• BMB Reports
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• v.40 no.4
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• pp.547-553
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• 2007

Many motifs along the 1.2 kb myostatin promoter (MSTNpro) in sheep have been found by the MatInspecter program in our recent study. To further verify the role of the motifs and better understand the transcriptional regulation mechanism of the myostatin gene in sheep, the reporter gene EGFP (enhanced green fluorescent protein) was selected and the wild-type (W) vector MSTNPro$^W$-EGFP or motif-mutational (M) vector MSTNPro$^M$-EGFP were constructed. The transcriptional regulation activities were analyzed by detecting the fluorescence strength of EGFP in C2C12 myoblasts transfected with the vectors. The results showed that E-box (E) 3, E4, E5 and E7, particularly E3, E5 and E7, had important effects on the activity of the 1.2 kb sheep myostatin promoter. In addition, we also detected several other important motifs such as MTBF (muscle-specific Mt binding factor), MEF2 (myocyte enhancer factor 2), GRE (glucocorticoid response elements) and PRE (progesterone response elements) along the sheep myostatin promoter by the mutational analysis.

• Nuclear Engineering and Technology
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• v.52 no.8
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• pp.1661-1668
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• 2020

A physical protection system (PPS) is used for the protection of critical facilities. This paper proposes a structure analytic hierarchy approach (SAHA) for the hierarchical evaluation of the PPS effectiveness in critical infrastructure. SAHA is based on the traditional analysis methods "estimate of adversary sequence interruption, EASI". A community algorithm is used in the building of the SAHA model. SAHA is applied to cluster the associated protection elements for the topological design of complicated PPS with graphical vertexes equivalent to protection elements.

• Nuclear Engineering and Technology
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• v.52 no.10
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• pp.2290-2298
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• 2020

The damage of first wall material in fusion reactor due to the bubbles caused by plasma has been studied by introducing a relation between the von Mises equivalent stress and the temperature field. The locations and shapes of the bubbles and the synergetic effect between the different bubbles under steady operational conditions have been studied using the finite elements method. Under transient heat loads, plastic deformations have been found to occur, and are significantly enhanced by the presence of the bubbles. The calculated concentration locations of von Mises equivalent stress are well consistent with the observed crack positions of the tungsten surface in many test experiments. Our simulations show that the damage of the bubbles is not severe enough to lead to catastrophic failure of the tungsten armor; however, it can cause local and gradual detachment of tungsten surface, which provides a reasonable explanation for the observed pits and rough or hairy surface morphology etc. Considering the transient heat loads, the lower bound of the security thickness of the tungsten tile is estimated to be greater than 2 mm.

• Research in Plant Disease
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• v.24 no.2
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• pp.87-98
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• 2018

The fungal species contain diverse transposable elements and repetitive sequences up to ~10% of their genome. It has been reported that distribution of transposable elements tends to correlate with the host range of the pathogen. Moreover, transposable elements cause the loss of an avirulence gene in the pathogen, which resulted in disease on a resistance cultivar. Thus, the transposable elements in the fungal pathogens may be one of the key factors driving the plant-fungus interactive evolution. In this article, we reviewed classification and biological functions of transposable elements in Magnaporthe species.

• Geomechanics and Engineering
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• v.13 no.3
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• pp.489-504
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• 2017

The localized shear and the slip lines are easily observed in elastic-brittle-plastic rock. After yielding, the strength of the brittle rock suddenly drops from the peak value to the residual value, and there are slip lines which divide the macro rock into numbers of elements. There are slippages of elements along the slip lines and the displacement field in the plastic region is discontinuous. With some restraints, the discontinuities can be described by the combination of two smooth functions, one is for the meaning of averaging the original function, and the other is for characterizing the breaks of the original function. The slip lines around the circular opening in the plastic region of an isotropic H-B rock which subjected to a hydrostatic in situ stress can be described by the logarithmic spirals. After failure, the deformation mechanism of the plastic region is mainly attributed to the slippage, and a slippage parameter is introduced. A new analytical solution is presented for the plane strain analysis of displacements around circular openings. The displacements obtained by using the new solution are found to be well coincide with the exact solutions from the published sources.

