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Association between the lead exposure index and plasma homocysteine, and blood pressure in retired lead workers  

Kim, Nam-Soo (Institute of Environmental and Occupational Medicine, Soonchunhyang University)
Jung, Kyung-Sick (Institute of Environmental and Occupational Medicine, Soonchunhyang University)
Lee, Byung-Kook (Institute of Environmental and Occupational Medicine, Soonchunhyang University)
Publication Information
Journal of Korean Society of Occupational and Environmental Hygiene / v.21, no.4, 2011 , pp. 193-200 More about this Journal
Abstract
Objectives: Blood lead and hyperhomocysteinemia have been found to be associated with cardiovascular disease. The objective of the present study was to assess the relationship of lead biomarkers on plasma homocysteine and blood pressure. Methods: To evaluate the effect of lead biomarkers including blood lead on plasma homocysteine and blood pressure in retired lead workers, 66 retired lead workers without any occupational exposure to organic solvent, mercury and arsenic were agreed to participate this study. For the control subjects 42 controls were recruited from same area of retired lead workers with consideration of demographic characteristics. Results: The mean levels of blood lead and ZPP of retired lead workers were significantly higher than control group. There were positive significant correlations between blood lead and plasma homocysteine, also systolic and diastolic blood pressure. The multiple linear regression analysis also reveled that plasma homocysteine was significantly associated with blood lead after adjusting for age, gender, body mass index, lead exposure, smoking and drinking. Diastolic blood pressure was significantly associated with blood lead, plasma homocysteine, and total cholesterol; whereas, systolic blood pressure was significantly associated with plasma homocysteine only. Conclusions: Blood lead showed significant association with plasma homocysteine and blood pressure even after more than mean 10 years from their retirements.
Keywords
plasma homocysteine; blood pressure; retired lead worker;
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Times Cited By KSCI : 2  (Citation Analysis)
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