• 한국구조물진단유지관리공학회 논문집
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• 제17권5호
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• pp.13-20
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• 2013

구조물의 지진응답을 저감시키기 위하여 추가적인 감쇠기나 진동제어장치가 일반적으로 사용된다. 이때, 추가적인 감쇠장치의 제어성능은 대상구조물 특성의 변화 없이 검토된다. 본 연구에서는 구조물과 스마트 제어장치의 다목적 통합최적화를 수행하였고 스마트 최상층 면진시스템이 설치된 구조물의 구조물량 저감의 가능성을 분석하였다. 이를 위하여 20층 예제구조물이 사용되었으며 MR 감쇠기와 저감쇠 탄성베어링을 사용하여 스마트 면진시스템을 구성하였다. 중약진지역의 설계스펙트럼을 바탕으로 생성된 인공지진하중을 사용하여 구조해석을 수행하였다. 수치해석결과, 스마트 최상층 면진시스템이 중약진지역에 있는 구조물의 응답과 면진층 변위를 동시에 효과적으로 줄일 수 있는 것을 확인하였다. 본 연구에서 제안된 통합최적설계기법으로 구조물량 및 감쇠기 용량을 적절하게 줄이면서도 우수한 제어성능을 발휘하는 다양한 설계 대안을 제공할 수 있었다.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.253-263
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• 2023

The biogenesis and biological roles of extracellular vesicles (EVs) in the progression of liver diseases have attracted considerable attention in recent years. EVs are membrane-bound nanosized vesicles found in different types of body fluids and contain various bioactive materials, including proteins, lipids, nucleic acids, and mitochondrial DNA. Based on their origin and biogenesis, EVs can be classified as apoptotic bodies, microvesicles, and exosomes. Among these, exosomes are the smallest EVs (30-150 nm in diameter), which play a significant role in cell-to-cell communication and epigenetic regulation. Moreover, exosomal content analysis can reveal the functional state of the parental cell. Therefore, exosomes can be applied to various purposes, including disease diagnosis and treatment, drug delivery, cell-free vaccines, and regenerative medicine. However, exosome-related research faces two major limitations: isolation of exosomes with high yield and purity and distinction of exosomes from other EVs (especially microvesicles). No standardized exosome isolation method has been established to date; however, various exosome isolation strategies have been proposed to investigate their biological roles. Exosome-mediated intercellular communications are known to be involved in alcoholic liver disease and nonalcoholic fatty liver disease development. Damaged hepatocytes or nonparenchymal cells release large numbers of exosomes that promote the progression of inflammation and fibrogenesis through interactions with neighboring cells. Exosomes are expected to provide insight on the progression of liver disease. Here, we review the biogenesis of exosomes, exosome isolation techniques, and biological roles of exosomes in alcoholic liver disease and nonalcoholic fatty liver disease.

• Earthquakes and Structures
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• 제24권4호
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• pp.259-274
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• 2023

In this paper, mechanical properties of periodic foundation made of concrete and rubber are investigated by a parametric study using the finite element method (FEM). Periodic foundation is a special type of seismic isolation foundation used in civil engineering, which is inspired by the meso-scale structure of phononic crystals in solid-state physics. This type of foundation is capable of reducing the seismic wave propagating though the foundation, therefore providing additional protection for the structures. In the FEM analysis, layered periodic foundation is frequently modelled due to its simplicity in numerical modeling. However, the isolation effect of periodic foundation on nuclear power plant has not been fully discussed to the best knowledge of authors. In this work, we construct four numerical models of nuclear power plant with different foundations to investigate the seismic isolation effects of periodic foundations. The results show that the layered periodic foundation can increase the natural period of the nuclear power plant like traditional base isolation systems, which is beneficial to the structures. In addition, the seismic response of the nuclear power plant can also be effectively reduced in both vertical and horizontal directions when the frequencies of the incident waves fall into some specific frequency bandgaps of the periodic foundation. Furthermore, it is demonstrated that the layered periodic foundation can reduce the amplitude of the floor response spectrum, which plays an important role in the protection of the equipment.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2000년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall 2000
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• pp.432-439
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• 2000

According as ground acceleration becomes to exceed gravity acceleration recently, design is impossible or economical efficiency is poor in existing seismic design method. So increase of seismic isolated bridges is currently in progress. However, because base isolation design method is developed in high seismic regions. it may not be compatible in Korea. Therefore, this research has objective to evaluate ductility of pier and response modification factor according to the ductility of pier in seismic isolated bridges and to adapt to seismic characteristics in Korea. For this purpose, nonlinear analysis is accomplished with so many time histories derived from spectral density function compatible with response spectrum described in the design code and base isolation system modeled linear system, bi-linear system, and friction system. Through application of the proposed method, we had result that it may be compatible that response modification factor for the seismic isolated bridges is smaller than half of that for the conventional bridges when natural period of structures exceeds proper level.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1239-1243
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• 2005