• Structural Engineering and Mechanics
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• v.81 no.2
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• pp.179-194
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• 2022

The bending, buckling and free vibration responses of functionally graded material (FGM) beams are investigated semi-analytically by the scaled boundary finite element method (SBFEM) in this paper. In the concepts of the SBFEM, the dimension of computational domain can be reduced by one, therefore only the axial dimension of the beam is discretized using the higher order spectral element, which reduces the amount of calculation and greatly improves the calculation efficiency. The governing equation of FGM beams is derived in detail by the means of the principle of virtual work. Compared with the higher-order beam theory, fewer parameters and simpler control equations are used. And the governing equation is transformed into a first-order ordinary differential equation by introducing intermediate variables. Analytical solutions of the governing equation can be obtained by pade series expansion in the direction of thickness. Numerical example are compared with the numerical solutions provided by the previous researchers to verify the accuracy and applicability of the proposed method. The results show that the proposed formulations can quickly converge to the reference solutions by increasing the order of higher order spectral elements, and high accuracy can be achieved by using a small number of the elements. In addition, the influence of the structural sizes, material properties and boundary conditions on the mechanical behaviors of FG beams subjected to different load types is discussed.

• Journal of Korean Society of Archives and Records Management
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• v.20 no.1
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• pp.27-46
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• 2020

The need for changes in archival studies curriculum has been steadily raised because of the wide variation of the curriculum in each graduate school. In this study, the foreign archival studies guidelines and certification standards were compared and analyzed to derive key categories and elements for developing the Korean guidelines for a graduate program in archival studies. The five key categories and elements of the guideline include introduction, mission and goal, knowledge categories, administrative factors, and conclusion. On the other hand, the 10 knowledge categories to be learned by archivists include ① The Nature of Records and Archives, ② Selection, Appraisal, and Acquisition, ③ Arrangement and Description, ④ Preservation, ⑤ Reference and Access, ⑥ Outreach, Instruction, and Advocacy, ⑦ Management and Administration, ⑧ Social and Cultural Systems, ⑨ Legal and Financial Systems, and ⑩ Information Technology. In the future, knowledge categories need to be actively reflected by the opinions of the academic community and archivists to improve the graduate curriculum.

• Korea Journal of Hospital Management
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• v.22 no.3
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• pp.118-132
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• 2017

This study developed key elements of dental service guidelines for the disabled patients. In order to provide consumer-oriented service guidelines for the dental patients with disability, service design method was applied. Using service design method guided by the double diamond design process, this study implemented consumer survey, observation, and contextual interviews for consumers' needs assessment. And customer journey map, mind maps, and blueprints were utilized to visualize consumer needs and guidelines for dental care services for the disabled. According to the study, disabled consumers have needs for expertise of the medical staff, dental care institutions specialized on the disabled, financial support, establishment of the facilities for the disabled, comfortable atmosphere in the institutions, and communication with medical staffs. Based on the needs of the disabled, 5 key elements of the dental care services were developed: convenience, expertise, empathy, financial support, and education and management. And service design guidelines were proposed to implement key elements of dental care services for the patients with disability. This study is significant in that it is the first attempt to apply the service design technique from the consumer perspectives in the field of dental care for the disabled. Furthermore the process of this study has become a reference that can be utilized and applied to other medical institution.

• Journal of the Optical Society of Korea
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• v.17 no.5
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• pp.447-453
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• 2013

A micro zoom system without moving elements by use of two liquid lenses is designed and optimized in this paper. The zoom equations of the system composed of two liquid lenses are deduced. The structure parameters including radius and thickness of a conical double-liquid electrowetting based lens are analyzed and calculated. Because the liquid thickness varies non-linearly with the radius of the interface, it's very difficult to optimize a real liquid lens using commercial optical design software directly. Through the Application Programming Interface (API) of the optical design software CODE V, a zoom system with two real electrowetting based liquid lenses is modeled and optimized. A two-liquid-lens zoom system without moving elements, with a zoom factor of 1.8 and a compact structure of 10 mm is designed for illustration. This can be useful for the camera design of mobile phones, tablets and so on. And this paper presents a convenient way of designing and optimizing a zoom system including liquid lenses by commercial optical design software.

• Design Convergence Study
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• v.18 no.4
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• pp.1-15
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• 2019

As the game industry is steadily becoming the spotlight industry, the importance of user experience design in game industry is increasing. This study tried to approach game from the viewpoint of user experience design and aimed to analyze the onboarding process focusing on user accessibility and retention in an online game. First, through literature review, onboarding process was devided into three stages. Then each stages were analyzed into experience design, game design elements to derive the key UX factors. Second, based on the UX elements, the game experience and cognitive element analysis frame was presented. With this frame, five domestic online games were qualitatively analyzed and cognitive elements of each game's onboarding process were derived. Key cognitive factors in each stages were, selective attention in the discovery stage, working memory and active learning in the learning stage, and participation and motivation in the immersion stage. Finally, improvement direction were presented, focusing on the key cognitive factors. These studies highlight the importance of the user entry process in online games and suggests improvements to lower entry barriers.