 13.2%. The proportions of ALAD1-2 genotype of lead workers were 14.0%(their mean air lead level below $0.024mg/m^3$), 10.4%($0.025-0.049mg/m^3$), 11.8%($0.050-0.099mg/m^3$), and 9.4%(above $0.100mg/m^3$), respectively. In the logistic analysis of 15 lead related symptoms, 'arthralgia'(S7) symptom of ALAD1-2 was significantly lower (OR=0.481; 95% CI=0.248-0.932) than that of ALAD1-1, but 'feeling of irritation'(S11) of ALAD1-2 was significantly higher(OR=1.636; 95% CI=1.035-2.586) than that of ALAD1-1 after controlling possible confounder (blood lead, work duration, smoking and drinking habit).

• 환경위생공학
• /
• 제18권1호
• /
• pp.30-40
• /
• 2003

The study subjects included the workers who were estimated to have been exposed in a low density of lead-laden glaze from pottery manufacturers. They were evaluated in terms of PbB and PbU as indices of lead concentration in the body, and Hb, Hct, ALAD, and FEP as indices of biochemical lead poisoning. Consequently, the study results revealed the relationship between each of indices and its effectiveness to indicate the degree of occupational lead exposure. 1. The mean of PbB was $22.85{\;}{\mu}g/d{\ell}$(range; $4.2~44.7{\;}{\mu}g/d{\ell}$) and PbU $45.69{\mu}g/d{\ell}$(range; $6.7~87.5{\mu}g/d{\ell}$), to indicate the level of lead exposure in the subjects. 2. While there was a high, linear correlation between PbB, PbU and FEP (r=0.835, r=0.855, respectively), a low correlation existed between PbB and ALAD(r=-0.240). 3. While there was a high, linear correlation between PbU and FEP(r=0.825), a low correlation existed between PbU and ALAD(r=-0.352). The above results suggest that FEP can be used as a highly useful biochemical index of lead poisoning, based on its high correlation with PbB and PbU indicating lead concentration in the body.

• 국제학술발표논문집
• /
• The 6th International Conference on Construction Engineering and Project Management
• /
• pp.336-338
• /
• 2015

This research is to propose an applicable framework for real-time health surveillance and safety monitoring at construction sites. First this study aims at finding (1) a framework for health surveillance that is likely to benefit employers and employees in the industry, (2) a valid way to identify factors or conditions with potential health concerns that can occur under particular work conditions, (3) An effective way to apply wireless/mobile sensors to construction workers using real-time/live data transmission methods, and (4) A relationship between a worker's vital signs and job site environment. Biosensors for physiological response and devices for weather/work related data are to collect real-time data. Relationships between jobs and physiological responses are analyzed and factors that touched particularly contributing to certain responses are identified. When data are incorporated with tasks, factors affecting tasks can be identified to estimate the magnitude of the factors. By comparing work and normal responses possible precautionary actions can be considered. In addition, the study would be lead to improving (1) trade-specific dynamic work schedules for workers which would be based on various factors affecting worker health level and (2) reevaluating worker productivity with health status and work schedule, thereby seeking ways to maximize worker productivity. Through a study, the paper presents expected benefits of implementing health monitoring.

• 한국산업보건학회지
• /
• 제29권2호
• /
• pp.195-207
• /
• 2019

Objectives: This study was performed to confirm whether plasma lead can be used as a chronic biomarker for the biological monitoring of exposure to lead. Methods: Lead concentrations in 66 plasma samples from retired lead workers (G.M. 60.25 years, Median 61.00 years) and 42 plasma samples from the general population (G.M. 53.76 years, Median 56.50 years) were measured using ICP/Mass. Tibia, whole blood, hemoglobin, hematocrit, and blood zinc protophorphyrin (ZPP) concentrations and urinary ${\delta}$-aminolevulinic acid (${\delta}-ALA$) were measured for correlation analysis with plasma lead. Results: The geometric mean concentration of lead in plasma was $0.23{\mu}g/L$ for the retired lead workers and $0.10{\mu}g/L$ for the general population sample. A simple correlation analysis of biomarkers showed that plasma lead concentration among the retired lead workers was highly correlated with lead concentration in the tibia and with blood lead concentration, and the plasma lead concentration among the general population correlated with ZPP concentration in the blood. The lead concentration in the tibia and the lead concentration in the whole blood increased with length of working period. As the period in the lead workplace increased, the ratio of lead in plasma to lead concentration in whole blood decreased. Conclusion: This study confirmed the possibility of a chronic biomarker of lead concentration in blood plasma as a biomarker. In the future, comparative studies with specific indicators will lead to more fruitful results.