A multipath mitigation method using the fault detection and isolation technique is proposed for the CDGPS. The base station is assumed to be immune to the effect of the multipath. With this reasonable assumption, the effect of multipath in moving station is mitigated. For that, the double difference measurement is produced, and then another additional difference between code pseudorange and acclumulated carrier phase is calculated. The test statistic is constituted with those differences. The hypothesis testing is applied to that test statistic. The proposed test statistic makes use of the effect of multipath in code pseudoranges and it does not use time differences. Therefore the detection ability for multipath is improved in most environments. However, the increased number of differences makes the measurement noises larger. The performance of the method is compared with that of the conventional parity space method with code pseudorange.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.669-674
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• 2004

In this study, the analytical method to evaluate the response of rotor-bearing system subjected to base excitation was presented. The equations of motion contain speed dependent gyroscopic terms, base rotation dependent parametric terms and several forcing function terms which depend on linear accelerations, rotational accelerations and a combination of linear and rotational combination. The study of rotor-bearing system excited by its base motion is not only able to predict the rotational performance, but provides the fundamental data for vibration isolation. In order to illustrate transient response, transient response analysis of a practical application sample were performed. The transient response was carried out for the given base excitation by using the state-space Newmark method that incorporates the average velocity concept.

• 전기학회논문지
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• 제56권12호
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• pp.2240-2246
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• 2007

Optically coupled linear isolation amplifier requires special care to avoid oscillation in actual applications. In this paper methods to analyze the frequency characteristics of the amplifier are proposed to reveal the cause of oscillation and to provide design guidelines. The loop gain of the amplifier obtained through the equivalent circuit model shows that the phase margin is too small to ensure stable operations. Methods to get non-oscillatory response are proposed and the resulting frequency responses are analyzed. The common method adding a small capacitor to the amplifier is shown to degrade the frequency bandwidth. The frequency response of output voltage explains the need of filter capacitor in output stage. The usefulness of the method is verified through experiments.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 1999년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall
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• pp.220-227
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• 1999

The Purpose of this paper is to evaluate the buckling strength of conceptually designed KALIMER reactor vessel. For evaluation of the buckling load buckling load the design equations and the finite element analysis are used. In finite element method the eigenvalue buckling analysis nonlinear elastic buckling analysis using snap-through buckling method and nonlinear elastic-plastic buckling analysis are carried out. the calculated buckling loads of KALIMER reactor vessel using the finite element method are in well agreement with those of the design equations. From the calculated results of buckling load in KALIMER rector vessel it is shown that the plasticity of vessel materials significantly affects the buckling load but the initial imperfection has little effects, In checking the limits of bucking load of KALIMER reactor vessel using the ASME B & PV Section III. Subsection NH the non-seismic isolation design can not satisfy the buckling limit requirements but the seismic isolation design can sufficiently satisfy the requirements.

• 한국항해항만학회지
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• 제32권2호
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• pp.133-140
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• 2008

In this paper, a fault detection method for operator failures using the observation technique is proposed. The suggested algorithm is extended using the conventional sensor/actuator fault detection method. First, it is assumed that operator failure affects human work operations, as it is an external input signal. With this assumption, a human work model with operator failure is suggested. Second, an unknown input observer with proportional and integral gains is introduced. The characteristic of this observer of estimating an external signal without an exact input is shown, and the conditions for the detection of an operator failure are proposed. Finally, by simulating the container crane operations, it is verified that the observer can accurately detect an operator failure and estimate its magnitude from the given internal signal.

• 대한임베디드공학회논문지
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• 제9권5호
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• pp.253-260
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• 2014

European Space Agency has recognized Integrated Modular Avionics and ARINC specification 653 as avionics computer system for space application. Integrated Modular Avionics specification reduces the space by integrating a system composed of many electronic devices into a computer. recent researches have been studying how to apply the ARINC 653 into an open source operating system, such as Linux. These studies have concentrated on partition scheduling for time separation. However, requirements to guarantee spatial separation should be further analyzed to ensure deterministic execution time. Therefore, memory management is needed to verify spatial isolation on Linux systems. This research proposes a new method to accomplish spatial isolation for the ARINC 653 specification in Linux. We have added new data structures and system calls to handle functionalities for spatial separation. They are used during the partition startup process. The proposed method was evaluated on the LEON4 processor, which is the next generation microprocessor to be used in the future space missions. All implementations confirm that spatial isolation of the ARINC 653 specification was accomplished.